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1.
Bratisl Lek Listy ; 120(11): 827-831, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31747762

RESUMO

BACKGROUND: This study was aimed to reveal whether there is a relationship between Raynaud Phenomenon (RP) and Helicobacter Pylori (HP). MATERIAL AND METHODS: Seventy-nine patients, who had been referred to outpatient clinic with Raynaud in the last 9 years were retrospectively screened. Of these, 29 patients with access to their data and who had HP screening tests were included in the study. RESULTS: HP direct antigen was found in feces in only one of 29 patients. When we compared the results of this study to the results of previous literature, it was observed that the patients admitted with RP symptoms by a gastroenterology outpatient clinic had a higher incidence for HP (+) scanning than the patients admitted with RP symptoms by a cardiovascular surgery policlinic (CVSOC). CONCLUSION: Although previous literature reports that HP leads to RP in the group of patients referred to other outpatient clinics, the same relation is very low in the Raynaud patient group in CVSOC. Patients admitted with RP in the CVSOC shouldn't be prescribed empirical antibiotic therapy for the eradication of HP. However, as the appropriate antibiotic regimen can resolve Raynaud symptoms in the presence of a HP(+) test, it makes this scanning rational for all symptomatic patients (Tab. 1, Fig. 1, Ref. 23).


Assuntos
Infecções por Helicobacter/complicações , Doença de Raynaud/complicações , Helicobacter pylori , Humanos , Doença de Raynaud/microbiologia , Estudos Retrospectivos
3.
Int J Dermatol ; 51(10): 1149-61, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22994661

RESUMO

Breastfeeding is thought to be the most optimal form of infant nutrition. Nursing mothers are generally advised to continue breastfeeding until the infant is two years of age or beyond. Unfortunately, however, a majority of nursing mothers will discontinue breastfeeding much earlier than recommended. The most common reason for early discontinuation of breastfeeding is nipple pain. It is, therefore, essential that dermatologists know how to appropriately diagnose and effectively treat nipple pain associated with nipple dermatitis among nursing mothers. This review article provides a detailed discussion on the clinical features and management of various causes of nipple dermatitis during lactation, including problems with infant latch-on, congenital oral anomalies, plugged lactiferous ducts, atopic dermatitis, irritant contact dermatitis, allergic contact dermatitis, yeast infections, bacterial infections, herpes simplex virus, and Raynaud's phenomenon of the nipple.


Assuntos
Aleitamento Materno/efeitos adversos , Dermatite Atópica/diagnóstico , Dermatite de Contato/diagnóstico , Mães , Mamilos , Comportamento de Sucção/fisiologia , Dermatite Atópica/complicações , Dermatite Atópica/microbiologia , Dermatite de Contato/complicações , Dermatite de Contato/microbiologia , Dermatomicoses/complicações , Dermatomicoses/diagnóstico , Feminino , Herpes Simples/complicações , Herpes Simples/diagnóstico , Humanos , Recém-Nascido , Glândulas Mamárias Humanas/fisiopatologia , Dor/etiologia , Psoríase/diagnóstico , Doença de Raynaud/complicações , Doença de Raynaud/diagnóstico , Doença de Raynaud/microbiologia , Dermatopatias Bacterianas/complicações , Dermatopatias Bacterianas/diagnóstico
4.
J Mal Vasc ; 37(4): 207-12, 2012 Jul.
Artigo em Francês | MEDLINE | ID: mdl-22749761

RESUMO

About ten to fifteen percent of the French population suffer from Raynaud's phenomenon. Most of the time, it is considered as primary Raynaud's phenomenon, without underlying disease. The aim of this expert consensus from the "microcirculation group" for the French Society of Vascular Medicine and the French Society for Microcirculation, was to define clinical guidelines in patients consulting for Raynaud's phenomenon. The recommended minimal screening includes clinical examination, nailfold capillaroscopy and antinuclear antibodies. In particular, the aim of this screening is to identify patients with a significant risk for scleroderma, who would need a careful follow up.


Assuntos
Doença de Raynaud/diagnóstico , Anticorpos Antinucleares/sangue , Suscetibilidade a Doenças , França/epidemiologia , Humanos , Microcirculação , Angioscopia Microscópica , Unhas/irrigação sanguínea , Exame Físico , Doença de Raynaud/epidemiologia , Doença de Raynaud/etiologia , Doença de Raynaud/microbiologia , Doença de Raynaud/fisiopatologia , Escleroderma Sistêmico/complicações , Escleroderma Sistêmico/diagnóstico , Escleroderma Sistêmico/epidemiologia , Avaliação de Sintomas
6.
Curr Microbiol ; 59(1): 59-64, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19330378

RESUMO

Lactational Raynaud's syndrome may be misdiagnosed as infectious mastitis on the basis of the breast pain. The objective of this work was to elucidate if microbiological analysis of milk may contribute to the differentiation of both conditions. Ten lactating women clinically diagnosed by Spanish lactation consultants were included in the study. Of these, five suffered from mastitis and the remaining five suffered from Raynaud's syndrome. Breast milk samples were inoculated on diverse culture media. Seventy isolates were selected and identified by 16S rDNA PCR sequencing. Parallel, PCR-DGGE and quantitative real-time PCR were used to assess the presence of bacterial DNA in the samples. Neither bacteria nor yeasts could be detected in the milk samples provided by the women suffering from Raynaud's syndrome. In contrast, large numbers of bacteria were isolated from those with infectious lactational mastitis. Globally, the levels of bacterial DNA were significantly higher in the milk of mastitis-suffering women. Bacteriological analysis of milk can be an useful tool to facilitate the differential diagnosis between the infectious mastitis and Raynaud's syndrome during lactation.


Assuntos
Bactérias/isolamento & purificação , Lactação , Mastite/microbiologia , Leite Humano/microbiologia , Doença de Raynaud/microbiologia , Adulto , Bactérias/classificação , Bactérias/genética , DNA Bacteriano/genética , DNA Ribossômico/genética , Feminino , Humanos , Dados de Sequência Molecular , RNA Ribossômico 16S/genética , Adulto Jovem
8.
Rev Med Interne ; 27(10): 736-41, 2006 Oct.
Artigo em Francês | MEDLINE | ID: mdl-16978744

RESUMO

PURPOSE: Recent studies have suggested that the prevalence of Helicobacter pylori may be more frequent in patients with primary Raynaud's phenomenon (PRP) compared to healthy subjects. These data prompted us to conduct this prospective study, in order to assess the prevalence of H. pylori infection in a large series of patients with PRP. METHODS: Forty consecutive patients with a definite diagnosis of PRP were included in the study. The findings in the PRP patients were compared with those of 80 age- and sex-matched healthy subjects. H. pylori infection was diagnosed using serology and urease breath test. RESULTS: The prevalence of H. pylori infection was as high as 12.5% in PRP patients using both serology and urease breath test, whereas it was found to be 16.7% and 18%, respectively, in healthy controls. CONCLUSION: As prevalence of H. pylori infection was similar in PRP patients compared to controls (P=0.53 and 0.43, respectively), our data underscore that H. pylori infection may not play a role in the genesis of PRP-related vascular complication onset. Interestingly, PRP patients exhibited more commonly digestive symptoms consistent with H. pylori infection compared to controls (P<0.05).


Assuntos
Infecções por Helicobacter/complicações , Helicobacter pylori/isolamento & purificação , Doença de Raynaud/microbiologia , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Feminino , França/epidemiologia , Gastrite/complicações , Gastrite/microbiologia , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Doença de Raynaud/diagnóstico , Doença de Raynaud/epidemiologia , Inquéritos e Questionários
9.
Med Pr ; 53(4): 333-7, 2002.
Artigo em Polonês | MEDLINE | ID: mdl-12474414

RESUMO

The paper presents the current state-of-the-art concerning the effect of Helicobacter pyroli infection on the progress of some skin diseases (Raynaud's disease, purpura hyperergica, rosacea, prurigo nodularis, atopic dermatitis, chronic urticaria). The attention was turned to the lack of unanimity among authors respective to the effect of Helicobacter pylori on the progress of some skin diseases, especially those of allergic etiology. The methods of bacteria identification were discussed. The methods are as follows: invasive tests involving endoscopy of the upper segment of the alimentary tract--a traumatic test, histologic examination and bacteria culture as well as noninvasive tests: respiratory test and serological tests able to detect the humoral response to infection or examination of the bacteria genetic material by means of PCR. The therapeutic methods used to eradicate effectively the infection, recommended by the Working Group of the Polish Association of Gastroenterology (a three-component treatment for seven days--a drug able to diminish gastric secretion and two antibiotics) are also discussed.


Assuntos
Infecções por Helicobacter/complicações , Infecções por Helicobacter/diagnóstico , Helicobacter pylori/isolamento & purificação , Dermatopatias/diagnóstico , Dermatopatias/microbiologia , Dermatite Atópica/diagnóstico , Dermatite Atópica/microbiologia , Infecções por Helicobacter/tratamento farmacológico , Humanos , Prurigo/diagnóstico , Prurigo/microbiologia , Doença de Raynaud/diagnóstico , Doença de Raynaud/microbiologia , Rosácea/diagnóstico , Rosácea/microbiologia , Urticária/diagnóstico , Urticária/microbiologia
11.
Scand J Gastroenterol ; 35(12): 1251-4, 2000 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11199362

RESUMO

BACKGROUND: Raynaud phenomenon (RP) is a vasospastic condition that manifests itself as cold-induced ischemic attacks of the fingers with skin color changes. It may be classified as primary (PRP) or secondary (SRP), if associated to other diseases, mainly connective-tissue diseases. Recently, the association between PRP and Helicobacter pylori infection has been reported. The aims of this study were to evaluate the prevalence of gastric H. pylori infection in a large group of patients affected by PRP and SRP and to assess whether it was more evident in patients with more recent onset of RP. METHODS: Ninety-eight consecutive patients (93 F and 5 M), referring to our videocapillaroscopic service for the diagnosis of vascular and connective-tissue diseases, were evaluated. Forty-nine of them were affected by PRP and 49 by SRP. Patients were classified as having PRP on the basis of normal serological and immunological findings, normal videocapillaroscopic examination and exclusion of other conditions inducing RP. H. pylori infection was diagnosed by 13C-urea breath test (UBT). Two groups of 49 age-and sex-matched controls, respectively, were also evaluated. RESULTS: Patients with SRP resulted significantly older than those with PRP (P < 0.006). UBT was found positive in 22/49 patients with PRP (45%) and in 29/49 patients with SRP (59%). The positivity of the respective control groups was 36% and 53% (P = NS). There was no higher prevalence of H. pylori infection in patients with RP lasting for less than 4 years. CONCLUSIONS: The results do not confirm the previously reported high prevalence of H. pylori infection in patients with PRP. A high association was not even found between the presence of the microorganism and SRP. There was no difference in the prevalence of H. pylori infection among the subgroups with more recent onset of both PRP and SRP.


Assuntos
Gastrite/microbiologia , Infecções por Helicobacter/complicações , Helicobacter pylori , Doença de Raynaud/microbiologia , Adulto , Feminino , Gastrite/complicações , Infecções por Helicobacter/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Raynaud/diagnóstico
12.
Orv Hetil ; 141(52): 2827-9, 2000 Dec 24.
Artigo em Húngaro | MEDLINE | ID: mdl-11202119

RESUMO

In this work, the effect of eradication of Helicobacter pylori on complaints and symptoms of infected, primary Raynaud's syndrome patients was studied. Altogether 92 Helicobacter pylori positive patients with gastric complaints and with primary Raynaud's syndrome received eradication therapy. In this prospective study, before and after the eradication the severity and frequency of the complaints and symptoms of the patients were recorded. The eradication was performable in 89 patients; in 75 cases the eradication was successful. In the eradicated patients frequency and duration of Raynaud attacks were improved related to those of the not eradicated group. These results might suggest a potential etiopathogenetical role of Helicobacter pylori infection in the pathogenesis of the primary Raynaud's syndrome.


Assuntos
Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori , Doença de Raynaud/diagnóstico , Doença de Raynaud/microbiologia , Doença Aguda , Adulto , Feminino , Infecções por Helicobacter/complicações , Helicobacter pylori/efeitos dos fármacos , Humanos , Estudos Prospectivos , Índice de Gravidade de Doença
13.
Dig Dis Sci ; 43(8): 1641-5, 1998 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9724144

RESUMO

Raynaud's phenomenon is defined by an intermittent vasospasm of the arterioles of the distal limbs. Helicobacter pylori infection has been recently associated with Raynaud's phenomenon. The aim of this study was to assess the effects of H. pylori eradication on Raynaud's attacks. Forty-six patients affected by primary Raynaud's phenomenon were evaluated. H. pylori infection was assessed by [13C]urea breath test. Eradication therapy was given to infected patients for seven days. Discomfort and the duration and frequency of attacks of Raynaud's phenomenon per week were assessed. Thirty-six subjects were infected with H. pylori; the bacterium was eradicated in 83% of these after therapy. Attacks of Raynaud's phenomenon completely disappeared in 17% of the patients with H. pylori eradication. Discomfort and the duration and frequency of attacks of Raynaud's phenomenon were significantly reduced in 72% of the remaining patients. Conversely, attacks of Raynaud's disease did not change significantly during the 12-week follow-up period either in the H. pylori-negative patients or in the infected subjects in whom the bacterium was not eradicated by therapy. The study shows that H. pylori eradication causes a significant decrease in clinical attacks of Raynaud's disease. The reduction of vasoactive substances determined by the eradication of the bacterium may be the pathogenetic mechanism underlying the phenomenon.


Assuntos
Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori , Doença de Raynaud/microbiologia , Adulto , Antibacterianos , Quimioterapia Combinada/uso terapêutico , Feminino , Gastrite/complicações , Gastrite/microbiologia , Infecções por Helicobacter/complicações , Infecções por Helicobacter/diagnóstico , Humanos , Masculino , Doença de Raynaud/fisiopatologia
15.
Ital J Gastroenterol Hepatol ; 30 Suppl 3: S307-9, 1998 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-10077761

RESUMO

Helicobacter pylori infection has recently been associated to some organic functional vascular disorders and, both observational and interventional studies have been carried out. A correlation between Helicobacter pylori infection and ischaemic heart disease was first described in 1994. Recent data, moreover, indicate a role of the bacterium in some functional vascular disorders such as primary headache and primary Raynaud phenomenon; indeed, some patients following eradication of Helicobacter pylori showed a significant improvement in the manifestations of these diseases. The host immune response against the bacterium may play an important role in the pathogenesis of vascular disorders, probably through a chronic stimulation of the release of vasoactive substances, such as cytokines, prostaglandins and others. However, various confounding factors such as co-infections, genetic and immunological host-factors, different strains of Helicobacter pylori or other may influence the data. Well designed case/control and randomized interventional studies are still needed to assess the real role of Helicobacter pylori in vascular disorders.


Assuntos
Infecções por Helicobacter/complicações , Helicobacter pylori , Doenças Vasculares/microbiologia , Anticorpos Antibacterianos/imunologia , Antígenos de Bactérias/imunologia , Citocinas/imunologia , Citocinas/metabolismo , Endotélio Vascular/imunologia , Endotélio Vascular/microbiologia , Seguimentos , Infecções por Helicobacter/microbiologia , Helicobacter pylori/imunologia , Helicobacter pylori/patogenicidade , Humanos , Doença de Raynaud/imunologia , Doença de Raynaud/microbiologia , Estudos Retrospectivos , Fatores de Risco , Doenças Vasculares/imunologia
17.
Eur J Gastroenterol Hepatol ; 9(3): 231-3, 1997 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9096420

RESUMO

Helicobacter pylori appears to be the most important cause of gastritis and gastric and duodenal ulcer. Its eradication, in fact, promotes healing of these diseases and significantly reduces ulcer recurrence. In the last few years, moreover, besides a local tissue damage, an association between H. pylori infection and various extraintestinal pathologies has also been described. The presence of more toxic strains of H. pylori and the multiplicity of the substances produced, directly or indirectly, in response to the bacterium, besides a genetic predisposition of the individual, are all factors which may enhance the ability of Helicobacter to generate both local and systemic damage.


Assuntos
Infecções por Helicobacter/complicações , Helicobacter pylori , Toxinas Bacterianas/farmacologia , Feminino , Infecções por Helicobacter/imunologia , Helicobacter pylori/imunologia , Humanos , Vasculite por IgA/microbiologia , Isquemia Miocárdica/microbiologia , Doença de Raynaud/microbiologia , Dermatopatias/microbiologia
18.
Br J Dermatol ; 118(1): 47-58, 1988 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-3342176

RESUMO

Nail infections caused by Candida species are normally associated with chronic paronychia or chronic mucocutaneous candidiasis (CMCC). However, the role of Candida in the pathogenesis of other primary nail dystrophies has been questioned in view of their response to antifungal therapy alone. In the present study of 86 patients with primary nail dystrophies from which Candida was isolated, three patterns of nail involvement were found. Nineteen patients, of whom 17 had CMCC, had total dystrophic onychomycosis of at least two nails. The second group consisted of 27 patients with paronychia and lateral onycholysis. In a further 40 patients, who did not have paronychia, Candida was isolated from nails showing primary distal and lateral onycholysis. These changes were mainly seen in patients with peripheral vascular disease, particularly Raynaud's disease, or Cushing's syndrome. Nail biopsies from patients in the latter two groups confirmed the presence of yeasts and mycelium in the nail plate and 17 (46%) of those receiving antifungal therapy with ketoconazole or itraconazole showed complete clearance of the nail dystrophy. Good responses to therapy were seen more frequently in patients with peripheral vascular disease or Cushing's syndrome of whom 15 (72%) recovered; distal erosion of the nail plate, mycelium in the nail plate on biopsy or direct microscopy together with the isolation of C. albicans were all associated with good responses to antifungals. In addition to patients with CMCC or paronychia, therefore, Candida appears to be a significant pathogen in some patients with primary onycholysis of the finger nails, particularly where there is underlying peripheral vascular disease or Cushing's syndrome.


Assuntos
Candidíase/microbiologia , Doenças da Unha/microbiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Candida/isolamento & purificação , Candidíase/patologia , Criança , Síndrome de Cushing/microbiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Unha/patologia , Unhas/patologia , Doença de Raynaud/microbiologia
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