Assuntos
Adenocarcinoma/secundário , Neoplasias do Colo/patologia , Neoplasias Hepáticas/cirurgia , Neoplasias de Tecido Fibroso/cirurgia , Neoplasias Peritoneais/cirurgia , Adenocarcinoma/cirurgia , Idoso , Anastomose Cirúrgica , Biópsia por Agulha , Colectomia/métodos , Neoplasias do Colo/cirurgia , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Seguimentos , Humanos , Imuno-Histoquímica , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/secundário , Masculino , Mesentério/patologia , Neoplasias de Tecido Fibroso/secundário , Neoplasias Peritoneais/diagnóstico , Neoplasias Peritoneais/secundário , Resultado do TratamentoRESUMO
PURPOSE: This study was performed to evaluate the factors affecting the diagnostic accuracy and rate of complications of CT-guided percutaneous transthoracic needle biopsy of mediastinal masses. MATERIALS AND METHODS: We reviewed 73 consecutive mediastinal biopsies in 70 patients. Final diagnoses were based on a retrospective analysis of surgical outcomes, results of repeat biopsies or findings of imaging and clinical follow-up lasting at least 4 months. Benign and malignant biopsy findings were compared with the final outcomes to determine the diagnostic accuracy of the method. Finally, we analysed the complications. RESULTS: CT-guided percutaneous transthoracic needle biopsy provided adequate samples in 61/73 cases, with a total sample rate of 83.6%. Of these 61 biopsies, 51 yielded a correct diagnosis with specific histological typing, mainly in the case of thymoma and metastasis. Lymphomas were less reliably diagnosed. The overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy values were 83.6%, 100%, 100%, 35.3% and 83.6%, respectively. Pneumothorax was the most common complication (5.5%). CONCLUSIONS: CT-guided percutaneous transthoracic needle biopsy is an easy, reliable and safe procedure that obviates the need for exploratory surgery in medically treatable or unresectable cases. It should be the first invasive procedure in the diagnostic workup of mediastinal masses.
Assuntos
Biópsia por Agulha/métodos , Doenças do Mediastino/diagnóstico , Radiografia Intervencionista/métodos , Tomografia Computadorizada por Raios X/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia por Agulha/efeitos adversos , Criança , Citodiagnóstico , Feminino , Seguimentos , Humanos , Linfoma/diagnóstico , Masculino , Doenças do Mediastino/patologia , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos , Neoplasias de Tecido Fibroso/diagnóstico , Neoplasias de Tecido Fibroso/secundário , Pneumotórax/etiologia , Valor Preditivo dos Testes , Estudos Retrospectivos , Segurança , Sensibilidade e Especificidade , Timoma/diagnóstico , Resultado do TratamentoRESUMO
We report a case of a 62-year-old female with a prior thoracotomy for solitary fibrous tumor of the diaphragmatic pleura. There was no clear evidence of malignant solitary fibrous tumor of the pleura (SFTP). In the 19th postoperative month, she had a disseminated recurrence of SFTP in the left thoracic cavity. There was no evidence of metastasis from medical imaging. Accordingly, a left extrapleural pneumonectomy was performed. Pathological examination revealed a disseminated recurrence of malignant SFTP, showing a higher grade of malignancy, because the resected specimen was identical to the only section suspicious of malignancy in the previous tumor. She had no complaint and kept better performance status until the 7th postoperative month after the re-resection, when she had a recurrence in the left thoracic cavity and dissemination in the peritoneal cavity. She died of the recurrence 15 months after the re-resection and 34 months after the prior thoracotomy.
Assuntos
Recidiva Local de Neoplasia/cirurgia , Neoplasias de Tecido Fibroso/cirurgia , Neoplasias Pleurais/cirurgia , Pneumonectomia/métodos , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias de Tecido Fibroso/secundário , Neoplasias Peritoneais/secundário , Neoplasias Pleurais/patologia , Reoperação , Cavidade Torácica/patologia , ToracotomiaRESUMO
BACKGROUND: Solitary fibrous tumor (SFT) of the pleura with malignant progression occurs uncommonly. Cardiac intracavitary extension of tumors is rarely seen, with left side location being exceptional. METHODS AND RESULTS: The authors report the first case of a malignant SFT metastatic to the heart occurring in a 74-year-old woman. The tumor first presented as a slow-growing pleural SFT that in 6 years reached a size of 16 cm. Two months after a complete surgical resection, the tumor was found to spread to the left atrium by intracavitary extension from the left upper pulmonary vein, simulating a cardiac myxoma. The primary tumor showed established features of malignancy including size greater than 10 cm; gross findings of necrosis; high cellularity, cytological atypia, and eight mitoses per 10 high-power fields. Immunohistochemical study revealed positivity of the tumor cells for CD34, bcl-2, and CD99. Aside from the present report, 52 previous cases of sarcoma with intracavitary extension to the left side of the heart have been described. Bone sarcoma is the type most frequently found. Peripheral arterial embolism can be a complication of advanced mesenchymal malignancy in 21% (11/53) of reported cases. CONCLUSION: Accurate histopathologic recognition of this rare type of metastatic disease is important because of the adverse prognosis as compared to cardiac myxoma.
Assuntos
Átrios do Coração/patologia , Neoplasias Cardíacas/secundário , Neoplasias de Tecido Fibroso/secundário , Neoplasias Pleurais/patologia , Idoso , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Mixoma/patologiaAssuntos
Recidiva Local de Neoplasia , Inoculação de Neoplasia , Neoplasias de Tecido Fibroso/secundário , Neoplasias Pleurais/secundário , Idoso , Biópsia por Agulha/efeitos adversos , Feminino , Humanos , Neoplasias de Tecido Fibroso/diagnóstico por imagem , Neoplasias Pleurais/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Ultrassonografia de IntervençãoRESUMO
BACKGROUND: The aim of this study was to define more precisely the surgical outcome and clinical course of solitary fibrous tumors of the pleura. METHODS: We conducted a retrospective review of the clinical records of patients who had undergone surgical resection for benign and malignant solitary fibrous tumors of the pleura during a 10-year period (1993 to 2003). RESULTS: Sixty-three patients were enrolled in the study (men, 29; women, 34; mean age, 49.6 years). Thirty-six patients (57.1%) were symptomatic at the time of diagnosis. Resection was performed through a thoracotomy (n = 37), by means of video-assisted thoracoscopy (n = 22), or through a sternotomy (n = 4). Mass excision only was performed in 34 cases, and en bloc excision including adjacent structures was performed in 29 cases. Forty-four cases (69.8%) were benign and 19 (30.2%) were malignant. Local recurrences occurred in three cases and distant metastases in eight. Recurrences occurred only in malignancy. Symptomatic presentation and the impression of a nonpleural tumor by imaging study were found to be related to a malignant pathologic diagnosis. The radiologic impression of solitary fibrous tumors of the pleura was also related to mass excision only. CONCLUSIONS: For malignant cases, complete surgical resection may be insufficient for the cure. Therefore, further study should be performed to define the role of preoperative and postoperative systemic treatment.
Assuntos
Neoplasias de Tecido Fibroso/cirurgia , Neoplasias Pleurais/cirurgia , Cirurgia Torácica Vídeoassistida , Toracotomia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia por Agulha Fina , Criança , Pré-Escolar , Feminino , Humanos , Achados Incidentais , Tábuas de Vida , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Neoplasias de Tecido Fibroso/diagnóstico por imagem , Neoplasias de Tecido Fibroso/mortalidade , Neoplasias de Tecido Fibroso/patologia , Neoplasias de Tecido Fibroso/secundário , Neoplasias Pleurais/diagnóstico por imagem , Neoplasias Pleurais/mortalidade , Neoplasias Pleurais/patologia , Estudos Retrospectivos , Esterno/cirurgia , Cirurgia Torácica Vídeoassistida/estatística & dados numéricos , Toracotomia/estatística & dados numéricos , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
A 61-year-old man with a history of malignant solitary fibrous tumor of the chest had development of unusual sites of metastasis involving the sphenoid wing of the orbit and soft tissues of the cheek. He was found to have a solitary fibrous tumor, an uncommon type of spindle cell neoplasm that most often arises in the pleura, which was metastatic to the orbit. This is the first reported case of malignant solitary fibrous tumor metastatic to the orbit. The clinical and histopathologic findings of metastatic malignant solitary fibrous tumor are described.
Assuntos
Neoplasias de Tecido Fibroso/secundário , Neoplasias Orbitárias/secundário , Neoplasias Pleurais/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecido Fibroso/diagnóstico por imagem , Neoplasias de Tecido Fibroso/cirurgia , Procedimentos Cirúrgicos Oftalmológicos , Neoplasias Orbitárias/diagnóstico por imagem , Neoplasias Orbitárias/cirurgia , Neoplasias Pleurais/diagnóstico por imagem , Neoplasias Pleurais/cirurgia , Tomografia Computadorizada por Raios XRESUMO
Increasing numbers of solitary fibrous tumors (SFTs) in the meninges have been reported since this entity was first recognized. While most cases previously reported were considered to be benign, the malignant potential of extrathoracic SFTs has not been excluded. The authors report a rare case of a meningeal SFT with malignant behavior occurring in a Japanese female patient, initially resected when she was 44 years old and recurring in the same place four times during a 26-year follow-up period. A metastatic tumor to the right lung arose 25 years after the resection of the first meningeal tumor and focal invasion into the cerebellum was also observed with her last (5th) meningeal tumor. Immunohistochemical analysis showed all tumors to be diffusely positive for CD34 and negative for EMA, with a so-called "patternless" histological pattern, featuring thin collagen fibers between tumor cells. A focal "staghorn" vascular pattern was also observed. Ki67 (MIB-1) labeling indices and mitosis rates were 3.1+/-1.2% and less than 1/10 high power fields (HPF) in the first meningeal tumor and 16.1+/-6.4% and 6/10HPF in the last (5th) one, respectively. Thus, the present case suggests that meningeal SFTs possess malignant potential so that careful long-term follow up is required.
Assuntos
Neoplasias Pulmonares/secundário , Neoplasias Meníngeas/patologia , Neoplasias de Tecido Fibroso/secundário , Adulto , Idoso , Antígenos CD34/análise , Biomarcadores Tumorais/análise , Feminino , Humanos , Técnicas Imunoenzimáticas , Antígeno Ki-67/análise , Neoplasias Pulmonares/química , Neoplasias Pulmonares/diagnóstico por imagem , Imageamento por Ressonância Magnética , Neoplasias Meníngeas/química , Neoplasias Meníngeas/cirurgia , Índice Mitótico , Recidiva Local de Neoplasia , Neoplasias de Tecido Fibroso/química , Neoplasias de Tecido Fibroso/cirurgia , Tomografia Computadorizada por Raios XRESUMO
Malignant solitary fibrous tumours (MSFTs) are rare tumours of fibrous origin, which can occur at all anatomical sites and represent 20% of solitary fibrous tumours. Fine-needle aspiration cytology is not able to distinguish benign from malignant disease, and sufficient tissue has to be obtained for accurate histological diagnosis to be made. Lesions > 10 cm in diameter and incomplete resection or non-resectability are predictive factors for poor long-term survival. We present a 57-year-old patient with a presumably metastatic MSFT from the peritoneal cavity to the skull-base who is in a stable state 17 months after surgical debulking of the skull-base and removal of the peritoneal lesion, followed by post-operative chemotherapy. We suggest the terminology metastatic malignant solitary fibrous tumour for a description of this disease.
Assuntos
Neoplasias de Tecido Fibroso/secundário , Neoplasias Peritoneais/patologia , Neoplasias da Base do Crânio/secundário , Antígenos CD34/análise , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doxorrubicina/administração & dosagem , Feminino , Humanos , Ifosfamida/administração & dosagem , Imuno-Histoquímica , Pessoa de Meia-Idade , Neoplasias de Tecido Fibroso/classificação , Neoplasias de Tecido Fibroso/tratamento farmacológico , Neoplasias de Tecido Fibroso/cirurgia , Neoplasias Peritoneais/tratamento farmacológico , Neoplasias da Base do Crânio/diagnóstico , Neoplasias da Base do Crânio/tratamento farmacológico , Neoplasias da Base do Crânio/cirurgia , Terminologia como AssuntoRESUMO
The majority of solitary fibrous tumors (SFTs) of the pleura are benign, but 10-30% locally recur or metastasize. Pathogenic factors relevant to the determinism of their biological properties are largely unknown. Cytogenetic data on SFTs of the pleura are sparse. We report herein a case of a malignant SFT of the pleura where successful karyotyping was obtained from the primary and recurrent tumors. The initial karyotype showed two abnormal clones: 48, XY; +8; +8; del(9)(q22; q32) [19] and 46, XY, t(1;16)(q25;p12) [7]. Culture of the recurrent tumor yielded one clone identical to the dominant clone of the initial karyotype. Demonstration of a recurrent abnormal karyotype largely supports its relevance to the malignant clone and suggests a role of supernumerary chromosome(s) 8 in the determinism of malignant behavior in SFT.
Assuntos
Aneuploidia , Bandeamento Cromossômico , Neoplasias de Tecido Fibroso/secundário , Neoplasias Pleurais/patologia , Deleção Cromossômica , Cromossomos Humanos Par 8 , Evolução Fatal , Humanos , Neoplasias Pulmonares/secundário , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Neoplasias de Tecido Fibroso/genética , Neoplasias de Tecido Fibroso/cirurgia , Neoplasias Pleurais/genética , Neoplasias Pleurais/cirurgia , Quinacrina , Translocação GenéticaAssuntos
Adenocarcinoma/metabolismo , Adenocarcinoma/secundário , Neprilisina/metabolismo , Neoplasias Pleurais/metabolismo , Neoplasias Pleurais/secundário , Neoplasias do Colo do Útero/patologia , Adenocarcinoma/diagnóstico por imagem , Adenocarcinoma/patologia , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias de Tecido Fibroso/metabolismo , Neoplasias de Tecido Fibroso/patologia , Neoplasias de Tecido Fibroso/secundário , Neoplasias Pleurais/diagnóstico por imagem , Neoplasias Pleurais/patologia , Tomografia Computadorizada por Raios XAssuntos
Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/secundário , Neoplasias de Tecido Fibroso/patologia , Neoplasias de Tecido Fibroso/secundário , Neoplasias Pleurais/patologia , Idoso , Feminino , Humanos , Neoplasias Pulmonares/cirurgia , Neoplasias de Tecido Fibroso/cirurgia , Neoplasias Pleurais/cirurgiaRESUMO
Pleural solitary fibrous tumors (SFTs) are uncommon tumors. Although these tumors have been well characterized, malignant pleural SFTs with liposarcomatous differentiation have not been reported. We report an unusual malignant pleural SFT intermixed with foci of well-differentiated liposarcoma. The patient was a 66-year-old, white man with a large, solid right pleural mass that measured 13.5 x 10.3 x 8.5 cm. The tumor was composed of spindle-shaped and plump cells embedded in dense collagenous stroma. The tumor cells were arranged in interlacing fascicles or in a patternless pattern. Marked nuclear atypia, a high mitotic rate (21 mitoses per 10 high-power fields), and areas of prominent necrosis were evident. In addition, numerous adipocytes mixed with typical lipoblasts were seen scattered throughout portions of the tumor. Immunohistochemistry revealed the tumor cells were strongly positive for CD34 and vimentin and negative for cytokeratin, desmin, smooth muscle actin (IA4), and S100. To the best of our knowledge, this case represents the first example of a malignant SFT with liposarcomatous differentiation.
Assuntos
Lipossarcoma/secundário , Neoplasias de Tecido Fibroso/secundário , Neoplasias Pleurais/patologia , Idoso , Antígenos CD34/análise , Núcleo Celular/patologia , Humanos , Imuno-Histoquímica , Lipossarcoma/química , Lipossarcoma/diagnóstico por imagem , Lipossarcoma/cirurgia , Masculino , Mitose , Necrose , Metástase Neoplásica/patologia , Neoplasias de Tecido Fibroso/química , Neoplasias de Tecido Fibroso/diagnóstico por imagem , Neoplasias de Tecido Fibroso/cirurgia , Neoplasias Pleurais/química , Neoplasias Pleurais/diagnóstico por imagem , Neoplasias Pleurais/cirurgia , Radiografia , Vimentina/análiseRESUMO
Solitary fibrous tumor (SFT) is a unique tumor composed of interstitial dendritic cells that was first described in the thorax and subsequently reported in diverse organs. Extrathoracic SFTs are predominantly benign but rare malignant cases have been documented. In the nervous system, SFT has been described as a meningeal lesion although all 14 previously reported cases were benign. The authors report the first case of a meningeal SFT occurring in a 55-year-old woman. The tumor first presented as a meningeal lesion that after three recurrences over a 10-year period metastasized to the soft tissues and lungs. The potentially malignant nature of cranial SFTs, especially those with atypical histological features and high mitotic counts, should be recognized.
Assuntos
Neoplasias Pulmonares/secundário , Neoplasias Meníngeas/patologia , Neoplasias de Tecido Fibroso/secundário , Neoplasias de Tecidos Moles/secundário , Feminino , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Radiografia Torácica , RecidivaAssuntos
Cromossomos Humanos Par 15/genética , Cromossomos Humanos Par 4/genética , Neoplasias Pulmonares/genética , Neoplasias de Tecido Fibroso/genética , Neoplasias Pleurais/genética , Translocação Genética , Idoso , Colágeno , Diagnóstico Diferencial , Humanos , Cariotipagem , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/secundário , Masculino , Neoplasias de Tecido Fibroso/patologia , Neoplasias de Tecido Fibroso/secundário , Neoplasias Pleurais/patologiaRESUMO
A malignant solitary fibrous tumor arising in the right buttock associated with metastatic parietal pleural and intrapulmonary tumors and pleural effusion was found in a 59-year-old man. A chest computed tomogram revealed three tumors attached to the parietal pleura with rib destruction, and a tumor in the left lower lung field. Histologically, the tumors of the buttock and parietal pleura were characterized by proliferation of bundles of spindle-shaped or oval cells separated by wavy hyalinized collagen tissue with no expression of cytokeratin, S-100 protein, muscle actin or epithelial membrane antigen, but these cells weakly expressed CD34 and strongly expressed vimentin.