RESUMO
Attention facilitates behavior by enhancing perceptual sensitivity (sensory processing) and choice bias (decisional weighting) for attended information. Whether distinct neural substrates mediate these distinct components of attention remains unknown. We investigate the causal role of key nodes of the right posterior parietal cortex (rPPC) in the forebrain attention network in sensitivity versus bias control. Two groups of participants performed a cued attention task while we applied either inhibitory, repetitive transcranial magnetic stimulation (n = 28) or 40 Hz transcranial alternating current stimulation (n = 26) to the dorsal rPPC. We show that rPPC stimulation - with either modality - impairs task performance by selectively altering attentional modulation of bias but not sensitivity. Specifically, participants' bias toward the uncued, but not the cued, location reduced significantly following rPPC stimulation - an effect that was consistent across both neurostimulation cohorts. In sum, the dorsal rPPC causally mediates the reorienting of choice bias, one particular component of visual spatial attention.
Assuntos
Atenção , Comportamento de Escolha , Lobo Parietal , Estimulação Transcraniana por Corrente Contínua , Estimulação Magnética Transcraniana , Humanos , Lobo Parietal/fisiologia , Masculino , Feminino , Adulto , Comportamento de Escolha/fisiologia , Adulto Jovem , Atenção/fisiologia , Viés de Atenção/fisiologia , Sinais (Psicologia) , Percepção Espacial/fisiologiaRESUMO
The executive control process of monitoring information in working memory depends on the mid-dorsolateral prefrontal cortical region (cytoarchitectonic areas 46 and 9/46) in interaction with the hippocampal memory system. Anatomical studies demonstrated strong connectivity between the mid-dorsolateral prefrontal cortex and the medial parietal area PGm that lies on the precuneus. Area PGm is also strongly connected with the attentional system on the lateral inferior parietal lobule (area PG) and the limbic retrosplenial/posterior cingulate region that interacts with the hippocampal memory system. Thus, in terms of anatomical connectivity, area PGm appears to be a critical node for the integration of executive control processing from the prefrontal cortex with the online attentional and memory related processing. This hypothesis was tested in macaque monkeys with the crossed unilateral lesion methodology. A unilateral lesion in the mid-dorsolateral prefrontal cortex was combined with a unilateral lesion in area PGm in the opposite hemisphere. The results demonstrated an impairment on the externally ordered working memory task that assesses the monitoring of information in working memory. Thus, the medial parietal area PGm is a critical node in mediating the functional interaction between the prefrontal region for the executive control process of monitoring information and the memory system.
Assuntos
Memória de Curto Prazo , Lobo Parietal , Animais , Memória de Curto Prazo/fisiologia , Lobo Parietal/fisiologia , Masculino , Vias Neurais/fisiologia , Macaca mulatta , Córtex Pré-Frontal Dorsolateral/fisiologia , Córtex Pré-Frontal/fisiologiaRESUMO
Approximately one third of the population is prone to motion sickness (MS), which is associated with the dysfunction in the integration of sensory inputs. Transcranial alternating current stimulation (tACS) has been widely used to modulate neurological functions by affecting neural oscillation. However, it has not been applied in the treatment of motion sickness. This study aims to investigate changes in brain oscillations during exposure to MS stimuli and to further explore the potential impact of tACS with the corresponding frequency and site on MS symptoms. A total of 19 subjects were recruited to be exposed to Coriolis stimuli to complete an inducing session. After that, they were randomly assigned to tACS stimulation group or sham stimulation group to complete a stimulation session. Electroencephalography (EEG), electrocardiogram, and galvanic skin response were recorded during the experiment. All the subjects suffering from obvious MS symptoms after inducing session were observed that alpha power of four channels of parieto-occipital lobe significantly decreased (P7: t =3.589, p <0.001; P8: t =2.667, p <0.05; O1: t =3.556, p <0.001; O2: t =2.667, p <0.05). Based on this, tACS group received the tACS stimulation at 10Hz from Oz to CPz. Compared to sham group, tACS stimulation significantly improved behavioral performance and entrained the alpha oscillation in individuals whose alpha power decrease during the inducing session. The findings show that parieto-occipital alpha oscillation plays a critical role in the integration of sensory inputs, and alpha tACS on parieto-occipital can become a potential method to mitigate MS symptoms.
Assuntos
Ritmo alfa , Eletroencefalografia , Resposta Galvânica da Pele , Enjoo devido ao Movimento , Lobo Occipital , Lobo Parietal , Estimulação Transcraniana por Corrente Contínua , Humanos , Enjoo devido ao Movimento/prevenção & controle , Enjoo devido ao Movimento/fisiopatologia , Masculino , Lobo Occipital/fisiologia , Feminino , Lobo Parietal/fisiologia , Adulto , Estimulação Transcraniana por Corrente Contínua/métodos , Adulto Jovem , Resposta Galvânica da Pele/fisiologia , EletrocardiografiaRESUMO
BACKGROUND: Prior work has shown that transcranial alternating current stimulation (tACS) of parietooccipital alpha oscillations (8-14 Hz) can modulate working memory (WM) performance as a function of the phase lag to endogenous oscillations. However, leveraging this effect using real-time phase-tuned tACS has not been feasible so far due to stimulation artifacts preventing continuous phase tracking. OBJECTIVES AND HYPOTHESIS: We aimed to develop a system that tracks and adapts the phase lag between tACS and ongoing parietooccipital alpha oscillations in real-time. We hypothesized that such real-time phase-tuned tACS enhances working memory performance, depending on the phase lag. METHODS: We developed real-time phase-tuned closed-loop amplitude-modulated tACS (CLAM-tACS) targeting parietooccipital alpha oscillations. CLAM-tACS was applied at six different phase lags relative to ongoing alpha oscillations while participants (N = 21) performed a working memory task. To exclude that behavioral effects of CLAM-tACS were mediated by other factors such as sensory co-stimulation, a second group of participants (N = 25) received equivalent stimulation of the forehead. RESULTS: WM accuracy improved in a phase lag dependent manner (p = 0.0350) in the group receiving parietooccipital stimulation, with the strongest enhancement observed at 330° phase lag between tACS and ongoing alpha oscillations (p = 0.00273, d = 0.976). Moreover, across participants, modulation of frontoparietal alpha oscillations correlated both in amplitude (p = 0.0248) and phase (p = 0.0270) with the modulation of WM accuracy. No such effects were observed in the control group receiving frontal stimulation. CONCLUSIONS: Our results demonstrate the feasibility and efficacy of real-time phase-tuned CLAM-tACS in modulating both brain activity and behavior, thereby paving the way for further investigation into brain-behavior relationships and the exploration of innovative therapeutic applications.
Assuntos
Ritmo alfa , Memória de Curto Prazo , Estimulação Transcraniana por Corrente Contínua , Humanos , Memória de Curto Prazo/fisiologia , Estimulação Transcraniana por Corrente Contínua/métodos , Masculino , Feminino , Adulto , Ritmo alfa/fisiologia , Adulto Jovem , Lobo Parietal/fisiologia , Lobo Occipital/fisiologiaRESUMO
Natural behaviors occur in closed action-perception loops and are supported by dynamic and flexible beliefs abstracted away from our immediate sensory milieu. How this real-world flexibility is instantiated in neural circuits remains unknown. Here, we have male macaques navigate in a virtual environment by primarily leveraging sensory (optic flow) signals, or by more heavily relying on acquired internal models. We record single-unit spiking activity simultaneously from the dorsomedial superior temporal area (MSTd), parietal area 7a, and the dorso-lateral prefrontal cortex (dlPFC). Results show that while animals were able to maintain adaptive task-relevant beliefs regardless of sensory context, the fine-grain statistical dependencies between neurons, particularly in 7a and dlPFC, dynamically remapped with the changing computational demands. In dlPFC, but not 7a, destroying these statistical dependencies abolished the area's ability for cross-context decoding. Lastly, correlational analyses suggested that the more unit-to-unit couplings remapped in dlPFC, and the less they did so in MSTd, the less were population codes and behavior impacted by the loss of sensory evidence. We conclude that dynamic functional connectivity between neurons in prefrontal cortex maintain a stable population code and context-invariant beliefs during naturalistic behavior.
Assuntos
Macaca mulatta , Neurônios , Córtex Pré-Frontal , Animais , Masculino , Córtex Pré-Frontal/fisiologia , Neurônios/fisiologia , Lobo Temporal/fisiologia , Lobo Parietal/fisiologia , Comportamento Animal/fisiologiaRESUMO
Studying the neural basis of human dynamic visual perception requires extensive experimental data to evaluate the large swathes of functionally diverse brain neural networks driven by perceiving visual events. Here, we introduce the BOLD Moments Dataset (BMD), a repository of whole-brain fMRI responses to over 1000 short (3 s) naturalistic video clips of visual events across ten human subjects. We use the videos' extensive metadata to show how the brain represents word- and sentence-level descriptions of visual events and identify correlates of video memorability scores extending into the parietal cortex. Furthermore, we reveal a match in hierarchical processing between cortical regions of interest and video-computable deep neural networks, and we showcase that BMD successfully captures temporal dynamics of visual events at second resolution. With its rich metadata, BMD offers new perspectives and accelerates research on the human brain basis of visual event perception.
Assuntos
Mapeamento Encefálico , Encéfalo , Imageamento por Ressonância Magnética , Metadados , Percepção Visual , Humanos , Imageamento por Ressonância Magnética/métodos , Percepção Visual/fisiologia , Masculino , Feminino , Mapeamento Encefálico/métodos , Adulto , Encéfalo/fisiologia , Encéfalo/diagnóstico por imagem , Lobo Parietal/fisiologia , Lobo Parietal/diagnóstico por imagem , Adulto Jovem , Estimulação Luminosa , Gravação em VídeoRESUMO
The development and refinement of functional brain circuits crucial to human cognition is a continuous process that spans from childhood to adulthood. Research increasingly focuses on mapping these evolving configurations, with the aim to identify markers for functional impairments and atypical development. Among human cognitive systems, nonsymbolic magnitude representations serve as a foundational building block for future success in mathematical learning and achievement for individuals. Using task-based frontoparietal (FPN) and salience network (SN) features during nonsymbolic magnitude processing alongside machine learning algorithms, we developed a framework to construct brain age prediction models for participants aged 7-30. Our study revealed differential developmental profiles in the synchronization within and between FPN and SN networks. Specifically, we observed a linear increase in FPN connectivity, concomitant with a decline in SN connectivity across the age span. A nonlinear U-shaped trajectory in the connectivity between the FPN and SN was discerned, revealing reduced FPN-SN synchronization among adolescents compared to both pediatric and adult cohorts. Leveraging the Gradient Boosting machine learning algorithm and nested fivefold stratified cross-validation with independent training datasets, we demonstrated that functional connectivity measures of the FPN and SN nodes predict chronological age, with a correlation coefficient of .727 and a mean absolute error of 2.944 between actual and predicted ages. Notably, connectivity within the FPN emerged as the most contributing feature for age prediction. Critically, a more matured brain age estimate is associated with better arithmetic performance. Our findings shed light on the intricate developmental changes occurring in the neural networks supporting magnitude representations. We emphasize brain age estimation as a potent tool for understanding cognitive development and its relationship to mathematical abilities across the critical developmental period of youth. PRACTITIONER POINTS: This study investigated the prolonged changes in the brain's architecture across childhood, adolescence, and adulthood, with a focus on task-state frontoparietal and salience networks. Distinct developmental pathways were identified: frontoparietal synchronization strengthens consistently throughout development, while salience network connectivity diminishes with age. Furthermore, adolescents show a unique dip in connectivity between these networks. Leveraging advanced machine learning methods, we accurately predicted individuals' ages based on these brain circuits, with a more mature estimated brain age correlating with better math skills.
Assuntos
Lobo Frontal , Aprendizado de Máquina , Imageamento por Ressonância Magnética , Rede Nervosa , Lobo Parietal , Humanos , Adolescente , Criança , Adulto Jovem , Masculino , Feminino , Adulto , Lobo Parietal/fisiologia , Lobo Parietal/diagnóstico por imagem , Lobo Parietal/crescimento & desenvolvimento , Lobo Frontal/fisiologia , Lobo Frontal/crescimento & desenvolvimento , Lobo Frontal/diagnóstico por imagem , Rede Nervosa/diagnóstico por imagem , Rede Nervosa/fisiologia , Rede Nervosa/crescimento & desenvolvimento , Conceitos Matemáticos , ConectomaRESUMO
Hippocampus-parietal cortex circuits are thought to play a crucial role in memory and attention, but their neural basis remains poorly understood. We employed intracranial intracranial electroencephalography (iEEG) to investigate the neurophysiological underpinning of these circuits across three memory tasks spanning verbal and spatial domains. We uncovered a consistent pattern of higher causal directed connectivity from the hippocampus to both lateral parietal cortex (supramarginal and angular gyrus) and medial parietal cortex (posterior cingulate cortex) in the delta-theta band during memory encoding and recall. This connectivity was independent of activation or suppression states in the hippocampus or parietal cortex. Crucially, directed connectivity from the supramarginal gyrus to the hippocampus was enhanced in participants with higher memory recall, highlighting its behavioral significance. Our findings align with the attention-to-memory model, which posits that attention directs cognitive resources toward pertinent information during memory formation. The robustness of these results was demonstrated through Bayesian replication analysis of the memory encoding and recall periods across the three tasks. Our study sheds light on the neural basis of casual signaling within hippocampus-parietal circuits, broadening our understanding of their critical roles in human cognition.
Assuntos
Eletrocorticografia , Hipocampo , Memória Episódica , Lobo Parietal , Humanos , Hipocampo/fisiologia , Masculino , Lobo Parietal/fisiologia , Feminino , Adulto , Vias Neurais/fisiologia , Memória Espacial/fisiologia , Adulto Jovem , Rememoração Mental/fisiologia , EletroencefalografiaRESUMO
Recent neurophysiological studies provide inconsistent results of frontoparietal network (FPN) stimulation for altering working memory (WM) capacity. This study aimed to boost WM capacity by manipulating the activity of the FPN via dual-site high-definition transcranial direct current stimulation. Forty-eight participants were randomly assigned to three stimulation groups, receiving either simultaneous anodal stimulation of the frontal and parietal areas (double stimulation), or stimulation of the frontal area only (single stimulation), or the placebo stimulation (sham) to frontal and parietal areas. After the stimulation, we used an operation span task to test memory accuracy, mathematical accuracy, time of calculation and memorizing, and recall response time across the three groups. The results revealed an enhancement of memory accuracy and a reduction of time of calculation in the double stimulation group compared with that in others. In addition, recall response time was significantly decreased in the double and single stimulation groups compared with that in sham. No differences in mathematical accuracy were observed. Our results confirm the pivotal role of the FPN in WM and suggest its functional dissociation, with the frontal component more implicated in the retrieval stage and the parietal component in the processing and retention stages.
Assuntos
Lobo Frontal , Memória de Curto Prazo , Lobo Parietal , Estimulação Transcraniana por Corrente Contínua , Humanos , Memória de Curto Prazo/fisiologia , Masculino , Lobo Parietal/fisiologia , Feminino , Adulto Jovem , Lobo Frontal/fisiologia , Adulto , Cognição/fisiologia , Tempo de Reação/fisiologia , Rememoração Mental/fisiologia , Testes NeuropsicológicosRESUMO
Flexible cognitive functions, such as working memory (WM), usually require a balance between localized and distributed information processing. However, it is challenging to uncover how local and distributed processing specifically contributes to task-induced activity in a region. Although the recently proposed activity flow mapping approach revealed the relative contribution of distributed processing, few studies have explored the adaptive and plastic changes that underlie cognitive manipulation. In this study, we recruited 51 healthy volunteers (31 females) and investigated how the activity flow and brain activation of the frontoparietal systems was modulated by WM load and training. While the activation of both executive control network (ECN) and dorsal attention network (DAN) increased linearly with memory load at baseline, the relative contribution of distributed processing showed a linear response only in the DAN, which was prominently attributed to within-network activity flow. Importantly, adaptive training selectively induced an increase in the relative contribution of distributed processing in the ECN and also a linear response to memory load, which were predominantly due to between-network activity flow. Furthermore, we demonstrated a causal effect of activity flow prediction through training manipulation on connectivity and activity. In contrast with classic brain activation estimation, our findings suggest that the relative contribution of distributed processing revealed by activity flow prediction provides unique insights into neural processing of frontoparietal systems under the manipulation of cognitive load and training. This study offers a new methodological framework for exploring information integration versus segregation underlying cognitive processing.
Assuntos
Função Executiva , Imageamento por Ressonância Magnética , Memória de Curto Prazo , Humanos , Feminino , Masculino , Adulto Jovem , Adulto , Memória de Curto Prazo/fisiologia , Função Executiva/fisiologia , Mapeamento Encefálico , Atenção/fisiologia , Cognição/fisiologia , Encéfalo/fisiologia , Rede Nervosa/fisiologia , Rede Nervosa/diagnóstico por imagem , Lobo Parietal/fisiologiaRESUMO
Motor imagery is a higher-order cognitive brain function that mentally simulates movements without performing the actual physical one. Although motor imagery has attracted the interest of many researchers, and mental practice utilizing motor imagery has been widely used in sports training and post-stroke rehabilitation, neural bases that determine individual differences in motor imagery ability are not well understood. In this study, using controllability of motor imagery (CMI) test that can objectively evaluate individual ability to manipulate one's imaginary postures, we examined structural and functional features characterizing the brains of individuals with higher controllability of motor imagery, by analyzing T1-weighted structural MRI data obtained from 89 participants and functional MRI data obtained from 28 of 89 participants. The higher CMI test scorers had larger volume in the bilateral superior frontoparietal white matter regions. The CMI test activated the bilateral dorsal premotor cortex (PMD) and superior parietal lobule (SPL); specifically, the left PMD and/or the right SPL enhanced functional coupling with the visual body, somatosensory, and motor/kinesthetic areas in the higher scorers. Hence, controllability of motor imagery is higher for those who well-develop superior frontoparietal network, and for those whose this network accesses these sensory areas to predict the expected multisensory experiences during motor imagery. This study elucidated for the first time the structural and functional features characterizing the brains of individuals with higher controllability of motor imagery, and advanced understanding of individual differences in motor imagery ability.
Assuntos
Encéfalo , Imaginação , Imageamento por Ressonância Magnética , Humanos , Masculino , Feminino , Imageamento por Ressonância Magnética/métodos , Imaginação/fisiologia , Adulto , Encéfalo/fisiologia , Encéfalo/diagnóstico por imagem , Mapeamento Encefálico/métodos , Adulto Jovem , Córtex Motor/fisiologia , Córtex Motor/diagnóstico por imagem , Lobo Parietal/fisiologia , Lobo Parietal/diagnóstico por imagem , Substância Branca/diagnóstico por imagem , Substância Branca/fisiologia , Movimento/fisiologiaRESUMO
Disinhibition, characterized by a loss of dietary control, is a significant risk factor for diet failure and the onset of eating disorders in restrained eaters. This study employs resting-state functional connectivity and structural covariance network analyses to explore the neural associations underlying this behavior. By analyzing functional MRI data from 63 female college students, we found that increased disinhibition correlates with enhanced functional connectivity between the medial orbitofrontal cortex and key components of the inhibition system, particularly within the fronto-parietal network. Moreover, we observed a relationship between the structural covariance of the medial orbitofrontal cortex and the inferior parietal lobule and the severity of disinhibition. Importantly, the functional connectivity between the medial orbitofrontal cortex and the inferior parietal lobule predicts the severity of binge eating symptoms in these individuals. These findings indicate that imbalances in the interaction between the brain's reward and inhibition systems can lead to dietary failures and eating disorders, emphasizing the need for targeted interventions.
Assuntos
Imageamento por Ressonância Magnética , Vias Neurais , Lobo Parietal , Córtex Pré-Frontal , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Adulto Jovem , Lobo Parietal/fisiologia , Lobo Parietal/diagnóstico por imagem , Córtex Pré-Frontal/fisiologia , Córtex Pré-Frontal/diagnóstico por imagem , Vias Neurais/fisiologia , Vias Neurais/diagnóstico por imagem , Comportamento Alimentar/fisiologia , Comportamento Alimentar/psicologia , Adulto , Inibição Psicológica , Mapeamento Encefálico/métodos , Adolescente , Transtornos da Alimentação e da Ingestão de Alimentos/diagnóstico por imagem , Transtornos da Alimentação e da Ingestão de Alimentos/fisiopatologia , Transtornos da Alimentação e da Ingestão de Alimentos/psicologiaRESUMO
The abundance of distractors in the world poses a major challenge to our brain's limited processing capacity, but little is known about how selective attention modulates stimulus representations in the brain to reduce interference and support durable target memory. Here, we collected functional magnetic resonance imaging (fMRI) data in a selective attention task in which target and distractor pictures of different visual categories were simultaneously presented. Participants were asked to selectively process the target according to the effective cue, either before the encoding period (i.e., perceptual attention) or the maintenance period (i.e., reflective attention). On the next day, participants were asked to perform a memory recognition task in the scanner in which the targets, distractors, and novel items were presented in a pseudorandom order. Behavioral results showed that perceptual attention was better at enhancing target memory and reducing distractor memory than reflective attention, although the overall memory capacity (memory for both target and distractor) was comparable. Using multiple-voxel pattern analysis of the neural data, we found more robust target representation and weaker distractor representation in working memory for perceptual attention than for reflective attention. Interestingly, perceptual attention partially shifted the regions involved in maintaining the target representation from the visual cortex to the parietal cortex. Furthermore, the targets and distractors simultaneously presented in the perceptual attention condition showed reduced pattern similarity in the parietal cortex during retrieval compared to items not presented together. This neural pattern repulsion positively correlated with individuals' recognition of both targets and distractors. These results emphasize the critical role of selective attention in transforming memory representations to reduce interference and improve long-term memory performance.
Assuntos
Atenção , Imageamento por Ressonância Magnética , Memória de Longo Prazo , Memória de Curto Prazo , Lobo Parietal , Humanos , Atenção/fisiologia , Lobo Parietal/fisiologia , Masculino , Memória de Curto Prazo/fisiologia , Feminino , Memória de Longo Prazo/fisiologia , Adulto , Adulto Jovem , Objetivos , Mapeamento Encefálico , Estimulação Luminosa/métodos , Percepção Visual/fisiologiaRESUMO
Timing and motor function share neural circuits and dynamics, which underpin their close and synergistic relationship. For instance, the temporal predictability of a sensory event optimizes motor responses to that event. Knowing when an event is likely to occur lowers response thresholds, leading to faster and more efficient motor behavior though in situations of response conflict can induce impulsive and inappropriate responding. In turn, through a process of active sensing, coupling action to temporally predictable sensory input enhances perceptual processing. Action not only hones perception of the event's onset or duration, but also boosts sensory processing of its non-temporal features such as pitch or shape. The effects of temporal predictability on motor behavior and sensory processing involve motor and left parietal cortices and are mediated by changes in delta and beta oscillations in motor areas of the brain.
Assuntos
Córtex Motor , Humanos , Córtex Motor/fisiologia , Desempenho Psicomotor/fisiologia , Percepção do Tempo/fisiologia , Lobo Parietal/fisiologia , Animais , Atividade Motora/fisiologiaRESUMO
INTRODUCTION: Modular organization in brain regions often performs specific biological functions and is largely based on anatomically and/or functionally related brain areas. The current study aimed to explore changes in whole-brain modular organization affected by flight training.METHODS: The study included 25 male flight cadets and 24 male controls. The first assessment was performed in 2019, when the subjects were university freshmen. The second assessment was completed in 2022. High spatial resolution structural imaging (T1) and resting-state functional MRI data were collected. Then, 90 cerebral regions were organized into 6 brain modules. The intensity of intra- and intermodular communication was calculated.RESULTS: Mixed-effect regression model analysis identified significantly increased interconnections between the parietal and occipital modules in the cadet group, but significantly decreased interconnections in the control group. This change was largely attributed to flight training.DISCUSSION: Pilots need to control the aircraft (e.g., attitude, heading, etc.) using the stick and pedal in response to the current state of the aircraft displayed by the instrument panel; as such, flying requires a large amount of hand-eye coordination. Day-to-day flight training appeared to intensify the connection between the parietal and occipital modules among cadets.Chen X, Jiang H, Meng Y, Xu Z, Luo C. Increased functional connectivity between the parietal and occipital modules among flight cadets. Aerosp Med Hum Perform. 2024; 95(7):375-380.
Assuntos
Imageamento por Ressonância Magnética , Lobo Occipital , Lobo Parietal , Pilotos , Humanos , Masculino , Lobo Occipital/fisiologia , Lobo Occipital/diagnóstico por imagem , Lobo Parietal/diagnóstico por imagem , Lobo Parietal/fisiologia , Adulto Jovem , Adulto , Estudos de Casos e Controles , Medicina AeroespacialRESUMO
Neuroimaging studies have consistently demonstrated concurrent activation of the human precuneus and temporal pole (TP), both during resting-state conditions and various higher-order cognitive functions. However, the precise underlying structural connectivity between these brain regions remains uncertain despite significant advancements in neuroscience research. In this study, we investigated the connectivity of the precuneus and TP by employing parcellation-based fiber micro-dissections in human brains and fiber tractography techniques in a sample of 1065 human subjects and a sample of 41 rhesus macaques. Our results demonstrate the connectivity between the posterior precuneus area POS2 and the areas 35, 36, and TG of the TP via the fifth subcomponent of the cingulum (CB-V) also known as parahippocampal cingulum. This finding contributes to our understanding of the connections within the posteromedial cortices, facilitating a more comprehensive integration of anatomy and function in both normal and pathological brain processes. PRACTITIONER POINTS: Our investigation delves into the intricate architecture and connectivity patterns of subregions within the precuneus and temporal pole, filling a crucial gap in our knowledge. We revealed a direct axonal connection between the posterior precuneus (POS2) and specific areas (35, 35, and TG) of the temporal pole. The direct connections are part of the CB-V pathway and exhibit a significant association with the cingulum, SRF, forceps major, and ILF. Population-based human tractography and rhesus macaque fiber tractography showed consistent results that support micro-dissection outcomes.
Assuntos
Imagem de Tensor de Difusão , Macaca mulatta , Vias Neurais , Lobo Parietal , Lobo Temporal , Humanos , Lobo Temporal/diagnóstico por imagem , Lobo Temporal/fisiologia , Lobo Temporal/anatomia & histologia , Lobo Parietal/diagnóstico por imagem , Lobo Parietal/fisiologia , Lobo Parietal/anatomia & histologia , Animais , Imagem de Tensor de Difusão/métodos , Masculino , Adulto , Feminino , Vias Neurais/diagnóstico por imagem , Vias Neurais/anatomia & histologia , Vias Neurais/fisiologia , Adulto Jovem , Axônios/fisiologia , Conectoma , Substância Branca/diagnóstico por imagem , Substância Branca/anatomia & histologia , Substância Branca/fisiologia , Giro do Cíngulo/diagnóstico por imagem , Giro do Cíngulo/fisiologia , Giro do Cíngulo/anatomia & histologiaRESUMO
Prism adaptation (PA) induces the after-effects of adapted tasks and transfers after-effects of non-adapted tasks, in which PA with pointing movements transfers to postural displacement during eyes-closed standing. However, the neural mechanisms underlying the transfer of PA after-effects on standing postural displacement remain unclear. The present study investigated the region-specific effects of transcranial direct current stimulation (tDCS) over the posterior parietal cortex (PPC) and cerebellum during prism exposure (PE) on standing postural displacement in healthy adults. Forty-two healthy young adults were grouped into pointing during PE with cathodal tDCS over the right PPC, anodal tDCS over the right cerebellum, and sham tDCS groups. They received 20 min of tDCS, during which they pointed to the visual targets while wearing prism lenses with a leftward visual shift (30 diopters) for 15 min. During the early PE, the pointing errors in the cerebellum group were significantly displaced more accurately toward the targets than those in the PPC group. However, after leftward PE, all groups had similar rightward displacements of the straight-ahead pointing with eyes closed. The PPC group only exhibited significant rightward center-of-pressure displacement during eyes-closed standing with feet-closed after leftward PE. The perception of longitudinal body axis rotation, as an indicator of the subjective body vertical axis, did not differ significantly between the pre- and post-evaluations in all groups. These results show that the PPC during PE could make an important neural contribution to inducing transfer of PA after-effect on standing postural displacement.
Assuntos
Adaptação Fisiológica , Cerebelo , Lobo Parietal , Equilíbrio Postural , Estimulação Transcraniana por Corrente Contínua , Humanos , Masculino , Lobo Parietal/fisiologia , Feminino , Estimulação Transcraniana por Corrente Contínua/métodos , Adulto Jovem , Adaptação Fisiológica/fisiologia , Cerebelo/fisiologia , Equilíbrio Postural/fisiologia , Adulto , Postura/fisiologia , Percepção Visual/fisiologia , Desempenho Psicomotor/fisiologiaRESUMO
Facilitating data sharing in scientific research, especially in the domain of animal studies, holds immense value, particularly in mitigating distress and enhancing the efficiency of data collection. This study unveils a meticulously curated collection of neural activity data extracted from six electrophysiological datasets recorded from three parietal areas (V6A, PEc, PE) of two Macaca fascicularis during an instructed-delay foveated reaching task. This valuable resource is now accessible to the public, featuring spike timestamps, behavioural event timings and supplementary metadata, all presented alongside a comprehensive description of the encompassing structure. To enhance accessibility, data are stored as HDF5 files, a convenient format due to its flexible structure and the capability to attach diverse information to each hierarchical sub-level. To guarantee ready-to-use datasets, we also provide some MATLAB and Python code examples, enabling users to quickly familiarize themselves with the data structure.
Assuntos
Macaca fascicularis , Lobo Parietal , Animais , Lobo Parietal/fisiologiaRESUMO
BACKGROUND: In post-stroke rehabilitation, functional connectivity (FC), motor-related cortical potential (MRCP), and gait activities are common measures related to recovery outcomes. However, the interrelationship between FC, MRCP, gait activities, and bipedal distinguishability have yet to be investigated. METHODS: Ten participants were equipped with EEG devices and inertial measurement units (IMUs) while performing lower limb motor preparation (MP) and motor execution (ME) tasks. MRCP, FCs, and bipedal distinguishability were extracted from the EEG signals, while the change in knee degree during the ME phase was calculated from the gait data. FCs were analyzed with pairwise Pearson's correlation, and the brain-wide FC was fed into support vector machine (SVM) for bipedal classification. RESULTS: Parietal-frontocentral connectivity (PFCC) dysconnection and MRCP desynchronization were related to the MP and ME phases, respectively. Hemiplegic limb movement exhibited higher PFCC strength than nonhemiplegic limb movement. Bipedal classification had a short-lived peak of 75.1% in the pre-movement phase. These results contribute to a better understanding of the neurophysiological functions during motor tasks, with respect to localized MRCP and nonlocalized FC activities. The difference in PFCCs between both limbs could be a marker to understand the motor function of the brain of post-stroke patients. CONCLUSIONS: In this study, we discovered that PFCCs are temporally dependent on lower limb gait movement and MRCP. The PFCCs are also related to the lower limb motor performance of post-stroke patients. The detection of motor intentions allows the development of bipedal brain-controlled exoskeletons for lower limb active rehabilitation.
Assuntos
Eletroencefalografia , Marcha , Lobo Parietal , Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral , Humanos , Masculino , Acidente Vascular Cerebral/fisiopatologia , Acidente Vascular Cerebral/complicações , Feminino , Pessoa de Meia-Idade , Marcha/fisiologia , Lobo Parietal/fisiopatologia , Lobo Parietal/fisiologia , Potencial Evocado Motor/fisiologia , Lobo Frontal/fisiopatologia , Lobo Frontal/fisiologia , Idoso , Adulto , Córtex Motor/fisiopatologia , Córtex Motor/fisiologia , Máquina de Vetores de SuporteRESUMO
Time and space form an integral part of every human experience, and for the neuronal representation of these perceptual dimensions, previous studies point to the involvement of the right-hemispheric intraparietal sulcus and structures in the medial temporal lobe. Here we used multi-voxel pattern analysis (MVPA) to investigate long-term memory traces for temporal and spatial stimulus features in those areas. Participants were trained on four images associated with short versus long durations and with left versus right locations. Our results demonstrate stable representations of both temporal and spatial information in the right posterior intraparietal sulcus. Building upon previous findings of stable neuronal codes for directly perceived durations and locations, these results show that the reactivation of long-term memory traces for temporal and spatial features can be decoded from neuronal activation patterns in the right parietal cortex.