RESUMO
The presence of melanin pigment and/or melanocytes in pilomatricoma has been rarely documented. In this study, we analyzed the incidence and clinicopathological features of pigmented pilomatricoma. Fifty-seven consecutive pilomatricoma cases from 53 Japanese patients were examined in this study. In fourteen cases (24.6%), pigmentation was observed in pilomatricoma. This variant equally affected in males and females, and the common locations were the upper arm and face. Proliferation of dendritic melanocytes was observed within basaloid cell nests in all cases, and melanin pigment was also present within the cytoplasm of the basaloid cells in 11 cases. Melanin pigment was also present in the shadow cells in 7 cases. The incidence of pigmented pilomatricoma as documented in previous reports is approximately 10%. However, our analysis revealed that pigmented pilomatricoma was found in 24.6% of Japanese cases of pilomatricoma, thus, this variant is not uncommon and may be under-recognized.
Assuntos
Doenças do Cabelo/patologia , Melanócitos/patologia , Pilomatrixoma/patologia , Neoplasias Cutâneas/patologia , Adolescente , Adulto , Idoso , Povo Asiático , Biomarcadores Tumorais/análise , Proliferação de Células , Criança , Pré-Escolar , Feminino , Doenças do Cabelo/etnologia , Doenças do Cabelo/metabolismo , Humanos , Imuno-Histoquímica , Incidência , Japão/epidemiologia , Antígeno MART-1/análise , Masculino , Melaninas/análise , Melanócitos/química , Antígenos Específicos de Melanoma/análise , Pessoa de Meia-Idade , Pilomatrixoma/química , Pilomatrixoma/etnologia , Proteínas S100/análise , Neoplasias Cutâneas/química , Neoplasias Cutâneas/etnologia , Adulto Jovem , Antígeno gp100 de MelanomaRESUMO
Pilomatricomas are benign cutaneous neoplasms that occur frequently in children and usually present as slow-growing, firm, dermal nodules. They are the second most common skin lesion excised from children. A rare exophytic variety has been described, but to our knowledge this has not previously been reported in Asian children. We present this case to highlight the clinical features and to affirm that race may not play a role in the etiology of pilomatricomas. We also illustrate how these lesions can be effectively treated by shave excision.