RESUMO
We report the case of a 67-year-old female patient presenting swelling of the hands and feet and pain in both legs. Clinical examination and bone scintigraphy identify the triad "digital clubbing - arthritis - bilateral periostitis of the long bones", leading to a diagnosis of hypertrophic osteoarthropathy, a syndrome usually associated with pulmonary neoplasia. The thoracic CT-scan, followed by a biopsy, effectively diagnosed a right upper lobe adenocarcinoma. Surgical treatment of the neoplasia allowed the resolution of the clinical complaints and the pathological scintigraphic findings.
Nous rapportons le cas d'une patiente de 67 ans présentant des gonflements des mains et des pieds ainsi que des douleurs des deux jambes. L'examen clinique et la scintigraphie osseuse identifient la triade «hippocratisme digital - arthrites - périostite bilatérale des os longs¼, permettant de poser un diagnostic d'ostéoarthropathie hypertrophique, un syndrome habituellement associé à une néoplasie pulmonaire. Le scanner thoracique, suivi d'une biopsie, ont en effet diagnostiqué un adénocarcinome localisé au niveau du lobe supérieur droit. La prise en charge chirurgicale de la néoplasie a permis la résolution des plaintes cliniques et de l'aspect scintigraphique pathologique.
Assuntos
Adenocarcinoma , Artrite , Neoplasias Pulmonares , Osteoartropatia Hipertrófica Secundária , Periostite , Adenocarcinoma/complicações , Idoso , Artrite/complicações , Feminino , Humanos , Neoplasias Pulmonares/complicações , Osteoartropatia Hipertrófica Secundária/complicações , Osteoartropatia Hipertrófica Secundária/etiologia , Periostite/diagnóstico por imagem , Periostite/etiologiaAssuntos
Anticorpos Monoclonais Humanizados/uso terapêutico , Doenças da Unha/tratamento farmacológico , Osteoartropatia Hipertrófica Primária/tratamento farmacológico , Periostite/tratamento farmacológico , Idoso de 80 Anos ou mais , Feminino , Humanos , Doenças da Unha/etiologia , Osteoartropatia Hipertrófica Primária/etiologia , Periostite/etiologia , Psoríase/complicações , Indução de RemissãoAssuntos
Artrite Psoriásica/complicações , Artrite Psoriásica/psicologia , Doenças da Unha/patologia , Periostite/etiologia , Antimetabólitos Antineoplásicos/administração & dosagem , Antimetabólitos Antineoplásicos/uso terapêutico , Artrite Psoriásica/tratamento farmacológico , Artrite Psoriásica/patologia , Fatores Biológicos/uso terapêutico , Biópsia , Diagnóstico Diferencial , Feminino , Humanos , Metotrexato/administração & dosagem , Metotrexato/uso terapêutico , Doenças da Unha/etiologia , Periostite/diagnóstico , Qualidade de VidaRESUMO
Periostitis ossificans, also known as Garré osteomyelitis, is a specific type of chronic osteomyelitis that forms new bone under the periosteum resulting from a periosteal reaction to chronic inflammation or infections. It commonly affects the mandible secondary to odontogenic infection. The therapeutic approach involves eliminating the infectious cause and antibiotic administration. This report describes an unusual case of periostitis ossificans arising from the mandible of an 11-year-old boy. The cause of infection was correlated with a lower right unerupted third molar, which had no obvious connection with the oral cavity. The histologic diagnosis was chronic osteomyelitis with proliferative periostitis. The patient has been followed for 1 year, without any evidence of recurrence. Periostitis ossificans can be diagnostically problematic, and various conditions must be considered in the differential diagnosis.
Assuntos
Doenças Mandibulares/diagnóstico , Periostite/diagnóstico , Biópsia , Criança , Diagnóstico Diferencial , Diagnóstico por Imagem , Humanos , Masculino , Doenças Mandibulares/etiologia , Doenças Mandibulares/cirurgia , Dente Serotino , Periostite/etiologia , Periostite/cirurgia , Extração Dentária , Dente Impactado/complicações , Dente Impactado/cirurgiaRESUMO
BACKGROUND: Florid reactive periostitis (FRP) is a rare benign periosteal lesion, which mostly involves the tubular bones of the extremities. FRP of the long bone is especially rare. We here report a case series of long bone FRP and also discuss the differential diagnosis and clinical outcome of our series. PATIENTS AND METHODS: In total, four female and three male patients with long bone FRP and a mean age of 25.1 years were evaluated for this study, from which four upper extremity and three lower extremity FRP lesions were identified. Patients were classified according to the clinical, radiological and pathological manifestations of the lesion. RESULTS: Periosteal reaction and edema around the lesions were observed in all cases. Calcified mass, bone marrow edema and cortical erosion were observed in six out of seven patients. Moreover, two lesions with peripheral mineralization and zoning appearances were observed. Limb rest and anti-inflammatory therapy proved to be sufficient treatment in all cases. The lesions were spontaneously resolved in all cases, leaving a residual exostosis. CONCLUSION: Our report indicates that short bone and long bone FRP could reveal different characteristics in some aspects, including the choice of the therapeutic approach. In spite of the favorable clinical outcome of long bone FRP, its differentiation from more aggressive lesions, especially osteosarcoma and osteomyelitis, should still be taken into consideration. In addition, according to our evidence, the implication of the zonal pattern in differential diagnosis of FRP and myositis ossificans (MO) could be re-evaluated.
Assuntos
Neoplasias Ósseas/complicações , Previsões , Osteocondroma/complicações , Periostite/diagnóstico , Adolescente , Adulto , Biópsia com Agulha de Grande Calibre , Neoplasias Ósseas/diagnóstico , Criança , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Imageamento por Ressonância Magnética , Masculino , Osteocondroma/diagnóstico , Periostite/etiologia , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Adulto JovemRESUMO
OBJECTIVES: This study examines human adaptation to the 4000 BP climate change event, which is said to have increased the marginality of Inner Asian environments. We propose to define "marginal" environments not in relation to a specific economic activity (e.g., agriculture), but in relation to whether humans living there are physiologically stressed. METHODS: Three sites in the Hexi Corridor of Gansu were studied, one from the early and two from the late Bronze Age (N = 125). The study includes three indicators of physiological stress: linear enamel hypoplasias (LEH); tibial periosteal lesions; and fertility. The early and late Bronze Age groups were compared to examine whether human physiological stress increased. RESULTS: The percent of individuals with LEH declined dramatically, indicating fewer growth disruptions. Tibial periosteal reactions also changed, from mostly active to mostly healing at the time of death, indicating that frailty declined. Fertility, which is sensitive to changes in population health and resource availability, did not change significantly. CONCLUSIONS: Counter to the dominant narrative of environmental deterioration and subsistence system collapse, the Bronze Age residents of the Hexi Corridor show no skeletal evidence that they suffered from resource shortages or struggled to adapt in the fluctuating climate that pertained after the 4000 BP climate event. In fact, this study found that people suffered from less frailty and fewer growth disruptions after the unstable climate had persisted for some time. Therefore, in human biological terms, the Hexi Corridor did not become more marginal for human habitation during the Bronze Age.
Assuntos
Aclimatação , Arqueologia , Mudança Climática , Meio Ambiente , Estresse Fisiológico , China/epidemiologia , Hipoplasia do Esmalte Dentário/epidemiologia , Hipoplasia do Esmalte Dentário/etiologia , Fertilidade , Humanos , Periostite/epidemiologia , Periostite/etiologiaRESUMO
A case of Pachydermoperiostosis (PDP) presented to us in rheumatology clinic with complaints of enlargement and broadening of bilateral hands and feet, grade IV digital clubbing, coarsening of facial features, excessive sweating of the palms, soles during summers.
Assuntos
Osteoartropatia Hipertrófica Primária/diagnóstico , Periostite/etiologia , Adulto , Dermatoses Faciais/patologia , Dedos/patologia , Humanos , Masculino , Osteoartropatia Hipertrófica Primária/genética , Osteoartropatia Hipertrófica Primária/patologia , Periostite/patologia , Dedos do Pé/patologia , Articulação do Punho/patologiaAssuntos
Periostite/etiologia , Sarcoidose/complicações , Doenças da Traqueia/etiologia , Idoso , Diagnóstico Diferencial , Feminino , Fêmur/diagnóstico por imagem , Humanos , Periostite/diagnóstico , Tomografia por Emissão de Pósitrons , Sarcoidose/diagnóstico , Tomografia Computadorizada por Raios X , Doenças da Traqueia/diagnósticoRESUMO
Multiple myeloma is a disseminated neoplastic monoclonal gammopathy that usually affects the skull, clavicle, rib, pelvis, spinal column, and proximal portions of the humerus and femur. The initial manifestation of multiple myeloma in the sternum is rare. The classic radiological presentations of multiple myeloma are multiple "punched-out" areas of bone destruction, expansile lytic lesions, and generalized osteoporosis. Primary sclerotic presentation is rare and occurs in only 3 % of cases. A sclerotic multiple myeloma with a sunburst periosteal reaction occurring in the sternum has not been reported in the English literature. We report a case of sclerotic multiple myeloma of a 49-year-old woman. In the sternum, the lesion displayed extensive sclerosis mixed with mottled lytic areas with a sunburst periosteal reaction occurring in the periphery, which radiologically mimicked an osteosarcoma. Multiple focal areas of sclerosis were also found in the right clavicle, pelvis, multiple ribs, and vertebrae.
Assuntos
Neoplasias Ósseas/diagnóstico , Mieloma Múltiplo/diagnóstico , Periostite/diagnóstico , Esterno/diagnóstico por imagem , Esterno/patologia , Neoplasias Ósseas/complicações , Diagnóstico Diferencial , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Pessoa de Meia-Idade , Mieloma Múltiplo/complicações , Osteossarcoma/diagnóstico , Periostite/etiologia , Esclerose/diagnóstico , Esclerose/etiologia , Tomografia Computadorizada por Raios X/métodosAssuntos
Contratura/diagnóstico , Ossificação Heterotópica/diagnóstico , Periostite/diagnóstico , Periostite/cirurgia , Retalhos Cirúrgicos/irrigação sanguínea , Biópsia por Agulha , Terapia Combinada , Contratura/cirurgia , Feminino , Seguimentos , Antebraço/diagnóstico por imagem , Antebraço/patologia , Humanos , Imuno-Histoquímica , Imageamento por Ressonância Magnética/métodos , Pessoa de Meia-Idade , Ossificação Heterotópica/complicações , Ossificação Heterotópica/cirurgia , Osteotomia/métodos , Periostite/etiologia , Rádio (Anatomia)/diagnóstico por imagem , Rádio (Anatomia)/patologia , Índice de Gravidade de Doença , Retalhos Cirúrgicos/transplante , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento , Ulna/diagnóstico por imagem , Ulna/patologiaRESUMO
Na Ortopedia, o periósteo adquire relevância por estar associado à morfologia óssea, que pode ser modificada pelas demandas funcionais, contribuindo enormemente com o dinamismo oferecido pela remodelação, ou turnover, óssea. Estudar mais profundamente a capacidade adaptativa, reacional e reparatória do periósteo nos permite entender: 1) o comando dos osteócitos na determinação da morfologia óssea, inclusive durante o movimento dentário induzido; 2) a expansão rápida do palato e as mudanças ocorridas na forma da maxila; 3) o deslocamento mandibular por aparelhos ortopédicos funcionais; 4) a etiopatogenia da periostite ossificante, antigamente denominada de osteomielite de Garrè; 5) a expansão das corticais durante os crescimentos císticos e tumorais. Nesse trabalho, discorre-se sobre os eventos celulares e teciduais das reações periosteais e suas extrapolações clínicas.
Assuntos
Palato/fisiopatologia , Periósteo/fisiologia , Técnica de Expansão Palatina , Periostite/classificação , Periostite/etiologiaRESUMO
Pachydermoperiostosis is a primary form of hypertrophic osteoarthropathy, which presents with pachydermia, digital clubbing, and radiologic periostosis. Pachydermoperiostosis occurs owing to mutations of the gene encoding for 15-hydroxyprostaglandin dehydrogenase (15HPGD). Clinical manifestations of PDP are thought to relate to excessive collagen formation and dysregulation of matrix proteins because of fibroblastic hyperactivation. We present a very rare case of the complete form of pachydermoperiostosis in a young Indian male.
Assuntos
Osteoartropatia Hipertrófica Primária/complicações , Periostite/etiologia , Povo Asiático/genética , Humanos , Masculino , Mutação , Osteoartropatia Hipertrófica Primária/diagnóstico , Osteoartropatia Hipertrófica Primária/genética , Periostite/patologia , Adulto JovemRESUMO
We describe a 3-month-old infant who presented to our institution with interleukin (IL)-1 receptor antagonist deficiency (DIRA), which consists of neutrophilic pustular dermatosis, periostitis, aseptic multifocal osteomyelitis, and persistently high acute-phase reactants. Skin findings promptly improved upon initiation of treatment with anakinra (recombinant human IL-1 receptor antagonist), and the bony lesions and systemic inflammation resolved with continued therapy.
Assuntos
Doenças Hereditárias Autoinflamatórias/tratamento farmacológico , Proteína Antagonista do Receptor de Interleucina 1/uso terapêutico , Osteomielite/tratamento farmacológico , Periostite/tratamento farmacológico , Dermatopatias Vesiculobolhosas/tratamento farmacológico , Antirreumáticos/uso terapêutico , Feminino , Doenças Hereditárias Autoinflamatórias/complicações , Humanos , Lactente , Osteomielite/etiologia , Periostite/etiologia , Dermatopatias Vesiculobolhosas/etiologiaRESUMO
BACKGROUND: Orbital infection is an uncommon devastating infection and is usually a complication of paranasal sinus infection. Without appropriate treatment, orbital infection may lead to serious complications, even death. Prompt treatment is mandatory to avoid visual loss or intracranial complications. The literature shows that initially, intravenous antibiotics should be administered, and after 48 h, if no improvement appears, the affected orbit and the sinuses must be surgically drained. The authors describe two cases of orbital cellulitis with a brief literature review. CASE REPORT: The authors describe two cases of orbital abscess caused by paranasal sinus infection. In case 1, the patient presented a decreased visual acuity associated with ophthalmoplegia of the right eye. In case 2, the patient presented a decreased visual acuity. Thus, administration of intravenous antibiotic combined with surgical drainage was performed. After surgical procedure, eye movements were normalized in case 1, and in both patients, the visual acuity returned to normal parameters. DISCUSSION: The authors recommend early surgical drainage with parenteral antibiotic administration and careful postoperative observations by monitoring the signs and symptoms of the orbital complaint.