RESUMO
Tooth eruption is characterized by a concert of mechanisms that result in the emergence of teeth in the oral cavity. Genetic variants seem to regulate this process and the formation of a gingival sulcus around the teeth. Interindividual variability in the response to microbial triggers in the sulcus plays an important role in the onset and progression of periodontal diseases. Host genetic variants can influence this variability, affecting the response of the host to the subgingival biofilm. Genetic factors affecting tooth eruption could potentially influence susceptibility to periodontal diseases and, specifically, susceptibility to localized aggressive periodontitis. This review aims to discuss the evidence available for the role of host genetic variants in tooth eruption and to and to give some directions for prospective research in this topic.
Assuntos
Variação Genética/genética , Gengiva/crescimento & desenvolvimento , Gengiva/microbiologia , Erupção Dentária/genética , Erupção Dentária/fisiologia , Periodontite Agressiva , Biofilmes , Progressão da Doença , Loci Gênicos/genética , Loci Gênicos/fisiologia , Humanos , Doenças Periodontais/genética , Periodontite/genética , Periodontite/microbiologia , Migração de Dente/genética , Migração de Dente/microbiologia , Migração de Dente/patologia , Raiz Dentária/crescimento & desenvolvimento , Raiz Dentária/microbiologiaRESUMO
Transmigration is the pre-eruptive intrabony migration of a tooth across the midline. This rare phenomenon, the etiology of which is unknown, is usually seen in canines. Two cases of transmigration in the mandibular canines are reported; one shows the transposition of a mandibular canine and premolar. Familial occurence of this phenomenon and a 5-year follow-up showing a change in the inclination of the impacted tooth are outlined.
Assuntos
Dente Canino/fisiopatologia , Migração de Dente/genética , Adolescente , Feminino , Humanos , Masculino , Mandíbula , Irmãos , Extração Dentária , Migração de Dente/complicações , Migração de Dente/terapia , Técnicas de Movimentação Dentária , Dente Impactado/complicaçõesRESUMO
Mandibular lateral incisor-canine (Mn.I2.C) transposition is a rare developmental disturbance of tooth order characterized by positional interchange of the two teeth. In children with Mn.I2.C anomaly, the mandibular lateral incisor shows distal ectopic eruption and the adjacent canine subsequently erupts mesial to it. A sample of 60 orthodontic patients with Mn.I2.C transposition was studied using roentgenograms taken at the time of diagnosis. Two age-related phenotypes of the anomaly were identified: early-stage (median age, 9 years) and mature-stage (median age, 12 years). Mn.I2.C transposition occurred bilaterally in 10 subjects (17%) and favored female expression (sex ratio, M1:F3) and right-side occurrence (68% of unilateral cases). Statistically significant associations were found between Mn.I2.C transposition and increased frequency of tooth agenesis (M3, p < 0.01; MnP2, p < 0.01) and peg-shaped maxillary lateral incisors (p < 0.0001). The results from this study and the analysis of 50 previously published cases provide evidence that Mn.I2.C transposition is a disturbance of tooth order and eruptive position probably caused by genetic influences. The Mn.I2.C anomaly likely results from genetic mechanisms similar to those responsible for occurrences of its associated dental anomalies, such as tooth agenesis and peg-shaped maxillary lateral incisors. In an appendix, clinical orthodontic management of Mn.I2.C transposition is discussed, based on treatment data derived from the study sample.
Assuntos
Dente Canino/fisiopatologia , Incisivo/fisiopatologia , Erupção Ectópica de Dente/genética , Migração de Dente/genética , Adolescente , Adulto , Anodontia/complicações , Anodontia/genética , Criança , Feminino , Humanos , Masculino , Má Oclusão/genética , Má Oclusão/terapia , Mandíbula , Pessoa de Meia-Idade , Razão de Chances , Ortodontia Corretiva , Fatores Sexuais , Anormalidades Dentárias/complicações , Anormalidades Dentárias/genética , Erupção Ectópica de Dente/complicações , Migração de Dente/complicaçõesRESUMO
The prevalence of tooth rotation concomitant with aplasia of nonadjacent teeth in uncrowded, nonsyndromic subjects was assessed. The sample consisted of 1620 subjects (mean age 14 years 9 months). The findings were compared with the prevalence calculated for a matched control group of 1000 subjects. Rotation of maxillary lateral incisors in subjects with premolar aplasia and rotation of premolars in subjects presenting with maxillary lateral incisor aplasia were studied. Associations between both tooth position anomalies and tooth aplasia were significant (p < 0.01). In addition, the presence of rotated maxillary lateral incisors was also associated with aplasia of the homologous tooth on the opposite side of the dental arch; the same result was found for premolars. These data suggest a genetic component in the etiology of tooth malpositions, such as tooth rotation, which may be considered a covariable in a complex of genetically controlled dental disturbances, including tooth aplasia.