Assuntos
Mioepitelioma , Recidiva Local de Neoplasia , Neoplasias Parotídeas , Retalhos Cirúrgicos , Coxa da Perna , Humanos , Masculino , Mioepitelioma/cirurgia , Mioepitelioma/radioterapia , Mioepitelioma/diagnóstico por imagem , Recidiva Local de Neoplasia/cirurgia , Glândula Parótida/cirurgia , Neoplasias Parotídeas/cirurgia , Neoplasias Parotídeas/radioterapia , Neoplasias Parotídeas/patologia , Procedimentos de Cirurgia Plástica/métodos , Coxa da Perna/cirurgia , Resultado do Tratamento , IdosoRESUMO
Salivary gland cancers are rare in general and salivary duct carcinoma and epithelial myoepithelial carcinomas are rare subtypes. This topic discussion will review the characteristics of these uncommon cancers. Additionally, it will briefly discuss available guidelines for salivary cancers and summarize author opinions on the role of adjuvant radiation therapy for these cases.
Assuntos
Mioepitelioma , Neoplasias das Glândulas Salivares , Humanos , Neoplasias das Glândulas Salivares/radioterapia , Neoplasias das Glândulas Salivares/patologia , Radioterapia Adjuvante/métodos , Mioepitelioma/radioterapia , Mioepitelioma/patologia , Ductos Salivares/patologiaRESUMO
Myoepithelial tumor of lung is a rare tumor; the histopathological findings resemble the myoepithelial tumors of the salivary gland. Distinguishing low-grade nonmetastatic myoepithelial carcinoma from benign myoepithelioma can be challenging both radiologically and histomorphologically. We present a case report of a low-grade myoepithelial carcinoma of lung with contralateral lung metastasis which was treated with low-dose external beam radiotherapy.
Assuntos
Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/radioterapia , Mioepitelioma/diagnóstico por imagem , Mioepitelioma/radioterapia , Idoso , Humanos , Pulmão/diagnóstico por imagem , Pulmão/patologia , Neoplasias Pulmonares/classificação , Neoplasias Pulmonares/secundário , Masculino , Mioepitelioma/classificação , Mioepitelioma/secundário , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Resultado do TratamentoRESUMO
INTRODUCTION: Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade malignancy that occurs primarily in the parotid gland and is most common in women aged 60 to 70 years. Cases of parotid EMC have been reported previously. Furthermore, some studies have suggested an increased risk of salivary gland tumors with secondary primary malignancies. There have been few reports of parotid EMC with other primary tumors. PATIENT CONCERNS: A 62-year-old Chinese man visited the hospital with a complaint of a mass on his left cheek that had persisted for 20 years. Routine pulmonary computed tomography showed a local ground glass shadow in the lower lobe of the right lung. DIAGNOSIS: The pathological diagnosis of lung was right lower lobe lung adenocarcinoma (pT1N0). Immunohistochemistry analysis showed that cytokeratin (CK)-7, NapsinA, and thyroid transcription factor-1 tested positive, while CK5/6, P40, and ALKD5F3 tested negative. The pathological diagnosis of left parotid gland: EMC. On immunohistochemistry staining, the outer cells expressed myoepithelial markers, such as CK5/6, P63, smooth muscle actin, while the inner cells expressed glandular epithelial markers, such as low-molecular-weight CK7 and CK8. INTERVENTIONS: The patient underwent resection of the lung and parotid tumors, and received preventive radiotherapy in the parotid gland area. OUTCOMES: The patient is in good condition. No symptom recurrence, distant metastatic spread or significant toxicity occurred during or after the treatment. The patient remains under regular surveillance. CONCLUSION: We report a rare case of parotid EMC with a second primary lung adenocarcinoma. This case is the third case of primary lung cancer associated with parotid EMC reported to date and the first to be reported in nearly 30 years.
Assuntos
Adenocarcinoma de Pulmão/patologia , Neoplasias Pulmonares/patologia , Mioepitelioma/patologia , Segunda Neoplasia Primária/patologia , Neoplasias Parotídeas/patologia , Adenocarcinoma de Pulmão/cirurgia , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/cirurgia , Masculino , Pessoa de Meia-Idade , Mioepitelioma/radioterapia , Mioepitelioma/cirurgia , Segunda Neoplasia Primária/radioterapia , Segunda Neoplasia Primária/cirurgia , Neoplasias Parotídeas/radioterapia , Neoplasias Parotídeas/cirurgiaRESUMO
INTRODUCTION: Myoepithelial carcinoma (MEC) is an extremely rare low grade salivary gland neoplasm [1-4]. A surgical resection is considered as corner stone of therapy. Role of adjuvant therapy is not clear. METHODOLOGY: We performed systematic review and individual patient data analysis of 691 patients to look into the impact of adjuvant therapy and different prognostic variable for MEC. RESULTS: Data of 691 individual patients were retrieved from 340 publications. Median age of presentation was 56â¯years (Range: 0-103â¯years) with a trend of increasing incidence for increase in age. Major salivary glands (36.4%) were the commonest sub-site followed by minor salivary glands, skin and soft tissue, and breast. Median PFS and OS of entire cohort was 48â¯months (95% CI: 30-65â¯months) and 167â¯months (95% CI: 82-251â¯months). In univariate analysis A R0 resection was associated with significantly better PFS and OS. Median PFS and OS were significantly worse for patients with tumour size >5â¯cm compared to smaller tumours and for patients with a mitotic index >10/10 high power field (hpf) compared to lower mitotic index. Adjuvant radiation was found to reduce loco-regional recurrence. Adjuvant radiation and chemotherapy both were associated with negative impact on survival in univariate analysis. This negative impact on survival was lost in multivariate analysis. CONCLUSION: MEC appears to be a low grade malignancy with good survival outcome. A R0 resection should be the standard of care. Adjuvant radiation should be considered for patients with adverse risk features to improve loco-regional disease control.
Assuntos
Mioepitelioma/radioterapia , Neoplasias das Glândulas Salivares/radioterapia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Estudos de Coortes , Terapia Combinada , Análise de Dados , Humanos , Lactente , Recém-Nascido , Pessoa de Meia-Idade , Mioepitelioma/mortalidade , Neoplasias das Glândulas Salivares/mortalidade , Adulto JovemRESUMO
Myoepithelial carcinoma (MC) is a rare, locally aggressive malignant neoplasm of the salivary glands. Only few evidences on its metastatic behavior are available in the literature. We herein present a unique case of MC of left parotid gland which metastasized to bilateral cavernous sinuses. The patient was successfully treated with palliative radiotherapy and chemotherapy.
Assuntos
Carcinoma/patologia , Mioepitelioma/diagnóstico , Segunda Neoplasia Primária/diagnóstico , Carcinoma/tratamento farmacológico , Carcinoma/radioterapia , Carcinoma/secundário , Seio Cavernoso/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Mioepitelioma/tratamento farmacológico , Mioepitelioma/patologia , Mioepitelioma/radioterapia , Metástase Neoplásica , Segunda Neoplasia Primária/tratamento farmacológico , Segunda Neoplasia Primária/radioterapia , Segunda Neoplasia Primária/secundário , Glândula Parótida/patologia , Neoplasias Parotídeas/diagnóstico , Neoplasias Parotídeas/tratamento farmacológico , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/radioterapia , Neoplasias das Glândulas Salivares/tratamento farmacológico , Neoplasias das Glândulas Salivares/patologia , Neoplasias das Glândulas Salivares/radioterapia , Neoplasias das Glândulas Salivares/secundárioRESUMO
Myoepithelial tumors of the soft tissue are a rare tumor displaying myoepithelial elements and lacking obvious ductal differentiation. The rarity of these precludes any evidence-based consensus regarding optimal management. Nevertheless, the current approach to these lesions begins with amputation or complete excision. The efficacy of neoadjuvant or adjuvant radiation therapy or chemotherapy has not been established. Here, we present the first report to the authors' knowledge of neoadjuvant radiation therapy for the treatment of this rare soft tissue neoplasm and review the management and outcomes of published cases of myoepithelial carcinoma. A patient with a soft tissue myoepithelial carcinoma that declined both amputation and chemotherapy was treated with neoadjuvant radiation therapy and wide surgical excision followed by a brachytherapy boost to the resected tumor bed. Neoadjuvant radiation therapy resulted in an excellent response with extensive treatment-related changes consisting predominantly of fibrosis, hyalinization and hemorrhage and only 10% residual viable myoepithelial carcinoma present in the surgical specimen.
Assuntos
Mioepitelioma/radioterapia , Neoplasias de Tecidos Moles/radioterapia , Braço , Braquiterapia , Humanos , Masculino , Pessoa de Meia-Idade , Mioepitelioma/cirurgia , Terapia Neoadjuvante , Radioterapia Adjuvante , Neoplasias de Tecidos Moles/cirurgiaAssuntos
Lipoma/cirurgia , Mioepitelioma/patologia , Mioepitelioma/cirurgia , Neoplasias de Tecidos Moles/cirurgia , Biópsia por Agulha , Feminino , Virilha/patologia , Virilha/cirurgia , Humanos , Imuno-Histoquímica , Achados Incidentais , Lipoma/patologia , Pessoa de Meia-Idade , Mioepitelioma/radioterapia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Prognóstico , Radioterapia Adjuvante , Medição de Risco , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/radioterapia , Coxa da Perna/patologia , Coxa da Perna/cirurgia , Resultado do TratamentoRESUMO
OBJECTIVES: Malignant myoepithelioma of salivary glands is a rare neoplasm; most arise in the parotid gland and minor salivary glands of the palate. Surgery has been the mainstay of treatment. METHODS: This is case report of a patient treated with primary radical radiotherapy and retrospective review of institutional experience. RESULTS: An 87-year-old man with locoregionally advanced malignant myoepithelioma of the parotid gland received radiotherapy alone with complete clinical response and sustained 39 months of posttreatment. Between 1981 and 2012, 15 cases of malignant myoepithelioma of the parotid were seen. Thirteen patients received surgical excision and adjuvant radiotherapy. At a median follow-up of 47 months, 12 patients were alive without recurrence, 2 died without recurrence, and 1 died with metastatic myoepithelioma. CONCLUSIONS: Durable locoregional disease control and disease-free-survival was achieved in the majority of patients. The case reported suggests radiation therapy may be an effective treatment option for inoperable cases.
Assuntos
Mioepitelioma/radioterapia , Neoplasias Parotídeas/radioterapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Colúmbia Britânica , Intervalo Livre de Doença , Feminino , Seguimentos , Humanos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Mioepitelioma/secundário , Mioepitelioma/cirurgia , Neoplasia Residual , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/cirurgia , Radioterapia Adjuvante , Resultado do Tratamento , Adulto JovemRESUMO
Myoepithelial carcinoma of the breast is an extremely rare tumor composed entirely of malignant spindle cells with myoepithelial differentiation. The majority of previously reported cases have mainly described the clinicopathological features of the disease, and few have presented cytogenetic data. We herein present the case of a 48-year-old woman who was admitted with a left-sided breast lump in the inner upper quadrant that was initially diagnosed as a myoepithelioma with potentially malignant disorder. At 12 months after resection, she complained about a newly developed solid mass in the subareolar region of the ipsilateral breast that was diagnosed as an invasive ductal carcinoma. In addition, 16 months after the initial admission, a re-growing remnant lesion recurred in the inner upper quadrant and was ultimately diagnosed as a myoepithelial carcinoma. Lymph node metastasis of the myoepithelial carcinoma was also observed in her left axillary region 11 months after local recurrence. A cytogenetic analysis showed recurring specific chromosomal alterations both in the locally recurrent and in the lymph-node metastatic lesion: 48, XX, t(5;18)(q13;q23),del(6)(q?),+14. + mar1. To our knowledge, this is the first published report of clonal chromosomal rearrangements in myoepithelial carcinoma of the breast that presented as metachronic double cancer with invasive ductal carcinoma in the ipsilateral breast.
Assuntos
Neoplasias da Mama/genética , Carcinoma Ductal de Mama/genética , Aberrações Cromossômicas , Mioepitelioma/genética , Neoplasias da Mama/radioterapia , Neoplasias da Mama/cirurgia , Carcinoma Ductal de Mama/radioterapia , Análise Citogenética , Feminino , Humanos , Metástase Linfática , Pessoa de Meia-Idade , Mioepitelioma/radioterapia , Mioepitelioma/cirurgia , Recidiva Local de Neoplasia/genética , Recidiva Local de Neoplasia/radioterapia , Segunda Neoplasia Primária/genética , Segunda Neoplasia Primária/radioterapiaRESUMO
PURPOSE/OBJECTIVE: The role of radiation therapy in the treatment of myoepithelial carcinoma (MC) is unknown. We present a case of a high-grade soft-tissue MC in a pediatric patient and retrospectively examine the effect of postoperative radiation on survival in patients with MC. MATERIALS AND METHODS: Our patient was treated with 4 cycles of ifosfamide, cisplatin, and etoposide followed by 3 cycles of ifosfamide vincristine and etoposide. Radiation was delivered to a total dose of 5580 cGy in 180 cGy/fraction to the surgical bed with a 2 cm margin starting after the third cycle of chemotherapy. The Surveillance, Epidemiology, and End Results (SEER) registry database was queried for cases of surgically resected MC. Retrospective analysis was performed with the endpoint of overall survival (OS). RESULTS: Two hundred thirty-four cases of MC were identified; for 62 of these cases, the grade of the tumor wasidentified. Of these 62 patients, 27 received postoperative radiation. OS was improved with adjuvant radiation therapy in patients with grade III or IV MC (P<0.01) as determined by the log-rank test. CONCLUSIONS: This analysis of SEER data showed an OS benefit with adjuvant radiation therapy in the treatment of high-grade MC. Physicians should report all cases of MC to improve clinical decision making in the treatment of this rare disease.
Assuntos
Mioepitelioma/radioterapia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Criança , Cisplatino/administração & dosagem , Etoposídeo/administração & dosagem , Humanos , Ifosfamida/administração & dosagem , Masculino , Radioterapia Adjuvante/métodos , Estudos Retrospectivos , Programa de SEER , Taxa de Sobrevida , Vincristina/administração & dosagemRESUMO
PURPOSE: This study evaluated the treatment of myoepithelial carcinoma (MC) of the oral and maxillofacial region with radioactive iodine ((125)I) seed implantation. METHODS AND MATERIALS: Twenty-seven patients with MC in the oral and maxillofacial region were treated with (125)I seed implantation between March 2006 and October 2012. Thirteen of the 27 patients (8/8 patients with primary disease and 5/19 patients with recurrent disease) were treated on an adjuvant setting after resections, and the other 14 patients were treated by brachytherapy after a recurrence precluding a surgical resection for salvage. The sites of the MC were the parotid for 18 patients, oral cavity for 2 patients, and base of skull for 7 patients. Recurrence-free survival (RFS), overall survival (OS) rates, and side effects were retrospectively reviewed. RESULTS: Patients were followed for 6-105 months (median 37 months). The 3- and 5-year RFS rates were 51.9% and 46.1%, respectively. The 3- and 5-year OS rates were 68.6% and 51.5%, respectively. The OS and RFS were significantly better among the 8 patients treated upfront in comparison with the 19 patients treated for salvage at relapse. The OS was worst for the 7 patients with base of skull region disease. No severe complications were observed during followup. CONCLUSIONS: This study showed (125)I brachytherapy is a feasible and effective modality for the treatment of MC. These findings should be interpreted cautiously due to the small number of patients and the relatively short followup.
Assuntos
Braquiterapia , Carcinoma/radioterapia , Radioisótopos do Iodo/uso terapêutico , Neoplasias Bucais/radioterapia , Mioepitelioma/radioterapia , Recidiva Local de Neoplasia/radioterapia , Neoplasias Parotídeas/radioterapia , Neoplasias da Base do Crânio/radioterapia , Adolescente , Adulto , Idoso , Braquiterapia/efeitos adversos , Carcinoma/cirurgia , Criança , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/cirurgia , Mioepitelioma/cirurgia , Neoplasias Parotídeas/cirurgia , Radioterapia Adjuvante , Estudos Retrospectivos , Terapia de Salvação , Neoplasias da Base do Crânio/cirurgia , Taxa de Sobrevida , Adulto JovemRESUMO
Epithelial-myoepithelial carcinoma (EMC) in the salivary glands is rare. Tumours originating from salivary glands are also rare in children. Radical resection is the main treatment used for EMC in salivary glands. However, this surgery is commonly associated with functional and/or cosmetic deficits. There is also a high percentage of local recurrence after a tumourectomy. We present a typical case of recurrent EMC in the left parotid gland of an 8-year-old girl. The patient was treated with iodine-125 brachytherapy. At the 2-month follow-up, the tumour size was reduced by 80%, and at 1 year, no tumour tissue was detected on positron emission tomography/computed tomography. At the 6-year follow-up, no local recurrence or distant metastasis was found and no complications had occurred. Iodine-125 brachytherapy is a potentially appropriate alternative treatment for EMC in the salivary glands, especially for paediatric patients.
Assuntos
Braquiterapia/métodos , Radioisótopos do Iodo/uso terapêutico , Mioepitelioma/radioterapia , Neoplasias Parotídeas/radioterapia , Criança , Feminino , Humanos , Mioepitelioma/diagnóstico por imagem , Mioepitelioma/patologia , Recidiva Local de Neoplasia , Neoplasias Parotídeas/diagnóstico por imagem , Neoplasias Parotídeas/patologia , Tomografia Computadorizada por Raios XRESUMO
Myoepithelial carcinoma of the vulva is extremely rare, with only five cases reported. Here, we describe a case of vulvar myoepithelial carcinoma along with a review of the literature. The patient, a 49-year-old woman, was referred for a tumor on the right labium majora. She underwent a wide local excision and bilateral inguinal lymph node dissection. Pathological examination revealed an unencapsulated, infiltrative pattern, with solid, nested and trabecular components and areas with myxoid or hyalinized stroma. The tumor consisted of oval to round epithelioid cells with moderate nuclear pleomorphism. By immunohistochemistry, the tumor cells were diffusely positive for cellular adhesion molecule (CAM) 5.2, epithelial membrane antigen (EMA), S-100 protein, and vimentin and focally positive for carcinoembryonic antigen (CEA) and p63, while negative for alpha- smooth muscle actin (SMA). The tumor was diagnosed as a myoepithelial carcinoma of the vulva, with metastases to the bilateral inguinal lymph nodes. Following completion of adjuvant radiotherapy, the patient remained alive without any evidence of recurrence at 56 months. A review of six cases of this tumor (including the present case), demonstrated variable morphology with some overlapping features. Therefore, immunohistochemistry using a panel of epithelial and myogenic markers is essential for definitive diagnosis. Two cases had inguinal lymph node metastases and received adjuvant radiotherapy or concurrent chemoradiotherapy, which resulted in good local control. One case had lung metastasis and was successfully treated by chemotherapy. Given the rarity of this disease and its uncertain prognosis, no clinical trials have been conducted regarding the necessity of adjuvant therapy. Myoepithelial carcinomas of the vulva are extremely rare making case series the most viable means of optimizing diagnosis and therapy.
Assuntos
Carcinoma/patologia , Carcinoma/cirurgia , Mioepitelioma/patologia , Mioepitelioma/cirurgia , Neoplasias Vulvares/patologia , Neoplasias Vulvares/cirurgia , Carcinoma/metabolismo , Carcinoma/radioterapia , Feminino , Humanos , Pessoa de Meia-Idade , Mioepitelioma/metabolismo , Mioepitelioma/radioterapia , Resultado do Tratamento , Neoplasias Vulvares/metabolismo , Neoplasias Vulvares/radioterapiaRESUMO
A case report of laryngeal myoepithelial carcinoma (MEC) is presented and the literature concerning prognostic factors in MEC is reviewed. A 61-year old man was admitted to hospital with hoarseness and progressive dyspnoea. On examination, both vocal cords were fixed in the midline with a glottic fissure of only 3 mm. No tumour was seen, but the subglottis was not completely visible. A computed tomography scan showed a soft mass below the right vocal cord obstructing two-thirds of the larynx. On suspension laryngoscopy, a dull mass (1.5 x 1.5 cm) was seen below the right vocal cord, which was malignant on frozen biopsy. A total laryngectomy was performed and the patient received radiotherapy. He died of recurrence 25 months later. The tumour was positive for cytokeratin 14, S-100 protein and calponin. MEC of the larynx is extremely rare. The clinical behaviour of MEC is variable and prognostic factors have been poorly analysed. Calponin expression may be a prognostic factor, but other factors also affect the outcome in MEC.
Assuntos
Biomarcadores Tumorais/metabolismo , Proteínas de Ligação ao Cálcio/metabolismo , Neoplasias Laríngeas/metabolismo , Proteínas dos Microfilamentos/metabolismo , Mioepitelioma/metabolismo , Humanos , Técnicas Imunoenzimáticas , Neoplasias Laríngeas/radioterapia , Neoplasias Laríngeas/cirurgia , Laringectomia , Masculino , Pessoa de Meia-Idade , Mioepitelioma/radioterapia , Mioepitelioma/cirurgia , CalponinasRESUMO
Malignant myoepithelioma of the breast (MMB) is a rare and often aggressive disease with poor prognosis. Little is known regarding its optimal treatment and progression. We describe the clinical history of a woman following excision of a benign adenomyoepithelioma which recurred years later as a radioresistant malignant myoepithelioma with high levels of ataxia telangiectasia mutated protein and mutant p53 (Cys135Phe). MMB requires close follow-up and aggressive treatment. If adjuvant radiotherapy is adopted to improve local control, minimal postoperative delay and higher doses than for standard post-mastectomy radiation are recommended.
Assuntos
Neoplasias da Mama/metabolismo , Neoplasias da Mama/radioterapia , Proteínas de Ciclo Celular/análise , Proteínas de Ligação a DNA/análise , Mioepitelioma/radioterapia , Proteínas Serina-Treonina Quinases/análise , Proteínas Supressoras de Tumor/análise , Proteínas Mutadas de Ataxia Telangiectasia , Feminino , Humanos , Pessoa de Meia-Idade , Falha de TratamentoRESUMO
We describe the case of a 41-year-old woman who presented with a malignant myoepithelioma (MME) in her left maxillary sinus. Exploratory biopsy of the left maxillary sinus was performed and pathological examination demonstrated that the tumour was positive for calponin and cytokeratin 14, which are indicative of MME. Lateral rhinotomy and left total maxillectomy were undertaken and the patient received radiotherapy and chemotherapy post-surgery. Primary recurrence and metastasis to the left angle of the mandible occurred 9 months after the surgery. The patient died of cachexia 13 months after the surgery.
Assuntos
Neoplasias do Seio Maxilar/diagnóstico , Mioepitelioma/diagnóstico , Adulto , Proteínas de Ligação ao Cálcio/análise , Evolução Fatal , Feminino , Humanos , Queratina-14/análise , Neoplasias do Seio Maxilar/química , Neoplasias do Seio Maxilar/radioterapia , Neoplasias do Seio Maxilar/cirurgia , Proteínas dos Microfilamentos/análise , Mioepitelioma/química , Mioepitelioma/radioterapia , Mioepitelioma/cirurgia , Tomografia Computadorizada por Raios X , CalponinasRESUMO
Epithelial-myoepithelial carcinomas are rare, low-grade, malignant salivary gland tumors. They are mostly seen in the parotid gland. The submandibular gland is a rare localization. A 54-year-old woman presented with a painless lump on the left side of the neck. Examination showed a mass with smooth surface in the left submandibular region. Fine needle aspiration cytology of the mass was reported as malignant epithelial tumor metastasis. Computed tomography of the neck showed left submandibular gland hypertrophy. Left submandibular gland excision with functional neck dissection was performed. The histopathological diagnosis was epithelial-myoepithelial carcinoma of the submandibular gland with one lymph node metastasis.
Assuntos
Mioepitelioma/diagnóstico , Neoplasias da Glândula Submandibular/diagnóstico , Terapia Combinada , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Mioepitelioma/diagnóstico por imagem , Mioepitelioma/patologia , Mioepitelioma/radioterapia , Mioepitelioma/cirurgia , Neoplasias da Glândula Submandibular/diagnóstico por imagem , Neoplasias da Glândula Submandibular/patologia , Neoplasias da Glândula Submandibular/radioterapia , Neoplasias da Glândula Submandibular/cirurgia , Tomografia Computadorizada por Raios XRESUMO
This report concerns a patient with symptomatic lung metastases from an epithelial-myoepithelial carcinoma of the submandibular gland. Although the efficacy of chemotherapy is unknown in this disease, our patient was treated with cisplatin combined with 5-fluorouracil and later with paclitaxel and cyclophosphamide. Chemotherapy allowed disease stabilization and relief of the pulmonary symptoms. This is the first report on the use of chemotherapy in this very rare salivary gland carcinoma.