Magnetic resonance-based computed tomography metal artifact reduction using Bayesian modelling.

Metal artifact reduction (MAR) algorithms reduce the errors caused by metal implants in x-ray computed tomography (CT) images and are an important part of error management in radiotherapy. A promising MAR approach is to leverage the information in magnetic resonance (MR) images that can be acquired for organ or tumor delineation. This is however complicated by the ambiguous relationship between CT values and conventional-sequence MR intensities as well as potential co-registration issues. In order to address these issues, this paper proposes a self-tuning Bayesian model for MR-based MAR that combines knowledge of the MR image intensities in local spatial neighborhoods with the information in an initial, corrupted CT reconstructed using filtered back projection. We demonstrate the potential of the resulting model in three widely-used MAR scenarios: image inpainting, sinogram inpainting and model-based iterative reconstruction. Compared to conventional alternatives in a retrospective study on nine head-and-neck patients with CT and T1-weighted MR scans, we find improvements in terms of image quality and quantitative CT value accuracy within each scenario. We conclude that the proposed model provides a versatile way to use the anatomical information in a co-acquired MR scan to boost the performance of MAR algorithms.

Calculation of water equivalent ratios for various materials at proton energies ranging 10-500 MeV using MCNP, FLUKA, and GEANT4 Monte Carlo codes.

Dosimetry of proton beams is generally evaluated in liquid water, or alternatively in solid phantoms via water equivalent ratios (WER). WER is defined as the ratio of proton range in liquid water to that in a phantom of certain material. Presently, WER is not available in the literature neither for a wide range of energies nor for variety of relevant materials. Thus, the goal of this study is to provide such data through Monte Carlo simulations. WER is calculated for 10-500 MeV energies for compact bone, adipose tissue, polymethyl methacrylate (PMMA), PTFE (teflon), graphite (C), aluminum (Al), copper (Cu), titanium (Ti), and gold (Au) using MCNPX.2.70, GEANT4, and FLUKA Monte Carlo (MC) codes. The MCNPX code was considered as the reference to which other codes were compared. The mean values of WER obtained through the MCNPX simulations for Au, Cu, Ti, Al, PTFE, graphite, PMMA, bone, and adipose tissue were 8.83, 5.40, 3.18, 2.03, 1.87, 1.52, 1.13, 1.71, and 0.96, respectively, for 10-500 MeV energy range. The maximum deviations of WER values between MCNPX and GEANT4 results were about 6.85% for adipose tissue at energies <20 MeV, whereas they were about 7.74%, 7.74% between MCNPX and FLUKA, for adipose and Al, respectively. This inter-code uncertainties are mainly due to different physic models and stopping powers in each code. Comparing the results to that in the literature, the range of discrepancy was found to be 0-8% with greatest discrepancy for Au. Based on the materials evaluated, the PMMA remained the closest to water, for a non-tissue solid material, with an average WER of 1.13, for proton energy ranging 10-500 MeV.

Metal Artifact Reduction of CT Scans to Improve PET/CT.

In recent years, different metal artifact reduction methods have been developed for CT. These methods have only recently been introduced for PET/CT even though they could be beneficial for interpretation, segmentation, and quantification of the PET/CT images. In this study, phantom and patient scans were analyzed visually and quantitatively to measure the effect on PET images of iterative metal artifact reduction (iMAR) of CT data. Methods: The phantom consisted of 2 types of hip prostheses in a solution of 18F-FDG and water. 18F-FDG PET/CT scans of 14 patients with metal implants (either dental implants, hip prostheses, shoulder prostheses, or pedicle screws) and 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) PET/CT scans of 7 patients with hip prostheses were scored by 2 experienced nuclear medicine physicians to analyze clinical relevance. For all patients, a lesion was located in the field of view of the metal implant. Phantom and patients were scanned in a PET/CT scanner. The standard low-dose CT scans were processed with the iMAR algorithm. The PET data were reconstructed using attenuation correction provided by both standard CT and iMAR-processed CT. Results: For the phantom scans, cold artifacts were visible on the PET image. There was a 30% deficit in 18F-FDG concentration, which was restored by iMAR processing, indicating that metal artifacts on CT images induce quantification errors in PET data. The iMAR algorithm was useful for most patients. When iMAR was used, the confidence in interpretation increased or stayed the same, with an average improvement of 28% ± 20% (scored on a scale of 0%-100% confidence). The SUV increase or decrease depended on the type of metal artifact. The mean difference in absolute values of SUVmean of the lesions was 3.5% ± 3.3%. Conclusion: The iMAR algorithm increases the confidence of the interpretation of the PET/CT scan and influences the SUV. The added value of iMAR depends on the indication for the PET/CT scan, location and size/type of the prosthesis, and location and extent of the disease.

Polyenergetic known-component CT reconstruction with unknown material compositions and unknown x-ray spectra.

Metal artifacts can cause substantial image quality issues in computed tomography. This is particularly true in interventional imaging where surgical tools or metal implants are in the field-of-view. Moreover, the region-of-interest is often near such devices which is exactly where image quality degradations are largest. Previous work on known-component reconstruction (KCR) has shown the incorporation of a physical model (e.g. shape, material composition, etc) of the metal component into the reconstruction algorithm can significantly reduce artifacts even near the edge of a metal component. However, for such approaches to be effective, they must have an accurate model of the component that include energy-dependent properties of both the metal device and the CT scanner, placing a burden on system characterization and component material knowledge. In this work, we propose a modified KCR approach that adopts a mixed forward model with a polyenergetic model for the component and a monoenergetic model for the background anatomy. This new approach called Poly-KCR jointly estimates a spectral transfer function associated with known components in addition to the background attenuation values. Thus, this approach eliminates both the need to know component material composition a prior as well as the requirement for an energy-dependent characterization of the CT scanner. We demonstrate the efficacy of this novel approach and illustrate its improved performance over traditional and model-based iterative reconstruction methods in both simulation studies and in physical data including an implanted cadaver sample.

Rapid Annealing of Cu-In-Ga-Se Precursors by Electron Beam Irradiation Method.

Cu-In-Ga-Se precursors were prepared by RF- and DC-sputtering methods and then irradiated with an in-situ electron beam irradiation unit. Ternary (In,Ga)Se2 and binary CuSe targets were simultaneously used for preparation of precursors. The electron dose and irradiation time were kept constant at 300 seconds and 200 W of RF power, respectively, while intensities of accelerated electrons were varied from 2.5 to 4.5 keV. The thickness of all e-beam irradiated CuInGaSe2 (CIGS) films decreased from 1,250 nm to 470 nm. The crystalline properties of e-beam irradiated CIGS films were clearly shown on all samples and the highest intensity of (112) peak at 3.5 keV. The compositional ratio of Cu/(In + Ga) in the e-beam sample irradiated at 3.5 keV was coincident with that of the precursors. The degree of Ga content on the depth of the e-beam sample irradiated at 3.5 keV was uniformly distributed between the TCO/CdS layer and Mo back contact. Electron beam irradiation onto Cu-In-Ga-Se precursors as a rapid annealing method could be an excellent candidate for crystallization to the Cu(In,Ga)Se2 films.

[Consequences of prosthesis on quality of the radiation therapy]. / Implications de la pose de matériel « inerte ¼ dans l'organisme humain sur la qualité de la radiothérapie.

Dose prescription, delineation and dose calculation are clearly complicated when a patient have been operated on with insertion of prosthesis. Knowledge of the physical and material characteristics is needed to decrease incertitude of calculations. Recommendations for each step of treatments are proposed in this article allowing to optimization of the treatment safety.

Bond strength of metal brackets bonded to a silica-based ceramic with light-cured adhesive : Influence of various surface treatment methods.

OBJECTIVE: The purpose of this work was to evaluate the effects of several surface treatment methods on the shear bond strengths of metal brackets bonded to a silica-based ceramic with a light-cured adhesive. MATERIALS AND METHODS: Silica-based ceramic (IPS Classic(®)) with glazed surfaces was cut into discs that were used as substrates. A total of 80 specimens were randomly divided into four groups according to the method used: 9.6 % hydrofluoric acid (group 1), 9.6 % hydrofluoric acid (HF) + silane coupling agent (group 2), sandblasting (aluminum trioxide, 50 µm) + silane (group 3), and tribochemical silica coating (CoJet™ sand, 30 µm) + silane (group 4). Brackets were bonded to the treated specimens with a light-cure adhesive (Transbond XT, 3 M Unitek). Shear bond strength was tested after bracket bonding, and the Adhesive Remnant Index (ARI) scores were quantified after debonding. RESULTS: Group 4 showed the highest bond strength (12.3 ± 1.0 MPa), which was not significantly different from that of group 3 (11.6 ± 1.2 MPa, P > 0.05); however, the bond strength of group 4 was substantially higher than that of group 2 (9.4 ± 1.1 MPa, P < 0.05). The shear bond strength of group 1 (3.1 ± 0.6 MPa, P< 0.05) was significantly lower than that of the other groups. CONCLUSION: Shear bond strengths exceeded the optimal range of ideal bond strength for clinical practice, except for the isolated HF group. HF acid etching followed by silane was the best suited method for bonding on IPS Classic(®). Failure modes in the sandblasting and silica-coating groups revealed signs of damaged ceramic surfaces.

Direct welding of glass and metal by 1 kHz femtosecond laser pulses.

In the welding process between similar or dissimilar materials, inserting an intermediate layer and pressure assistance are usually thought to be necessary. In this paper, the direct welding between alumina-silicate glass and metal (aluminum, copper, and steel), under exposure from 1 kHz femtosecond laser pulses without any auxiliary processes, is demonstrated. The micron/nanometer-sized metal particles induced by laser ablation were considered to act as the adhesive in the welding process. The welding parameters were optimized by varying the pulse energy and the translation velocity of the sample. The shear joining strength characterized by a shear force testing equipment was as high as 2.34 MPa. This direct bonding technology has potential for applications in medical devices, sensors, and photovoltaic devices.

Electron dose distributions caused by the contact-type metallic eye shield: Studies using Monte Carlo and pencil beam algorithms.

A metallic contact eye shield has sometimes been used for eyelid treatment, but dose distribution has never been reported for a patient case. This study aimed to show the shield-incorporated CT-based dose distribution using the Pinnacle system and Monte Carlo (MC) calculation for 3 patient cases. For the artifact-free CT scan, an acrylic shield machined as the same size as that of the tungsten shield was used. For the MC calculation, BEAMnrc and DOSXYZnrc were used for the 6-MeV electron beam of the Varian 21EX, in which information for the tungsten, stainless steel, and aluminum material for the eye shield was used. The same plan was generated on the Pinnacle system and both were compared. The use of the acrylic shield produced clear CT images, enabling delineation of the regions of interest, and yielded CT-based dose calculation for the metallic shield. Both the MC and the Pinnacle systems showed a similar dose distribution downstream of the eye shield, reflecting the blocking effect of the metallic eye shield. The major difference between the MC and the Pinnacle results was the target eyelid dose upstream of the shield such that the Pinnacle system underestimated the dose by 19 to 28% and 11 to 18% for the maximum and the mean doses, respectively. The pattern of dose difference between the MC and the Pinnacle systems was similar to that in the previous phantom study. In conclusion, the metallic eye shield was successfully incorporated into the CT-based planning, and the accurate dose calculation requires MC simulation.

Gel phantom study with high-intensity focused ultrasound: influence of metallic stent containing either air or fluid.

We aimed to investigate whether a cylindrical structure containing either air or fluid and with or without a metallic stent affects the volume and density of cavitation produced by high-intensity focused ultrasound via a gel phantom study. Sixteen tissue-mimicking phantoms based on a polyacrylamide gel mixed with bovine serum albumin with a cylindrical hole 1 cm in diameter and 7.5 cm in length were divided into four groups of four phantoms with air in the holes (group 1), four phantoms with fluid in the holes (group 2), four phantoms with air-containing metallic stents (group 3) and four phantoms with fluid-containing metallic stents (group 4). A pulsed high-intensity focused ultrasound beam (50% duty cycle, 40-Hz pulse repetition frequency) at 75 W of acoustic power was directed perpendicularly to the longitudinal axis of the hole, with its focus at the posterior wall of the hole. The size of the cavitation on the x-, y-, and z-axes was measured, and the volumes of cavitation and coagulation were calculated using the formula for the volume of an elliptical cone. The density of cavitation was measured in the tissue phantom anterior to the hole with a 1 × 1-cm square region of interest. For statistical analysis, the Kruskal-Wallis test and Mann-Whitney U-test were used. The phantoms with air-containing holes (groups 1 and 3) developed larger and denser cavitations anterior to the focus, without unnecessary coagulation posterior to the focus, compared with the phantoms with fluid-containing holes (groups 2 and 4), regardless of the presence of stents. All of the axes and volumes of the anterior cavitations were significantly larger than those of the posterior cavitations in groups 1 and 3 (all p-values <0.05). The results of this study might be applied to maximize cavitation to enhance drug delivery into tumors.

Femtosecond fiber laser welding of dissimilar metals.

In this paper, welding of dissimilar metals was demonstrated for the first time, to the best of our knowledge, by using a high-energy high-repetition-rate femtosecond fiber laser. Metallurgical and mechanical properties were investigated and analyzed under various processing parameters (pulse energy, repetition rate, and welding speed). Results showed that the formation of intermetallic brittle phases and welding defects could be effectively reduced. Strong welding quality with more than 210 MPa tensile strength for stainless steel-aluminum and 175 MPa tensile strength for stainless steel-magnesium has been demonstrated. A minimal heat affected zone and uniform and homogenous phase transformation in the welding region have been demonstrated. This laser-welding technique can be extended for various applications in semiconductor, automobile, aerospace, and biomedical industries.

Spectral investigation of hot spot and cavity resonance effects on the terahertz radiation from high-T(c) superconducting Bi2Sr2CaCu2O(8+δ) mesas.

Terahertz (THz) electromagnetic radiation emitted from single and series-connected rectangular mesa devices of high-Tc superconducting Bi2Sr2CaCu2O8+δ is investigated spectroscopically during simultaneous temperature distribution observations using a microcrystalline SiC photoluminescence technique. In single mesas, a hot-spot region with its temperature T locally exceeding Tc was observed to jump suddenly in position under small current I-bias changes. Although these hot-spot position jumps cause large changes in the output power with small changes in I, as long as the voltage V per junction number N is kept constant, they do not affect the output frequency f, which is given by the ac Josephson frequency fJ. f can lock onto that of a particular mesa cavity resonance frequency fc, which enhances the emission power and serves as the primary mechanism for the synchronization of the emissions from each of the intrinsic Josephson junctions in the mesa.

Photocatalytical nanocomposites: a review.

This review focuses on photocatalytically active nanocomposites that are based on the photoactive nanoparticles, or nanostructured particles captured on the surface of the different powderized carriers. Nanosized and nanostructured oxides and sulfides with selected metal cations (Ti, Zn, Cd, Fe, etc.) are intensively studied as the photocatalysts for different purposes. The nanodimension of these particles brings several disadvantages, among them being the negative impact on human health, which is a widely discussed topic nowadays. The nanoparticles can permeate through living tissue and enter living cells and thus a strong effort focused on diminishing this problem is the subject of research activities by many groups. One possible way to achieve control of the nanoparticles' mobility is capturing them on the surface of suitable particulate carriers with dimensions on the order of tenths and hundredths of microns whereas this approach leads to formation of new composite material. Clay minerals, silicates, carbonaceous materials, and other particulate matter are intensively studied for these purposes and proper selection of the substrate can bring additional functionality to the final composite. Very often the photoactivity, antibacterial properties, electrical conductivity, and other properties are significantly enhanced in the case of this kind of composite materials. Strong adhesion between the nanoparticles and the surface of the selected substrate is essential for the stability of the final composites. Characterization of the adhesion energies using laboratory experiments is quite difficult and molecular modeling can bring valuable information about the character of interactions at the interface of nanoparticles and substrate.

Effect of oblique force source induced by laser ablation on ultrasonic generation.

The effect of asymmetry caused by oblique line-shaped laser ablation on the generation of ultrasonic waves in metal, especially the effect of transverse component of the ablation force source on the ultrasonic waves is analyzed. Due to the oblique force source, the displacements of shear wave increase obviously by the enhanced shear force, the energy concentration area of longitudinal wave deflects to the small range centered on the incident direction while that of shear wave is approximately perpendicular to incident direction. In addition, surface wave enhances in the direction of transverse power flow. Furthermore, some ultrasonic characteristics under vortex laser ablation condition are inferred.

Influence of preliminary ultrasonic treatment upon the steady-state creep of metals of different stacking fault energies.

This paper addresses the issue of the ultrasound effects upon the creep deformation of metals with different levels of stacking fault energy. The influence of preliminary ultrasound irradiation time upon the steady state creep rate is considered. Synthetic theory of irrecoverable deformation is taken as a mathematical apparatus. The analytical results show good agreement with experimental data.

Modelling harmonic generation measurements in solids.

Harmonic generation measurements typically make use of the plane wave result when extracting values for the nonlinearity parameter, ß, from experimental measurements. This approach, however, ignores the effects of diffraction, attenuation, and receiver integration which are common features in a typical experiment. Our aim is to determine the importance of these effects when making measurements of ß over different sample dimensions, or using different input frequencies. We describe a three-dimensional numerical model designed to accurately predict the results of a typical experiment, based on a quasi-linear assumption. An experiment is designed to measure the axial variation of the fundamental and second harmonic amplitude components in an ultrasonic beam, and the results are compared with those predicted by the model. The absolute ß values are then extracted from the experimental data using both the simulation and the standard plane wave result. A difference is observed between the values returned by the two methods, which varies with axial range and input frequency.

General properties of the surface charge pattern of one-dimensional metallic gratings.

Under light illumination, metallic gratings present unexpected and fascinating phenomena, which are due to the complex charge patterns generated on the grating surfaces. The moving electrons are due to the launching of surface plasmon polaritons (SPPs), but only in part. We derive analytical expressions quantifying the plasmonic character of the surface charge patterns, i.e. the contribution of SPPs to its formation. The expressions have a general significance, in the sense that they may be applied to a variety of geometries and spectral ranges, irrespective of whether the grating absorbs, transmits, reflects, or how strongly it resonates.

Low-loss light transmission in a rectangular-shaped hybrid metal trench at 1550 nm.

A hybrid plasmonic waveguide consisting of a high-index dielectric core embedded inside a rectangular-shaped metallic trench is proposed and its guiding properties are investigated at the wavelength of 1550 nm. Numerical simulations based on the finite element method have demonstrated that the introduced dielectric core could greatly reduce the modal loss of the metal trench while maintaining strong confinement of light. The effects of dielectric core size, material of the cladding and the dielectric core on the modal properties have been systematically investigated. The proposed hybrid plasmonic structure can be realized employing fabrication techniques of the traditional metal trench waveguides and could be leveraged as important elements for highly-integrated photonic circuits.

Accuracy improvement of quantitative analysis by spatial confinement in laser-induced breakdown spectroscopy.

To improve the accuracy of quantitative analysis in laser-induced breakdown spectroscopy, the plasma produced by a Nd:YAG laser from steel targets was confined by a cavity. A number of elements with low concentrations, such as vanadium (V), chromium (Cr), and manganese (Mn), in the steel samples were investigated. After the optimization of the cavity dimension and laser fluence, significant enhancement factors of 4.2, 3.1, and 2.87 in the emission intensity of V, Cr, and Mn lines, respectively, were achieved at a laser fluence of 42.9 J/cm(2) using a hemispherical cavity (diameter: 5 mm). More importantly, the correlation coefficient of the V I 440.85/Fe I 438.35 nm was increased from 0.946 (without the cavity) to 0.981 (with the cavity); and similar results for Cr I 425.43/Fe I 425.08 nm and Mn I 476.64/Fe I 492.05 nm were also obtained. Therefore, it was demonstrated that the accuracy of quantitative analysis with low concentration elements in steel samples was improved, because the plasma became uniform with spatial confinement. The results of this study provide a new pathway for improving the accuracy of quantitative analysis of LIBS.

Photonic de Haas-van Alphen effect.

Based on the recently proposed concept of effective gauge potential and magnetic field for photons, we numerically demonstrate a photonic de Haas-van Alphen effect. We show that in a dynamically modulated photonic resonator lattice exhibiting an effect magnetic field, the trajectories of the light beam at a given frequency have the same shape as the constant energy contour for the photonic band structure of the lattice in the absence of the effective magnetic field.