RESUMO
Favism is a hemolytic disease due to the ingestion of fava beans in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. There is wide inter- and intra-individual variability in the development of hemolytic crisis, and several factors influence it: quantity, quality, ripeness of fava beans, and age of onset. In this narrative review of case reports and case series, we reported the predisposing factors and clinical features for four different age groups classified as follows: pregnant women and infants (i.e., exclusively breastfed children); children, from weaned to 11 years; preadolescents and adolescents, from 11 to 18 years; and adults (18 years and older). Some symptoms developed only in specific age groups: death in infants; visual impairment in children; systolic murmur in infants, children, and adolescents; and renal failure in adults. In youngest children or pregnant women the severity is the highest. Some other symptoms were present in all: jaundice, increased bilirubin, splenomegaly, hepatomegaly, discolored urine, tachycardia, pallor, abdominal pain, malaise, vomit, nausea, and dizziness. Laboratory findings are characterized by anemia, reticulocytosis, elevated bilirubin level, and sometimes urinary urobilinogen and methemoglobinemia. In most cases the symptomatology is self-limited and does not release sequelae, but hospitalization and transfusion are often required.
Assuntos
Favismo , Deficiência de Glucosefosfato Desidrogenase , Vicia faba , Gravidez , Criança , Lactente , Adolescente , Adulto , Humanos , Feminino , Favismo/complicações , Favismo/diagnóstico , Deficiência de Glucosefosfato Desidrogenase/complicações , Deficiência de Glucosefosfato Desidrogenase/diagnóstico , Hemólise , BilirrubinaRESUMO
Favism is an acute hemolytic syndrome caused by the ingestion of fava bean (FB) in glucose 6-phosphate dehydrogenase (G6PD) deficient individuals. However, little is known about the global transcripts alteration in liver tissue after FB ingestion in G6PD-normal and -deficient states. In this study, deep sequencing was used to analyze liver genes expression alterations underlying the effects of FB in C3H (Wild Type, WT) and G6PD-deficient (G6PDx) mice and to evaluate and visualize the collective annotation of a list of genes to Gene Ontology (GO) terms associated with favism. Our results showed that FB resulted in a decrease of glutathione (GSH)-to-oxidized glutathione (GSSG) ratio and an increase of malondialdehyde (MDA) both in the G6PDx and WT-control check (CK) mice plasma. Significantly, liver transcript differences were observed between the control and FB-treated groups of both WT and G6PDx mice. A total of 320 differentially expressed transcripts were identified by comparison of G6PDx-CK with WT-CK and were associated with immune response and oxidation-reduction function. A total of 149 differentially expressed genes were identified by comparison of WT-FB with WT-CK. These genes were associated with immune response, steroid metabolic process, creatine kinase activity, and fatty acid metabolic process. A total of 438 differential genes were identified by comparing G6PDx-FB with G6PD-CK, associated with the negative regulation of fatty acid metabolic process, endoplasmic reticulum, iron binding, and glutathione transferase activity. These findings indicate that G6PD mutations may affect the functional categories such as immune response and oxidation-reduction.
Assuntos
Favismo/genética , Deficiência de Glucosefosfato Desidrogenase/genética , Fígado/efeitos dos fármacos , Transcriptoma , Vicia faba/toxicidade , Animais , Favismo/complicações , Favismo/imunologia , Favismo/patologia , Perfilação da Expressão Gênica , Regulação da Expressão Gênica , Ontologia Genética , Deficiência de Glucosefosfato Desidrogenase/complicações , Deficiência de Glucosefosfato Desidrogenase/imunologia , Deficiência de Glucosefosfato Desidrogenase/patologia , Glutationa/sangue , Sequenciamento de Nucleotídeos em Larga Escala , Imunidade Inata , Fígado/metabolismo , Masculino , Malondialdeído/sangue , Camundongos , Camundongos Endogâmicos C3H , Camundongos Knockout , Anotação de Sequência Molecular , Oxirredução , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/toxicidade , Vicia faba/químicaRESUMO
Intolerance to fava beans in subjects with glucose-6-phosphate-dehydrogenase deficiency (favism) may lead to severe hemolytic crises and decreased renal function. Renal biopsy findings exploring the molecular mechanisms of renal damage in favism have not been previously reported. We report a case of favism-associated acute kidney injury in which renal biopsy showed acute tubular necrosis and massive iron deposits in tubular cells. Interestingly, iron deposit areas were characterized by the presence of oxidative stress markers (NADPH-p22 phox and heme-oxigenase-1) and macrophages expressing the hemoglobin scavenger receptor CD163. In addition, iron deposits, NADPH-p22 phox, hemeoxigenase- 1 and CD163 positive cells were observed in some glomeruli. These results identify both glomerular and tubular involvement in favism-associated acute kidney injury and suggest novel therapeutic targets to prevent or accelerate recovery from acute kidney injury.
Assuntos
Injúria Renal Aguda/etiologia , Favismo/complicações , Glomérulos Renais/química , Túbulos Renais/química , Injúria Renal Aguda/diagnóstico , Injúria Renal Aguda/metabolismo , Injúria Renal Aguda/terapia , Antígenos CD/análise , Antígenos de Diferenciação Mielomonocítica/análise , Biomarcadores/análise , Biópsia , Favismo/diagnóstico , Heme Oxigenase-1/análise , Humanos , Imuno-Histoquímica , Glomérulos Renais/patologia , Necrose Tubular Aguda/etiologia , Necrose Tubular Aguda/metabolismo , Túbulos Renais/patologia , Macrófagos/química , Masculino , Pessoa de Meia-Idade , NADPH Oxidases/análise , Receptores de Superfície Celular/análise , Diálise Renal , Fatores de Tempo , Resultado do TratamentoRESUMO
Background: We report a 67-year-old man presenting with abdominal pain of acute onset, pallor, jaundice and behavioral changes after ingestion of fava beans. In the initial evaluation he appeared acutely ill and had resting dyspnea, edema and jaundice. His initial laboratory assessment disclosed azotemia, elevated lactate dehydrogenase levels, a low hemoglobin concentration (4.9 /dL) and a high corrected reticulocyte count (4,7%) with negative direct and indirect Coombs' test. The patient was transferred to the ICU, where he received support therapy with hemodialysis, mechanical ventilation, vasoactive drugs and transfusions of packed red cells. The evolution after 1 month was favorable and he was discharged without anemia and with normal renal function. Three months after discharge, the glucose-6-phosphate-dehydrogenase screening study did not demonstrate detectable enzymatic activity.
Assuntos
Idoso , Humanos , Masculino , Injúria Renal Aguda/etiologia , Favismo/complicações , Injúria Renal Aguda/diagnóstico , Favismo/diagnósticoRESUMO
We report a 67-year-old man presenting with abdominal pain of acute onset, pallor, jaundice and behavioral changes after ingestion of fava beans. In the initial evaluation he appeared acutely ill and had resting dyspnea, edema and jaundice. His initial laboratory assessment disclosed azotemia, elevated lactate dehydrogenase levels, a low hemoglobin concentration (4.9 /dL) and a high corrected reticulocyte count (4,7%) with negative direct and indirect Coombs' test. The patient was transferred to the ICU, where he received support therapy with hemodialysis, mechanical ventilation, vasoactive drugs and transfusions of packed red cells. The evolution after 1 month was favorable and he was discharged without anemia and with normal renal function. Three months after discharge, the glucose-6-phosphate-dehydrogenase screening study did not demonstrate detectable enzymatic activity.
Assuntos
Injúria Renal Aguda/etiologia , Favismo/complicações , Injúria Renal Aguda/diagnóstico , Idoso , Favismo/diagnóstico , Humanos , MasculinoRESUMO
We report the occurrence of symptomatic methemoglobinemia in a previously healthy boy, who presented with severe acute hemolysis after fava bean ingestion. The methemoglobinemia revealed a previously unrecognized glucose-6-phosphate dehydrogenase (G6PD) deficiency. We discuss the pathophysiology of severe methemoglobinemia when associated with acute hemolysis, favism, and the common African G6PD A-variant [G6PD, VAL68MET, ASN126ASP]. In conclusion, screening for G6PD deficiency must be considered in symptomatic methemoglobinemia, especially in young boys, when associated with intravascular hemolysis.
Assuntos
Favismo/diagnóstico , Deficiência de Glucosefosfato Desidrogenase/diagnóstico , Glucosefosfato Desidrogenase/sangue , Metemoglobinemia/diagnóstico , Argélia , Criança , Ingestão de Alimentos , Favismo/complicações , Favismo/fisiopatologia , Glucosefosfato Desidrogenase/genética , Deficiência de Glucosefosfato Desidrogenase/complicações , Deficiência de Glucosefosfato Desidrogenase/fisiopatologia , Hemólise/efeitos dos fármacos , Hemolíticos/administração & dosagem , Hemolíticos/efeitos adversos , Humanos , Masculino , Metemoglobinemia/complicações , Metemoglobinemia/fisiopatologia , Mutação , Vicia faba/efeitos adversosRESUMO
A 1-year-old Moroccan boy was referred because of jaundice. A peripheral blood smear showed 'blister cells'. This finding is characteristic for haemolysis caused by glucose-6-phosphate dehydrogenase deficiency. It appeared hemolysis occurred because the boy ate fava beans.
Assuntos
Deficiência de Glucosefosfato Desidrogenase/diagnóstico , Glucosefosfato Desidrogenase/genética , Favismo/complicações , Favismo/diagnóstico , Favismo/enzimologia , Favismo/genética , Glucosefosfato Desidrogenase/sangue , Deficiência de Glucosefosfato Desidrogenase/complicações , Deficiência de Glucosefosfato Desidrogenase/enzimologia , Deficiência de Glucosefosfato Desidrogenase/genética , Hemólise , Humanos , Lactente , Icterícia/diagnóstico , Icterícia/etiologia , Masculino , Marrocos/etnologia , Países BaixosRESUMO
OBJECTIVE: To evaluate the G6PD(C563T) Mediterranean mutation among Jordanian females who were admitted to Princess Rahma Teaching Hospital (PRTH) with/or previous history of favism. STUDY DESIGN: A descriptive study. PLACE AND DURATION OF STUDY: Jordanian University of Science and Technology and PRTH, from October 2003 to October 2004. METHODOLOGY: After obtaining approval from the Ethics Committee of Jordanian University of Science and Technology, a total of 32 females were included in this study. Samples from 15 healthy individual females were used as a negative control. Blood samples from these patients were collected and analyzed by allele-specific polymerase chain reaction (AS-PCR) to determine the G6PD(C563T) mutation. RESULTS: Twenty one out of 32 patients were found to be G6PD(C563T) Mediterranean mutation (65.6%) positive. Three out of 21 patients were homozygous and remaining 18 were heterozygous for G6PD(C563T) Mediterranean mutation. Eleven (34.4%) out of 32 patients were found to be negative for G6PD(C563T) mutation indicating the presence of other G6PD mutations in the study sample. CONCLUSION: G6PD(C563T) Mediterranean mutation accounted for 65.6% of the study sample with favism in the North of Jordan. There is likely to be another G6PD deficiency variant implicated in acute hemolytic crisis (favism).
Assuntos
Favismo/genética , Deficiência de Glucosefosfato Desidrogenase/genética , Glucosefosfato Desidrogenase/genética , Hemólise/genética , Mutação , Doença Aguda , Favismo/complicações , Feminino , Deficiência de Glucosefosfato Desidrogenase/complicações , Humanos , JordâniaRESUMO
We describe the case of a 64-year-old patient with glucose-6-phosphate dehydrogenase deficiency who was referred to our hospital because of an acute inferior myocardial infarction.Given the possible risk of acute haemolytic anaemia, aspirin was not given in the acute phase, and the patient was successfully treated by balloon angioplasty of the right coronary artery.After functional and genetic testing showing the presence of the Mediterranean mutation, known to be a class II variant, the patient received oral daily aspirin (100 mg) under strict monitoring in order to promptly detect any sign of haemolysis. After 4 days, a complex percutaneous coronary intervention with an implantation of two drug-eluting stents was successfully performed on the left coronary artery. After 3 months, the patient is free from adverse events.Glucose-6-phosphate dehydrogenase deficiency is commonly considered a contraindication to aspirin intake; however, this case shows that aspirin at low, antiplatelet dosage is well tolerated and should not be denied to patients with ischaemic heart disease and complex coronary anatomy.
Assuntos
Anemia Hemolítica/induzido quimicamente , Angioplastia Coronária com Balão/instrumentação , Aspirina/efeitos adversos , Stents Farmacológicos , Favismo/complicações , Infarto do Miocárdio/terapia , Inibidores da Agregação Plaquetária/efeitos adversos , Administração Oral , Anemia Hemolítica/genética , Angioplastia Coronária com Balão/efeitos adversos , Aspirina/administração & dosagem , Angiografia Coronária , Favismo/enzimologia , Favismo/genética , Glucosefosfato Desidrogenase/genética , Humanos , Masculino , Pessoa de Meia-Idade , Mutação , Infarto do Miocárdio/complicações , Infarto do Miocárdio/diagnóstico por imagem , Infarto do Miocárdio/tratamento farmacológico , Inibidores da Agregação Plaquetária/administração & dosagem , Medição de Risco , Resultado do TratamentoAssuntos
Lactente , Humanos , Favismo/diagnóstico , Anemia/etiologia , Evolução Clínica , Favismo/complicações , Icterícia/etiologiaRESUMO
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a frequent congenital human enzyme defect, is the most frequent cause of hemolytic anemia triggered by drugs or infectious diseases. Drugs which induce acute hemolysis in patients with G6PD deficiency are often used in anesthesia and perioperative pain therapy. Considering the fact that patients from geographic regions with a high prevalence of the disease are often treated in European hospitals, special attention should be paid to this problem. We report a case of a 30-year-old female patient with favism and review the disease and anesthesia-related implications.
Assuntos
Anestesia , Favismo/complicações , Deficiência de Glucosefosfato Desidrogenase/complicações , Adulto , Anestésicos/efeitos adversos , Diagnóstico Diferencial , Favismo/sangue , Favismo/genética , Feminino , Deficiência de Glucosefosfato Desidrogenase/sangue , Deficiência de Glucosefosfato Desidrogenase/genética , Glutationa/metabolismo , Hemólise/efeitos dos fármacos , Humanos , Medicação Pré-Anestésica , TireoidectomiaRESUMO
Megaesophagus is a severe esophageal malformation. We report a case of megaesophagus in an asthmatic patient affected by congenital non-haemolytic anaemia and undergoing beta2 stimulant treatment by inhalation. Our case could be due to chronic beta2 receptor stimulation with imbalance of alpha and beta receptor, without any implication of favism.
Assuntos
Asma/complicações , Acalasia Esofágica/complicações , Favismo/complicações , Adulto , Acalasia Esofágica/fisiopatologia , Acalasia Esofágica/terapia , Humanos , Terapia RespiratóriaRESUMO
The objective of this study is to study the absolute number of nucleated red blood cells (RBC) at birth, an index of active fetal erythropoiesis, in infants with G6PD deficiency and in controls. We tested the hypothesis that hematocrit and hemoglobin would be lower, and absolute nucleated RBC counts higher, in the G6PD deficient and that these changes would be more prominent in infants exposed passively to fava bean through maternal diet. Thirty-two term infants with G6PD deficiency were compared with 30 term controls. Complete blood counts with manual differential counts were obtained within 12 hours of life. Absolute nucleated RBC and corrected leukocyte counts were computed from the Coulter results and the differential count. G6PD deficient patients did not differ from controls in terms of gestational age, birth weight, or Apgar scores or in any of the hematologic parameters studied, whether or not the mother reported fava beans consumption in the days prior to delivery. Although intrauterine hemolysis is possible in G6PD deficient fetuses exposed passively to fava beans, our study supports that such events must be very rare.
Assuntos
Eritroblastos , Doença de Depósito de Glicogênio Tipo I/sangue , Adulto , Eritroblastose Fetal/etiologia , Contagem de Eritrócitos , Favismo/complicações , Feminino , Doença de Depósito de Glicogênio Tipo I/etiologia , Hematócrito , Humanos , Recém-Nascido , Projetos Piloto , Gravidez , Efeitos Tardios da Exposição Pré-Natal , Estudos ProspectivosRESUMO
Two nursing neonates deficient in glucose-6-phosphate dehydrogenase developed severe hyperbilirubinemia despite phototherapy. Mothers of both the infants had recently eaten fava beans. The hemolytic triggers found in fava beans may have been absorbed by the mothers and excreted in their breast milk. Carboxyhemoglobin determination performed on one of the infants reflected ongoing hemolysis.
Assuntos
Aleitamento Materno , Favismo/complicações , Favismo/etiologia , Icterícia Neonatal/etiologia , Carboxihemoglobina/análise , Transfusão Total , Fabaceae , Feminino , Deficiência de Glucosefosfato Desidrogenase/complicações , Hemólise , Humanos , Recém-Nascido , Icterícia Neonatal/sangue , Icterícia Neonatal/terapia , Masculino , Fototerapia , Plantas MedicinaisRESUMO
BACKGROUND: It has recently been suggested that primary lactase deficiency might have been selected for by malaria, as has been previously shown to occur for thalasaemia and glucose 6-phosphate dehydrogenase (G6PD) deficiency. AIMS: To test this hypothesis, the prevalence of primary lactase deficiency in G6PD deficient subjects and in controls from the area of Sassari (Northern Sardinia) was determined, which in the past was characterised by an intermediate malarial endemicity. SUBJECTS: 70 adult subjects with G6PD deficiency, 34 of whom had a past history of favism, and 50 age matched control subjects. METHODS: The capacity to absorb lactose was assessed by measuring breath hydrogen production after oral administration of lactose (50 g) by a gas chromatographic method. RESULTS: Twenty per cent of G6PD deficient subjects with a positive history of favism and 22% of G6PD deficient subjects without a positive history of favism were lactose absorbers compared with 14% lactose absorbers in the control group. The differences were not statistically significant. CONCLUSIONS: These data show that the prevalence of primary lactase deficiency in the area of Sassari is relatively high, but comparable to that seen in the adult population from another area of southern Italy (Naples) where malaria was less endemic.
Assuntos
Favismo/complicações , Doença de Depósito de Glicogênio/metabolismo , Lactose/farmacocinética , Adulto , Estudos de Casos e Controles , Feminino , Doença de Depósito de Glicogênio/complicações , Doença de Depósito de Glicogênio/epidemiologia , Humanos , Hidrogênio/análise , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , PrevalênciaAssuntos
Anemia Hemolítica/complicações , Favismo , Deficiência de Glucosefosfato Desidrogenase/genética , Doenças Metabólicas/complicações , Combinação Trimetoprima e Sulfametoxazol/efeitos adversos , Anemia Hemolítica/induzido quimicamente , Etnicidade , Favismo/complicações , Favismo/genética , Feminino , França/epidemiologia , Deficiência de Glucosefosfato Desidrogenase/diagnóstico , Hemólise/efeitos dos fármacos , Humanos , Lactente , Itália/epidemiologia , Icterícia/etiologia , Masculino , Doenças Metabólicas/enzimologia , Doenças Metabólicas/genética , Cromossomo XRESUMO
We report the case of a 2-year-old Japanese boy with acute favism who was treated with human haptoglobin products. He had been exhibiting chronic nonspherocytic haemolytic anaemia until the diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency when 14 months old. He suffered a favic crisis at 24 months of age, when the administration of haptoglobin was effective for relieving bilirubinaemia and haemoglobinuria. Serum-free Hb rapidly decreased to normal levels despite the sustained level of serum lactate dehydrogenase. His G6PD gene was G6PD Guadalajara. This is the first application of haptoglobin therapy for acute favism and the first reported case of Japanese G6PD deficiency with typical favic crisis. Haptoglobin treatment might be helpful for managing the haemolytic crisis in the disease.