RESUMO
We report a case of Sneathia amnii as the causative agent of maternal chorioamnionitis and congenital pneumonia resulting in a late fetal death in Mozambique, with strong supportive postmortem molecular and histopathologic confirmation. This rare, fastidious gram-negative coccobacillus has been reported to infrequently cause abortions, stillbirths, and neonatal infections.
Assuntos
Corioamnionite/diagnóstico , Corioamnionite/microbiologia , Infecções por Fusobacteriaceae/diagnóstico , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia , Complicações Infecciosas na Gravidez/diagnóstico , Complicações Infecciosas na Gravidez/microbiologia , Natimorto , Adulto , Autopsia , Corioamnionite/epidemiologia , Feminino , Infecções por Fusobacteriaceae/epidemiologia , Humanos , Imuno-Histoquímica , Pulmão/microbiologia , Pulmão/patologia , Moçambique/epidemiologia , Gravidez , Complicações Infecciosas na Gravidez/epidemiologiaRESUMO
We report the first case of an association between Leptotrichia trevisanii and an episode of pelvic inflammatory disease (PID) and the second case of the isolation of this infection in the cervical canal. A 45-yr-old woman was admitted to our emergency department with clinical and radiological signs and symptoms compatible with an episode of PID. She was hospitalized for intravenous antibiotic control and treatment and the subsequent surgical drainage of abscesses. Cultures were taken throughout the process, but only cultures from cervical canal exudate were positive, with the growth of L. trevisanii species. It appears important to carry out a complete microbiological screening, not limited to conventional agents, on adequate clinical samples to detect possible infectious agents that may be missed in these cases.
Assuntos
Infecções por Fusobacteriaceae/diagnóstico , Leptotrichia/isolamento & purificação , Doença Inflamatória Pélvica/diagnóstico , Doenças do Colo do Útero/diagnóstico , Abscesso/microbiologia , Abscesso/cirurgia , Administração Intravenosa , Antibacterianos/administração & dosagem , Feminino , Infecções por Fusobacteriaceae/microbiologia , Humanos , Pessoa de Meia-Idade , Doença Inflamatória Pélvica/microbiologia , Doenças do Colo do Útero/microbiologiaRESUMO
Very long fusiform gram-negative bacilli were observed after Gram staining of amniotic fluid from a 36-year-old multigravida woman. At 24 hours, pure, abundant growth of smooth, gray, only slightly convex catalase-positive and oxidase-negative colonies measuring about 2 mm were observed. Growth was greater in anaerobic than in aerobic conditions. The bacterium was identified as Leptotrichia trevisanii by matrix-assisted laser desorption ionization time of flight mass spectrometry. Ampicillin and gentamicin were prescribed for chorioamnionitis, and vaginal prostaglandins were administered to terminate the pregnancy. The patient remained afebrile throughout 48 hours and was discharged. Microscopic examination of the placenta revealed severe acute chorioamnionitis with a maternal inflammatory response and abundant bacillary-shaped microorganisms. To our knowledge, this isolate constitutes the first reported case of chorioamnionitis caused by L. trevisanii.
Assuntos
Corioamnionite/microbiologia , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/isolamento & purificação , Complicações na Gravidez/microbiologia , Adulto , Ampicilina/administração & dosagem , Antibacterianos/administração & dosagem , Feminino , Infecções por Fusobacteriaceae/tratamento farmacológico , Gentamicinas/administração & dosagem , Humanos , Leptotrichia/efeitos dos fármacos , Leptotrichia/genética , Leptotrichia/fisiologia , Gravidez , Complicações na Gravidez/tratamento farmacológico , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por MatrizRESUMO
Leptotrichia amnionii, a recently described fastidious gram-negative anaerobic bacterium, is an opportunistic pathogen of the female urogenital tract. We report a rare case of L. amnionii bacteremia in a patient with postpartum endometritis which was successfully treated by amoxicilline-clavunalate. There is more and more evidence that L. amnonii has its role in Pelvic Inflammatory Disease and postpartum endometritis.
Assuntos
Endometrite/microbiologia , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia , Adulto , Endometrite/diagnóstico , Feminino , Infecções por Fusobacteriaceae/diagnóstico , Humanos , Leptotrichia/genética , Leptotrichia/isolamento & purificação , Leptotrichia/patogenicidade , Período Pós-PartoRESUMO
BACKGROUND: The presence of more than one bacterial agent is relatively rare in infective endocarditis, although more common in prosthetic cases. Molecular diagnosis from a removed heart tissue is considered a quick and effective way to diagnose fastidious or intracellular agents. CASE PRESENTATION: Here we describe the case of postpartum polymicrobial prosthetic valve endocarditis in a young woman. Sneathia sanguinegens and Mycoplasma hominis were simultaneously detected from the heart valve sample using broad range 16S rRNA polymerase chain reaction (PCR) followed by sequencing while culture remained negative. Results were confirmed by independent PCR combined with denaturing gradient gel electrophoresis. Before the final agent identification, the highly non-compliant patient left from the hospital against medical advice on empirical intravenous treatment with aminopenicillins, clavulanate and gentamicin switched to oral amoxycillin and clavulanate. Four months after surgery, no signs of inflammation were present despite new regurgitation and valve leaflet flail was detected. However, after another 5 months the patient died from sepsis and recurrent infective endocarditis of unclarified etiology. CONCLUSIONS: Mycoplasma hominis is a rare causative agent of infective endocarditis. To the best of our knowledge, presented case is the first report of Sneathia sanguinegens detected in this condition. Molecular techniques were shown to be useful even in polymicrobial infective endocarditis samples.
Assuntos
Endocardite Bacteriana/microbiologia , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/patogenicidade , Mycoplasma hominis/patogenicidade , Infecções Relacionadas à Prótese/microbiologia , Adulto , Amoxicilina/uso terapêutico , Antibacterianos/uso terapêutico , Endocardite Bacteriana/tratamento farmacológico , Feminino , Próteses Valvulares Cardíacas , Humanos , Leptotrichia/genética , Leptotrichia/isolamento & purificação , Masculino , Infecções por Mycoplasma/tratamento farmacológico , Infecções por Mycoplasma/microbiologia , Mycoplasma hominis/genética , Período Pós-Parto , Gravidez , Infecções Relacionadas à Prótese/tratamento farmacológico , RNA Ribossômico 16S/genéticaRESUMO
Leptotrichia is a pencil-shaped Gram-negative rod and is known as an uncommon pathogen of bacteremia in immunocompromised patients. However, because culture and identification of Leptotrichia species is difficult in clinical laboratories, Leptotrichia goodfellowii is grossly underestimated as a human pathogen. In this study, we report a case of L. goodfellowii bacteremia in an immunocompetent patient and review 5 previously reported cases describing infection with L. goodfellowii.
Assuntos
Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/fisiologia , Idoso , Ceftriaxona/farmacologia , Ceftriaxona/uso terapêutico , Infecções por Fusobacteriaceae/tratamento farmacológico , Humanos , Leptotrichia/efeitos dos fármacos , Leptotrichia/isolamento & purificação , MasculinoRESUMO
OBJECTIVES: To describe the incidence and nature of bloodstream infections (BSI) among children with juvenile idiopathic arthritis (JIA) followed-up prospectively from disease onset. METHODS: The Social Insurance Institution's (SII) national register on individuals with reimbursement for medication of chronic diseases was used to identify children with JIA from 2004 through 2011 and their medications. The National Infectious Disease Register (NIDR) collects data of all blood culture positive samples from all microbiology laboratories in Finland. We combined the NIDR and SII registers to identify JIA patients with BSI. Clinical and laboratory data of each JIA-BSI patient were collected from hospital records. RESULTS: There were 1604 JIA patients and 6630 person-years of follow-up. Five patients had BSI. During the first 5 years after diagnosis the cumulative emergence of BSI was 0.38% [95% confidence interval (CI) 0.16% to 0.92%]. The incidence rates were 7.5/10 000 follow-up years for JIA (95% CI 2.4-17.6) and 2.8/10 000 follow-up years for the age-matched general population (95% CI 2.7-2.9). The standardised incidence ratio was 3.0 (95% CI 1.2 to 7.2). The causative bacteria were Streptococcus pneumoniae, Staphylococcus aureus, Escherichia coli and Fusobacterium necrophorum. Three patients were on anti-rheumatic drugs, including two on TNF inhibitors. All patients responded rapidly to antimicrobial therapy and recovered uneventfully. CONCLUSIONS: Although BSI is rare among children with JIA, the incidence is 3-fold higher than among the general population.
Assuntos
Artrite Juvenil/epidemiologia , Infecções Bacterianas/epidemiologia , Adolescente , Antibacterianos/uso terapêutico , Antirreumáticos/uso terapêutico , Artrite Juvenil/diagnóstico , Artrite Juvenil/tratamento farmacológico , Infecções Bacterianas/diagnóstico , Infecções Bacterianas/tratamento farmacológico , Infecções Bacterianas/microbiologia , Pré-Escolar , Infecções por Escherichia coli/epidemiologia , Infecções por Escherichia coli/microbiologia , Feminino , Finlândia/epidemiologia , Infecções por Fusobacteriaceae/epidemiologia , Infecções por Fusobacteriaceae/microbiologia , Humanos , Imunossupressores/uso terapêutico , Incidência , Masculino , Infecções Pneumocócicas/epidemiologia , Infecções Pneumocócicas/microbiologia , Estudos Prospectivos , Sistema de Registros , Fatores de Risco , Infecções Estafilocócicas/epidemiologia , Infecções Estafilocócicas/microbiologia , Fatores de Tempo , Resultado do TratamentoRESUMO
INTRODUCTION: The aim of the present study was to investigate the composition of the root canal microbiota in endodontic failures in order to identify and quantify these microorganisms. METHODS: Microbiological samples were taken from 36 root canals with persistent endodontic infection. The presence, levels, and proportions of 79 bacterial species were determined by checkerboard DNA-DNA hybridization. The Pearson correlation coefficient was used to investigate the relations between bacterial counts and clinical conditions (P ≤ .05). RESULTS: Enterococcus faecium (36%), Streptococcus epidermidis (36%), Eubacterium saburreum (28%), Parvimonas micra (28%), Streptococcus sanguis (28%), Capnocytophaga sputigena (28%), Leptotrichia buccalis (28%), Enterococcus faecalis (28%), and Staphylococcus warneri (28%) were the most prevalent species; and there was a low prevalence of Treponema socranskii (3%), Fusobacterium periodonticum (3%), Capnocytophaga gingivalis (3%), and Spiroplasma ixodetis (3%). The highest mean levels were found for the following species: E. faecium, Dialister pneumosintes, Staphylococcus epidermidis and Helicobacter pylori. There was a statistically significant difference between the levels of gram-negative species and gram-positive species (13.5 × 10(5) vs 6.5 × 10(5), respectively). A positive correlation was found between the area of the periapical lesion and the levels of gram-negative and rod species (P < .05). CONCLUSIONS: The microbiota from teeth with persistent apical periodontitis presents a mixed and complex profile, hosting E. faecium and S. epidermidis as the most highly prevalent species. No correlation was found between any of the species tested and clinical findings; however, periapical lesions with the largest areas presented higher counts of gram-negative and rod species.
Assuntos
DNA Bacteriano/análise , Cavidade Pulpar/microbiologia , Microbiota , Periodontite Periapical/microbiologia , Dente não Vital/microbiologia , Adulto , Idoso , Capnocytophaga/isolamento & purificação , Enterococcus faecalis/isolamento & purificação , Enterococcus faecium/isolamento & purificação , Eubacterium/isolamento & purificação , Feminino , Infecções por Fusobacteriaceae/microbiologia , Bacilos Gram-Negativos Anaeróbios Retos, Helicoidais e Curvos/isolamento & purificação , Infecções por Bactérias Gram-Negativas/microbiologia , Infecções por Bactérias Gram-Positivas/microbiologia , Infecções por Helicobacter/microbiologia , Helicobacter pylori/isolamento & purificação , Humanos , Leptotrichia/isolamento & purificação , Masculino , Pessoa de Meia-Idade , Hibridização de Ácido Nucleico/métodos , Peptostreptococcus/isolamento & purificação , Doenças Periapicais/microbiologia , Infecções Estafilocócicas/microbiologia , Staphylococcus epidermidis/isolamento & purificação , Infecções Estreptocócicas/microbiologia , Streptococcus sanguis/isolamento & purificaçãoRESUMO
BACKGROUND: Approximately 45% of nongonococcal urethritis cases have no identified etiology. Novel bacteria recently associated with bacterial vaginosis (BV) in women may be involved. We evaluated the association of idiopathic nongonococcal urethritis and 5 newly described BV-associated bacteria (BVAB). METHODS: Heterosexual men 16 years or older attending a sexually transmitted disease clinic in Seattle, Washington, from May 2007 to July 2011 and negative for Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, and Ureaplasma urealyticum-biovar2 were eligible. Cases had urethral discharge or 5 or more polymorphonuclear leukocytes per high-power field in urethral exudates. Controls had no urethral discharge and less than 5 polymorphonuclear leukocytes per high-power field. Urine was tested for Atopobium spp., BVAB-2, BVAB-3, Megasphaera spp., and Leptotrichia/Sneathia spp. using quantitative taxon-directed polymerase chain reaction. RESULTS: Cases (n = 157) and controls (n = 102) were of similar age, education, and income, and most were white. Leptotrichia/Sneathia spp. was significantly associated with urethritis (24/157 [15.3%] vs. 6/102 [5.9%], P = 0.03). BVAB-2 was more common in cases than in controls (7/157 [4.5%] vs. 1/102 [1.0%], P = 0.15), and BVAB-3 (n = 2) and Megasphaera spp. (n = 1) were only detected in men with urethritis, but these bacteria were found only in men who also had Leptotrichia/Sneathia spp. Atopobium spp. was not associated with urethritis. The quantity of bacteria did not differ between cases and controls. Among treated cases, doxycycline was more effective than azithromycin for clinical cure of men with Leptotrichia/Sneathia spp. (9/10 vs. 7/12, P = 0.16) and BVAB-2 (3/3 vs. 0/3, P = 0.10). CONCLUSIONS: Leptotrichia/Sneathia spp. may be urethral pathogens or contribute to a pathogenic microbiota that can also include BVAB-2, BVAB-3, and Megasphaera spp. Doxycycline may be more effective than azithromycin against these newly identified bacteria.
Assuntos
Infecções por Fusobacteriaceae/microbiologia , Infecções por Bactérias Gram-Negativas/microbiologia , Heterossexualidade , Leptotrichia/patogenicidade , Megasphaera/patogenicidade , Uretrite/microbiologia , Vaginose Bacteriana/microbiologia , Adulto , Antibacterianos/uso terapêutico , Reservatórios de Doenças/microbiologia , Doxiciclina/uso terapêutico , Feminino , Infecções por Fusobacteriaceae/transmissão , Infecções por Bactérias Gram-Negativas/transmissão , Humanos , Masculino , Comportamento Sexual , Parceiros Sexuais , Fatores Socioeconômicos , Uretrite/etiologia , Vaginose Bacteriana/transmissãoRESUMO
We present two cases of bacteremia caused by Leptotrichia trevisanii: a 12-year-old girl with recurrent myeloid leukemia of the mandible and a 66-year-old man with esophageal carcinoma. As this filamentous bacillus showed indefinite Gram staining and the identification based on biochemical enzymatic reactions was not definitive, identification required 16s rRNA analysis. For this organism, drug sensitivity testing showed susceptiblity to each ß-lactam antibiotics and clindamycin, but resistance to fluoroquinolone and erythromycin. This filamentous bacillus needs careful identification and appropriate antibiotic treatment.
Assuntos
Bacteriemia/microbiologia , Neutropenia Febril/microbiologia , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/isolamento & purificação , Idoso , Criança , Neoplasias Esofágicas/microbiologia , Feminino , Humanos , Leucemia Mieloide/microbiologia , Masculino , Doenças Mandibulares/microbiologiaRESUMO
'Leptotrichia amnionii' is an underestimated fastidious inhabitant of the vaginal flora that can cause upper genital tract infections when predisposing factors are present. We describe here what is believed to be the first reported case of early onset meningitis due to 'L. amnionii' in a neonate with intrauterine growth retardation. The outcome was favourable after cefotaxime treatment.
Assuntos
Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/isolamento & purificação , Meningites Bacterianas/microbiologia , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Cefotaxima/administração & dosagem , Cefotaxima/uso terapêutico , Farmacorresistência Bacteriana , Quimioterapia Combinada , Feminino , Retardo do Crescimento Fetal , Infecções por Fusobacteriaceae/tratamento farmacológico , Humanos , Recém-Nascido , Leptotrichia/classificação , Leptotrichia/genética , Meningites Bacterianas/tratamento farmacológico , Dados de Sequência Molecular , Netilmicina/administração & dosagem , Netilmicina/uso terapêutico , Gravidez , Complicações Infecciosas na Gravidez/microbiologia , Adulto JovemRESUMO
Leptotrichia spp. are anaerobic, pencil-shaped, Gram-negative rods that are part of the normal oral and intestinal human flora. Although not typically considered pathogenic, invasive Leptotrichia infections have been reported in immunosuppressed patients. A perceived rise in the identification of Leptotrichia spp. at our institution prompted a retrospective evaluation of these infections. Laboratory and clinical records were reviewed to identify Leptotrichia culture-positive patients. Over a 5-year period, 68 Leptotrichia-positive specimens were identified. Of these, 21% (14/68) were identified in original samples submitted from 13 different patients at our institution, and the remainder (79% [54/68]) were unknown isolates referred from outside hospitals for molecular identification. All in-house Leptotrichia were identified from blood cultures. Only 64% (9/14) of these grew on solid media, and 5 were a part of polymicrobial bacteremias containing other enteric pathogens. All local patients were receiving chemotherapy and a majority received hematopoietic stem cell transplant (HSCT) (11/13). All had neutropenic fever with symptoms of mucositis and/or enteritis. Most of the HSCT patients (73% [8/11]) were autologous recipients hospitalized after recent high-dose chemotherapy for multiple myeloma. L. hongkongensis, a novel species, was found in the majority of myeloma cases (63% [5/8]). In conclusion, we suggest that Leptotrichia spp. may be an underappreciated cause of bacteremia, particularly in multiple myeloma patients receiving cytotoxic chemotherapy for autologous HSCT. In our cohort, these infections were associated with neutropenic fever from an enteric source, and most isolates remained sensitive to standard antibiotics.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Bacteriemia/microbiologia , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/genética , Antibacterianos/farmacologia , Transplante de Células-Tronco Hematopoéticas , Humanos , Leptotrichia/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Tipagem Molecular , Mieloma Múltiplo/complicações , Mieloma Múltiplo/terapia , Filogenia , RNA Bacteriano/genética , RNA Ribossômico 16S/genética , Estudos RetrospectivosRESUMO
BACKGROUND: Fusobacterium nucleatum, a commensal opportunistic oral bacterium, is capable of invading gingival epithelial cells, but the entrance into human primary oral fibroblast cells has not been documented. This study evaluated the ability of three strains of F. nucleatum (F. nucleatum ssp. nucleatum, F. nucleatum ssp. polymorphum, and F. nucleatum ssp. vincentii) to enter gingival fibroblasts (GFs) and periodontal ligament fibroblasts (PLFs). METHODS: GFs and PLFs were cocultured for various periods of time with different strains of F. nucleatum. Scanning and transmission electron microscopy, together with confocal laser scanning microscopy, were used to visualize the entrance and presence of bacteria in host cells. Flow cytometry was performed to compare the load of internalized bacteria in GFs and PLFs exposed for 3 and 5 hours to live F. nucleatum labeled with fluorescein isothiocyanate. RESULTS: All three strains of F. nucleatum were found entering and located in the cytoplasm of GFs and PLFs after 1 hour of exposure. Flow cytometry tests revealed a significant increase in the fluorescent signal, compared to baseline, derived from bacteria internalized in fibroblasts exposed for 3 hours (P <0.001); a further increase was found at 5 hours. The greatest bacterial mass in exposed fibroblasts of both types was of F. nucleatum ssp. polymorphum; the smallest was of F. nucleatum ssp. vincentii. Although not statistically significant, PLFs had a higher bacterial load than corresponding GFs. CONCLUSION: F. nucleatum was capable of entering GFs and PLFs in a manner that is dependent on the cell type and the bacterial strain.
Assuntos
Fibroblastos/microbiologia , Fusobacterium nucleatum/fisiologia , Interações Hospedeiro-Patógeno/fisiologia , Aderência Bacteriana/fisiologia , Células Cultivadas , Técnicas de Cocultura , Fibroblastos/fisiologia , Infecções por Fusobacteriaceae/microbiologia , Fusobacterium nucleatum/patogenicidade , Gengiva/citologia , Humanos , Valores de Referência , Especificidade da Espécie , VirulênciaRESUMO
We present the first case of severe pneumonia possibly caused by Leptotrichia species with oral bacteria. This was found in a healthy but elderly subject whose bronchoalveolar lavage fluid was analyzed by 16S rRNA gene sequencing analysis. The combination of this method and microscopic observation provided useful information for diagnosis and treatment.
Assuntos
Líquido da Lavagem Broncoalveolar/microbiologia , Infecções por Fusobacteriaceae/diagnóstico , Leptotrichia/isolamento & purificação , Pneumonia Bacteriana/diagnóstico , Idoso , DNA Bacteriano/química , DNA Bacteriano/genética , DNA Ribossômico/química , DNA Ribossômico/genética , Infecções por Fusobacteriaceae/microbiologia , Humanos , Leptotrichia/genética , Masculino , Pneumonia Bacteriana/microbiologia , RNA Ribossômico 16S/genética , Radiografia Torácica , Análise de Sequência de DNARESUMO
Leptotrichia species typically colonize the oral cavity and genitourinary tract. These anaerobic bacteria belong to the normal flora of humans and are seldom found in clinically significant specimens. However, on rare occasions, Leptotrichia has been isolated from blood cultures of patients with lesions in the oral mucosa, in particular from patients with neutropenia. These organisms should be considered potential pathogens in neutropenic patients, especially when breaks in the mucosal barriers are present through which they frequently spread to the bloodstream. Leptotrichia has also been recovered from immunocompetent persons, e.g. patients with endocarditis. Although their role in infections remains elusive and not much is known, they have been suggested as emerging pathogens. The present review deals with taxonomy, diagnosis, clinical importance, pathogenesis, host defence, infection control, and spectrum of Leptotrichia infections, and ends with a few typical case reports. Currently, six species have been validly published, but a number of yet uncultivable species exist. Molecular methods recovering uncultivable species should be used to get a real idea of their role as pathogens.
Assuntos
Infecções por Fusobacteriaceae , Leptotrichia , Adolescente , Adulto , Idoso , Bacteriemia/microbiologia , Sangue/microbiologia , Criança , Pré-Escolar , Feminino , Infecções por Fusobacteriaceae/diagnóstico , Infecções por Fusobacteriaceae/imunologia , Infecções por Fusobacteriaceae/microbiologia , Infecções por Fusobacteriaceae/fisiopatologia , Humanos , Leptotrichia/classificação , Leptotrichia/genética , Leptotrichia/patogenicidade , Masculino , Pessoa de Meia-Idade , Boca/microbiologia , Filogenia , RNA Ribossômico 16S/genéticaRESUMO
Leptotrichia species typically colonize the oral cavity and genitourinary tract. We report the first two cases of endocarditis secondary to L. goodfellowii sp. nov. Both cases were identified using 16S rRNA gene sequencing. Review of the English literature revealed only two other cases of Leptotrichia sp. endocarditis.
Assuntos
Endocardite Bacteriana/microbiologia , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/isolamento & purificação , Idoso , DNA Bacteriano/genética , DNA Ribossômico/genética , Feminino , Humanos , Leptotrichia/genética , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , RNA Ribossômico 16S/genética , Análise de Sequência de DNARESUMO
Leptotrichia amnionii, a recently described, very fastidious, gram-negative anaerobic bacterium, is an opportunistic pathogen of the female urogenital tract. We report a case of second-trimester abortion in a patient with chorioamnionitis and L. amnionii bacteremia and a case of renal abscess in a female 5 weeks postpartum.
Assuntos
Doenças Transmissíveis Emergentes/microbiologia , Infecções por Fusobacteriaceae/diagnóstico , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/isolamento & purificação , Infecções Urinárias/microbiologia , Adulto , Antibacterianos/farmacologia , Feminino , HumanosRESUMO
Leptotrichia amnionii is an organism that rarely causes female genital tract infection. We describe a case of a male patient with arthritis on the left knee joint due to this organism.
Assuntos
Artrite Infecciosa/microbiologia , Infecções por Fusobacteriaceae/microbiologia , Leptotrichia/isolamento & purificação , Feminino , Humanos , Articulação do Joelho/microbiologia , Leptotrichia/classificação , Leptotrichia/genética , Masculino , Pessoa de Meia-Idade , Gravidez , Complicações Infecciosas na Gravidez/microbiologia , Líquido Sinovial/microbiologiaRESUMO
The anaerobic bacterium, Leptotrichia buccalis (Lb), belongs to the normal oral flora of humans and is seldom found in clinically significant specimens. However, on rare occasions, Lb has been isolated from blood cultures from patients with lesions of the oral mucosa, in particular from patients with neutropenia. Over a period of 6 months, Lb was isolated from blood cultures in our laboratory from 2 immunocompetent patients. The identification characteristics of Lb are described including the typical morphology at microscopy. Furthermore, we review the bacteraemic cases reported so far together with present knowledge of the pathogenicity and epidemiology of Lb.