RESUMO
Pagetoid reticulosis (PR) is a rare lymphoproliferative disorder with indolent behavior considered a variant of mycosis fungoides. It is characterized by marked epidermotropism of the neoplastic lymphocytes. Since its original description, five cases have been reported in children. We report a new case of PR with an immunohistochemical profile not previously described in children.
Assuntos
Imuno-Histoquímica/métodos , Reticulose Pagetoide/metabolismo , Neoplasias Cutâneas/patologia , Administração Tópica , Adolescente , Biópsia , Criança , Pré-Escolar , Clobetasol/administração & dosagem , Clobetasol/uso terapêutico , Feminino , Glucocorticoides/administração & dosagem , Glucocorticoides/uso terapêutico , Humanos , Imunofenotipagem/métodos , Linfócitos/patologia , Linfócitos/ultraestrutura , Transtornos Linfoproliferativos/patologia , Masculino , Micose Fungoide/patologia , Pele/patologia , Resultado do TratamentoAssuntos
Queratina-7/metabolismo , Neoplasias Labiais/cirurgia , Cirurgia de Mohs , Reticulose Pagetoide/cirurgia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Idoso , Feminino , Humanos , Imuno-Histoquímica , Neoplasias Labiais/metabolismo , Neoplasias Labiais/patologia , Reticulose Pagetoide/metabolismo , Reticulose Pagetoide/patologia , Neoplasias Cutâneas/metabolismoRESUMO
We describe a 60-year-old man with a history of primary cutaneous anaplastic large cell lymphoma on the chest, who presented with a new scaly red plaque on the same site 11 years after radiation therapy. Histological examination revealed a dense epidermotropic infiltrate of atypical mononuclear cells consistent with pagetoid reticulosis. Immunohistochemistry revealed the infiltrate to be CD4, CD8, and CD30. Remarkably, all the atypical cells were strongly CD30, and furthermore, the CD30 cells were found exclusively in the epidermis. In the initial cutaneous anaplastic large cell lymphoma lesion, the CD4, CD8, and focally CD30 atypical cells were well confined within the dermis with no epidermal component. To our knowledge, the present case seems to be the first description of pagetoid reticulosis presenting at the site of a previously treated dermal anaplastic large cell lymphoma. This case also represents an extreme presentation of epidermotropism and CD30 expression in pagetoid reticulosis.