RESUMO
BACKGROUND: Pulmonary sclerosing hemangioma (PSH) is a rare tumor that usually develops in middle-aged Asian women. PSH has four histological types (hemorrhagic, sclerotic, solid, and papillary) and often grows slowly in a lower lobe of the lung. Preoperative misdiagnosis frequently occurs because of the absence of specific clinical manifestations and imaging findings. Few reports have described PSH in women of advanced age. Case presentation: A 75-year-old woman presented to our hospital in China with a 5-day history of productive cough and intermittent hemoptysis. Computed tomography indicated bronchiectasis and a large mass in the left inferior lobe of the lung. Treatment of the bronchiectasis provided no symptom relief. The hemoptysis resolved following left lower pulmonary lobectomy, and PSH was pathologically diagnosed following surgery. At the time of this writing (after 6 months of follow-up), the tumor had not recurred, no metastases had been detected, and close follow-up was ongoing. CONCLUSIONS: Both bronchiectasis and PSH can cause hemoptysis. This case demonstrates that PSH should be included as a differential diagnosis of hemoptysis in women of advanced age. For patients with chronic hemoptysis, the diagnosis of PSH should be considered if the therapeutic effect of bronchiectasis is poor.
Assuntos
Hemangioma Esclerosante Pulmonar/complicações , Nódulo Pulmonar Solitário/complicações , Idoso , Feminino , Humanos , Hemangioma Esclerosante Pulmonar/diagnóstico por imagem , Hemangioma Esclerosante Pulmonar/patologia , Hemangioma Esclerosante Pulmonar/cirurgia , Nódulo Pulmonar Solitário/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
RATIONALE: Sclerosing pneumocytoma accompanied with other type of tumor in one patient is very rare. Here, we report a case of a sclerosing pneumocytoma mixed with a typical carcinoid tumor in a same neoplasm. PATIENT CONCERNS: A 55-year-old woman incidentally detected a space-occupying lesion of right lung in routine health examination. The patient was asymptomatic and there were no positive findings in routine laboratory examination, physical examination, and pulmonary function test. Computed tomography revealed a solitary round mass in the middle lobe of the right lung. DIAGNOSIS: The lesion was diagnosed as a sclerosing pneumocytoma accompanied with a typical carcinoid tumor of the right lung. INTERVENTION: The patient underwent thoracoscopic lobectomy in our hospital. OUTCOMES: The postoperative course was uneventful. LESSONS: This case is rare and noteworthy for a lesion containing two different types of neoplasms, which may cause diagnostic difficulties.
Assuntos
Tumor Carcinoide/complicações , Tumor Carcinoide/diagnóstico , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/diagnóstico , Hemangioma Esclerosante Pulmonar/complicações , Hemangioma Esclerosante Pulmonar/diagnóstico , Tumor Carcinoide/cirurgia , Feminino , Humanos , Neoplasias Pulmonares/cirurgia , Pessoa de Meia-Idade , Pneumonectomia , Hemangioma Esclerosante Pulmonar/cirurgia , Toracoscopia , Tomografia Computadorizada por Raios XRESUMO
Sclerosing pneumocytoma (SP) is an uncommon benign tumor, and metastasis of SP has been rarely reported. Here, we report the case of a 26-year-old woman with surgically confirmed SP. The tumor diameter was 40 mm, and metastasis to mediastinal and regional lymph nodes was observed. Immunohistochemically, both surface and round cells were positive for epithelial membrane antigen, thyroid transcription factor 1, and vimentin. Only surface cells expressed creatine kinase, carcinoembryonic antigen, napsin A, and cytokeratin 7, and only round cells expressed progesterone receptor. Ki-67 was detected in ~3% of cells, and the rate of weak positive p53 staining was 3%. Both cell types were negative for chromogranin A, synaptophysin, CD3, and CK20. Multiple metastases in a young SP patient are very rare, and potential mechanisms of metastasis may be related to epithelial-mesenchymal transformation.
Assuntos
Linfonodos/fisiologia , Hemangioma Esclerosante Pulmonar/complicações , Hemangioma Esclerosante Pulmonar/patologia , Adulto , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/genética , Biópsia , Feminino , Humanos , Imuno-Histoquímica , Linfonodos/citologia , Metástase Linfática , Mucina-1/genética , Mucina-1/imunologia , Hemangioma Esclerosante Pulmonar/diagnóstico , Hemangioma Esclerosante Pulmonar/cirurgia , Fator Nuclear 1 de Tireoide/genética , Fator Nuclear 1 de Tireoide/imunologia , Vimentina/genética , Vimentina/imunologiaRESUMO
Pulmonary sclerosing hemangioma is an uncommon tumor, thought to be a benign neoplasm. Pericardial cysts are also uncommon benign abnormalities, most often found incidentally on chest radiography. We describe the case of a 51-year-old woman in whom both lesions were incidentially detected on a routine chest radiograph. Enucleation of the pulmonary sclerosing hemangioma and simultaneous resection of the pericardial cyst were undertaken.
Assuntos
Cisto Mediastínico/complicações , Hemangioma Esclerosante Pulmonar/complicações , Biópsia , Feminino , Humanos , Cisto Mediastínico/diagnóstico , Cisto Mediastínico/cirurgia , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Hemangioma Esclerosante Pulmonar/diagnóstico , Hemangioma Esclerosante Pulmonar/cirurgia , ToracotomiaRESUMO
Pulmonary sclerosing hemangioma (PSH) is a rare tumor accounting for 0.2-1% of all primary lung tumors. Simultaneous occurrence of PSH with breast cancer has very rarely been reported in the literature. We describe here a case of simultaneous occurrence of PSH with breast cancer. A pathological diagnosis of PSH was confirmed by computed tomography (CT)-guided biopsy. Due to the patient's poor performance status and the benign nature of PSH, surgical excision was not considered and the patient was managed conservatively with regular follow-up. Although surgical excision is the preferred treatment for PSH, conservative management may be a reasonable option in carefully selected patients.
Assuntos
Neoplasias da Mama/complicações , Carcinoma Ductal de Mama/complicações , Neoplasias Pulmonares/complicações , Hemangioma Esclerosante Pulmonar/complicações , Idoso , Neoplasias da Mama/terapia , Carcinoma Ductal de Mama/terapia , Feminino , Humanos , Neoplasias Pulmonares/terapia , Hemangioma Esclerosante Pulmonar/terapiaAssuntos
Dor no Peito/etiologia , Neoplasias Pulmonares/complicações , Neoplasias Primárias Múltiplas/complicações , Hemangioma Esclerosante Pulmonar/complicações , Adulto , Emergências , Feminino , Hemotórax/etiologia , Hemotórax/cirurgia , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Neoplasias Primárias Múltiplas/diagnóstico por imagem , Neoplasias Primárias Múltiplas/patologia , Neoplasias Primárias Múltiplas/cirurgia , Pneumonectomia , Tomografia por Emissão de Pósitrons , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Hemangioma Esclerosante Pulmonar/diagnóstico por imagem , Hemangioma Esclerosante Pulmonar/patologia , Hemangioma Esclerosante Pulmonar/cirurgia , ReoperaçãoRESUMO
Sclerosing haemangioma (SH) is a rare benign lung tumour with distinctive variety of histological patterns. SH typically presents as asymptomatic peripheral, solitary well-circumscribed lesion in women with median age at diagnosis in the fifth decade. Preoperative diagnosis of this tumour is difficult, and sometimes even intraoperative frozen sections cannot differentiate it from malignant tumours. Here, we present our experiences in investigating its characteristics. We report a case of a 19-year-old girl who presented with chest pain, cough and sputum and off and on haemoptysis for 6 months. Anti-tubercular treatment was given but provided no relief. CT chest showed a well-defined hypodense solid mass lesion with a soft tissue alternation. Lobectomy was performed. Microscopy revealed a tumour comprising of two distinct populations of cells surface and stromal cells which disposed in papillary, solid, sclerotic and haemorrhagic growth patterns. Histology and immunohistochemistry confirmed the diagnosis of SH of the lung.
Assuntos
Hemangioma Esclerosante Pulmonar/complicações , Nódulo Pulmonar Solitário/etiologia , Diagnóstico Diferencial , Feminino , Humanos , Pneumonectomia/métodos , Hemangioma Esclerosante Pulmonar/diagnóstico , Hemangioma Esclerosante Pulmonar/cirurgia , Nódulo Pulmonar Solitário/diagnóstico , Tomografia Computadorizada por Raios X , Adulto JovemRESUMO
A 44-year-old woman underwent surgery for lung cancer. Although preoperative computed tomography did not reveal a tiny nodule, pathological examination of the background lung showed that type II pneumocyte-like tumor cells grew papillary in an area of approximately 2.3 × 1.2 mm. This lesion exhibited hemorrhage, hemosiderosis, calcification, and varying degrees of fibrosis, leading to the diagnosis of sclerosing hemangioma. This is the first reported case of microscopic sclerosing hemangioma undetectable by chest computed tomography.
Assuntos
Adenocarcinoma/cirurgia , Neoplasias Pulmonares/cirurgia , Pneumonectomia , Hemangioma Esclerosante Pulmonar/patologia , Adenocarcinoma/complicações , Adenocarcinoma/diagnóstico por imagem , Adenocarcinoma/patologia , Adulto , Biópsia por Agulha , Feminino , Humanos , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/patologia , Valor Preditivo dos Testes , Hemangioma Esclerosante Pulmonar/complicações , Hemangioma Esclerosante Pulmonar/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Pulmonary sclerosing hemangioma (SH) is a rare tumor of the lung predominantly affecting Asian women in their fifth decade of life. SH is thought to evolve from primitive respiratory epithelium and mostly shows benign biological behavior; however, cases of lymph node metastases, local recurrence and multiple lesions have been described. CASE PRESENTATION: We report the case of a 21-year-old Caucasian male with a history of locally advanced and metastatic rectal carcinoma (UICC IV; pT4, pN1, M1(hep)) that was eventually identified as having hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome). After neoadjuvant chemotherapy followed by low anterior resection, adjuvant chemotherapy and metachronous partial hepatectomy, he was admitted for treatment of newly diagnosed bilateral pulmonary metastases. Thoracic computed tomography showed a homogenous, sharply marked nodule in the left lower lobe. We decided in favor of atypical resection followed by systematic lymphadenectomy. Histopathological analysis revealed the diagnosis of SH. CONCLUSIONS: Cases have been published with familial adenomatous polyposis (FAP) and simultaneous SH. FAP, Gardner syndrome and Li-Fraumeni syndrome, however, had been ruled out in the present case. To the best of our knowledge, this is the first report describing SH associated with Lynch syndrome.
Assuntos
Neoplasias Colorretais Hereditárias sem Polipose/terapia , Hemangioma Esclerosante Pulmonar/cirurgia , Neoplasias Retais/terapia , Neoplasias Colorretais Hereditárias sem Polipose/complicações , Humanos , Masculino , Pneumonectomia , Hemangioma Esclerosante Pulmonar/complicações , Neoplasias Retais/complicações , Adulto JovemAssuntos
Sequestro Broncopulmonar/diagnóstico , Hemangioma Esclerosante Pulmonar/diagnóstico por imagem , Diagnóstico Diferencial , Feminino , Hemoptise/etiologia , Humanos , Pessoa de Meia-Idade , Pneumonectomia , Hemangioma Esclerosante Pulmonar/complicações , Hemangioma Esclerosante Pulmonar/patologia , Hemangioma Esclerosante Pulmonar/cirurgia , RadiografiaRESUMO
Sclerosing hemangioma of the lung, a rare disease, is a low grade malignancy possibly originating from type II pneumocytes or Clara cells. We report the clinical characteristics of 8 patients who underwent surgical resection for sclerosing hemangioma between 2005 and 2010 in our hospital. All cases were female, and the average age was 50 (range: 28-83) years old. The median tumor doubling time was 965 days, suggesting they were slowly growing tumors. In the present cases, five patients had another lung disease: lung cancer in two, metastatic lung tumor in one and atypical adenomatous hyperplasia in two patients. Intraoperative frozen section examinations were performed in seven cases. Five patients were diagnosed correctly, but two patients were diagnosed with adenocarcinoma and organizing pneumonia. As a clinical characteristics, sclerosing hemangioma in the present study showed well-demarcated and slow-growing tumor. The postoperative clinical courses of all cases were uneventful, and no findings of recurrence distant metastasis, lymph node metastasis and local recurrence after surgery were observed in any of the patients.
Assuntos
Hemangioma Esclerosante Pulmonar/cirurgia , Adulto , Idoso de 80 Anos ou mais , Feminino , Humanos , Neoplasias Pulmonares/complicações , Pessoa de Meia-Idade , Hemangioma Esclerosante Pulmonar/complicações , Hemangioma Esclerosante Pulmonar/patologia , Resultado do TratamentoRESUMO
O hemangioma pulmonar esclerosante é um tumor pouco freqüente, que se manifesta como nódulo pulmonar solitário. Entretanto, o seu comportamento biológico ainda não está definido adequadamente. O diagnóstico e a evolução dessas lesões são dificultados pelos achados radiológicos inespecíficos e a dificuldade de interpretação das biópsias de congelação. Os autores descrevem um caso em que o tumor foi completamente retirado com a lobectomia, e o diagnóstico histopatológico definitivo foi de hemangioma esclerosante de pulmão. A ressecção em cunha é realizada na maioria dos casos; porém, quando o diagnóstico não é definido no intra-operatório, é recomendada ressecção mais extensa e linfadenectomia sistemática. Mais estudos são necessários para avaliar a extensão da doença, apesar das metástases não alterarem o excelente prognóstico.
Lung sclerosing hemangioma is an uncommon tumor that presents as a solitary asymptomatic nodule. However, the biologic behavior of this tumor has not yet been characterized adequately. Diagnostic evaluation of this lesion is a diagnostic challenge due to the nonspecific radiological findings, potential intraoperative dilemmas like difficult frozen section interpretation.We describe a case of lung sclerosing hemangioma. The tumour was completely removed by lobectomy and the definitive biopsy was informed as a lung sclerosing hemangioma. Generally, wedge resection is justified in the majority of cases, but in cases of uncertain intraoperative diagnosis, extensive resection with systematic lymphadenectomy is recommended.More studies are needed to evaluate extension of this disease, despite metastasis does not seem to change theexcellent prognosis.
Assuntos
Humanos , Masculino , Adulto , Hemangioma Esclerosante Pulmonar/complicações , Hemangioma Esclerosante Pulmonar/diagnóstico , Neoplasias Pulmonares , Nódulo Pulmonar SolitárioRESUMO
We describe the case of an 18-year-old female with Cowden syndrome in whom a simple x-ray detected a solitary pulmonary nodule that was identified as a sclerosing hemangioma. Pulmonary sclerosing hemangioma is an unusual lung neoplasm which typically presents as a solitary peripheral nodule in asymptomatic women. Although the histology of this entity is well defined, its origin and treatment is debated. One of the main diagnostic problems is to histologically differentiate a pulmonary sclerosing hemangioma from a papillary lung carcinoma.