RESUMO
We present the report of trismus due to hyperadrenocorticism-associated myotonia diagnosed by electromyography in a dog. An intact female Miniature Dachshund, 13 years and 9 months old, presented with stiff gait and trismus as well as polyuria and polydipsia. Abdominal ultrasonography showed enlarged adrenal glands. An adrenocorticotropic hormone stimulation test revealed an exaggerated response. Based on these findings, this case was diagnosed with hyperadrenocorticism. Electromyography revealed myotonic discharge in the temporalis muscle and limbs. Therefore, trismus was considered to be caused by hyperadrenocorticism-associated myotonia, and the case was treated with oral trilostane (1.3 mg/kg, once daily). During the 4-month follow-up period, despite the partial improvement in stiff gait, trismus did not recover. Long-term data on more cases are warranted to assess the prognosis and clinical characteristics of trismus due to hyperadrenocorticism-associated myotonia.
Assuntos
Hiperfunção Adrenocortical , Doenças do Cão , Miotonia , Cães , Feminino , Animais , Miotonia/complicações , Miotonia/veterinária , Trismo/veterinária , Trismo/complicações , Doenças do Cão/diagnóstico , Doenças do Cão/tratamento farmacológico , Doenças do Cão/etiologia , Hiperfunção Adrenocortical/complicações , Hiperfunção Adrenocortical/veterinária , Hormônio AdrenocorticotrópicoRESUMO
Myotonic dystrophy type 1 or Steinert's disease is an autosomal dominant multisystem disease which is characterized by consistent contracture of muscle following stimulation (myotonia). Hypothermia, shivering, mechanical or electric stimulation during surgery can precipitate episodes of myotonia which may complicate the course of anaesthesia. The present case report focuses on successful strategies for providing general anaesthesia for laparoscopic cholecystectomy in a patient affected by this genetic disorder, at a hospital which does not have the facility for postoperative ventilation.
Assuntos
Colecistectomia Laparoscópica , Miotonia , Distrofia Miotônica , Anestesia Geral , Anestesia Intravenosa , Humanos , Miotonia/complicações , Distrofia Miotônica/complicações , Distrofia Miotônica/genéticaAssuntos
Colchicina/efeitos adversos , Febre Familiar do Mediterrâneo/tratamento farmacológico , Miotonia/induzido quimicamente , Dor/induzido quimicamente , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Moduladores de Tubulina/efeitos adversos , Idoso , Febre Familiar do Mediterrâneo/complicações , Febre Familiar do Mediterrâneo/diagnóstico , Feminino , Humanos , Miotonia/complicações , Miotonia/diagnóstico , Dor/complicações , Dor/diagnóstico , Doenças do Sistema Nervoso Periférico/complicações , Doenças do Sistema Nervoso Periférico/diagnósticoAssuntos
Doença de Depósito de Glicogênio Tipo IIb/diagnóstico , Doença de Depósito de Glicogênio Tipo IIb/genética , Miocárdio Ventricular não Compactado Isolado/diagnóstico , Proteína 2 de Membrana Associada ao Lisossomo/genética , Mutação , Miotonia/diagnóstico , Doença de Depósito de Glicogênio Tipo IIb/complicações , Doença de Depósito de Glicogênio Tipo IIb/fisiopatologia , Humanos , Miocárdio Ventricular não Compactado Isolado/complicações , Miocárdio Ventricular não Compactado Isolado/genética , Masculino , Miotonia/complicações , Miotonia/genética , Linhagem , Fenótipo , Adulto JovemAssuntos
Doenças do Ânus/cirurgia , Endoscopia Gastrointestinal/métodos , Endossonografia/métodos , Músculo Esquelético/cirurgia , Miotonia/cirurgia , Cirurgia Endoscópica Transanal/métodos , Doenças do Ânus/complicações , Doenças do Ânus/diagnóstico por imagem , Constipação Intestinal/diagnóstico por imagem , Constipação Intestinal/etiologia , Constipação Intestinal/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Músculo Esquelético/diagnóstico por imagem , Músculo Esquelético/fisiopatologia , Miotonia/complicações , Miotonia/diagnóstico por imagem , Adulto JovemRESUMO
Centronuclear myopathy (CNM) is a rare hereditary myopathy characterized by centrally located muscle fiber nuclei. Mutations in the dynamin 2 (DNM2) gene are estimated to account for about 50 % of CNM cases. Electromyographic recordings in CNM may show myopathic motor unit potentials without spontaneous activity at rest. Myotonic discharges, a distinctive electrical activity caused by membrane hyperexcitability, are characteristic of certain neuromuscular disorders. Such activity has been reported in only one CNM case without a known genetic cause. We sequenced the DNM2 gene and the genes associated with myotonia (CLCN1, SCN4A, DMPK and ZNF9) in a sporadic adult patient with CNM and myotonic discharges. Sequencing the entire coding region and exon-intron boundaries revealed a heterozygous c.1106g-a substitution in exon 8, resulting in a R369Q change in the DNM2. Sequencing the CLCN1, SCN4A, DMPK and ZNF9 genes ruled out mutations in these genes. This is the first report of DNM2-related CNM presenting with myotonia. The diagnosis of CNM should be considered in patients with myotonic discharges of an unknown cause.
Assuntos
Dinamina II/genética , Miopatias Congênitas Estruturais/complicações , Miopatias Congênitas Estruturais/genética , Miotonia/complicações , Miotonia/genética , Adulto , Sequência de Bases , Canais de Cloreto/genética , Análise Mutacional de DNA , Eletromiografia , Feminino , Humanos , Músculo Esquelético/patologia , Músculo Esquelético/fisiopatologia , Miopatias Congênitas Estruturais/patologia , Miopatias Congênitas Estruturais/fisiopatologia , Miotonia/patologia , Miotonia/fisiopatologia , Miotonina Proteína Quinase/genética , Canal de Sódio Disparado por Voltagem NAV1.4/genética , Proteínas de Ligação a RNA/genéticaRESUMO
Mutations in the pore-forming subunit of the skeletal muscle sodium channel (SCN4A) are responsible for hyperkalemic periodic paralysis, paramyotonia congenita and sodium channel myotonia. These disorders are classified based on their cardinal symptoms, myotonia and/or paralysis. We report the case of a Japanese boy with a novel mutation of SCN4A, p.I693L, who exhibited severe episodic myotonia from infancy and later onset mild paralytic attack. He started to have apneic episodes with generalized hypertonia at age of 11 months, then developed severe episodic myotonia since 2 years of age. He presented characteristic generalized features which resembled Schwarz-Jampel syndrome. After 7 years old, paralytic episodes occurred several times a year. The compound muscle action potential did not change during short and long exercise tests. Functional analysis of the mutant channel expressed in cultured cell revealed enhancement of the activation and disruption of the slow inactivation, which were consistent with myotonia and paralytic attack. The severe clinical features in his infancy may correspond to myotonia permanence, however, he subsequently experienced paralytic attacks. This case provides an example of the complexity and overlap of the clinical features of sodium channel myotonic disorders.
Assuntos
Mutação/genética , Miotonia/diagnóstico , Canal de Sódio Disparado por Voltagem NAV1.4/genética , Paralisia/diagnóstico , Paralisia/genética , Índice de Gravidade de Doença , Criança , Humanos , Masculino , Miotonia/complicações , Miotonia/genética , Paralisia/complicaçõesRESUMO
The myotonias and familial periodic paralyses are muscle channelopathies. They have in common an impaired muscle excitation that is caused by mutations in voltage-gated Na(+), K(+), Ca(2+), and Cl(-) channels. Membrane hyperexcitability usually results in myotonic stiffness; with increasing membrane depolarization hyperexcitability can be transiently turned into hypoexcitability causing transient weakness as in severe myotonia. Hypoexcitability due to long-lasting depolarization that inhibits action potential generation is the common mechanism for the periodic paralyses. Interictally, the ion channel malfunction may be compensated, so that specific exogenous or endogenous provocative factors are required to produce symptoms in the patients. An especially obvious triggering agent is the level of serum potassium, the ion decisive for resting membrane potential and degree of excitability. Periodic paralysis mutations for which the ion channel malfunction is not fully compensated interictally cause progressive myopathy.
Assuntos
Canalopatias/genética , Canais Iônicos/genética , Músculo Esquelético/fisiopatologia , Miotonia/genética , Paralisia/genética , Canalopatias/complicações , Humanos , Mutação , Miotonia/complicações , Paralisia/complicaçõesRESUMO
To determine self-reported health status in non-dystrophic myotonias (NDM) and its relationship to painful myotonia and fatigue. In a cross-sectional study, 32 NDM patients with chloride and 30 with sodium channelopathies, all off treatment, completed a standardised interview, the fatigue assessment scale (FAS), and the 36-item Short-Form Health Survey (SF-36). Beside formal assessment of pain, assessment of painful or painless myotonia was determined. The domain scores of the SF-36 were compared with Dutch community scores. Apart from the relationship among SF-36 scores and (1) painful myotonia and (2) fatigue, regression analyses in both NDM groups were conducted to determine the strongest determinants of the SF-36 domains general health perception, physical component (PCS) and mental component summary (MCS). All physically oriented SF-36 domains in both NDM groups (P Assuntos
Fadiga/complicações
, Nível de Saúde
, Miotonia/complicações
, Miotonia/psicologia
, Dor/complicações
, Adulto
, Idoso
, Canais de Cloreto
, Estudos Transversais
, Feminino
, Humanos
, Entrevista Psicológica
, Masculino
, Pessoa de Meia-Idade
, Análise Multivariada
, Análise de Regressão
, Reprodutibilidade dos Testes
, Índice de Gravidade de Doença
, Canais de Sódio
, Adulto Jovem
RESUMO
Severe motor and intellectual disabilities (SMID) syndrome is a heterogeneous group of disorders with severe physical disabilities and mental retardation. Higher incidence of sudden death is also known in these patients. However, little is known about the cardiovascular features of patients with SMID. We examine the patients with severe motor and intellectual disabilities using echocardiogram and clarify their characterization of ventricular function. We performed electrocardiographic and echocardiographic analyses in SMID patients. In all patients, two-dimensional echocardiography with tissue Doppler analysis in the pulsed Doppler mode was performed. Of 121 patients, 104 patients had abnormal findings: 81 had poor R-wave progression, and 15 patients had low-voltage QRS on ECG. These findings strongly correlated with the degree of physical disability. However, on echocardiography, most patients had LVEF in the normal range, while LV Tei indices were significantly higher (0.43 vs 0.31 cm/s) and left ventricular end-diastolic dimension significantly smaller than healthy controls (P<0.05 for each comparison). Patients had significantly decreased early diastolic tissue Doppler velocities at the lateral mitral (5.3 vs 6.7 cm/s), tricuspid (6.7 vs 9.2 cm/s), and septal (5.9 vs 8.8 cm/s) annuli compared with controls (P<0.05 for each comparison). We show for the first time that SMID patients have low E/Ea ratios on tissue Doppler imaging while LV contractions are normal, suggesting the existence of latent diastolic dysfunction. This may be one of the reasons why the incidence of sudden death is higher in SMID patients.
Assuntos
Avaliação da Deficiência , Ecocardiografia Doppler/métodos , Eletrocardiografia/métodos , Deficiência Intelectual/reabilitação , Miotonia/reabilitação , Disfunção Ventricular/diagnóstico , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Deficiência Intelectual/complicações , Masculino , Pessoa de Meia-Idade , Miotonia/complicações , Prognóstico , Estudos Retrospectivos , Volume Sistólico/fisiologia , Disfunção Ventricular/complicações , Disfunção Ventricular/reabilitação , Adulto JovemRESUMO
BACKGROUND: Myotonia is observed in classic congenital myotonia caused by CLCN1 mutations and in sodium-channel myotonia (SCM) due to SCN4A mutations. METHODS: We assessed 66 electrically proven cases of myotonia belonging to 17 French-Canadian families living in the Saguenay Lac St-Jean area of Quebec, a region well known for its genetic founder effects. The CLCN1 gene was sequenced in one affected member of each family. SCN4A exons with known SCM mutations were subsequently sequenced in families where no CLCN1 mutations were found. RESULTS: Six families, 33% of cases (22/66), presenting classic congenital myotonia phenotypes were found to carry two previously identified CLCN1 mutations. In the other 11 families comprising 66% of cases (44/66), a new dominant SCN4A mutation in exon 24 (M1476I) was uncovered and segregated with a variable SCM phenotype. Although all carriers of this novel mutation had electrical myotonia, some were asymptomatic (25%) and age at onset was variable in the others (5 to 67, mean 21). Cold aggravated myotonia was observed in 41% of cases and painful myotonia in 18%. Additional features observed include aggravation of symptoms with pregnancies (7%), localized muscle swelling (2%), myotonic reactions to anesthesia (2%), and food-induced paralysis (2%). CONCLUSIONS: This cohort is the largest described with a variable sodium-channel myotonia phenotype caused by a single SCN4A mutation. The clinical variability observed in this cohort underlines the phenotypic heterogeneity of SCN4A mutations and suggests that variants in other genes likely modulate clinical expression.
Assuntos
Temperatura Baixa/efeitos adversos , Efeito Fundador , Miotonia/genética , Dor/genética , Canais de Sódio/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , França/etnologia , Humanos , Masculino , Pessoa de Meia-Idade , Mutação , Miotonia/complicações , Miotonia/diagnóstico , Canal de Sódio Disparado por Voltagem NAV1.4 , Dor/complicações , Dor/diagnóstico , Quebeque , População Branca/genéticaRESUMO
A 6-year-old boy with Schwartz-Jampel syndrome and severe myotonia-induced blepharospasm and ptosis did not respond to botulinum toxin A injections in the orbicularis muscle. The clinical diagnosis was further supported by electromyography. Surgical management using a combination of techniques in one operation produced a satisfactory result for both function and appearance. Muscle biopsy was also done during surgery.
Assuntos
Blefaroplastia/métodos , Blefaroptose/cirurgia , Blefarospasmo/cirurgia , Toxinas Botulínicas Tipo A/administração & dosagem , Miotonia/complicações , Fármacos Neuromusculares/administração & dosagem , Osteocondrodisplasias/complicações , Blefaroptose/tratamento farmacológico , Blefaroptose/etiologia , Blefarospasmo/tratamento farmacológico , Blefarospasmo/etiologia , Criança , Humanos , Injeções Intramusculares , Masculino , Miotonia/tratamento farmacológico , Miotonia/patologia , Músculos Oculomotores/patologia , Músculos Oculomotores/cirurgia , Osteocondrodisplasias/tratamento farmacológico , Osteocondrodisplasias/cirurgia , Falha de TratamentoRESUMO
Schwartz-Jampel syndrome (SJS) is a rare, inherited disorder defined by myotonia, skeletal malformations, muscular stiffness, and growth retardation. The clinical signs and symptoms of SJS are seen in the maxillofacial region. The combination of skeletal and muscular abnormalities predisposes affected individuals to a number of primary and secondary orodental manifestations. Although several studies have discussed the clinical features of SJS from a medical perspective, few reports have addressed the oral findings or dental treatment in children and adolescents with the disorder. This article reviews the dental manifestations and impairments of Schwartz-Jampel syndrome. The case histories of two siblings diagnosed with this disorder are described as well as their dental care.
Assuntos
Anodontia/complicações , Contratura/complicações , Assistência Odontológica para Doentes Crônicos , Anormalidades Maxilofaciais/complicações , Micrognatismo/complicações , Saúde Bucal , Osteocondrodisplasias/complicações , Adolescente , Anodontia/diagnóstico por imagem , Arco Dental , Feminino , Humanos , Masculino , Má Oclusão/complicações , Má Oclusão/diagnóstico por imagem , Micrognatismo/diagnóstico por imagem , Miotonia/complicações , Radiografia , IrmãosRESUMO
OBJECTIVE: In this paper we report a painful nondystrophic myotonia which has not been previously described. Pain is a rare symptom in myotonia. We report a myotonic disorder in a 34-year-old woman and her 14-year-old daughter. Painful cramps occur during and after exercise in the mother, and both patients can demonstrate unusual contractions in the tongue. In the present study we try to evaluate the mechanisms behind the unique finding of trains of high amplitude of positive waves, not seen in the earlier known myotonic conditions. METHODS: Clinical investigations and electromyography with single and dual channel recordings and muscle morphometry were performed. RESULTS: The electromyographic recordings reveal positive waves, fibrillation potentials and myotonic discharges. In addition, extraordinary findings were made of trains of high frequency positive potentials with very high amplitudes and with conduction block along the muscle fibres. CONCLUSIONS: In this new form of myotonia with likely dominant heredity, the specific finding of trains of high amplitude positive waves indicates ephaptic transmission within bundles of neighbouring muscle fibres.
Assuntos
Miotonia/complicações , Miotonia/fisiopatologia , Dor/etiologia , Dor/fisiopatologia , Língua/fisiopatologia , Adolescente , Adulto , Eletromiografia , Feminino , Humanos , Cãibra Muscular/etiologia , Cãibra Muscular/genética , Cãibra Muscular/fisiopatologia , Miotonia/genética , Dor/genética , Linhagem , Língua/inervaçãoRESUMO
OBJECTIVES: To describe a case of equine muscular dystrophy with myotonia. METHODS: A 5-year-old horse presented with hypertrophy and delayed relaxation of the muscles of the hindlimbs from age 2 months. Testicular atrophy developed from 2 years of age. Action and percussion myotonia was associated with weakness in these muscles, and EMG showed diffuse myotonic discharges and myopathic features. Biopsy of the gluteal muscle showed adipose and connective tissue infiltration, marked variation in muscle fibre size, and moth-eaten, ring and whorled fibres. RESULTS: Injection of apamin, a peptide blocker of calcium-activated potassium channels, which inhibits myotonia in human myotonic dystrophy, was ineffective in blocking myotonic discharges. Discharges promptly abated with 2% lidocaine injection. CONCLUSIONS: Myotonia in this horse is associated with dystrophic changes similar to human myotonic dystrophy, though there are some pharmacological differences.
Assuntos
Doenças dos Cavalos , Distrofia Muscular Animal/complicações , Miotonia/veterinária , Anestésicos Locais/uso terapêutico , Animais , Apamina/uso terapêutico , Atrofia , Eletromiografia , Membro Posterior , Doenças dos Cavalos/tratamento farmacológico , Doenças dos Cavalos/patologia , Doenças dos Cavalos/fisiopatologia , Cavalos , Hipertrofia , Lidocaína/uso terapêutico , Masculino , Relaxamento Muscular , Debilidade Muscular/etiologia , Músculo Esquelético/efeitos dos fármacos , Músculo Esquelético/patologia , Músculo Esquelético/fisiopatologia , Distrofia Muscular Animal/tratamento farmacológico , Distrofia Muscular Animal/patologia , Distrofia Muscular Animal/fisiopatologia , Miotonia/complicações , Miotonia/tratamento farmacológico , Miotonia/fisiopatologia , Condução Nervosa , Testículo/patologia , Falha de TratamentoAssuntos
Miotonia/história , Mixedema/história , Adulto , História do Século XIX , Humanos , Masculino , Músculo Esquelético/fisiopatologia , Miotonia/complicações , Miotonia/fisiopatologia , Mixedema/complicações , Mixedema/tratamento farmacológico , Hormônios Tireóideos/história , Hormônios Tireóideos/uso terapêutico , Urina/químicaRESUMO
A 37-year-old man with sarcoidosis developed severe electrical and clinical myotonia while taking pravastatin for hypercholesterolemia. Myotonia associated with sarcoidosis is rare. Pravastatin is associated with myotonia in animals. This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.