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1.
World J Urol ; 42(1): 272, 2024 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-38683217

RESUMO

PURPOSE: To investigate the safety of transurethral ureteroscopy (URS) for urolithiasis in bedridden patients and to identify bedridden patient-specific risk factors for postoperative complications. METHODS: The patients who underwent URS for urolithiasis were divided into bedridden patients and good performance status (PS) patients, and the groups were compared regarding their clinical characteristics and postoperative complications. A multivariable logistic regression analysis was performed to evaluate independent predictors of postoperative febrile urinary tract infection (fUTI). RESULTS: A total of 1626 patients were included, 276 in the bedridden patient group, and 1350 in the good PS patient group. The bedridden patient group had a significantly higher age and higher proportion of females and had multiple comorbidities. In 77 patients (27.9%), 88 postoperative complications developed for the bedridden patient group. Clavien-Dindo grade III or IV complications were observed in only 8 patients. No grade V complications were observed. The most common complication was fUTI. The frequency of fUTI with grade III or IV for the bedridden patient group (2.2%) was higher compared with the good PS patient group (0.5%), but the difference was not statistically significant (p = 0.13). Bedridden patient-specific risk factors for fUTI included female sex, diabetes mellitus, cerebrovascular comorbidities, lower extremity contracture, and prolonged operative time. CONCLUSION: URS for urolithiasis is a feasible and acceptable procedure in bedridden patients, despite the moderate rate of postoperative complications. The identified risk factors provide a framework for risk stratification and individualized care in this unique patient population.


Assuntos
Pessoas Acamadas , Complicações Pós-Operatórias , Ureteroscopia , Urolitíase , Humanos , Feminino , Masculino , Ureteroscopia/efeitos adversos , Ureteroscopia/métodos , Idoso , Urolitíase/cirurgia , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos , Estudos de Viabilidade , Fatores de Risco , Idoso de 80 Anos ou mais , Infecções Urinárias/epidemiologia , Infecções Urinárias/etiologia , Adulto
2.
Int Wound J ; 21(3): e14676, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38439163

RESUMO

To evaluate the effect of predictive nursing interventions on pressure ulcers in elderly bedridden patients by meta-analysis. Applied computer searches of PubMed, Embase, Google Scholar, Cochrane Library, China National Knowledge Infrastructure and Wanfang databases for randomised controlled trials (RCTs) on the effect of predictive nursing in preventing pressure ulcers in elderly bedridden patients from the database inception to November 2023. Two researchers independently screened the literature, extracted data and performed quality assessment based on inclusion and exclusion criteria. Stata 17.0 software was utilised for data analysis. Eighteen RCTs involving 6504 patients were finally included. The analysis revealed the implementation of predictive nursing interventions had a significant advantage in reducing the incidence of pressure ulcers in elderly bedridden patients compared with conventional nursing (odds ratio [OR] = 0.20, 95% confidence interval [CI]: 0.15-0.28, p < 0.001), while the patients' satisfaction with nursing care was higher (OR = 3.70, 95% CI: 2.99-4.57, p < 0.001). This study shows that the implementation of a predictive nursing interventions for elderly bedridden patients can effectively reduce the occurrence of pressure ulcers and significantly improve patients' satisfaction with nursing care, which is worthy of clinical promotion and application.


Assuntos
Pessoas Acamadas , Úlcera por Pressão , Idoso , Humanos , China , Análise de Dados , Bases de Dados Factuais , Úlcera por Pressão/enfermagem , Úlcera por Pressão/terapia
3.
Int Wound J ; 21(3): e14690, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38453139

RESUMO

The study explores the impact of predictive nursing interventions on pressure ulcers (PUs) in elderly bedridden patients. A total of 120 elderly bedridden patients from the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture between August 2019 and August 2023 were selected as the subjects of the study and were randomly divided into an observation group and a control group using a random number table method. The control group received conventional nursing care, while the observation group received predictive nursing interventions. The study compared the incidence of PUs, Braden scale scores, the onset time of PUs, self-rating anxiety scale (SAS) scores, self-rating depression scale (SDS) scores, and nursing satisfaction between the two groups. In elderly bedridden patients, the application of predictive nursing interventions significantly reduced the incidence of PUs (p < 0.001), significantly lowered the SAS and SDS scores (p < 0.001), and also significantly increased Braden scale scores (p < 0.001) and delayed the onset time of PUs (p < 0.001). Additionally, it improved patients' nursing satisfaction (p = 0.008). Predictive nursing interventions in elderly bedridden patients have good application effects, reducing the occurrence of PUs, delaying the time of onset in patients, improving patients' negative emotions and enhancing nursing satisfaction rates. It is worthy of widespread use.


Assuntos
Úlcera por Pressão , Humanos , Idoso , Úlcera por Pressão/etiologia , Pessoas Acamadas , Pacientes , Incidência , Supuração/complicações
4.
Med Eng Phys ; 124: 104096, 2024 02.
Artigo em Inglês | MEDLINE | ID: mdl-38418025

RESUMO

INTRODUCTION: Pressure Ulcers (PUs) are a major healthcare issue leading to prolonged hospital stays and decreased quality of life. Monitoring body position changes using sensors could reduce workload, improve turn compliance and decrease PU incidence. METHOD: This systematic review assessed the clinical applicability of different sensor types capable of in-bed body position detection. RESULTS: We included 39 articles. Inertial sensors were most commonly used (n = 14). This sensor type has high accuracy and is equipped with a 2-4 hour turn-interval warning system increasing turn compliance. The second-largest group were piezoresistive (pressure) sensors (n = 12), followed by load sensors (n = 4), piezoelectric sensors (n = 3), radio wave-based sensors (n = 3) and capacitive sensors (n = 3). All sensor types except inertial sensors showed a large variety in the type and number of detected body positions. However, clinically relevant position changes such as trunk rotation and head of bed elevation were not detected or tested. CONCLUSION: Inertial sensors are the benchmark sensor type regarding accuracy and clinical applicability but these sensors have direct patient contact and (re)applying the sensors requires the effort of a nurse. Other sensor types without these disadvantages should be further investigated and developed. We propose the Pressure Ulcer Position System (PUPS) guideline to facilitate this.


Assuntos
Úlcera por Pressão , Humanos , Úlcera por Pressão/diagnóstico , Pessoas Acamadas , Qualidade de Vida , Postura
5.
BMJ Open ; 14(1): e077083, 2024 01 29.
Artigo em Inglês | MEDLINE | ID: mdl-38286702

RESUMO

OBJECTIVES: Patients with stroke often remain bedridden despite rehabilitation. Serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels increase after stroke. Our study aimed to investigate the difference in NT-pro-BNP levels between bedridden and non-bedridden patients with stroke and to explore the factors influencing NT-pro-BNP levels in bedridden patients. DESIGN: A single-centre, cross-sectional study. SETTING: This study was conducted in a hospital, Shenzhen, China. PARTICIPANTS: Between January 2019 and December 2022, 465 participants were included in this study. OUTCOME MEASURES: The collected data included basic information, laboratory data and echocardiographic parameters. Binary logistic regression analysis and receiver operating characteristic curves were used to identify factors associated with high NT-pro-BNP levels. RESULTS: Bedridden patients with stroke had higher levels of NT-pro-BNP, D-dimer, high-sensitivity C reactive protein (hs-CRP) and lower levels of creatinine, high-density lipoprotein cholesterol, albumin and haemoglobin, as well as lower left ventricular ejection fraction, fractional shortening and the ratio between the peak velocities of early and late diastolic filling than non-bedridden patients. In bedridden patients, age ≥75 years, high levels of hs-CRP and creatinine, and low levels of albumin were associated with high NT-pro-BNP levels. In non-bedridden patients, age ≥75 years and high creatinine levels were associated with high NT-pro-BNP levels. In bedridden patients with stroke, the area under the curve (AUC) of hs-CRP was 0.700 (p<0.001, 95% CI 0.638 to 0.762) with a cut-off value of 5.12 mg/L. The AUC of albumin was 0.671 (p<0.001, 95% CI 0.606 to 0.736) with a cut-off value of 37.15 g/L. CONCLUSIONS: NT-pro-BNP levels were higher in bedridden patients with stroke than in non-bedridden patients. Decreased albumin and elevated hs-CRP levels were associated with high levels of NT-pro-BNP in bedridden patients. Further studies are needed to explore the risk stratification and potential treatments for elevated NT-pro-BNP in bedridden patients with stroke.


Assuntos
Peptídeo Natriurético Encefálico , Acidente Vascular Cerebral , Humanos , Idoso , Proteína C-Reativa/metabolismo , Estudos Transversais , Volume Sistólico , Pessoas Acamadas , Creatinina , Função Ventricular Esquerda , Fragmentos de Peptídeos , Biomarcadores
7.
J Mater Chem B ; 11(35): 8541-8552, 2023 09 13.
Artigo em Inglês | MEDLINE | ID: mdl-37609719

RESUMO

For long-term bedridden patients who need to wear diapers, the timely replacement of diapers is very important to ensure their quality of life. Therefore, it is urgent to develop a pressure sensor that can monitor the physiological conditions of patients in real time. Inspired by the multi-scale network structure of the multi-fiber protein in the muscle, a multi-scale hydrogel as a pressure sensor was prepared by introducing micron-scale hydrogel microspheres as physical crosslinking agents. Compared with the traditional polyacrylamide hydrogel (0.17 MPa of compressive strength), the multi-scale hydrogel showed a higher compressive strength of up to 1.37 MPa. Meanwhile, the hydrogel exhibited better pressure sensitivity (0.59 kPa-1) than the existing hydrogels (0.27-0.40 kPa-1). The sensor prepared by this hydrogel could monitor the patient's physiological condition (urine outflow and urinary filling) in real time through the conductivity response to ion concentration and pressure, and then transmit the signal to the caregivers in time to avoid skin damage. This multi-scale hydrogel provided a great convenience for the physiological monitoring of long-term bedridden patients by acting as a pressure sensor.


Assuntos
Líquidos Corporais , Hidrogéis , Humanos , Pessoas Acamadas , Qualidade de Vida , Força Compressiva
8.
J Stroke Cerebrovasc Dis ; 32(9): 107254, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37487318

RESUMO

OBJECTIVES: This study aimed to evaluate the life satisfaction of bedridden patients with stroke and explore its relationship with demographic, social, and medical factors. MATERIAL AND METHODS: This multicenter cross-sectional study was conducted in two steps. The Longshi scale was used to select the study population and assess patients' ability to perform activities of daily living. Subsequently, a multidimensional questionnaire was used to obtain the participants' information and evaluate their level of life satisfaction. The chi-squared test and binary logistic regression methods were employed to analyze the factors influencing the life satisfaction of bedridden patients with stroke. RESULTS: A total of 3,639 bedridden patients with stroke were included in this study, of them, only 27.2% reported satisfaction with their current lives. Factors associated with higher life satisfaction include female sex, older age, and primary school education or lower (P<0.05). Patients who had experienced a single stroke episode had chronic diseases, and rated their health as good were more satisfied with their lives than those who did not. The results of the binary logistic regression confirmed that age, education, religion, household income, cohabitation, social participation, number of chronic diseases, self-rated health status, and disability level significantly influenced the life satisfaction of bedridden patients with stroke (P<0.05). CONCLUSION: Our study showed that the overall life satisfaction of bedridden patients with stroke was low, with several factors influencing their life satisfaction. Therefore, effective measures should be implemented to improve life satisfaction and quality of life.


Assuntos
Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral , Humanos , Feminino , Qualidade de Vida , Atividades Cotidianas , Estudos Transversais , Pessoas Acamadas , Satisfação do Paciente , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/terapia , Satisfação Pessoal
9.
Ann Surg Oncol ; 30(8): 4604-4612, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37149549

RESUMO

BACKGROUND: Although functional outcomes are important in surgery for elderly patients, the long-term functional prognosis following oncologic surgery is unclear. We retrospectively investigated the long-term, functional and survival prognosis following major oncologic surgery according to age among elderly patients. METHODS: We used a Japanese administrative database to identify 11,896 patients aged ≥ 65 years who underwent major oncological surgery between June 2014 and February 2019. We investigated the association between age at surgery and the postoperative incidence of bedridden status and mortality. Using the Fine-Gray model and restricted cubic spline functions, we conducted a multivariable, survival analysis with adjustments for patient background characteristics and treatment courses to estimate hazard ratios for the outcomes. RESULTS: During a median follow-up of 588 (interquartile range, 267-997) days, 657 patients (5.5%) became bedridden and 1540 (13%) died. Patients aged ≥ 70 years had a significantly higher incidence of being bedridden than those aged 65-69 years; the subdistribution hazard ratios of the age groups of 70-74, 75-79, 80-84, and ≥ 85 years were 3.20 (95% confidence interval [CI], 1.53-6.71), 3.86 (95% CI 1.89-7.89), 6.26 (95% CI 3.06-12.8), and 8.60 (95% CI 4.19-17.7), respectively. Restricted cubic spline analysis demonstrated an increase in the incidence of bedridden status in patients aged ≥ 65 years, whereas mortality increased in patients aged ≥ 75 years. CONCLUSIONS: This large-scale, observational study revealed that older age at oncological surgery was associated with poorer functional outcomes and higher mortality among patients aged ≥ 65 years.


Assuntos
Pessoas Acamadas , População do Leste Asiático , Neoplasias , Idoso , Humanos , Prognóstico , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Análise de Sobrevida , Estado Funcional , Neoplasias/mortalidade , Neoplasias/cirurgia , Risco , Idoso de 80 Anos ou mais
11.
Niger J Clin Pract ; 26(3): 253-259, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37056096

RESUMO

Background: Taking care of bedridden patients at home is a very difficult task for caregivers. In this care process, caregivers can be supported with the interventions given by the nurses at home. Aim: This study mainly aimed to compare the anxiety and care burden levels of caregivers of bedridden patients at home after nursing interventions which a personal care handbook, regular home visits, and telephone counseling. Subject and Methods: To proceed with this study, 51 caregivers have included in this study between January 1 and July 21, 2018. The Barthel Index for Activities of Daily Living (BIADL) was used to measure levels of independence in patient's activities, State and Trait Anxiety Scale (SAI and TAI) was used to measure the anxiety levels, and Burden Interview (BI) care burden problems of caregivers who participated in the study. Also, Sociodemographic Characteristics Form was used for demographic data of patients and caregivers. Results: The analysis of the responses showed the proportions of the caregivers who had lower SAI- TAI and BI scores after taking nursing intervention at home. The state anxiety level of caregivers (pre-test: Mean; 54.06+-7.97; post-test: Mean; 38.43+-6.41) and the trait anxiety level of the caregivers (pre-test: Mean; 51.45+-5.94; post-test: Mean; 41.59+-7.05) and the burden level of caregivers (pre-test: Mean; 75.75+-11.41; post-test: Mean; 57.69+-13.39) was determined. The differences between the pre and post-test mean scores of SAI, TAI, and BI were statistically significant (P < 0.05). Conclusions: Our study highlights that the burden and anxiety levels of the caregivers had lower post-test levels than the pre-test levels.


Assuntos
Sobrecarga do Cuidador , Cuidadores , Humanos , Cuidadores/psicologia , Atividades Cotidianas , Pessoas Acamadas , Ansiedade
13.
Rev Assoc Med Bras (1992) ; 69(1): 61-65, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36820714

RESUMO

OBJECTIVE: The aim of this study was to evaluate serum 25(OH)D concentrations in the homebound elderly people and relate them to level of dementia, nutritional risk, and route of dietary administration. METHODS: This is a cross-sectional study involving 207 bedridden elderly people assisted by the Home Care Service in the city of Santo André - SP, from June to December 2016. The following factors were evaluated: dietary intake of vitamin D, arm circumference, triceps skin fold thickness, calf circumference, nutritional risk by Mini-Nutritional Assessment, level of dementia by the adapted Clinical Dementia Rating questionnaire, and laboratory tests such as serum concentrations of 25(OH)D, ultrasensitive C-reactive protein, alkaline phosphatase, serum calcium, and parathormone. RESULTS: The mean age of the elderly people was 81.6 (9.2) years. Deficiency of 25(OH)D was observed in 76.3% of the elderly people. There was an inverse correlation between serum concentrations of 25(OH)D: parathormone (r=-0.418, p<0.001) and alkaline phosphatase (r=-0.188, p=0.006) and a direct correlation with serum calcium (r=-0.158, p=0.022). Logistic regression showed that vitamin D deficiency was directly and independently associated with oral feeding (odds ratio 7.71; 95%CI 2.91-20.40). CONCLUSION: Bedridden households showed high prevalence of vitamin D deficiency without association with nutritional risk and level of dementia. Oral diet was associated with vitamin D deficiency, possibly due to low consumption of source foods.


Assuntos
Demência , Deficiência de Vitamina D , Idoso , Idoso de 80 Anos ou mais , Humanos , Fosfatase Alcalina , Cálcio , Estudos Transversais , Demência/complicações , Hormônio Paratireóideo , Vitamina D/sangue , Deficiência de Vitamina D/complicações , Pessoas Acamadas
14.
Clin. biomed. res ; 43(2): 109-115, 2023. tab
Artigo em Português | LILACS | ID: biblio-1517468

RESUMO

Introdução: A fisioterapia na unidade de terapia intensiva (UTI) apresenta como objetivo utilizar estratégias de mobilização precoce a fim de reduzir o impacto da fraqueza muscular adquirida na UTI. Logo, este estudo apresenta como objetivo avaliar a efetividade de um plano de metas fisioterapêuticas para pacientes internados em uma Unidade de Terapia Intensiva.Métodos: Estudo de coorte retrospectivo e prospectivo comparativo realizado em uma UTI de um hospital público de Porto Alegre. Foram incluídos pacientes internados entre os meses de janeiro e junho de 2019, maiores de 18 anos e que tiveram alta da UTI. A coleta de dados foi realizada através de informações e relatório que constam no prontuário eletrônico utilizado na Instituição. Foi analisado o desfecho das metas estabelecidas na admissão para sentar fora do leito e deambular.Resultados: A maioria dos pacientes foi do sexo masculino (57,5%). A média de idade foi de 60,52 ± 17,64 anos. A maioria das metas estabelecidas, tanto para sentar fora do leito como para deambular, foram atingidas (89% e 86,9%, respectivamente). Houve correlação significativa entre o alcance de meta para deambulação e ganho de força muscular pelo escore MRC (p = 0,041) e ganho de força muscular quando comparada admissão e alta da UTI (p = 0,004).Conclusão: Este estudo observou que estabelecer metas para sentar fora do leito e deambular para pacientes internados em UTI é efetivo.


Introduction: Physiotherapy in the intensive care unit (ICU) aims to use early mobilization strategies in order to reduce the impact of muscle acquired weakness in the ICU. Therefore, this study aims to evaluate the effectiveness of a physiotherapeutic goal plan for patients admitted to an Intensive Care Unit. Methods: Retrospective and comparative prospective cohort study carried out in an ICU of a public hospital in Porto Alegre. Patients hospitalized between January and June 2019, over 18 years old and discharged from the ICU were included. Data collection was carried out through information and report contained in the electronic medical record used in the Institution. The outcome of goals established at admission for sitting out of bed and walking was analyzed. Results: Most patients were male (57.5%). The mean age was 63.2 ± 16.2 years. Most established goals, both for sitting out of bed and walking, were achieved (89% and 86.9%, respectively). There was a significant correlation between reaching the ambulation goal and muscle strength gain by the MRC score (p= 0.041) and muscle strength gain when comparing admission and discharge from the ICU (p = 0.004). Conclusion: This study observed that establishing goals for sitting out of bed and walking for ICU patients is effective.


Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Deambulação Precoce/estatística & dados numéricos , Força Muscular , Terapia Precoce Guiada por Metas/organização & administração , Pessoas Acamadas , Serviço Hospitalar de Fisioterapia/organização & administração , Unidades de Terapia Intensiva/organização & administração
15.
São Paulo; s.n; 2023. 60 p.
Tese em Português | CONASS, Sec. Est. Saúde SP, SESSP-ISPROD, Sec. Est. Saúde SP, SESSP-ISACERVO | ID: biblio-1537949

RESUMO

O crescente aumento da população idosa no Brasil e em todo o mundo, juntamente com o aumento das doenças crônicas não transmissíveis e dos acidentes de trânsito, que resultam em incapacidade motora temporária ou permanente, torna evidente a necessidade de reexaminar a metodologia de trabalho e desenvolver novos conhecimentos no modelo de atenção à saúde Com este olhar dentro da Atenção Primária, temos a Atenção Domiciliar como um instrumento de cuidado motivado por vários olhares no bem-estar, como: desospitalização, organização do cuidado domiciliar, planejamento para a assistência principalmente para pacientes acamados e restritos, utilizando a organização e os princípios do SUS ­ universalidade, equidade, integralidade, descentralização, planejamento e sistematização para esta população. Objetivo: Descrever como os Enfermeiros da cidade de Itatiba, um município de médio porte, que trabalham na Unidade de Saúde da Família realizam a sistematização para a elegibilidade e frequência na Atenção Domiciliar para acamados e restritos. Metodologia: Foram aplicados questionários para conhecer como as unidades selecionam e definem a atenção domiciliar, as práticas realizadas pelas unidades de saúde, o conhecimento dos Enfermeiros em escalas e protocolos, se já aplicados ou não para este fim. Resultados: A Atenção Domiciliar é realizada em todas as Unidades de Saúde da Família de Itatiba. No município, há o total de 19 equipes, mas apenas 16 enfermeiros participaram do estudo. Observou-se que a Atenção Domiciliar é realizada em 100% das unidades, mas a maneira com que cada uma define seus critérios é divergente e, apesar de muitas conhecerem os protocolos já existentes para este fim, não os utilizam na sua prática diária alegando falta de orientação ou educação permanente para assegurar a utilização dos protocolos. O uso de recursos como o matriciamento, o acesso ao SISAB e os dados coletados pelos Agentes Comunitários de Saúde, também costuma ser ignorado para definir quando ou quem irá realizar esta assistência. Conclusão: Por fim, observa-se que mesmo não existindo um protocolo linear as enfermeiras se esforçam com as ferramentas que possuem para a atenção domiciliar, porém tendo dificuldades em garantir a equidade desta assistência. Ao final do estudo, apresentamos duas escalas, como sugestão, na elaboração dos protocolos sugeridos para classificação deste público específico tratado na investigação e a reflexão de utilizar a ciência da implementação para reorganizar o trabalho.


Assuntos
Serviço Hospitalar de Assistência Social , Pessoas Acamadas , Planejamento em Saúde
16.
São Paulo; Instituto de Saúde; 2023. 1 p. ilus.
Não convencional em Português | CONASS, Sec. Est. Saúde SP, SESSP-ISPROD, Sec. Est. Saúde SP, SESSP-ISACERVO | ID: biblio-1552289

RESUMO

A Atenção Domiciliar é uma das práticas assistenciais feita na atenção básica e por profissionais de nível superior, que também oferece cuidados de saúde e uma série de benefícios tanto para o paciente quanto para os sistemas de saúde. Esta prática visa proporcionar cuidados humanizados e personalizados no conforto do lar dos familiares e cuidadores, promovendo a continuidade do tratamento e a melhoria da qualidade de vida.


Assuntos
Serviço Hospitalar de Assistência Social , Pessoas Acamadas , Planejamento em Saúde
17.
Biomolecules ; 12(12)2022 12 13.
Artigo em Inglês | MEDLINE | ID: mdl-36551295

RESUMO

Absent or reduced physical activity and spontaneous movement over days, weeks, or even years may lead to problems in almost every major organ/system in the human body. In this study, we investigated whether the dysregulation and alteration of plasma protein inflammatory profiling can stratify chronic bedridden conditions observed in 22 elderly chronic bedridden (CBR) individuals with respect to 11 age-matched active (OLD) controls. By using a combination of immune-assay multiplex techniques, a complex of 27 inflammatory mediators was assessed in the plasma collected from the two groups. A specific plasma protein signature is indeed able to distinguish IPO individuals from age-matched OLD controls; while significantly (p < 0.001) higher protein levels of IL-2, IL-7, and IL-12p70 were measured in the plasma of CBR with respect to OLD individuals, significantly (p < 0.01) higher levels of seven inflammatory mediators, including IL-9, PDGF-b, CCL4 (MIP-1b), CCL5 (RANTES), IL-1Ra, CXCL10 (IP10), and CCL2 (MCP-1), were identified in OLD individuals with respect to CBR individuals. These data suggest that the chronic absence of physical activity may contribute to the dysregulation of a complex molecular pattern occurring with ageing and that specific plasma protein signatures may represent potential biomarkers as well as new potential therapeutic targets for new treatments aimed at improving health expectancy.


Assuntos
Pessoas Acamadas , Mediadores da Inflamação , Interleucina-12 , Idoso , Humanos , Biomarcadores/sangue , Doença Crônica , Citocinas/metabolismo , Mediadores da Inflamação/metabolismo , Plasma/metabolismo
18.
Comput Math Methods Med ; 2022: 9557330, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36267309

RESUMO

Objective: This study intended to explore the nursing outcome-oriented intervention's effect on airway management in elderly long-term bedridden patients. Methods: A total of 120 cases of elderly long-term bedridden patients admitted to our hospital from May 2018 to June 2020 were enrolled and randomly divided into the observation group (n = 60) and control group (n = 60). The control group received the routine nursing intervention, while the observation group received the nursing outcome-oriented intervention. Forced expiratory volume (FEV1), forced vital capacity (FVC), and maximal voluntary ventilation (MVV) in the first second were compared between the two groups before and after the intervention. The pulmonary infection of the two groups was observed. Total protein, hemoglobin, albumin, and cholesterol levels were compared between the two groups. Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were used to evaluate the two groups' psychological status before and after the intervention. The Generic Quality of Life Inventory-74 (GQOLI-74) assessed the two groups' quality of life. Results: After the intervention, the levels of FEV1, FVC, and MVV; total protein, hemoglobin, albumin, and cholesterol; and scores of physical function, psychological function, social function, and material life function in the observation group were higher than those in the control group. Pulmonary infection, secondary infection, the infection rate is more than 3%, HAMA, and HAMD scores, and the incidence of pressure ulcers, aspiration, constipation, and the falling bed was lower than those in the control group, with statistical significance (all P < 0.05). Conclusion: Nursing outcome-oriented intervention can effectively improve lung function, pulmonary infection, nutritional status, negative mood, and quality of life of long-term bedridden elderly patients.


Assuntos
Pessoas Acamadas , Qualidade de Vida , Humanos , Idoso , Testes de Função Respiratória , Manuseio das Vias Aéreas , Albuminas
19.
Int. j. med. surg. sci. (Print) ; 9(3): 1-14, sept. 2022. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1518667

RESUMO

La neumonía adquirida en la comunidad constituye una de las afecciones respiratorias que provoca más demanda de asistencia médica, y es responsable del mayor número de fallecidos por enfermedades infecciosas en Cuba. El objetivo del estudio ha sido determinar el comportamiento de características seleccionadas en pacientes hospitalizados por neumonía y precisar la existencia de asociaciones entre algunas de estas características.Se realizó un estudio observacional, con diseño descriptivo, que incluyó 1,809 pacientes hospitalizados por neumonía entre enero de 2012 y febrero de 2020. Fueron analizadas características relacionadas con las condiciones de base, clínico-radiológicas, y relativas al manejo y la evolución, mediante análisis bivariante y multivariante (regresión logística). La serie estuvo constituida fundamentalmente por pacientes ancianos (79%), mientras que el 20% presentaba la condición de encamamiento. Esta condición se asoció significativamente con el estado de demencia avanzada (OR 7,6[5,5;10,4]), y fue determinante en la presentación "solapada" del proceso (OR 1,5[1,09;2]). La presentación "solapada" de la neumonía estuvo significativamente asociada al ingreso tardío (OR 1,6[1,2;2,2]). Como conclusiones se ratifica el lugar que ocupan varios elementos en las características de la morbilidad por neumonía: edad avanzada, presencia de comorbilidades, y presentación no clásica del proceso. Fueron constatadas interrelaciones de importancia práctica entre la presencia de comorbilidades particulares, las formas clínicas de presentación, el momento del ingreso, y la utilización de antimicrobianos durante la atención prehospitalaria del paciente. Se destaca el papel del encamamiento en la extensión radiológica del proceso neumónico y en la presencia de derrame pleural de mediana o gran cuantía al momento del ingreso.


Community-acquired pneumonia is one of the respiratory conditions that causes the greatest demand for medical care, and is responsible for the largest number of deaths from infectious diseases in Cuba. The objective of the study was to determine the behavior of selected characteristics in patients hospitalized for pneumonia and to specify the existence of associations between some of these characteristics. An observational study, with a descriptive design, was carried out, which included 1,809 patients hospitalized for pneumonia between January 2012 and February 2020. Characteristics related to the basic, clinical-radiological conditions, and relative to management and evolution were analyzed, through analysis bivariate and multivariate (logistic regression). The series consisted mainly of elderly patients (79%), while 20% were bedridden. This condition was significantly associated with the state of advanced dementia (OR 7.6[5.5;10.4]) and was decisive in the "overlapping" presentation of the process (OR 1.5[1.09;2]). The "overlapping" presentation of pneumonia was significantly associated with late admission (OR 1.6[1.2;2.2]). As conclusions, the place occupied by several elements in the characteristics of pneumonia morbidity is ratified: advanced age, presence of comorbidities, and non-classical presentation of the process. Interrelationships of practical importance were found between the presence of comorbidities, the clinical forms of presentation, the time of admission, and the use of antimicrobials during the patient's prehospital care. The role of bed rest in the radiological extension of the pneumonic process and in the presence of medium or large pleural effusion at the time of admission is highlighted.


Assuntos
Humanos , Pessoa de Meia-Idade , Idoso , Admissão do Paciente , Pneumonia/epidemiologia , Infecções Comunitárias Adquiridas/epidemiologia , Derrame Pleural/epidemiologia , Pneumonia/tratamento farmacológico , Fatores de Tempo , Consumo de Bebidas Alcoólicas/epidemiologia , Fumar/epidemiologia , Comorbidade , Modelos Logísticos , Análise de Variância , Infecções Comunitárias Adquiridas/tratamento farmacológico , Doença Pulmonar Obstrutiva Crônica/epidemiologia , Demência , Diabetes Mellitus/epidemiologia , Pessoas Acamadas , Insuficiência Cardíaca/epidemiologia , Hospitalização , Antibacterianos/uso terapêutico
20.
J Med Eng Technol ; 46(8): 658-669, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-35801990

RESUMO

Pressure ulcers have been part of tissue damage without effectiveness in medical, surgical, and intensive care units. This study aims to focus on developing lateral tilt positions for effective pressure ulcer relief for bedridden patients. A repositioning mattress was placed in the side-lying left lateral tilt position (15°, 30°, 45°), sheering (0.680, 1.323, 1.870), interface pressure (2.550, 2.290, 2.830), and placed at 1.5 m long piece of polyethylene rubber. The design strength was set at 6000 N and 2100 mm x 1105 mm (σt,0,d = 42, σc,0,d = 34). The design shows the greatest supine position at 30°, 1.323, 2.290, pressure load (Δp0 = 1.125 (1820) ≈ 2050 psi, Δp3000 = 1.125 (620) ≈ 700 psi), tensile stress (σt,0,d (MPa) = 42), compressive stress (σc,0,d (MPa) = 34), and FOS (σt,0,d = 42, σc,0,d = 34). The factor of safety illustrated that the 30° lateral tilt position is more consistent in repositioning for pressure ulcer prevention compared to the supine-to-tilt region. Further, an application of repositioning mattresses was developed to test in bedridden patients with tissue ulcers in nursing homes.


Assuntos
Úlcera por Pressão , Humanos , Úlcera por Pressão/prevenção & controle , Pessoas Acamadas , Leitos , Pressão , Triazóis
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