1.
Xenobiotica
; 20(7): 653-6, 1990 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2238700
RESUMO
1. p-Hydroxymephentermine (p-hydroxy-MP) and p-hydroxyphentermine (p-hydroxy-Ph) were isolated as hydrochlorides from urine of male Wistar rats repeatedly dosed with mephentermine (MP). In addition, p-hydroxy-Ph was isolated as the hydrochloride from urine of the rats dosed with phentermine (Ph). 2. These results substantiate previous indications that p-hydroxylation of MP and Ph was a primary metabolic reaction in the rat.
Assuntos
Compostos de Anilina/metabolismo , Mefentermina/urina , Fentermina/urina , Compostos de Anilina/farmacocinética , Compostos de Anilina/urina , Animais , Cromatografia Gasosa , Cromatografia Gasosa-Espectrometria de Massas , Hidroxilação , Espectroscopia de Ressonância Magnética , Masculino , Mefentermina/análogos & derivados , Mefentermina/isolamento & purificação , Fentermina/análogos & derivados , Fentermina/isolamento & purificação , Ratos , Ratos Endogâmicos
2.
Pharmazie
; 31(11): 818-9, 1976 Nov.
Artigo
em Alemão
| MEDLINE
| ID: mdl-1023252