RESUMO
BACKGROUND: A recent meta-analysis revealed that vagally mediated heart rate variability (vmHRV; a biomarker of emotion regulation capacity) significantly decreases in the luteal phase of the menstrual cycle. As two follow-up studies suggest, these vmHRV decreases are driven primarily by increased luteal progesterone (P4). However, analyses also revealed significant interindividual differences in vmHRV reactivity to the cycle, which is in line with longstanding evidence for interindividual differences in mood sensitivity to the cycle. The present study begins to investigate whether these interindividual differences in vmHRV cyclicity can explain who is at higher risk of showing premenstrual emotional changes. We expected a greater degree of midluteal vmHRV decrease to be predictive of a greater premenstrual increase in negative affect. METHODS: We conducted an observational study with a naturally cycling community sample (N = 31, M = 26.03 years). Over a span of six weeks, participants completed (a) daily ratings of negative affect and (b) counterbalanced lab visits in their ovulatory, midluteal, and perimenstrual phases. Lab visits were scheduled based on positive ovulation tests and included assessments of baseline vmHRV and salivary ovarian steroid levels. RESULTS: In line with previous research, multilevel models suggest that most of the sample shows ovulatory-to-midluteal vmHRV decreases which, however, were not associated with premenstrual emotional changes. Interestingly, it was only the subgroup with luteal increases in vmHRV whose negative affect markedly worsened premenstrually and improved postmenstrually. CONCLUSION: The present study begins to investigate cyclical changes in vmHRV as a potential biomarker of mood sensitivity to the menstrual cycle. The results demonstrate a higher level of complexity in these associations than initially expected, given that only atypical midluteal increases in vmHRV are associated with greater premenstrual negative affect. Potential underlying mechanisms are discussed, among those the possibility that luteal vmHRV increases index compensatory efforts to regulate emotion in those with greater premenstrual negative affect. However, future studies with larger and clinical samples and more granular vmHRV assessments should build on these findings and further explore associations between vmHRV cyclicity and menstrually related mood changes.
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Frequência Cardíaca , Fase Luteal , Progesterona , Humanos , Feminino , Fase Luteal/fisiologia , Fase Luteal/psicologia , Frequência Cardíaca/fisiologia , Adulto , Progesterona/sangue , Emoções/fisiologia , Afeto/fisiologia , Nervo Vago/fisiologia , Adulto Jovem , Síndrome Pré-Menstrual/fisiopatologia , Síndrome Pré-Menstrual/psicologiaRESUMO
INTRODUCTION: Although there is potential for the menstrual cycle to impact psychophysiological responses to exercise, there has been a paucity of studies investigating this aspect, specifically in the context of high-intensity interval training (HIIT). PURPOSE: This exploratory study aimed to examine the psychophysiological responses to HIIT over the menstrual cycle. METHODS: Twenty-three healthy and physically active young women were recruited. Each woman completed a cycle ergometer HIIT session in the menstrual, follicular, and luteal phases of the menstrual cycle in a random order. Psychophysiological variables of interest were collected at baseline, and during and after exercise. Primary variables of interest were anxiety, mood, motivation, enjoyment, arousal, affect, and menstrual distress. RESULTS: Higher pain, water retention, behavior change (related to social interactions, eating habits, and self-performance), and autonomic reactions (consisting of nausea, dizziness, hot flashes, and cold sweats) were observed before HIIT during the menstrual phase compared with the follicular phase ( P < 0.05). Participants exhibited worse psychological responses to HIIT sessions during the menstrual phase, followed by the luteal phase. Findings also noted participants arrived to the laboratory with lower motivation to initiate HIIT sessions during the luteal and menstrual phases compared with the follicular phase. This difference was observed before and during HIIT. Motivation and depressive symptoms showed a significant reduction from pre-HIIT to post-HIIT ( P < 0.05), regardless of menstrual phase. CONCLUSIONS: The findings revealed that the menstrual cycle had a significant impact on psychophysiological responses. Moreover, HIIT could be adopted to improve motivation and depressive symptoms; however, further research is needed to explore the effects of HIIT across the menstrual cycle in women with clinical depression.
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Afeto , Ansiedade , Treinamento Intervalado de Alta Intensidade , Ciclo Menstrual , Motivação , Prazer , Humanos , Feminino , Treinamento Intervalado de Alta Intensidade/psicologia , Adulto Jovem , Ciclo Menstrual/fisiologia , Afeto/fisiologia , Adulto , Nível de Alerta/fisiologia , Fase Luteal/fisiologia , Fase Luteal/psicologia , Fase Folicular/fisiologia , Fase Folicular/psicologiaRESUMO
Dysregulated food craving is a complex weight-related behavior. To identify novel targets for enhancing the efficacy of weight loss interventions, we examined whether food craving varies across the menstrual cycle according to the abdominal obesity type and premenstrual dysphoric disorder (PMDD) diagnosis, and, if so, whether it is related to affective symptomatology. Reproductive-age women were classified into one of the four study groups according to whether they have abdominal obesity (AO) or are abdominally lean (AL), and the presence of PMDD: (1) AO:PMDD+ (n = 13), (2) AL:PMDD+ (n = 14), (3) AO:PMDD- (n = 15), and (4) AL:PMDD- (n = 16). Self-report measures as well as urinary luteinizing hormone (LH) tests were provided by the participants across 2-3 menstrual cycles. The ratings of food cravings were similar across the menstrual cycle, except the last, late luteal subphase as the AO:PMDD+ participants had the highest food craving rating. Irritability and depression were correlated with food cravings, but not in a distinctive manner across the menstrual cycle by group. Our study found that women with abdominal obesity and PMDD display a temporal vulnerability to a food-related behavior. The possibility of shared neurobiology between the two conditions is discussed and should be examined in future studies.
Assuntos
Transtorno Disfórico Pré-Menstrual , Feminino , Humanos , Transtorno Disfórico Pré-Menstrual/psicologia , Fissura , Luteína , Fase Luteal/psicologia , Obesidade Abdominal , Ciclo Menstrual , ObesidadeRESUMO
Women experience greater difficulties in quitting smoking than men, though the hormonal factors contributing to this sex difference remain to be clarified. The current study aimed to examine menstrual cycle effects on smoking cue-induced cravings as well as examine dynamic reproductive hormone change as a potential mediator underlying any cycle effects observed. Twenty-one women who smoke underwent two laboratory sessions - one in the mid-follicular phase and the other in the late luteal phase - involving an in-vivo smoking cue task, administered before and after exposure to a psychosocial laboratory stressor. Heart rate variability (HRV) and subjective smoking cravings were assessed in response to the cue task. The degree of change in the urinary metabolites of estradiol and progesterone from 2â days before to the day of each laboratory session was measured. Results revealed that both before and following exposure to psychosocial stress, highly nicotine-dependent women exhibited smaller cue-induced increases in HRV relative to the follicular phase. In contrast, less nicotine-dependent women exhibit an increase in HRV in both menstrual cycle phases. Results furthermore suggest that menstrual cycle effects seen in highly nicotine-dependent women are driven by the decline in estradiol and progesterone occurring in the late luteal phase. Though limited by a small sample size, this study suggests that withdrawal from reproductive hormones in the late luteal phase may alter highly nicotine-dependent women's physiological response to smoking cues, which may reflect greater difficulty resisting temptation. These findings may provide some insight regarding women's greater difficulty in maintaining abstinence after quitting smoking.
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Sinais (Psicologia) , Nicotina , Feminino , Humanos , Masculino , Frequência Cardíaca , Nicotina/farmacologia , Progesterona/farmacologia , Fissura , Ciclo Menstrual/fisiologia , Fase Luteal/fisiologia , Fase Luteal/psicologia , Fase Folicular/psicologia , Estradiol/farmacologia , FumarRESUMO
Cognitive impairment is a key feature of depressive disorder. Various forms of cognitive function have yet to be investigated in women with premenstrual dysphoric disorder (PMDD) during early luteal (EL) and late luteal (LL) phases. Therefore, we evaluated response inhibition and attention in PMDD in these two phases. We also examined the associations between cognitive functions, impulsivity, decision-making style, and irritability. There is a total of 63 female participants with PMDD and 53 controls, as determined through psychiatric diagnostic interviewing and a weekly symptoms checklist. The participants completed a Go/No-go task, Dickman's impulsivity inventory, Preference for Intuition and Deliberation scale, and the Buss-Durkee Hostility Inventory: Chinese Version-Short Form at the EL and LL phases. The women with PMDD had poorer attention in the Go trials at the LL phase and poorer response inhibition in the No-go trials at the EL and LL phases. Repeated measures analysis of variance revealed an LL exacerbation of deficit in attention among PMDD group. In addition, impulsivity negatively correlated with response inhibition at the LL phase. Preference for deliberation correlated with attention at the LL phase. Women with PMDD experienced LL declined attention and impaired response inhibition across the luteal phase. Response inhibition is linked to impulsivity. The deficit in attention links preference for deliberation among women with PMDD. These results reveal the different courses in different domains of cognitive impairment in PMDD. Further studies are required to elucidate the mechanism underlying cognitive dysfunction in PMDD.
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Transtorno Disfórico Pré-Menstrual , Síndrome Pré-Menstrual , Feminino , Humanos , Transtorno Disfórico Pré-Menstrual/psicologia , Fase Luteal/psicologia , Síndrome Pré-Menstrual/psicologia , Comportamento Impulsivo , Atenção , Ciclo Menstrual/fisiologiaRESUMO
Premenstrual syndrome (PMS) is one of the most common problems for women of reproductive age. The physical, mental and behavioural symptoms recur during the luteal phase of the cycle in daily life and cause a deterioration in the quality of life, affecting the patient's social, work and family relationships. Symptoms typically disappear spontaneously within a few days after the onset of menstruation. The onset and severity of PMS are determined by the cyclical functioning of the hypothalamic-pituitary-ovarian axis and the combined presence of other physiological (e.g., chronobiological and circadian) and psychological stressors, which interact with each other. The diagnosis of PMS and premenstrual dysphoric disorder (PMDD) is based on the following criteria, as recommended by the International Society for Premenstrual Disorders (ISPMD): in PMS, the woman has 1-4 symptoms, which may be physical, behavioural or affective/psychological, or at least five symptoms, which may be physical or behavioural. However, if a woman has 5 or more symptoms, and one of these is affective (e.g., irritability, mood swings, anger) in addition to physical or behavioural symptoms, a more accurate diagnosis of PMDD can be made. Since, in addition to the general and gynecological history, the prospective scales (e.g., Prospective record of the impact and severity of menstrual symptoms - PRISM; Daily record of severity of problems - DRSP) completed daily by the physician are helpful in confirming the diagnosis of PMS and PMDD, it is important to take into account the severity of symptoms, the woman's plans for conception or contraceptive needs, her other associated medical conditions, her response to previous treatment methods, and her history of other medical conditions when formulating a treatment plan. Therapeutic options include regular aerobic exercise, stress relief, cognitive behavioural therapy, drug treatments (selective serotonin reuptake inhibitors - SSRIs, combined oral estrogen-progestin contraceptives - COCs, GnRH agonists), -depending on the severity of PMS and PMDD.
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Transtorno Disfórico Pré-Menstrual , Síndrome Pré-Menstrual , Feminino , Humanos , Fase Luteal/psicologia , Transtorno Disfórico Pré-Menstrual/complicações , Transtorno Disfórico Pré-Menstrual/tratamento farmacológico , Síndrome Pré-Menstrual/tratamento farmacológico , Síndrome Pré-Menstrual/terapia , Estudos Prospectivos , Qualidade de Vida , Inibidores Seletivos de Recaptação de Serotonina/uso terapêuticoRESUMO
Premenstrual syndrome (PMS) is one of the most common problems for women of reproductive age worldwide, along with painful menstruation and genital inflammation. The physical, mental and behavioural symptoms recur during the luteal phase of the cycle and cause a deterioration in the quality of life, affecting the patient's social, work and family relationships. Symptoms typically disappear spontaneously within a few days after the onset of menstruation. A severe form of PMS is premenstrual dysphoric disorder (PMDD), which requires psychiatric management. The onset and severity of PMS with multifactorial pathogenesis is triggered by psychoneuroendocrine mechanisms that are influenced by the cyclical functioning of the hypothalamic-pituitary-ovarian axis, altering the neurotransmitter or neuropathway functions of the brain, e.g., the serotoninergic system. The psychoneuroendocrine mechanisms contribute to the development of physical, psychological and behavioural symptoms, which are also influenced by the combined presence of other physiological (genetical background, metabolic and chronic inflammatory processes, chronobiological and circadian disorders) and psychological stressors and their interaction.
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Transtorno Depressivo Maior , Transtorno Disfórico Pré-Menstrual , Síndrome Pré-Menstrual , Feminino , Humanos , Fase Luteal/psicologia , Transtorno Disfórico Pré-Menstrual/complicações , Transtorno Disfórico Pré-Menstrual/psicologia , Síndrome Pré-Menstrual/diagnóstico , Síndrome Pré-Menstrual/etiologia , Síndrome Pré-Menstrual/psicologia , Qualidade de VidaRESUMO
BACKGROUND: Although previous studies report an association between Premenstrual Dysphoric Disorder (PMDD) and suicidal ideation, most studies have only established a provisional and retrospective diagnosis of PMDD fundamentally invalidating the diagnosis. Therefore, the aim of this study was to describe the prevalence and to explore correlates of current suicidal ideation in the late luteal phase in women with prospectively assessed and confirmed PMDD. METHODS: Participants were 110 women who attended the pre-randomization baseline visit of two randomized placebo-controlled clinical trials between January 15, 2017 and October 19, 2019. PMDD was diagnosed prospectively in line with DSM-5 criteria. Current suicidal ideation was measured by the MADRS-S in the late luteal phase. Descriptive statistics were presented and logistic regression analyses were carried out to explore the association between psychosocial and health characteristics and current suicidal ideation, presenting unadjusted odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Current suicidal ideation was reported by nearly 40% of women with confirmed PMDD (n = 43, 39.1%). Previous psychological treatment for PMDD and higher depressive symptoms in the late luteal phase were positively associated with current suicidal ideation (OR 5.63, 95% CI 1.07-29.49, and OR 1.17, 95% CI 1.10-1.25, respectively), whereas higher ratings of self-rated health were associated with lower odds ratios for current suicidal ideation (OR 0.98, 95% CI 0.96-0.99). CONCLUSIONS: A substantial proportion of women with confirmed PMDD report current suicidal ideation in the late luteal phase. Results point to a need for better awareness and screening of suicidal ideation in women with PMDD.
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Transtorno Disfórico Pré-Menstrual , Síndrome Pré-Menstrual , Feminino , Humanos , Fase Luteal/psicologia , Transtorno Disfórico Pré-Menstrual/epidemiologia , Transtorno Disfórico Pré-Menstrual/psicologia , Síndrome Pré-Menstrual/epidemiologia , Síndrome Pré-Menstrual/psicologia , Prevalência , Estudos Retrospectivos , Ideação SuicidaRESUMO
PURPOSE: This study aimed to test the hypothesis that aerobic exercise performance is impaired in the midluteal (ML) compared with the midfollicular (MF) phase of the menstrual cycle. METHODS: Twelve recreationally active eumenorrheic women (25 ± 6 yr) completed exercise sessions during the MF and the ML phases. Each session consisted of an 8-km cycling time trial that was preceded by 10 min of cycling performed at a constant power below and above gas exchange threshold. Heart rate, ventilation, and oxygen uptake were continuously measured. RPE and ratings of fatigue were assessed during the time trial using visual analog scales. Total mood disturbance was calculated from the POMS questionnaire administered before and 20 min postexercise. RESULTS: Salivary progesterone concentration was 578 ± 515 pg·mL-1 higher in ML compared with MF phase (P < 0.01), whereas estradiol concentration did not differ between phases (167 ± 55 vs 206 ± 120 pg·mL-1, P = 0.31). Total mood disturbance before exercise was greater during the ML phase compared with the MF phase (P < 0.01), but this difference was abolished postexercise (P = 0.14). Mean power output was lower during the ML phase (115 ± 29 vs 125 ± 28 W, P < 0.01), which led to a slower time trial in the ML phase (18.3 ± 2.0 min) compared with the MF phase (17.8 ± 1.7 min, P = 0.03). Ratings of fatigue were greater during the ML phase from 2 to 8 km (P ≤ 0.01), whereas no differences in RPE were observed. Heart rate (P = 0.85), minute ventilation (P = 0.53), and oxygen uptake (P = 0.32) did not differ between phases during the time trial. CONCLUSION: Aerobic exercise performance is worse in the ML phase compared with the MF phase in recreationally active women, which was accompanied by a more negative mood state preexercise and increased ratings of fatigue.
Assuntos
Desempenho Atlético/fisiologia , Exercício Físico/fisiologia , Fase Luteal/fisiologia , Adulto , Afeto , Desempenho Atlético/psicologia , Exercício Físico/psicologia , Teste de Esforço , Feminino , Fase Folicular/fisiologia , Fase Folicular/psicologia , Frequência Cardíaca/fisiologia , Humanos , Fase Luteal/psicologia , Consumo de Oxigênio/fisiologia , Percepção/fisiologia , Esforço Físico/fisiologia , Troca Gasosa Pulmonar , Respiração , Adulto JovemRESUMO
OBJECTIVES: In this study, we evaluated the changes in leptin and ghrelin concentrations, eating behavior, depression, and impulsivity and their correlations within the luteal phase among women with premenstrual dysphoric disorder (PMDD). METHODS: In 63 women with PMDD and 53 healthy controls, we prospectively evaluated serum levels of leptin and ghrelin, Body Mass Index(BMI), and self-reported sweet cravings, cognitive restraint, uncontrolled eating, emotional eating, depression, and impulsivity during the early luteal (EL) and late luteal (LL) phases. RESULTS: Compared with the controls, the women with PMDD had higher BMI, higher leptin concentrations in the EL and LL phase, and leptin concentrations increased from the EL to the LL phase. However, there is no significant difference in ghrelin. Women with PMDD increased sweet cravings and uncontrolled eating from EL to LL phase. No significant correlation was observed between the EL-LL changes in leptin or ghrelin concentrations and those in eating behaviors. Both depression and impulsivity correlated with sweet craving and uncontrolled eating. Depression mediated the association between PMDD and uncontrolled eating. The BMI of women with PMDD positively correlated with their EL-LL change in leptin, and LL depression levels and emotional eating. CONCLUSION: Young women with PMDD had higher leptin concentrations and BMI in the luteal phase. The LL leptin level was not the primary factor responsible for the increased uncontrolled eating of PMDD. Whether the increased eating and depression in the LL phase contribute to the risk of obesity or hyperleptinemia among women with PMDD need to be evaluated in the future.
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Comportamento Alimentar/fisiologia , Grelina/sangue , Leptina/sangue , Fase Luteal , Transtorno Disfórico Pré-Menstrual , Adulto , Índice de Massa Corporal , Estudos de Casos e Controles , Emoções/fisiologia , Comportamento Alimentar/psicologia , Transtornos da Alimentação e da Ingestão de Alimentos/sangue , Transtornos da Alimentação e da Ingestão de Alimentos/fisiopatologia , Transtornos da Alimentação e da Ingestão de Alimentos/psicologia , Feminino , Humanos , Fase Luteal/sangue , Fase Luteal/psicologia , Transtorno Disfórico Pré-Menstrual/sangue , Transtorno Disfórico Pré-Menstrual/fisiopatologia , Transtorno Disfórico Pré-Menstrual/psicologia , Adulto JovemRESUMO
BACKGROUND AND OBJECTIVE: Immunosuppression is characteristic of the luteal phase of the menstrual cycle and is accompanied by an adaptive disgust response to reduce contact with pathogens. However, research has not examined the effects of emotion regulation on disgust during the menstrual cycle. Accordingly, the present study examines the effect of suppression and reappraisal on disgust during the luteal and follicular phases of the menstrual cycle. METHOD: Menstrual cycle phase was estimated in a sample of naturally cycling women (n = 73), and those in the follicular or luteal phase were assigned to suppress or reappraise disgust while watching a disgust-inducing video. Physiological arousal during the video and avoidance of disgust cues in a public restroom after the video were also assessed. RESULTS: No differences were observed in self-reported disgust to the video between those who suppressed and those who reappraised in the luteal phase. However, women in the follicular phase who suppressed reported less disgust than those who reappraised. The emotion regulation strategies did not influence physiology during the video or avoidance after the video as a function of menstrual cycle phase. LIMITATIONS: Hormone assay data was not collected to confirm menstrual cycle phase and a relatively small sample of naturally cycling women was used. CONCLUSIONS: Suppression may be a more effective strategy than reappraisal for reducing verbal disgust in the follicular phase but not in the luteal phase. The implications of these findings for the treatment of disgust-based disorders among women are discussed.
Assuntos
Asco , Regulação Emocional , Ciclo Menstrual/psicologia , Feminino , Fase Folicular/psicologia , Humanos , Fase Luteal/psicologia , Adulto JovemRESUMO
BACKGROUND: Premenstrual dysphoric disorder (PMDD) is a new Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis characterized by the cyclical emergence of emotional and physical symptoms in the luteal phase of the menstrual cycle, with symptom remission in the follicular phase. Converging evidence highlights the possibility of distinct subtypes of PMDD with unique pathophysiologies, but temporal subgroups have yet to be explored in a systematic way. METHODS: In the current work, we use group-based trajectory modeling to identify unique trajectory subgroups of core emotional and total PMDD symptoms across the perimenstrual frame (days -14 to +9, where day 0 is menstrual onset) in a sample of 74 individuals prospectively diagnosed with DSM-5 PMDD. RESULTS: For the total daily symptom score, the best-fitting model was comprised of three groups: a group demonstrating moderate symptoms only in the premenstrual week (65%), a group demonstrating severe symptoms across the full 2 weeks of the luteal phase (17.5%), and a group demonstrating severe symptoms in the premenstrual week that were slow to resolve in the follicular phase (17.5%). CONCLUSIONS: These trajectory groups are discussed in the context of the latest work on the pathophysiology of PMDD. Experimental work is needed to test for the presence of possible pathophysiologic differences in trajectory groups, and whether unique treatment approaches are needed.
Assuntos
Transtorno Disfórico Pré-Menstrual/fisiopatologia , Adulto , Emoções , Feminino , Fase Folicular/psicologia , Humanos , Individualidade , Fase Luteal/psicologia , Ciclo Menstrual/psicologia , Transtorno Disfórico Pré-Menstrual/classificação , Transtorno Disfórico Pré-Menstrual/psicologia , Inquéritos e Questionários , Adulto JovemRESUMO
PURPOSE: A single bout of aerobic or resistance exercise improves executive function. We sought to determine whether menstrual cycle variations in ovarian hormone concentrations differentially influence the expression and/or magnitude of a postexercise executive benefit. METHODS: Eumenorrheic female participants completed 20-min single bouts of aerobic exercise (via cycle ergometer) at a moderate intensity (i.e., 80% of estimated lactate threshold) during the early follicular and midluteal phases of their menstrual cycle. Pre- and postexercise executive function was examined via antisaccades-an executive task requiring a saccade mirror-symmetrical to a visual stimulus. Antisaccades are an ideal tool for examining postexercise executive changes because the task is mediated via the same frontoparietal networks as modified following single-bout and chronic exercise. RESULTS: Antisaccade reaction times decreased from the pre- to postexercise assessments by an average of 22 ms (P = 0.003), and this benefit was independent of changes in directional errors or end point accuracy (P's > 0.26). In other words, participants did not decrease their postexercise reaction times at the cost of increased planning times or execution errors. Most notably, the postexercise antisaccade benefit did not vary in magnitude across follicular or luteal phases (P = 0.33) and a two one-sided test statistic (i.e., equivalence testing) provided support for the null hypothesis (P = 0.008). CONCLUSIONS: A postexercise executive benefit is independent of hormonal variations in the menstrual cycle. Further, our results evince that the phase of a female participant's menstrual cycle should not be a limiting factor in determining their inclusion in exercise neuroscience research.
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Função Executiva/fisiologia , Exercício Físico/fisiologia , Exercício Físico/psicologia , Fase Folicular/fisiologia , Fase Folicular/psicologia , Fase Luteal/fisiologia , Fase Luteal/psicologia , Aptidão Cardiorrespiratória/fisiologia , Estrogênios/sangue , Movimentos Oculares/fisiologia , Feminino , Humanos , Progesterona/sangue , Tempo de Reação , Adulto JovemRESUMO
OBJECTIVES: The compensatory prophylaxis hypothesis (CPH) proposes that evolved psychological mechanisms enhance the avoidance of potential contaminants during periods of reproductive immunomodulation in order to decrease a chance of infection. However, the results of previous studies are inconclusive. Our aim was to investigate the differences in disgust sensitivity during phases of menstrual cycle in regularly cycling young healthy women and among women who reported having an infection. METHODS: The disgust sensitivity was measured using Two Domains of the Three Domain Disgust Scale (TDDS), Padua Inventory (PI), and photographs during the internet-based survey. Women (N = 527) were divided by phases of menstrual cycle using two different methods on the basis of reported cycle length and the number of days since the onset of their most recent menstrual bleeding. RESULTS: The women who had an infection and who were in luteal phase had higher scores in Pathogen Disgust Domain than women in follicular phase. However, they did not differ in other assessments of disgust sensitivity. CONCLUSIONS: The results provide weak support for the CPH hypothesis. We found differences in disgust sensitivity in women who declared having an infection-participants in the luteal phase scored higher in the Pathogen Domain Scale of TDDS than women in the follicular phase. We suggest that future studies should measure levels of sex steroids and immunological markers of infection.
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Asco , Fase Folicular/psicologia , Infecções/psicologia , Fase Luteal/psicologia , Adulto , Feminino , Humanos , Infecções/etiologia , Pessoa de Meia-Idade , Polônia , População Rural , População Urbana , Adulto JovemRESUMO
Although selective head-cooling has been reported to decrease scalp and tympanic temperature and improve sleep quality, whether head-cooling during sleep can improve sleep quality in women during the luteal phase has not been elucidated. This randomized, controlled crossover open trial aimed to investigate the effect of head cooling during sleep on sleep quality in women during the luteal phase. Female university students aged 19-25 years with increased daytime sleepiness during the luteal phase were recruited by poster advertisement at their university from May to June 2016 and from May to June 2017. Fourteen women aged 19-22 years participated in this study. The temperature-controllable cooling sheet containing tubes filled with circulating water was used for head-cooling, and the head-cooling and the controlled temperature were set at 25°C and 35°C, respectively. Electroencephalogram data were obtained using a single-channel portable electroencephalogram device. The difference in sleep-related variables and tympanic temperature between head-cooling and control were analyzed using a linear mixed model. The proportion of arousal was lower with head cooling than with the control. In contrast, the proportion of non-REM3 and the delta power were higher with head cooling than with the control. The proportion of non-REM2 and non-REM3 among sleep EEG stages were positively and negatively correlated with the mean tympanic temperature during sleep, respectively. However, arousal and REM were not correlated with tympanic temperature. We considered the reduction of arousal time by head-cooling might be related to scalp temperature rather than tympanic temperature. Further, our results suggested that head-cooling also improved subjective sleep comfort. In conclusion, head-cooling during sleep could improve sleep quality in young women during the luteal phase.
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Temperatura Baixa , Fase Luteal/psicologia , Sono/fisiologia , Adulto , Eletroencefalografia , Feminino , Humanos , Projetos Piloto , Estudantes/estatística & dados numéricos , Universidades , Adulto JovemRESUMO
Factors underlying HIV acquisition in women remain incompletely understood. This study evaluated ex vivo mucosal HIV-1BaL infection (ectocervix, endocervix), T cell frequencies and phenotype (ectocervix, endocervix, peripheral blood), and HIV-1BaL-induced tissue immune responses (ectocervix) in the proliferative and secretory phases of the menstrual cycle using samples obtained from women undergoing hysterectomies. Tissue infectivity (number of productively infected explants) and infection level following 500 and/or fifty 50% tissue culture infectious dose (TCID50) HIV-1BaL challenge were similar in the proliferative and secretory phases. Although not associated with infection outcomes, higher frequencies of HIV target CD4+α4ß7+ T cells, and stronger HIV-1BaL-induced proinflammatory responses were detected in ectocervix in the secretory versus proliferative phase. Independently of the cycle phase, serum E2 concentrations were inversely associated with ectocervical and endocervical tissue infection levels following high-dose 500 TCID50 HIV-1BaL challenge, with frequencies of CD4+α4ß7+ T cells in endocervix, and with HIV-induced interleukin (IL)2R and IL4 in ectocervix. Although serum P4 concentrations and P4/E2 ratios were neither associated with tissue infection level nor infectivity, high P4 concentrations and/or P4/E2 ratios correlated with high frequencies of CD4+α4ß7+ T cells in ectocervix, low frequencies of CD4+CD103+ blood T cells, low CD4+LFA-1+ T cells in endocervix, and high proinflammatory (IL1ß, IL17, tumor necrosis factor α) ectocervical tissue responses to HIV-1BaL. The data suggest an inhibitory effect of E2 on mucosal HIV infection, provide insights into potential mechanisms of E2-mediated anti-HIV activity, and highlight P4-associated immune changes in the mucosa.
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Suscetibilidade a Doenças/virologia , Fase Folicular/psicologia , Infecções por HIV/virologia , HIV-1/genética , Fase Luteal/psicologia , Mucosa/virologia , Adulto , Linfócitos T CD4-Positivos/metabolismo , Colo do Útero/virologia , Citocinas/análise , Estradiol/sangue , Feminino , Humanos , Histerectomia , Pessoa de Meia-Idade , Progesterona/sangue , Reação em Cadeia da Polimerase em Tempo RealRESUMO
OBJECTIVE: To evaluate the relationship between the inflammatory profile and mood states in the different phases of the menstrual cycle in soccer players with and without premenstrual syndrome (PMS). METHODS: Data on the menstrual cycle and mood states were collected using the Daily Symptom Report and the Brunel Mood Scale. Cytokine and stress hormone concentrations were measured in urine by flow cytometry before and after a game in the luteal phase and in the follicular phase of one menstrual cycle. RESULTS: In all, 59.6% of the athletes had PMS. The PMS group showed higher concentrations of interleukin (IL)-1ß, IL-6, and IL-8 than the athletes without PMS. After the game, IL-6 decreased in the follicular phase and the luteal phase. The tumor necrosis factor-α levels were higher in the group without PMS during the post-game follicular phase than before the game. In the PMS group, tension was higher in the follicular phase before the game and depression was higher in the pre-game luteal phase than in the group without PMS. The PMS group also presented a negative correlation between depression and IL-10 levels in the pre-game follicular phase. Finally, in the pre-game luteal phase were found positive correlations between growth hormone and IL-10. CONCLUSION: PMS influences the inflammatory condition related to mood states and stress hormones in female soccer players.
Assuntos
Afeto , Ansiedade/psicologia , Citocinas/imunologia , Depressão/psicologia , Inflamação/imunologia , Síndrome Pré-Menstrual/imunologia , Síndrome Pré-Menstrual/psicologia , Futebol , Adolescente , Ansiedade/imunologia , Ansiedade/urina , Atletas , Citocinas/urina , Depressão/imunologia , Depressão/urina , Feminino , Fase Folicular/psicologia , Fase Folicular/urina , Hormônio do Crescimento Humano/urina , Humanos , Inflamação/urina , Interleucina-1beta/imunologia , Interleucina-1beta/urina , Interleucina-6/imunologia , Interleucina-6/urina , Interleucina-8/imunologia , Interleucina-8/urina , Fase Luteal/psicologia , Fase Luteal/urina , Síndrome Pré-Menstrual/urina , Fator de Necrose Tumoral alfa/imunologia , Fator de Necrose Tumoral alfa/urina , Adulto JovemRESUMO
Humans can detect aspects of identity, reproductive status, and emotional state from body odor. Women have shown a distinctive neural response to male sexually-aroused (vs. resting) sweat. The present study examined olfactory sexual arousal contagion in men. Axial sweat was collected from naturally cycling women when they were sexually aroused and when they were resting, during both their follicular and their luteal phase. Men were exposed to both aroused and resting sweat in a state of low-level sexual arousal. Participants smelling follicular phase sweat reported greater subjective sexual arousal and an increased likelihood to self-disclose than men smelling luteal phase sweat. They also showed increased genital arousal but this effect was moderated by the arousal state of the women; genital responding was greater in men smelling sexually aroused (vs. resting) sweat for those exposed to luteal (but not those exposed to follicular) phase body odor. Being able to detect the scent of sexual arousal could enhance perceiver arousal and provide information on whether to approach someone for sexual interaction.
Assuntos
Nível de Alerta/fisiologia , Ciclo Menstrual/psicologia , Odorantes , Comportamento Sexual/psicologia , Olfato/fisiologia , Adulto , Feminino , Fase Folicular/metabolismo , Fase Folicular/psicologia , Humanos , Fase Luteal/metabolismo , Fase Luteal/psicologia , Masculino , Ciclo Menstrual/metabolismo , Suor , Adulto JovemRESUMO
The impact of sex and the menstrual cycle phase on the autonomic response to psychosocial stress remains controversial. This study explored autonomic nervous system activity through salivary alpha-amylase, heart rate, and heart rate variability responses to the Trier Social Stress Test (TSST) in healthy young people. The sample was composed of 25 men, 26 women in the luteal phase, and 25 women in the follicular phase, from 18 to 25 years of age. Participants were exposed to the TSST or a control condition. The results indicate that women in their follicular phase showed a blunted alpha-amylase response to stress compared to men and women in the luteal phase. In addition, men showed higher sympatho-vagal activity in the stress condition compared to the two groups of women. These results confirm that sex and the menstrual cycle phase are potential modulators of autonomic nervous system reactivity to psychosocial stress.
Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Ciclo Menstrual/psicologia , Fatores Sexuais , Estresse Psicológico/fisiopatologia , alfa-Amilases/metabolismo , Adolescente , Adulto , Feminino , Fase Folicular/metabolismo , Fase Folicular/psicologia , Frequência Cardíaca/fisiologia , Humanos , Fase Luteal/metabolismo , Fase Luteal/psicologia , Masculino , Ciclo Menstrual/metabolismo , Saliva/metabolismo , Estresse Psicológico/metabolismo , Adulto JovemRESUMO
There is evidence that frequency of suicide attempts of fertile women is related to the menstrual cycle phases, while the influence of hormonal and psychiatric features has been hypothesized. This study aims to explore the distribution and possible differences in clinical characteristics of women who attempted suicide in relation to menstrual cycle. Seventy fertile female psychiatric patients, hospitalized in psychiatric department after a suicide attempt, were studied. Depression was assessed using Beck Depression Inventory, suicide intent with the Suicide Intent Scale, and aggression using the Buss-Perry Aggression Questionnaire. A profile of psychopathology was obtained by using Symptom Check List SCL-90-R. Attempts were more frequent during the last 4 days of luteal phase and during the 4 days of menses, with 59% of attempts to occur during these 8 days. Patterns of number of attempts and cycle phase were similar for subgroups regarding diagnosis, violent/non-violent mode of suicide attempt, and one or repeated attempts. Although attempts were unequally distributed during the cycle, none of the psychiatric features assessed in the present study were related to the higher frequency of attempts during premenstrual/menstrual days, indicating the need to include additional aspects of suicidal behavior in future studies.