RESUMO
Bovine ocular squamous cell carcinoma (BOSCC) also called cancer eye, represents the most economically important neoplasm in large animals. Hereditary factors, environmental factors, lack of eyelid pigmentation, age and dietary habits have all been reported to play a role in the etiopathogenesis of bovine ocular squamous cell carcinoma. In group I, six animals with small, localized eye cancer where vision was not affected were included and subjected to intralesional injection of Bacillus Calmette- Guerin (BCG) vaccine at 0, 14, 35, and 56 days interval. In group II (six animals), surgical excision and Mitomycin C 0.04% topically on alternate weeks for two months as adjunctive therapy. All the animals recovered completely with no recurrence for a follow up period of one year.
Assuntos
Antibióticos Antineoplásicos/uso terapêutico , Vacina BCG/normas , Carcinoma de Células Escamosas/veterinária , Doenças dos Bovinos/tratamento farmacológico , Neoplasias Oculares/veterinária , Mitomicina/uso terapêutico , Administração Intravesical , Animais , Antibióticos Antineoplásicos/administração & dosagem , Antibióticos Antineoplásicos/normas , Vacina BCG/administração & dosagem , Vacina BCG/uso terapêutico , Carcinoma de Células Escamosas/tratamento farmacológico , Bovinos , Terapia Combinada/veterinária , Neoplasias Oculares/tratamento farmacológico , Feminino , Humanos , Masculino , Mitomicina/administração & dosagem , Mitomicina/normas , Inibidores da Síntese de Ácido Nucleico/administração & dosagem , Inibidores da Síntese de Ácido Nucleico/normas , Inibidores da Síntese de Ácido Nucleico/uso terapêutico , Estudos Prospectivos , Neoplasias da Bexiga Urinária/tratamento farmacológico , Neoplasias da Bexiga Urinária/patologia , Neoplasias da Bexiga Urinária/veterináriaRESUMO
OBJECTIVE: To determine the chemical stability of various mitomycin C (MMC) solutions used in glaucoma filtering surgery. METHODS: A survey of the MMC solutions currently in use in 21 hospitals (11 in Canada, 10 in the United States) was conducted. A comparative study of the chemical stability of five different representative solutions was performed. The effects of buffer and storage variables on the chemical breakdown of MMC in the solutions were studied by means of high-performance liquid chromatography (HPLC). RESULTS: The survey revealed 33 different variations (including recipes and storage conditions) in the preparation of MMC solutions. Although the majority of the hospitals (15 of 21; 72%) were preparing stable solutions, six of the hospitals (28%) were preparing potentially unstable solutions. The stability of the solutions varied in a nonuniform manner when stored at different temperatures in different buffers. CONCLUSION: The lack of standardization and quality control of MMC solutions used in filtering surgery allows for the possibility of hospitals preparing unstable solutions.
