Assuntos
Doenças Biliares/induzido quimicamente , Tetracloreto de Carbono/toxicidade , Inseticidas/toxicidade , Mirex/toxicidade , Adenosina Trifosfatases/metabolismo , Alanina Transaminase/sangue , Animais , Aspartato Aminotransferases/sangue , Imipramina/metabolismo , Fígado/enzimologia , Fígado/patologia , Masculino , Mirex/efeitos da radiação , Ratos , Fatores de TempoRESUMO
The absorption, distribution, and excretion of photomirex were investigated in the rat. Photomirex was absorbed slowly after oral administration, appeared in the blood at 1.5 hr, and reached the peak concentration 4 hr after dosing. Elimination from the blood was studied in rats receiving single intravenous doses; the semilog-arithmic decay curve was found to be triphasic. The highest concentrations were present in the rat, liver, and skin. Approximately 38--42% of the orally dosed photomirex was excreted in the feces in the first 3 days and 51--55% was eliminated in 28 days. Only trace amounts of photomirex were found in the urine (less than 0.09% of the total dose in 24 hr). Photomirex constituted about 95% of the total radioactivity found in the tissues and feces. No metabolite was detected in the radioactive material extracted from tissues or feces.
Assuntos
Inseticidas/metabolismo , Mirex/metabolismo , Animais , Bile/metabolismo , Absorção Intestinal , Luz , Masculino , Mirex/análogos & derivados , Mirex/efeitos da radiação , Ratos , Fatores de Tempo , Distribuição TecidualRESUMO
Adult New Zealand white does were intubated orally with single daily doses of 0, 5, or 10 mg of photomirex (8-monohydromirex) per kg body weight from the 6th through to the 18th day of gestation. Pregnancies were interrupted at term by cesarian section and fetuses removed and evaluated by following routine teratologic methods. Both maternal and fetal tissues were analyzed for residues of photomirex. None of the treated does showed any sign of toxicity. Except for a significant reduction in the mean fetal weight of the 10 mg/kg group all other parameters which evaluated fetal survival and fetal development were within the control range. Photomirex was found in all tissues examined. In the doe, the highest levels were found in fat followed by liver, kidney, spleen, heart, brain and blood. Photomirex was readily transferred across the placenta and accumulated in the fetus. However, in the fetus the highest levels were found in the heart, followed by liver, brain and blood. There were no teratogenic effects at the doses used in this study.
Assuntos
Inseticidas/toxicidade , Mirex/toxicidade , Teratogênicos , Animais , Peso Corporal/efeitos dos fármacos , Feminino , Feto/efeitos dos fármacos , Mirex/análogos & derivados , Mirex/metabolismo , Mirex/efeitos da radiação , Gravidez , Prenhez/efeitos dos fármacos , Coelhos , Distribuição TecidualRESUMO
Three simulated marsh systems were constructed, containing sediment, marsh plants, oysters, blue crabs, fiddler crabs, and two species of top minnows. Seawater entered each of the pools by flowing across a trough, two of which contained Mirex bait. Tidal fluctuations were simulated. Samples of water, bait, and animals were periodically analyzed. All animals concentrated Mirex. Three photoproducts accumulated on the bait particles, and both oysters and one species of fish accumulated one of the photoproducts.