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1.
Br J Hosp Med (Lond) ; 85(4): 1-8, 2024 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-38708977

RESUMO

Skin ageing is a multifaceted process impacted by both intrinsic and extrinsic factors. Drier and less elastic skin with declining sebum levels in older age makes ageing skin more vulnerable to various skin conditions, including infections, inflammatory dermatoses, and cancers. Skin problems are common among older adults due to the effects of ageing, polypharmacy and multimorbidity impacting not only physical health but wellbeing and quality of life. In the UK, older adults in geriatric medicine wards may present with various skin conditions. Hospitalised older individuals may have undiagnosed skin problems unrelated to their admission, making hospitalisation an opportunity to manage unmet needs. Asteatotic eczema, incontinence associated dermatitis, seborrhoeic dermatitis, chronic venous insufficiency, and cellulitis are common disorders clinicians encounter in the geriatric medicine wards. This article outlines the importance of performing comprehensive skin assessments to help diagnose and commence management for these common conditions.


Assuntos
Dermatopatias , Humanos , Idoso , Dermatopatias/terapia , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Envelhecimento da Pele , Eczema/diagnóstico , Eczema/terapia , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/terapia , Dermatite Seborreica/terapia , Dermatite Seborreica/diagnóstico , Insuficiência Venosa/terapia , Insuficiência Venosa/complicações , Insuficiência Venosa/diagnóstico
2.
Br J Nurs ; 33(3): 104-108, 2024 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-38335106

RESUMO

This case study describes the successful management of a patient with primary lymphoedema, who was experiencing lymphorrhoea and epidermolysis, using a multidisciplinary approach. The patient had Klippel-Trenaunay syndrome. The multidisciplinary team, in an outpatient clinic in Japan, included a certified lymphoedema therapist, plastic surgeons, and a wound, ostomy and continence nurse. The team performed complex physical therapy and lymphaticovenular anastomosis, which promoted the resolution of the lymphorrhoea. This resulted in improvements in skin condition, the prevention of recurrent cellulitis, and no increase in limb circumferences during the 1-year follow-up period. This report highlights the importance of a multidisciplinary approach to lymphoedema management, including lymphorrhoea control that fitted in with the patient's daily life. It is hoped that this article will contribute to the improvement of the quality of life of patients with lymphoedema.


Assuntos
Linfedema , Qualidade de Vida , Humanos , Linfedema/prevenção & controle , Celulite (Flegmão)/terapia , Anastomose Cirúrgica/métodos , Convulsões
3.
Nurs Stand ; 39(2): 39-44, 2024 01 31.
Artigo em Inglês | MEDLINE | ID: mdl-38044818

RESUMO

Cellulitis is an acute bacterial infection that affects the deep dermis and surrounding subcutaneous tissue. Although it is a common condition, it is often misdiagnosed because it can mimic a range of conditions that also cause inflamed, red, irritated and painful skin. Such misdiagnoses may lead to unnecessary hospital admissions and antibiotic overuse, with most alternative diagnoses being non-infectious. Undertaking a holistic patient assessment, skin assessment and thorough clinical history is important in the diagnosis of cellulitis, and it is vital to use a collaborative multidisciplinary approach in its acute management and to prevent recurrence. This article defines the term cellulitis and explores its presenting features. The author also discusses the associated risk factors, clinical assessment techniques and effective management strategies, as well as outlining the actions that nurses can take to prevent recurrence.


Assuntos
Antibacterianos , Celulite (Flegmão) , Humanos , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/terapia , Celulite (Flegmão)/induzido quimicamente , Antibacterianos/uso terapêutico , Hospitalização , Erros de Diagnóstico/prevenção & controle , Diagnóstico Diferencial
4.
Medicine (Baltimore) ; 102(46): e36011, 2023 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-37986390

RESUMO

RATIONALE: Klipple-Trenaunary Syndrome (KTS) complicated by frequent cellulitis of lower extremity seriously affects a patient quality of life. The hemodynamic characteristics of the disease are still unclear. Direct skin incision or puncture to remove malformed veins at the lesion site carries the risk of non-healing of the surgical incision. Our aim is to explore initial management strategies based on the hemodynamic characteristics of this disease. PATIENT CONCERNS: A 29-year-old Manchu man was affected by KTS from childhood, characterized by an increase of the circumference and superficial varicose veins of the lower extremity. In the past 5 years, he suffered from frequent cellulitis in the left leg every 15 days or so. DIAGNOSES: KTS complicated by frequent cellulitis of lower extremity. INTERVENTIONS: The clinical and hemodynamic characteristics of KTS were evaluated by Doppler ultrasonography (DUS) combined with CT venography (CTV), and foam sclerotherapy and postoperative elastic bandage compression were performed accordingly. OUTCOMES: Based on evaluations, the reason for frequent cellulitis was the continuous increase of venous hypertension in the calf caused by the malformed superficial vein and its penetrating vein. After 3 operations, the patient had no recurrence of cellulitis of the leg. Follow-up for 1 year showed no recurrence of left leg cellulitis. LESSONS: This report emphasizes that foam sclerotherapy can significantly improve the clinical symptoms of KTS, such as cellulitis, and provide a safe skin environment for the implementation of other surgical methods, based on the evaluation of the pathological characteristics of KTS by DUS combined with CTV.


Assuntos
Escleroterapia , Varizes , Adulto , Humanos , Masculino , Celulite (Flegmão)/complicações , Celulite (Flegmão)/terapia , Extremidade Inferior , Qualidade de Vida , Veia Safena/cirurgia , Escleroterapia/métodos , Síndrome , Resultado do Tratamento , Varizes/complicações , Varizes/terapia
5.
Artigo em Inglês | MEDLINE | ID: mdl-36981782

RESUMO

The most common cause of the development of odontogenic infection is untreated dental caries, which initially leads to pulpitis. If an odontogenic infection is left untreated, it will pass through the limiting bone plate and will infiltrate deeper structures. Odontogenic infections are different in adults and children. The study was conducted at the Department of Pediatric Otolaryngology and Pediatric Head and Neck Surgery of Upper Silesian Children's Health Center in Katowice in the 2020-2022. We included 27 patients aged 2-16 in the study. Patients were diagnosed with an active, acute odontogenic inflammatory process in the head and neck area. We assessed pain, trismus, extraoral and intraoral swelling and the level of CRP [C Reactive Protein], WBC [White Blood Cells], NLR [Neutrophil Lymphocyte Ratio], D-dimers and Prealbumins. The results were analyzed in terms of the location of the source of inflammation: maxilla or mandible and the type of source of infection: deciduous tooth or permanent tooth. Deciduous teeth are more often the cause of odontogenic infection in the maxilla, while permanent teeth in the mandible. Trismus, extraoral, and intraoral swelling occurred in all infections caused by permanent teeth. The CRP and NLR ratio is statistically higher in infection, which originates from permanent teeth. The mean hospitalization time was also longer for infections from permanent teeth 3.42 days than for deciduous teeth 2.2 days. The varied clinical picture of odontogenic infections in children requires periodic analyzes of statistical data related to epidemiology, etiology, and symptomatology in order to update diagnostic and therapeutic procedures.


Assuntos
Celulite (Flegmão) , Cárie Dentária , Adulto , Criança , Humanos , Celulite (Flegmão)/epidemiologia , Celulite (Flegmão)/etiologia , Celulite (Flegmão)/terapia , Trismo/complicações , Cárie Dentária/epidemiologia , Cárie Dentária/terapia , Cárie Dentária/complicações , Hospitalização , Face , Edema/etiologia
6.
Am J Emerg Med ; 68: 1-9, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-36893591

RESUMO

INTRODUCTION: Orbital cellulitis is an uncommon but serious condition that carries with it a potential for significant morbidity. OBJECTIVE: This review highlights the pearls and pitfalls of orbital cellulitis, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence. DISCUSSION: Orbital cellulitis refers to infection of the globe and surrounding soft tissues posterior to the orbital septum. Orbital cellulitis is typically caused by local spread from sinusitis but can also be caused by local trauma or dental infection. It is more common in pediatric patients compared to adults. Emergency clinicians should first assess for and manage other critical, sight-threatening complications such as orbital compartment syndrome (OCS). Following this assessment, a focused eye examination is necessary. Though orbital cellulitis is primarily a clinical diagnosis, computed tomography (CT) of the brain and orbits with and without contrast is critical for evaluation of complications such as abscess or intracranial extension. Magnetic resonance imaging (MRI) of the brain and orbits with and without contrast should be performed in cases of suspected orbital cellulitis in which CT is non-diagnostic. While point-of-care ultrasound (POCUS) may be useful in differentiating preseptal from orbital cellulitis, it cannot exclude intracranial extension of infection. Management includes early administration of broad-spectrum antibiotics and ophthalmology consultation. The use of steroids is controversial. In cases of intracranial extension of infection (e.g., cavernous sinus thrombosis, abscess, or meningitis), neurosurgery should be consulted. CONCLUSION: An understanding of orbital cellulitis can assist emergency clinicians in diagnosing and managing this sight-threatening infectious process.


Assuntos
Oftalmologia , Celulite Orbitária , Doenças Orbitárias , Adulto , Criança , Humanos , Celulite Orbitária/diagnóstico por imagem , Celulite Orbitária/etiologia , Abscesso/tratamento farmacológico , Prevalência , Órbita/diagnóstico por imagem , Antibacterianos/uso terapêutico , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/terapia , Doenças Orbitárias/diagnóstico por imagem , Doenças Orbitárias/etiologia , Estudos Retrospectivos
7.
Int Wound J ; 20(6): 2129-2140, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36648008

RESUMO

This study aimed to estimate costs associated with managing patients with cellulitis from the UK National Health Service (NHS) perspective. The analysis was undertaken through the Secure Anonymised Information Linkage Databank, which brings together population-scale, individual-level anonymised linked data from a wide range of sources, including 80% of primary care general practices within Wales (population coverage ~3.2 million). The data covered a 20-year period from 1999 to 2019. All patients linked to the relevant codes were tracked through primary care settings, recording the number of general practice visits (number of days with an event recorded) and number of in-patient stays. Resources were valued in monetary terms (£ sterling), with costs determined from national published sources of unit costs. These resources were then extrapolated out to reflect UK NHS costs. This is the first attempt to estimate the financial burden of cellulitis using routine data sources on a national scale. The estimated direct annual costs to the Welsh NHS (£28 554 338) are considerable. In-Patient events and length of stay costs are the main cost drivers, with annual Welsh NHS estimates of £19 664 126 with primary care events costing £8 890 212. Initiatives to support patients and healthcare professionals in identifying early signs/risks of cellulitis, improve the accuracy of initial diagnosis, prevent cellulitis recurrence, and improve evidence-based treatment pathways would result in major financial savings, to both the Welsh and UK NHS. In light of these findings, Wales has developed the innovative National Lymphoedema cellulitis Improvement Programme to address these burdens; providing a proactive model of cellulitis care.


Assuntos
Celulite (Flegmão) , Medicina Estatal , Humanos , País de Gales , Celulite (Flegmão)/terapia , Custos e Análise de Custo , Análise Custo-Benefício
8.
Int J Low Extrem Wounds ; 22(3): 599-604, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34057385

RESUMO

Lymphedema is a chronic edema that sometimes occurs after treatment of gynecologic cancer, and cellulitis often occurs concomitantly with lymphedema. On the other hand, necrotizing fasciitis (NF) is a relatively rare, but life-threatening disease. The symptoms in cellulitis and NF are very similar. In this case report, we describe a case in which the diagnosis of NF in a lymphedematous limb was difficult. A 70-year-old woman had secondary lymphedema in bilateral legs and consulted our department. On the first day of lymphedema therapy, the patient complained of vomiting, diarrhea, and fever (37.7 °C) without local fever in the legs. She was diagnosed with acute gastroenteritis. On the next day, swelling and pain in her left leg occurred and her blood pressure was 59/44 mmHg. She was diagnosed with cellulitis accompanied by lower limb lymphedema and septic shock. On the second day, blisters appeared on the left leg, and computed tomography showed NF. We performed debridement under general anesthesia and her vital signs improved postoperatively. Streptococcus agalactiae (B) was detected in blood culture, and we administered bixillin and clindamycin. Postoperatively, necrosis in the skin and fat around the left ankle gradually spread, and it took 5 months to complete epithelialization. The diagnosis was more difficult than usual NF because patients with lymphedema often experience cellulitis. Clinicians should always think of NF to avoid mortality due to delayed treatment. This case report was approved by the institutional ethics committee.


Assuntos
Fasciite Necrosante , Linfedema , Choque Séptico , Humanos , Feminino , Idoso , Fasciite Necrosante/diagnóstico , Fasciite Necrosante/etiologia , Fasciite Necrosante/terapia , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/etiologia , Celulite (Flegmão)/terapia , Perna (Membro)/cirurgia , Choque Séptico/complicações , Linfedema/complicações , Linfedema/diagnóstico
9.
Pan Afr Med J ; 43: 64, 2022.
Artigo em Francês | MEDLINE | ID: mdl-36523283

RESUMO

Orbital cellulitis is a rare disease. Two anatomo-clinical forms can be distinguished: a preseptal "benign" form and a retroseptal "severe" form. The purpose of this study was to analyze the epidemiological, clinical, therapeutic and prognostic profile of orbital cellulitis in a third-line Hospital in Tunis, Tunisia. We conducted a retrospective study involving 109 patients hospitalized for orbital cellulitis. Two groups were distinguished: the retroseptal cellulitis group including 42 patients (38.5%) and the preseptal cellulitis group including 67 patients (61.5%). The average age of patients was 27.1 ± 34.8 years. The sex ratio M/F was 0.84 (45.9% of male patients). Acute sinusitis was the most frequently identified portal for retroseptal cellulitis entry (35.7%, n=15), while acute dacryocystitis was the most common cause of preseptal cellulitis (23.9%, n=16). Diabetes, non-functioning eye and prior use of non-steroidal anti-inflammatory drugs were associated with retroseptal cellulitis (p=0.007, p=0.022 and p=0.014 respectively). All patients received systemic antibiotic therapy. Ten patients (23.8%) of the retro-septal cellulitis group and 5 patients (7.46%) of the preseptal cellulitis group underwent surgery. Nine cases of blindness (8.2%), a case of septic shock and a case of death were reported. Poor prognostic factors were a time of consultation > 7 days (aOR = 4.277, 95% CI = 2.504-32.426, p = 0.006) and Chandler stage>III (aOR = 7.009, 95% CI = 1.69-51.839, p = 0.029). In developing countries and especially in Tunisia, orbital cellulitis can be sight threatening or even life-threatening. Early management could lead to a favorable outcome without sequelae.


Assuntos
Doenças Palpebrais , Celulite Orbitária , Doenças Orbitárias , Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Celulite Orbitária/diagnóstico , Celulite Orbitária/epidemiologia , Celulite Orbitária/terapia , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/epidemiologia , Celulite (Flegmão)/terapia , Estudos Retrospectivos , Prognóstico , Tunísia/epidemiologia , Antibacterianos/uso terapêutico , Doenças Orbitárias/diagnóstico
10.
BMC Infect Dis ; 22(1): 931, 2022 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-36503406

RESUMO

BACKGROUND: Severe odontogenic infections in the head and neck region, especially necrotizing soft tissue infection (NSTI) and deep neck abscess, are potentially fatal due to their delayed diagnosis and treatment. Clinically, it is often difficult to distinguish NSTI and deep neck abscess in its early stage from cellulitis, and the decision to perform contrast-enhanced computed tomography imaging for detection is often a challenge. This retrospective case-control study aimed to examine the utility of routine blood tests as an adjunctive diagnostic tool for NSTI in the head and neck region and deep neck abscesses. METHODS: Patients with severe odontogenic infections in the head and neck region that required hospitalization were classified into four groups. At admission, hematologic and inflammatory parameters were calculated according to the blood test results. In addition, a decision tree analysis was performed to detect NSTI and deep neck abscesses. RESULTS: There were 271 patients, 45.4% in Group I (cellulitis), 22.5% in Group II (cellulitis with shallow abscess formation), 27.3% in Group III (deep neck abscess), and 4.8% in Group IV (NSTI). All hematologic and inflammatory parameters were higher in Groups III and IV. The Laboratory Risk Indicator for Necrotizing Fasciitis score, with a cut-off value of 6 and C-reactive protein (CRP) + the neutrophil-to-lymphocyte ratio (NLR), with a cut-off of 27, were remarkably useful for the exclusion diagnosis for Group IV. The decision tree analysis showed that the systemic immune-inflammation index (SII) of ≥ 282 or < 282 but with a CRP + NLR of ≥ 25 suggests Group III + IV and the classification accuracy was 89.3%. CONCLUSIONS: Hematologic and inflammatory parameters calculated using routine blood tests can be helpful as an adjunctive diagnostic tool in the early diagnosis of potentially fatal odontogenic infections. An SII of ≥ 282 or < 282 but with a CRP + NLR of ≥ 25 can be useful in the decision-making for performing contrast-enhanced computed tomography imaging.


Assuntos
Fasciite Necrosante , Infecções dos Tecidos Moles , Humanos , Estudos Retrospectivos , Abscesso/diagnóstico , Estudos de Casos e Controles , Fasciite Necrosante/diagnóstico , Infecções dos Tecidos Moles/diagnóstico , Infecções dos Tecidos Moles/terapia , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/terapia , Proteína C-Reativa
11.
Adv Emerg Nurs J ; 44(3): 199-205, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35900239

RESUMO

Eye infection with or without swelling is a common complaint in pediatric patients. It commonly affects the eyelid, which can be confused with an insect bite, orbital pseudotumor, or panophthalmitis. The article highlights the differences between preseptal and orbital cellulitis. Preseptal and orbital cellulitis originate from other infections because of the thin bone barrier that separates the eye from other facial structures. The clinical manifestations of preseptal and orbital cellulitis may be perplexing, and emergency nurse practitioners must distinguish between the two infections. The incorrect diagnosis may lead to complications. The complications associated with orbital cellulitis are vision loss, brain abscess, vision loss, cavernous sinus thrombophlebitis, orbital cellulitis, subperiosteal abscess, and death. Thus, early diagnosis and treatment will prevent these complications.


Assuntos
Celulite Orbitária , Abscesso/diagnóstico , Abscesso/terapia , Antibacterianos/uso terapêutico , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/terapia , Criança , Edema , Humanos , Celulite Orbitária/tratamento farmacológico , Celulite Orbitária/terapia , Estudos Retrospectivos
12.
J Stomatol Oral Maxillofac Surg ; 123(6): e724-e730, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35853556

RESUMO

INTRODUCTION: Cervicofacial cellulitis is mainly due to neglected oral/pharyngeal diseases. Untreated or incorrectly treated, they can be complicated by thoraco-cervical necrosis, which has a gloomy prognosis and is difficult to manage, especially in an under-medicalized environment. The aim of this work was to report the difficulties of management in precarious context by underlining the interest of primary prevention. PATIENTS AND METHOD: This was a descriptive cross-sectional retrospective study from January 2018 to March. RESULTS: Fifty cases of thoracic-cervical necrosis were collected during this period. The man/woman sex ratio was 3.55. Dental etiology was found in 96% of cases. The main complications were: pneumopathy (n = 10), mediastinitis (n = 10), pleurisy (n = 3) and polyseritis (n = 2). The management combined medical and surgical treatment under local or general anesthesia. The mortality rate was 12.8%. The functional results were satisfactory in surviving cases. CONCLUSION: The management of thoracic-cervical necrosis remains a challenge in precarious conditions. Primary must play a major role in these conditions.


Assuntos
Celulite (Flegmão) , Feminino , Humanos , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/epidemiologia , Celulite (Flegmão)/terapia , Estudos Retrospectivos , Estudos Transversais , Necrose/complicações , Hospitais Universitários
13.
J Stomatol Oral Maxillofac Surg ; 123(6): e738-e742, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35623580

RESUMO

INTRODUCTION: Although most localized odontogenic infections can be managed successfully without complications, some can cause extensive morbidity through the onset of cervicofacial cellulitis. The management of these more severe infections generally requires emergency treatment, including surgical treatment under general anesthesia, and prolonged length of hospital stay. MATERIAL & METHODS: In this work, we assessed the impact of the provision of a hospital-based dental emergency department on the regional incidence of severe odontogenic cellulitis in a socioeconomically precarious region. Monthly case rates of odontogenic cellulitis treated between January 2010 and December 2019 at the hospital-based dental emergency department of Lille Medical University Hospital were collected. RESULTS: The mean number of monthly severe odontogenic cellulitis cases treated under general anesthesia was significantly higher before than after the inception of the hospital-based dental emergency service [14.07 (5.83) vs 8.79 (4.42); p<0.0001]. Conversely, the monthly mean number of collected odontogenic cellulitis cases treated under local anesthesia was significantly lower before the emergency service was set up [22.42 (12.73) vs 43.32 (23.41); p<0.0001]. CONCLUSION: The provision of a hospital-based dental emergency department resulted in a decrease in severe dental infections in a region with high indices of socioeconomic precarity, morbidity and mortality. Greater accessibility to dental care allows for the rationalization of care through more precocious and fewer burdensome procedures.


Assuntos
Celulite (Flegmão) , Serviço Hospitalar de Emergência , Humanos , Celulite (Flegmão)/epidemiologia , Celulite (Flegmão)/etiologia , Celulite (Flegmão)/terapia , Incidência , Estudos Retrospectivos , Hospitais
14.
Emerg Med Pract ; 24(5): 1-24, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35467810

RESUMO

Cellulitis and other skin and soft-tissue infections (SSTIs) are common presentations in the emergency department. This review describes the varied etiologies and patient presentations of the more common SSTIs: cellulitis, abscesses, and necrotizing soft-tissue infections. A discussion of the common diagnoses masquerading as SSTIs is presented, as well as a stepwise approach to avoiding misdiagnosis. Diagnostic studies are also evaluated, including discussions on ultrasound, computed tomography, and clinical decision rules. This review also provides an evidence-based analysis of the controversies in management of abscesses, including the commonly utilized techniques of incision and drainage, irrigation, packing, and concurrent antibiotic therapy.


Assuntos
Celulite (Flegmão) , Infecções dos Tecidos Moles , Abscesso/tratamento farmacológico , Abscesso/terapia , Antibacterianos/uso terapêutico , Celulite (Flegmão)/tratamento farmacológico , Celulite (Flegmão)/terapia , Drenagem/métodos , Serviço Hospitalar de Emergência , Humanos , Infecções dos Tecidos Moles/tratamento farmacológico , Infecções dos Tecidos Moles/terapia
16.
Transfus Clin Biol ; 29(3): 265-268, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35331893

RESUMO

Granulocyte transfusions can be used to treat infections when appropriate antibiotic and anti-fungal drugs have proved ineffective. We report a case of clinical efficacy of 18 granulocyte transfusions for perineal cellulitis in a 3-week-old RAC2-deficient newborn girl. This RAC2 deficiency is characterized by severe phagocyte defects including defective superoxide formation, adhesion and chemotaxis deficiency. In order to check that the granulocytes infused had reached the lesion site, the infiltration of donor cells was quantified by next generation sequencing (NGS) and digital droplet PCR after identification of DNA specific markers for donor and patient. After the 6th transfusion, 20% circulating cells and 55% cells isolated by swabbing from the lesion site were donor cells, confirming the infiltration of polynuclear cells in the perineal lesion site. These results strengthen the indication of granulocyte transfusions, and its continuation until the healing process of the skin is complete. This clinical case report highlights the potential efficacy of granulocyte transfusions to treat skin lesions in RAC2-deficient patients, a process which could be monitored by molecular biology tools for chimerism quantification.


Assuntos
Celulite (Flegmão) , Quimerismo , Celulite (Flegmão)/terapia , Feminino , Granulócitos , Humanos , Recém-Nascido , Contagem de Leucócitos , Transfusão de Leucócitos/métodos
17.
Rev Med Liege ; 77(3): 181-186, 2022 Mar.
Artigo em Francês | MEDLINE | ID: mdl-35258867

RESUMO

Cervical-facial cellulitis are infections of the cellular fatty spaces of the face and neck with a tendency towards locoregional extension, septic and thromboembolic complications that can affect the patient's vital and/or functional prognosis. The management is multidisciplinary including a medical component, surgical drainage associated with the treatment of the causal tooth. This is a retrospective study including 87 cases of odontogenic head and neck cellulitis hospitalized in the ENT and head and neck surgery department at Fattouma Bourguiba Monastir hospital over a period of 4 years between January 2017 and December 2020. The study included 48 women and 39 men. The most affected age group was young adults (54 %). The main contributing factors were poor oral hygiene (76 %), tobacco (41 %) and alcohol (19 %). Anti-inflammatory medicines intake was found in 31 % of cases. The average consultation time was 5 days. The main reason for consultation was painful head and neck swelling associated with trismus (70 %) and fever (52 %). The cervical-facial scan was performed in 93 % of patients. It revealed suppurative cellulitis (64 %), extension to upper aerodigestive ways (20 %), compression of upper aero-digestive tract (11,5 %), Lemierre syndrome (4,6 %) and gangrenous cellulitis with mediastinal extension (1,1 %). All patients received large spectrum antibiotic, associated in 25 % of cases with surgical drainage. Treatment of the dental cause was performed in all patients. The evolution was favourable in 98,9 % of cases. There is only one death due to a septic shock (1,1 %), which is consistent with most of the results reported in the literature. Head and neck cellulitis can affect the functional and vital prognosis of the patient in the absence of rapid and adequate management. The treatment remains primarily preventive.


Les cellulites cervico-faciales sont des infections des espaces cellulo-graisseux de la face et du cou. Leur gravité est corrélée à leur extension locorégionale. Les complications septiques et thromboemboliques peuvent mettre en jeu le pronostic vital et/ou fonctionnel du patient. La prise en charge est multidisciplinaire, se basant sur un trépied thérapeutique comportant un volet médical (antibiothérapie), un drainage chirurgical et un traitement de la dent causale. Il s'agit d'une étude rétrospective ayant colligé 87 cas de cellulites cervico-faciales odontogènes hospitalisés au service d'ORL et de Chirurgie cervico-faciale au CHU Fattouma Bourguiba Monastir sur une période de 4 ans entre janvier 2017 et décembre 2020. L'étude comportait 48 femmes et 39 hommes. La tranche d'âge la plus touchée était l'adulte jeune (54 %). Les principaux facteurs favorisants étaient la mauvaise hygiène bucco-dentaire (76 %), le tabac (41 %) et l'alcool (19 %). La notion de prise d'anti-inflammatoires non stéroïdiens était retrouvée dans 31 % des cas. Le délai moyen de consultation était de 5 jours. Le principal motif de consultation était une tuméfaction cervico-faciale douloureuse associée à un trismus (70 %) et une fièvre (52 %). Le scanner cervico-facial a été réalisé chez 93 % des patients. Il a objectivé une cellulite suppurée (64 %), une extension aux espaces profonds (20 %), une compression des voies aéro-digestives supérieures (11,5 %), un syndrome de Lemierre (4,6 %) et une cellulite gangréneuse avec extension médiastinale (1,1 %). Tous les malades ont bénéficié d'une antibiothérapie à large spectre. Seuls 25 % ont eu un drainage chirurgical associé. Le traitement de la porte d'entrée a été réalisé chez tous les patients. L'évolution a été favorable dans 98,9 % des cas. On recense un seul décès dû à un choc septique (1,1 %), ce qui est concordant avec la majorité des résultats rapportés dans la littérature. Les cellulites cervico-faciales peuvent mettre en jeu le pronostic fonctionnel et vital du patient en l'absence de prise en charge rapide et adéquate. Le traitement reste avant tout préventif.


Assuntos
Celulite (Flegmão) , Drenagem , Antibacterianos/uso terapêutico , Celulite (Flegmão)/tratamento farmacológico , Celulite (Flegmão)/terapia , Drenagem/métodos , Face , Feminino , Humanos , Masculino , Pescoço , Estudos Retrospectivos , Adulto Jovem
18.
Khirurgiia (Mosk) ; (2): 5-10, 2022.
Artigo em Russo | MEDLINE | ID: mdl-35146993

RESUMO

The increase in the number of purulent wound complications in the treatment of various surgical diseases in maxillofacial surgery determines the high importance of the medico-social problem of modern medicine. In this connection, the search for new approaches is urgent, including the complex application of 2 or more factors to increase the effectiveness of treatment and prevention of inflammatory diseases of the maxillofacial region. OBJECTIVE: To study the effect of a comprehensive physiotherapy program, including a low-frequency alternating electrostatic field and broadband electromagnetic therapy, on the severity of pain and local inflammation in patients with inflammatory diseases of the maxillofacial region. MATERIAL AND RESEARCH METHODS: 60 patients with acute pyoinflammatory diseases of the maxillofacial region (phlegmons, abscesses, abscessing boils of the maxillofacial region), mean age 41.2±3.5 years, who were divided into 2 groups: main - 30 patients who underwent a course of complex application of broadband electromagnetic therapy and a low-frequency alternating electrostatic field and control - 30 patients who received drug therapy (antibiotics, drugs of the metronidazole group, antihistamines, multivitamins, detoxification therapy, local treatment of the wound process), which served as a background in the main group. RESULTS: The combined use of a low-frequency alternating electrostatic field and broadband electromagnetic therapy contributes to a faster and more pronounced relief of the inflammatory process in the area of the pathological focus and pain syndrome in patients with inflammatory diseases of the maxillofacial region, which is confirmed by the data of an objective examination and indicators of the visual analogue scale VAS. CONCLUSION: The developed complex, which includes a low-frequency alternating electrostatic field and broadband electromagnetic therapy, has pronounced anti-inflammatory and analgesic effects in patients with inflammatory diseases of the maxillofacial region, which makes it possible to recommend it for use in wide surgical practice.


Assuntos
Magnetoterapia , Modalidades de Fisioterapia , Abscesso , Adulto , Celulite (Flegmão)/etiologia , Celulite (Flegmão)/terapia , Humanos , Medição da Dor
19.
J Fr Ophtalmol ; 45(2): 166-172, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34973820

RESUMO

Periorbital cellulitis is a diagnostic and therapeutic emergency, jeopardizing the prognosis for vision and survival. PURPOSE: The goal of this study was to analyze the epidemiological and therapeutic features and outcomes of periorbital cellulitis cases treated in the pediatric emergency department. PATIENTS AND METHODS: A retrospective study including all the children aged between 1 month and 15 years treated for periorbital cellulitis in the Pediatric Emergency Department of the Mohamed VI University Teaching Hospital in Marrakech over a period of 10 years (January 1, 2010-December 31, 2019). RESULTS: In all, 168 cases of periorbital cellulitis were recorded, with an increasing of the number of cases, from 2 in 2010 to 39 in 2019. The most affected age bracket was the group under 5 years of age (62.5%). The most frequent mode of entry was sinusitis (22%). Preseptal cellulitis was most common (76.7%). The main clinical signs found in orbital cellulitis were proptosis (64%) and chemosis (35.8%), versus conjunctival hyperemia (78%) in preseptal cellulitis. Ophthalmoplegia was present in two cases of orbital cellulitis. The right side was most affected (44%). An orbital CT scan was performed in all cases in our study, showing preseptal cellulitis in 129 patients (76.7%), orbital cellulitis in 14 cases (8.3%), subperiosteal abscess in 20 cases (12%) and orbital abscess in 5 cases (3%). Prior treatment with non-steroidal anti-inflammatory medication was noted in 6%. The most commonly used antibiotic was amoxicillin-clavulanic acid. Steroid treatment was prescribed in 6% of cases. Surgical treatment was indicated in 12 patients (7.1%). The mean hospital length of stay was 3 days for the preseptal cases and 8 days for the orbital cases. All patients had good outcomes with medical and/or surgical treatment. With follow-up of over one year, no complications were noted. CONCLUSION: The majority of our cases had positive outcomes, highlighting the advantage of early diagnosis, adapted antibiotic treatment and multidisciplinary care, rendering surgery rarely necessary.


Assuntos
Doenças Palpebrais , Celulite Orbitária , Abscesso/tratamento farmacológico , Antibacterianos/uso terapêutico , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/epidemiologia , Celulite (Flegmão)/terapia , Criança , Serviço Hospitalar de Emergência , Doenças Palpebrais/tratamento farmacológico , Humanos , Lactente , Celulite Orbitária/diagnóstico , Celulite Orbitária/epidemiologia , Celulite Orbitária/terapia , Estudos Retrospectivos
20.
J Emerg Med ; 62(1): 16-27, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34657784

RESUMO

BACKGROUND: Cellulitis and abscess are a common reason for presentation to the emergency department, although there are several nuances to the care of these patients. OBJECTIVE: The purpose of this narrative review article was to provide a summary of the background, pathophysiology, diagnosis, and management of cellulitis and abscesses with a focus on emergency clinicians. DISCUSSION: The most common bacteria causing cellulitis are Staphylococcus aureus, Streptococcus pyogenes, and other ß-hemolytic streptococci, and methicillin-resistant S. aureus is most common in abscesses. The history and physical examination are helpful in differentiating cellulitis and abscess in many cases, and point-of-care ultrasound can be a useful tool in unclear cases. Treatment for cellulitis typically involves a penicillin or cephalosporin, and treatment of abscesses is incision and drainage. Loop drainage is preferred over the traditional incision and drainage technique, and adjunctive antibiotics can be considered. Most patients can be managed as outpatient. CONCLUSIONS: It is essential for emergency physicians to be aware of the current evidence regarding the diagnosis and management of patients with cellulitis and abscess.


Assuntos
Abscesso , Staphylococcus aureus Resistente à Meticilina , Abscesso/diagnóstico , Abscesso/microbiologia , Abscesso/terapia , Antibacterianos/uso terapêutico , Celulite (Flegmão)/diagnóstico , Celulite (Flegmão)/microbiologia , Celulite (Flegmão)/terapia , Drenagem/métodos , Serviço Hospitalar de Emergência , Humanos , Ultrassonografia
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