1.
Curr Opin Struct Biol
; 57: 204-214, 2019 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31247512
RESUMO
The Hedgehog (HH) signalling pathway is a cell-cell communication system that controls the patterning of multiple tissues during embryogenesis in metazoans. In adults, HH signals regulate tissue stem cells and regenerative responses. Abnormal signalling can cause birth defects and cancer. The HH signal is received on target cells by Patched (PTCH1), the receptor for HH ligands, and then transmitted across the plasma membrane by Smoothened (SMO). Recent structural and biochemical studies have pointed to a sterol lipid, likely cholesterol itself, as the elusive second messenger that communicates the HH signal between PTCH1 and SMO, thus linking ligand reception to transmembrane signalling.
Assuntos
Colesterol/metabolismo , Proteínas Hedgehog/metabolismo , Receptores Patched/química , Receptores Patched/metabolismo , Transdução de Sinais , Receptor Smoothened/química , Receptor Smoothened/metabolismo , Animais , Humanos , Coluna Vertebral
2.
Am J Med Genet A
; 179(4): 518-519, 2019 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30864284