RESUMO
BACKGROUND: Nasopharyngeal amyloidoma is a rare, locally aggressive tumor that has been reported in the English literature in only 38 cases to date, most of which were in the form of case reports. The present study was aimed to summarize the characteristics of this rare tumor, with the goal of providing new insights for diagnosis and treatment. MATERIALS AND METHODS: We report three cases of nasopharyngeal amyloidoma diagnosed in our hospital following comprehensive medical examination and review the current literature on all cases of nasopharyngeal amyloidoma from PubMed. The journey of nasopharyngeal amyloidoma, including presentation, diagnostics, surgeries, and follow-up was outlined. RESULTS: None of the three patients had systemic amyloidosis. CT and nasal endoscopy showed irregular masses obstructing the nasopharyngeal cavity. Congo red staining confirmed the deposition of amyloid, and immunohistochemical analysis showed that the amyloid deposition was the AL light chain type. Through literature review, we found that nasopharyngeal amyloidoma most commonly occurred in individuals over the age of 40, patients usually had a good prognosis after complete tumor resection; however, there were still cases of recurrence, and unresected patients were at risk of progression to systemic amyloidosis. The efficacy of radiotherapy and chemotherapy was currently uncertain. CONCLUSION: Early clinical and pathological diagnosis is crucial, and surgical intervention is the primary treatment option for this disease. Although patients usually have a favorable prognosis, long-term monitoring is necessary to detect potential relapses and initiate timely intervention.
Assuntos
Amiloidose , Neoplasias Nasofaríngeas , Humanos , Masculino , Pessoa de Meia-Idade , Feminino , Amiloidose/patologia , Amiloidose/diagnóstico , Amiloidose/metabolismo , Neoplasias Nasofaríngeas/patologia , Neoplasias Nasofaríngeas/diagnóstico , Neoplasias Nasofaríngeas/cirurgia , Adulto , Doenças Nasofaríngeas/patologia , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/metabolismo , Doenças Nasofaríngeas/cirurgiaRESUMO
A 2-year-old Norwegian Forest cat was presented for evaluation of bilateral purulent nasal discharge and stertorous breathing. A computed tomography (CT) scan of the head revealed an intranasal mass of the left nasal cavity extending behind the tube openings and completely obstructing the nasopharynx. Rhinoscopy confirmed a pinkish, shiny mass. CT scan showed both compartments of the right middle ear filled with abnormal soft tissue attenuating material. There was no change in the bony outline of the middle ear. In the endoscopic examination, after endoscopically assisted tympanocentesis, this material in the accessible dorsolateral compartment proved to be classic polypous tissue in addition to highly viscous glue-like secretions. A secondary otitis media due to a drainage disorder was suspected.Using an endoscopic-interventional approach through the nostril, the nasopharyngeal mass was removed for histopathological examination, in order to restore the nasal airway, and to allow tube drainage. In contrast to cats with classical malignant nasal cavity masses, the cat showed several attachment points of the mass and multiple undulating elevations bilaterally in the nasopharyngeal mucosa.Cytological and histopathological examination identified the mass as a fungal granuloma in the context of a cryptococcus infection only rarely observed in Germany. Molecular genetic analysis confirmed an infection with Cryptococcus neoformans var. grubii.A single intranasal and nasopharyngeal endoscopic debridement resulted in a significant improvement of the clinical signs and a complete healing of the right middle ear (including the tympanic membrane) within 14 days, but not in a complete cure of the disease. The cat was therefore treated with oral itraconazole solution for several weeks.The case report shows that nasal cryptococcosis can also affect cats in Germany. Rhinoscopy reveals a nasopharyngeal mass with multiple attachment points, which is unusual for a neoplasia. In addition to the recommended removal of the mass, oral administration of systemic antimycotics is strongly advised.
Assuntos
Doenças do Gato , Criptococose , Animais , Gatos , Doenças do Gato/diagnóstico , Doenças do Gato/microbiologia , Doenças do Gato/patologia , Criptococose/veterinária , Criptococose/diagnóstico , Criptococose/microbiologia , Criptococose/patologia , Criptococose/tratamento farmacológico , Diagnóstico Diferencial , Neoplasias Nasofaríngeas/veterinária , Neoplasias Nasofaríngeas/diagnóstico , Alemanha , Tomografia Computadorizada por Raios X/veterinária , Doenças Nasofaríngeas/veterinária , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/microbiologia , Doenças Nasofaríngeas/patologiaRESUMO
This article presents a rare case of a large hairy polyp, a developmental malformation causing a benign tumor, within the nasopharynx. The patient, born with the polyp obstructing the airway, required immediate intubation and a combined transnasal-transoral surgical approach for excision. The case underscores the challenges in diagnosing and managing such polyps, emphasizing the importance of imaging for surgical planning, and the consideration of multiple approaches to ensure complete resection and prevent recurrence. Laryngoscope, 134:4118-4121, 2024.
Assuntos
Pólipos , Humanos , Recém-Nascido , Pólipos/cirurgia , Pólipos/complicações , Pólipos/diagnóstico , Feminino , Doenças Nasofaríngeas/cirurgia , Doenças Nasofaríngeas/complicações , Doenças Nasofaríngeas/diagnóstico , Nasofaringe/diagnóstico por imagem , Nasofaringe/cirurgia , Masculino , Obstrução das Vias Respiratórias/etiologia , Obstrução das Vias Respiratórias/cirurgiaRESUMO
Primary tuberculosis of the cavum is a rare entity. It can occur at any age, especially between the second and ninth decade. We report the case of a 17-years-old patient with nasal obstruction and left laterocervical adenomegaly. A cervico-facial CT scan showed a suspicious looking tumor process of the nasopharynx. Histological analysis of the biopsies taken showed chronic granulomatous inflammation with necrosis and the absence of tuberculosis lesions in the usual sites, especially the lungs, led to the diagnosis of primary tuberculosis of the cavum. There was a good evolution on antituberculosis drugs. This unusual location can be a source of difficulties and delay in diagnosis, especially because of the clinical presentation, which suggests a nasopharyngeal tumour. In developing countries, where this disease remains relatively endemic, cross-sectional imaging techniques and histopathological analysis are of great interest for the management of patients.
Assuntos
Doenças Nasofaríngeas , Neoplasias Nasofaríngeas , Tuberculose , Humanos , Adolescente , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/patologia , Tuberculose/diagnóstico , Tuberculose/patologia , Diagnóstico Diferencial , Tomografia Computadorizada por Raios XRESUMO
PURPOSE: To evaluate the results of conjunctival and nasopharyngeal swab tests in patients with confirmed COVID-19. METHODS: This prospective study included 45 patients who were hospitalized for confirmed COVID-19. Nasopharyngeal swab samples were obtained from the patients before hospitalization. Only one eye of each patient was randomly selected for-conjunctival sampling. All participants underwent a complete slit-lamp examination. Conjunctival and nasopharyngeal swab samples were analyzed by reversetranscriptase-polymerase-chain reaction (RT-PCR). RESULTS: Twenty seven (60%) of the patients were male and 18 (40%) were female. Conjunctival swab was positive in only one (2.22%) patient. None of the COVID-19 patients showed ocular changes and symptoms. There were no abnormalities of the ocular surface, anterior chamber or posterior segment at slit-lamp examination. CONCLUSIONS: The RT-PCR was not high positive in the conjunctiva as in nasopharyngeal swabs. Ocular changes were not common in COVID-19 patients.
Assuntos
COVID-19/diagnóstico , Túnica Conjuntiva/virologia , Nasofaringe/virologia , RNA Viral/análise , SARS-CoV-2/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , COVID-19/complicações , COVID-19/virologia , Criança , Pré-Escolar , Túnica Conjuntiva/patologia , Conjuntivite/diagnóstico , Conjuntivite/etiologia , Conjuntivite/virologia , Infecções Oculares Virais/diagnóstico , Infecções Oculares Virais/etiologia , Infecções Oculares Virais/virologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/etiologia , Doenças Nasofaríngeas/virologia , Nasofaringe/patologia , Estudos Prospectivos , Microscopia com Lâmpada de Fenda , Manejo de Espécimes/métodos , Adulto JovemRESUMO
Nasopharyngeal hairy polyps are rare benign tumors. We present a newborn case with a hairy polyp mass causing cyanosis and respiratory distress due to obstruction of the upper airway during the first 24 hours of life. The patient required resuscitation and endotracheal intubation. Diagnostic studies confirmed the presence of a mass in the lateral pharyngeal wall. Surgical treatment and removal of the mass was performed with satisfactory evolution of the patient.
Los pólipos pilosos nasofaríngeos son tumores benignos poco frecuentes. Se presenta el caso de esta patología en una paciente recién nacida, quien presentó cianosis y dificultad respiratoria por obstrucción de la vía aérea superior, durante las primeras 24 horas de vida. La paciente requirió maniobras de reanimación e intubación endotraqueal. Estudios diagnósticos confirmaron la presencia de una masa en la pared lateral de la faringe. Se realizó la extirpación quirúrgica exitosa con evolución satisfactoria de la paciente.
Assuntos
Obstrução das Vias Respiratórias/etiologia , Doenças Nasofaríngeas/diagnóstico , Pólipos/diagnóstico , Obstrução das Vias Respiratórias/diagnóstico , Obstrução das Vias Respiratórias/cirurgia , Feminino , Humanos , Recém-Nascido , Doenças Nasofaríngeas/complicações , Doenças Nasofaríngeas/cirurgia , Nasofaringe/patologia , Nasofaringe/cirurgia , Pólipos/complicações , Pólipos/cirurgiaAssuntos
Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/diagnóstico , Técnicas de Diagnóstico do Sistema Respiratório/normas , Surtos de Doenças/prevenção & controle , Hospitalização , Doenças Nasofaríngeas/diagnóstico , Pneumonia Viral/diagnóstico , Guias de Prática Clínica como Assunto , Adulto , Idoso , Idoso de 80 Anos ou mais , COVID-19 , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , SARS-CoV-2 , Adulto JovemRESUMO
Respiratory epithelial adenomatoid hamartoma (REAH) and seromucinous hamartoma (SH) are rare tumor-like lesions of the nasal cavity, paranasal sinuses, and nasopharynx. The pathogenesis of REAH/SH is still unclear. Neoplastic proliferation, chronic mechanical irritation, inflammation, or possible embryological tissue misplacement are speculated as possible mechanisms of their development. Low-grade tubulopapillary adenocarcinoma (LGTA) is a rare variant of nonsalivary, nonintestinal type sinonasal adenocarcinoma. The aim of this study was to evaluate the immunohistochemical and genetic profiles of 10 cases of REAH/SH, with serous, mucinous, and respiratory components evaluated separately and to compare these findings with the features of 9 cases of LGTA. All cases of REAH/SH and LGTA were analyzed immunohistochemically with a cocktail of mucin antigens (MUC1, MUC2, MUC4, MUC5AC, MUC6) and with epithelial (CK7, CK20, CDX2, SATB2) and myoepithelial markers (S100 protein, p63, SOX10). The next-generation sequencing assay was performed using FusionPlex Solid Tumor Kit (ArcherDx) in 10 cases of REAH/SH, and the EGFR-ZNF267 gene fusion was detected in 1 of them. Two female REAH/SH cases were assessed for the presence of clonality. Using the human androgen receptor assay, 1 case was proved to be clonal. The serous component of REAH/SH was positive for CK7/MUC1 and SOX10 similarly to LGTA. Although REAH/SH and LGTA are histopathologically and clinically separate entities, the overlap in their morphological and immunohistochemical profiles suggests that REAH/SH might be a precursor lesion of LGTA.
Assuntos
Adenocarcinoma/diagnóstico , Biomarcadores Tumorais , Hamartoma/diagnóstico , Imuno-Histoquímica , Técnicas de Diagnóstico Molecular , Mucosa Nasal/química , Doenças Nasofaríngeas/diagnóstico , Doenças Nasais/diagnóstico , Neoplasias Nasais/diagnóstico , Lesões Pré-Cancerosas/diagnóstico , Adenocarcinoma/química , Adenocarcinoma/genética , Adenocarcinoma/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/genética , Criança , Diagnóstico Diferencial , Feminino , Hamartoma/química , Hamartoma/genética , Hamartoma/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Mucosa Nasal/patologia , Doenças Nasofaríngeas/genética , Doenças Nasofaríngeas/metabolismo , Doenças Nasofaríngeas/patologia , Gradação de Tumores , Doenças Nasais/genética , Doenças Nasais/metabolismo , Doenças Nasais/patologia , Neoplasias Nasais/química , Neoplasias Nasais/genética , Neoplasias Nasais/patologia , Lesões Pré-Cancerosas/genética , Lesões Pré-Cancerosas/metabolismo , Lesões Pré-Cancerosas/patologia , Valor Preditivo dos Testes , Adulto JovemAssuntos
Infecções por Chlamydia , Chlamydia trachomatis/isolamento & purificação , Claritromicina/administração & dosagem , Endoscopia/métodos , Neoplasias Nasofaríngeas/diagnóstico , Adulto , Antibacterianos/administração & dosagem , Biópsia/métodos , Infecções por Chlamydia/diagnóstico , Infecções por Chlamydia/tratamento farmacológico , Infecções por Chlamydia/fisiopatologia , Diagnóstico Diferencial , Feminino , Humanos , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/tratamento farmacológico , Doenças Nasofaríngeas/microbiologia , Doenças Nasofaríngeas/fisiopatologia , Infecções Sexualmente Transmissíveis/diagnóstico , Infecções Sexualmente Transmissíveis/tratamento farmacológico , Infecções Sexualmente Transmissíveis/fisiopatologia , Resultado do TratamentoRESUMO
Even if tuberculosis is a major cause of morbidity and mortality, nasopharyngeal location is unusual and extremely rare. We report four new cases observed with short time interval suggesting a trend towards increased frequency. The diagnosis was confirmed by histological analysis after a biopsy. The evolution was favorable after anti tuberculosis chemotherapy. In the light of those observations and a review of the literature, we will discuss different characteristics of this disease and we will highlight the need of a systematic biopsy in order to confirm diagnosis and exclude undifferentiated carcinoma especially in endemic regions for both diseases.
Assuntos
Doenças Nasofaríngeas/diagnóstico , Neoplasias Nasofaríngeas/diagnóstico , Tuberculose/diagnóstico , Adolescente , Biópsia/métodos , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma Nasofaríngeo/diagnóstico , Doenças Nasofaríngeas/microbiologia , Adulto JovemAssuntos
Aspergilose/terapia , Doença Relacionada a Imunoglobulina G4/complicações , Seio Maxilar/microbiologia , Sinusite Maxilar/microbiologia , Doenças Nasofaríngeas/complicações , Aspergilose/diagnóstico , Endoscopia , Humanos , Doença Relacionada a Imunoglobulina G4/terapia , Seio Maxilar/cirurgia , Sinusite Maxilar/complicações , Sinusite Maxilar/diagnóstico , Sinusite Maxilar/terapia , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/terapia , Tomografia Computadorizada por Raios XRESUMO
OBJECTIVES: MRI can detect early-stage nasopharyngeal carcinoma (NPC), but the detection is more challenging in early-stage NPCs because they must be distinguished from benign hyperplasia in the nasopharynx. This study aimed to determine whether intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) MRI could distinguish between these two entities. METHODS: Thirty-four subjects with early-stage NPC and 30 subjects with benign hyperplasia prospectively underwent IVIM DWI. The mean pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) values were calculated for all subjects and compared between the 2 groups using Student's t test. Receiver operating characteristics with the area under the curve (AUC) was used to identify the optimal threshold for all significant parameters, and the corresponding diagnostic performance was calculated. A p value of < 0.05 was considered statistically significant. RESULTS: Compared with benign hyperplasia, early-stage NPC exhibited a significantly lower D mean (0.64 ± 0.06 vs 0.87 ± 0.11 × 10-3 mm2/s), ADC0-1000 mean (0.77 ± 0.08 vs 1.00 ± 0.13 × 10-3 mm2/s), ADC300-1000 (0.63 ± 0.05 vs 0.86 ± 0.10 × 10-3 mm2/s) and a higher D* mean (32.66 ± 4.79 vs 21.96 ± 5.21 × 10-3 mm2/s) (all p < 0.001). No significant difference in the f mean was observed between the two groups (p = 0.216). The D and ADC300-1000 mean had the highest AUC of 0.985 and 0.988, respectively, and the D mean of < 0.75 × 10-3 mm2/s yielded the highest sensitivity, specificity and accuracy (100%, 93.3% and 96.9%, respectively) in distinguishing early-stage NPC from benign hyperplasia. CONCLUSION: DWI has potential to distinguish early-stage NPC from benign hyperplasia and D and ADC300-1000 mean were the most promising parameters. KEY POINTS: ⢠Diffusion-weighted imaging has potential to distinguish early-stage nasopharyngeal carcinoma from benign hyperplasia in the nasopharynx. ⢠The pure diffusion coefficient, pseudo-diffusion coefficient from intravoxel incoherent motion model and apparent diffusion coefficient from conventional diffusion-weighted imaging were significant parameters for distinguishing these two entities in the nasopharynx. ⢠The pure diffusion coefficient, followed by apparent diffusion coefficient, may be the most promising parameters to be used in screening studies to help detect early-stage nasopharyngeal carcinoma.
Assuntos
Imagem de Difusão por Ressonância Magnética/métodos , Detecção Precoce de Câncer/métodos , Carcinoma Nasofaríngeo/diagnóstico , Neoplasias Nasofaríngeas/diagnóstico , Estadiamento de Neoplasias/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Hiperplasia/diagnóstico , Masculino , Pessoa de Meia-Idade , Doenças Nasofaríngeas/diagnóstico , Curva ROC , Reprodutibilidade dos TestesRESUMO
RATIONALE: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy. This disease almost always presents with cutaneous involvement. PATIENT CONCERNS: The 1st patient was a 16-year-old girl who presented with recurrent epistaxis. The 2nd patient was a 17-year-old female who presented with nasal obstruction and voice change for a month. DIAGNOSES: In the 1st patient, sinonasal computed tomography (CT) revealed a 2.9-cm sized, polypoid mass in the nasal cavity. In the 2nd patient, CT scans revealed a large enhancing nasopharyngeal mass involving adenoid and several small indeterminate lymph nodes at the neck. Cutaneous examination was unremarkable for either patient. Biopsy of these 2 masses and bone marrow biopsy were performed. Histologic diagnosis of the 2 cases was BPDCN. INTERVENTIONS: Both patients were treated with induction chemotherapy and received allogenic peripheral blood stem-cell transplant. OUTCOMES: No relapse was observed in the 2 patients for 14 and 11 months, respectively, after transplantation. Interestingly, they had no skin lesions at initial diagnosis or during the course of their illness. LESSONS: We 1st identified nasal cavity as an unusual site of BPDCN. BPDCN should be considered in differential diagnosis of blastic leukemia with an undifferentiated and ambiguous immunophenotype despite the absence of skin lesions.
Assuntos
Neoplasias Hematológicas/patologia , Doenças Nasofaríngeas/patologia , Adolescente , Células Dendríticas , Feminino , Neoplasias Hematológicas/diagnóstico , Neoplasias Hematológicas/terapia , Humanos , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/terapia , Tomografia Computadorizada por Raios XRESUMO
Thornwaldt cyst (Tc) is a benign mass, usually localized in the median plan of the nasopharynx. It is generate from permanent notochord remainings. The pharyngeal bursa-being an embryological residual-occurs in 3% of healthy adults. Closing of the orifice of a nasopharyngeal bursa results in the occurrence of Tc. When the Tc become infected or inflamed, causing to signs. The general indications for radiologic study in patients are nasopharyngeal symptoms, headache, seizures, and dizziness. Computed tomography is less effective than magnetic resonance imaging in the detection and characterization of Tc. On histopathologic study, the walls of Tc are seen to be infiltrated vaguely by lymphocytes and absent lymph follicles. Asymptomatic patients do not necessitate surgery, whereas symptomatic cysts need surgical treatment by a transnasal or transoral access. Marsupialization is the method of option to avoid recurrence. This review provides fundamental knowledge on Tc from an objective perspective.
Assuntos
Cistos/diagnóstico , Doenças Nasofaríngeas/diagnóstico , Nasofaringe/diagnóstico por imagem , Diagnóstico Diferencial , Humanos , Imageamento por Ressonância Magnética/métodos , Tomografia Computadorizada por Raios X/métodosRESUMO
The objective of the present study was to demonstrate the clinical significance and possibilities of diagnostics and treatment of the intra-adenoid cysts in the nasopharynx as exemplified by an original observation of an individual case. The cystic structures in the nasopharynx rarely manifest themselves clinically and are known to produce the non-specific symptoms. The patients admitted to the L.I. Sverzhevskiy Research Institute of Clinical Otorhinolaryngology for the surgical treatment of nasopharyngeal cysts account for 0.05% of the total number of the hospitalized subjects. This article reports a case of two large intra-adenoid cysts in the nasopharynx of one patient complicated by bilateral exudative otitis media. The successful outcome of the surgical treatment of this condition was achieved by means of endonasal marsupilization of the cysts under the laser-assisted endoscopic control with simultaneous bilateral shunting of the tympanic cavity.
Assuntos
Tonsila Faríngea , Cistos , Terapia a Laser/métodos , Ventilação da Orelha Média/métodos , Doenças Nasofaríngeas , Cirurgia Endoscópica por Orifício Natural/métodos , Otite Média com Derrame , Tonsila Faríngea/diagnóstico por imagem , Tonsila Faríngea/patologia , Cistos/complicações , Cistos/diagnóstico , Cistos/fisiopatologia , Cistos/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Nasofaríngeas/complicações , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/fisiopatologia , Doenças Nasofaríngeas/cirurgia , Otite Média com Derrame/diagnóstico , Otite Média com Derrame/etiologia , Resultado do TratamentoRESUMO
The nasopharyngeal cystic lesions are quite common (affecting up to 14% of the general population) even though the majority of the cases are asymptomatic. Sometimes this condition is associated with the obstruction of nasal breathing, runny nose, hearing impairment, and other non-specific clinical manifestations. The endoscopic examination of the nasal cavity allows the preliminary clinical diagnosis to be established, however, MRI and CT visualization are necessary for more reliable differential diagnostics of this pathology and adequate planning of its treatment. The nasopharyngeal cysts require the surgical treatment, with endoscopic transnasal marsupialization in the combination with coblation, radiowave or laser irradiation being the main currently available option.
Assuntos
Cistos , Perda Auditiva , Cavidade Nasal/diagnóstico por imagem , Obstrução Nasal , Doenças Nasofaríngeas , Doenças Assintomáticas , Cistos/complicações , Cistos/diagnóstico por imagem , Cistos/fisiopatologia , Cistos/cirurgia , Diagnóstico Diferencial , Perda Auditiva/diagnóstico , Perda Auditiva/etiologia , Humanos , Imageamento por Ressonância Magnética/métodos , Obstrução Nasal/diagnóstico , Obstrução Nasal/etiologia , Doenças Nasofaríngeas/complicações , Doenças Nasofaríngeas/diagnóstico , Doenças Nasofaríngeas/fisiopatologia , Doenças Nasofaríngeas/cirurgia , Cirurgia Endoscópica por Orifício Natural/métodos , Tomografia Computadorizada por Raios X/métodos , Resultado do TratamentoRESUMO
Primary non-neoplastic polyps originating from the nasopharynx have not been reported in the English language literature. We present the clinical and histopathological features of three primary nasopharyngeal polyps. Clinical data of three patients with primary nasopharyngeal polyps treated at the Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University between 2005 and 2015 were analyzed and presented. Three male patients from 45 to 63 years presented with nasopharyngeal masses. CT or MRI examination showed nasopharyngeal space-occupying lesions. Two patients were initially diagnosed with nasopharyngeal angiofibroma and one patient with nasopharyngeal carcinoma. After surgical excision, based on the histological examination, the tissue masses were all diagnosed as inflammatory polyps. Histologically, the polyps demonstrated significant oedema, collagen deposition, leukocytic infiltration, and epithelial remodelling. Primary nasopharyngeal polyps represent a distinct clinical entity and should be considered in the differential diagnosis of nasopharyngeal masses.