RESUMO
This study aimed to assess outcomes of microdissection testicular sperm extraction (MD-TESE) and identify predictors for sperm retrieval (SR) in patients with non-mosaic Klinefelter syndrome (NM-KFS). We retrospectively evaluated 37 patients with NM-KFS who underwent MD-TESE. Data of age at operation, body mass index (BMI), testicular volume, serum luteinizing hormone (LH), follicle stimulating hormone (FSH), preoperative and postoperative testosterone levels with reduction ratio between the two values, and FSH/preoperative testosterone ratio were analysed. These patients were divided into two groups according to success or failure of SR: the successful and failure groups. Factors related to SR were evaluated by statistical analyses using the Mann-Whitney U test and logistic regression modelling. Regarding these factors, the cut-off level was specified using the receiver operating characteristics (ROC) curve. Moreover, the percentage of SR at that level was assessed. A simple scoring model was developed based on the multivariate analysis. Fourteen patients underwent successful SR, whereas 23 experienced failure SR. Statistical analysis found preoperative testosterone and FSH levels to be significant factors associated with SR. On the ROC curve, the cut-off levels for preoperative testosterone and FSH were 2.34 ng/ml and 33.2 mIU/ml respectively. A new scoring model was developed, consisting of preoperative testosterone (≥2.34 ng/ml) and FSH (≤33.2 mIU/ml). The sperm retrieval rates (SRRs) were clearly discriminated by stratification according to the scoring model. The SRR of the cases of scores of 2, 1 and 0 were 87.5%, 31.6% and 10% respectively. At our hospital, the SRR of MD-TESE in patients with NM-KFS was 37.8%. The patients with high testosterone and low FSH levels tended to demonstrate successful SR.
Assuntos
Azoospermia , Síndrome de Klinefelter , Humanos , Masculino , Recuperação Espermática , Microdissecção , Síndrome de Klinefelter/cirurgia , Síndrome de Klinefelter/complicações , Testosterona , Estudos Retrospectivos , Sêmen , Testículo/cirurgia , Espermatozoides , Hormônio FoliculoestimulanteRESUMO
Klinefelter syndrome (KS), also known as 47, XXY, is characterized by a distinct set of physiological abnormalities, commonly including infertility. The molecular basis for Klinefelter-related infertility is still unclear, largely because of the cellular complexity of the testis and the intricate endocrine and paracrine signaling that regulates spermatogenesis. Here, we demonstrate an analysis framework for dissecting human testis pathology that uses comparative analysis of single-cell RNA-sequencing data from the biopsies of 12 human donors. By comparing donors from a range of ages and forms of infertility, we generate gene expression signatures that characterize normal testicular function and distinguish clinically distinct forms of male infertility. Unexpectedly, we identified a subpopulation of Sertoli cells within multiple individuals with KS that lack transcription from the XIST locus, and the consequence of this is increased X-linked gene expression compared to all other KS cell populations. By systematic assessment of known cell signaling pathways, we identify 72 pathways potentially active in testis, dozens of which appear upregulated in KS. Altogether our data support a model of pathogenic changes in interstitial cells cascading from loss of X inactivation in pubertal Sertoli cells and nominate dosage-sensitive factors secreted by Sertoli cells that may contribute to the process. Our findings demonstrate the value of comparative patient analysis in mapping genetic mechanisms of disease and identify an epigenetic phenomenon in KS Sertoli cells that may prove important for understanding causes of infertility and sex chromosome evolution.
Assuntos
Infertilidade Masculina/patologia , Síndrome de Klinefelter/complicações , Células Intersticiais do Testículo/patologia , Células de Sertoli/patologia , Análise de Célula Única/métodos , Testículo/patologia , Transcriptoma , Humanos , Infertilidade Masculina/etiologia , Infertilidade Masculina/metabolismo , Síndrome de Klinefelter/cirurgia , Células Intersticiais do Testículo/metabolismo , Masculino , RNA Longo não Codificante/genética , RNA Longo não Codificante/metabolismo , Células de Sertoli/metabolismo , Espermatogênese , Testículo/metabolismo , Inativação do Cromossomo XRESUMO
AIMS: The aims of the presented case report are to emphasize the importance of a proper diagnostics and treatment in the case of the coexistence of Klinefelter syndrome (KS, 47 XXY) and complete androgen insensitivity syndrome (CAIS). Since there is no causal treatment it is necessary to provide the patient with a good quality of life, including psychological and sexological support. MATERIALS AND METHODS: The presented case report is the retrospective analysis of the patient's medical history over the 3 years. RESULTS: At the age of 15, the patient was directed to genetic testing due to primary amenorrhea. The results of the patient showed an incorrect male karyotype with the SRY gene present (47, XXY). A molecular diagnostics revealed a very rare variant of the androgen receptor (AR) mutation responsible for tissue insensitivity to androgens. The detected mutation has not been described in the available databases so far. Following a diagnosis of the presence of Klinefelter syndrome (KS, 47 XXY) together with complete androgen insensitivity syndrome (CAIS), the patient underwent a bilateral gonadectomy. CONCLUSIONS: In women with KS and CAIS physiological reproduction and maintenance of normal sex, hormone levels are not possible. A gonadectomy is performed due to the risk of malignant testicular tumors.
Assuntos
Síndrome de Resistência a Andrógenos/diagnóstico , Síndrome de Klinefelter/diagnóstico , Adolescente , Amenorreia/diagnóstico , Amenorreia/etiologia , Amenorreia/genética , Amenorreia/cirurgia , Síndrome de Resistência a Andrógenos/complicações , Síndrome de Resistência a Andrógenos/genética , Síndrome de Resistência a Andrógenos/cirurgia , Castração , Feminino , Humanos , Cariotipagem , Síndrome de Klinefelter/complicações , Síndrome de Klinefelter/genética , Síndrome de Klinefelter/cirurgia , Masculino , Mutação , Receptores Androgênicos/genética , Estudos Retrospectivos , Proteína da Região Y Determinante do Sexo/genética , Testículo/cirurgiaRESUMO
BACKGROUND: The purpose of this study is to evaluate the prognostic factors for sperm retrieval and determine if Y chromosome deletion is associated with deleterious effects on spermatogenesis in non-mosaic Klinefelter patients. Whether Y chromosome deletion determines the sperm retrieval rate in non-mosaic Klinefelter patients has not yet been addressed. METHODS: We retrospectively collected medical records of azoospermic patients from Sep 2009 to Dec 2018, and enrolled 66 non-mosaic 47, XXY patients who were receiving mTESE. The predictive values of patients age, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, prolactin, estradiol and Y chromosome deletion were assessed for successful sperm recovery. RESULTS: Testicular sperm recovery was successful in 24 (36.4%) of 66 men. The mean age (36.0 vs. 36.6 years), and levels of FSH (30.0 vs 36.9 IU/L), LH (17.7 vs 21.9 IU/L), testosterone (2.4 vs. 2.1 ng/ml), prolactin (9.1 vs. 8.8 ng/ml), and estradiol (19.4 vs. 22.3 pg/ml) did not show any significant difference when comparing patients with and without successful sperm retrieval. Partial deletion of azoospermic factor c (AZFc) was noted in 5 (20.8%) of 24 patients with successful sperm retrieval, including three b2/b3 and two gr/gr deletion cases, whereas 4 (9.5%) of 42 patients with unsuccessful sperm retrieval were noted to have AZFc partial deletion (one b2/b3, one sY1206 and two gr/gr deletion), though the difference was not statistically significant (p = 0.27). CONCLUSION: According to present results, age and AZFc partial deletion status should not be a deterrent for azoospermic males with non-mosaic Klinefelter syndrome to undergo mTESE.
Assuntos
Azoospermia/genética , Deleção Cromossômica , Síndrome de Klinefelter/genética , Microdissecção/métodos , Recuperação Espermática , Espermatozoides/fisiologia , Adulto , Azoospermia/diagnóstico , Azoospermia/cirurgia , Humanos , Síndrome de Klinefelter/diagnóstico , Síndrome de Klinefelter/cirurgia , Masculino , Estudos Retrospectivos , Testículo/fisiologia , Testículo/cirurgiaRESUMO
Vestibuloplasty involves a series of surgical procedures designed to restore alveolar ridge height by lowering the muscles attached to the buccal, labial, and lingual aspects of the jaws. The technique is indicated in cases of insufficient vestibular depth that may result from atrophy of the alveolar ridge and/or high attachment of muscle or movable mucosa. This article focuses on a carbon dioxide (CO2) laser vestibular extension procedure performed in a patient with Klinefelter syndrome, which is caused by a chromosomal abnormality. The 10,600-nm CO2 laser is shown to offer several advantages over a conventional scalpel and other laser wavelengths for soft-tissue pre-prosthetic surgery, including vestibular extension.
Assuntos
Aumento do Rebordo Alveolar/métodos , Síndrome de Klinefelter/cirurgia , Vestibuloplastia/métodos , Adulto , Aumento do Rebordo Alveolar/instrumentação , Humanos , Síndrome de Klinefelter/complicações , Terapia a Laser/métodos , Lasers de Gás/uso terapêutico , Masculino , Vestibuloplastia/instrumentaçãoRESUMO
OBJECTIVE: To evaluate subcapsular orchiectomy as a method to retrieve spermatozoa from minute testicular foci in men with Klinefelter syndrome (KS). METHODS: Fourteen men with KS were consecutively recruited to unilateral subcapsular orchiectomy. Testicular tissue was dissected mechanically and enzymatically to identify possible sperm. Previous testosterone replacement therapy was interrupted for 10 months (range: 9-12 months) to minimize a possible effect on the spermatogenesis. Two men with high estrogen/testosterone ratios were treated with aromatase inhibitor (letrozol, 2.5 mg/d for 3 months) before operation. RESULTS: Testicular sperm were detected in 5 of 14 KS men giving an overall success rate of 36%. The success rate was 50% (5 of 10 men) after exclusion of the 4 men previous treated with androgen substitution. So far, 3 (21%) clinical pregnancies and 2 live births or ongoing pregnancies (14%) have been obtained. Testicular sperm could not be detected in the 2 men treated with aromatase inhibitor before operation. The maximum operative time was 20 minutes, and none had surgical complications such as pain, fever, or hematomas. The mean testosterone level, measured 1-4 months after orchiectomy, decreased to 72% (7.9 ± 2.4 nmol/L) of the preoperative level. CONCLUSION: Subcapsular orchiectomy appears to be easy and quick compared with conventional microtesticular sperm extraction. However, in this pilot study, it has not been possible to demonstrate pregnancy and live birth rates as high as that reported with microtesticular sperm extraction, and further studies are needed before the procedure should be used routinely for sperm retrieval in patients with KS.
Assuntos
Síndrome de Klinefelter/cirurgia , Orquiectomia/métodos , Recuperação Espermática , Adolescente , Adulto , Criopreservação , Feminino , Humanos , Masculino , Projetos Piloto , Gravidez , Injeções de Esperma Intracitoplásmicas/métodos , Adulto JovemRESUMO
It has been indicated that approximately 20% of azoospermic patients have chromosomal anomalies, 90% of which are sex-chromosome abnormalities. Even azoospermic patients with sex-chromosomal anomalies might be able to father children using an advanced assisted reproductive technique such as microdissection testicular sperm extraction (micro-TESE) with intracytoplasmic sperm injection (ICSI). To evaluate the effect of micro-TESE in azoospermic patients with various sex-chromosomal anomalies, we reviewed their clinical results. A chromosomal survey using the G-banding technique was performed on males whose semen analysis demonstrated azoospermia at the Division of Male Infertilities at our institution between January 2004 and December 2009. Forty-two of these subjects demonstrated sex-chromosomal anomalies. The mean patient age was 34.4 ± 4.3 years. We classified them into two groups: Klinefelter syndrome (47,XXY) and other sex-chromosome abnormalities. Thirty-five patients showed Klinefelter syndrome and seven patients showed other sex-chromosome abnormalities. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels were 36.3 ± 14.0 IU/L, 15.8 ± 6.7 IU/L, and 3.2 ± 2.0 ng/ml in Klinefelter syndrome, and 20.8 ± 10.4 IU/L, 8.2 ± 5.2 IU/L and 4.1 ± 1.5 ng/ml in other sex-chromosome abnormalities, respectively. The mean testicular volume was 4.0 ± 2.1 ml in Klinefelter syndrome and 9.9 ± 4.6 ml in other sex-chromosome abnormalities. Serum FSH and LH in Klinefelter syndrome were significantly higher than those in other sex-chromosome abnormalities, and the mean testicular volume in Klinefelter syndrome was significantly smaller than that in other sex-chromosome abnormalities. The sperm retrieval rate (SRR) for micro-TESE showed no significant difference between the two groups (42.4% vs. 42.9%). In this study, the outcome of micro-TESE appeared not to differ between Klinefelter syndrome and other sex-chromosome abnormalities.
Assuntos
Síndrome de Klinefelter/cirurgia , Aberrações dos Cromossomos Sexuais , Recuperação Espermática , Adulto , Hormônio Foliculoestimulante/sangue , Humanos , Infertilidade Masculina/genética , Infertilidade Masculina/cirurgia , Hormônio Luteinizante/sangue , Masculino , Microdissecção , Injeções de Esperma Intracitoplásmicas , Testosterona/sangue , Resultado do TratamentoRESUMO
Patients with non-obstructive azoospermia (NOA) were once considered to be infertile with few treatment options due to the absence of sperm in the ejaculate. In the last two decades, the advent of intracytoplasmic sperm injection (ICSI), and the application of various testicular sperm retrieval techniques, including fine needle aspiration (FNA), conventional testicular sperm extraction (TESE) and microdissection testicular sperm extraction (micro-TESE) have revolutionized treatment in this group of men. Because most men with NOA will have isolated regions of spermatogenesis within the testis, studies have illustrated that sperm can be retrieved in most men with NOA, including Klinefelter's syndrome (KS), prior history of chemotherapy and cryptorchidism. Micro-TESE, when compared with conventional TESE has a higher sperm retrieval rate (SRR) with fewer postoperative complications and negative effects on testicular function. In this article, we will compare the efficacy of the different procedures of sperm extraction, discuss the medical treatment and the role of testosterone optimization in men with NOA and describe the micro-TESE surgical technique. Furthermore, we will update our overall experience to allow counseling on the prognosis of sperm retrieval for the specific subsets of NOA.
Assuntos
Azoospermia/terapia , Microdissecção/métodos , Recuperação Espermática , Biópsia/efeitos adversos , Humanos , Síndrome de Klinefelter/cirurgia , Masculino , Injeções de Esperma Intracitoplásmicas/métodos , Testosterona/metabolismoAssuntos
Síndrome de Denys-Drash/complicações , Gonadoblastoma/complicações , Síndrome de Klinefelter/complicações , Sequência de Bases , Pré-Escolar , Síndrome de Denys-Drash/genética , Síndrome de Denys-Drash/cirurgia , Feminino , Gonadoblastoma/genética , Gonadoblastoma/cirurgia , Gônadas/patologia , Heterozigoto , Humanos , Lactente , Rim/patologia , Transplante de Rim , Síndrome de Klinefelter/genética , Síndrome de Klinefelter/cirurgia , Mutação de Sentido Incorreto/genética , Nefrectomia , Resultado do Tratamento , Proteínas WT1/genéticaRESUMO
At our institution, high-dose i.v. dexmedetomidine is used to provide sedation for pediatric patients undergoing nonpainful radiological imaging studies. Some of these patients exhibit marked bradycardia (more than 20% deviation from the lowest age-adjusted normal values) while maintaining an arterial blood pressure within an acceptable normal range. We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.
Assuntos
Adjuvantes Anestésicos/efeitos adversos , Adjuvantes Anestésicos/uso terapêutico , Bradicardia/induzido quimicamente , Bradicardia/tratamento farmacológico , Sedação Consciente , Dexmedetomidina/efeitos adversos , Glicopirrolato/efeitos adversos , Glicopirrolato/uso terapêutico , Hipertensão/induzido quimicamente , Hipnóticos e Sedativos/efeitos adversos , Adolescente , Bradicardia/fisiopatologia , Neoplasias Encefálicas/cirurgia , Criança , Pré-Escolar , Craniossinostoses/cirurgia , Frequência Cardíaca/efeitos dos fármacos , Humanos , Hipertensão/fisiopatologia , Síndrome de Klinefelter/cirurgia , Imageamento por Ressonância Magnética , Masculino , Neurofibromatose 1/cirurgia , Oxigênio/sangue , Mecânica Respiratória/efeitos dos fármacos , Esclerose Tuberosa/complicações , Esclerose Tuberosa/cirurgiaRESUMO
Klinefelter syndrome (KFS), is the most common disorder of the sex chromosomes, affecting 1/1000 male births, and presents with underdeveloped secondary sexual characteristics, infertility, and increased urinary excretion of gonadotropin. External genitourinary malformations in KFS are not common, except for small testes. We present identical twins with a 47XXY karyotype and discordant hypospadias and concomitant chordee. To our knowledge, this is the first report of such an association. The diverse possible etiologies explaining the relationship between the presenting congenital defects in identical twins are discussed. We believe that 1 known genetic malformation such as KFS warrants additional urologic assessment.
Assuntos
Transtornos do Desenvolvimento Sexual/etiologia , Hipospadia/complicações , Hipospadia/diagnóstico , Síndrome de Klinefelter/complicações , Síndrome de Klinefelter/diagnóstico , Anormalidades Múltiplas/diagnóstico , Criança , Doenças em Gêmeos , Transtornos do Desenvolvimento Sexual/diagnóstico , Transtornos do Desenvolvimento Sexual/cirurgia , Seguimentos , Humanos , Hipospadia/cirurgia , Síndrome de Klinefelter/cirurgia , Masculino , Doenças Raras , Medição de Risco , Resultado do Tratamento , Gêmeos Monozigóticos , Procedimentos Cirúrgicos Urogenitais/métodosRESUMO
Klinefelter syndrome is a well documented abnormality of sex differentiation, with an incidence of 1 in 600 newborn males. It is characterized by a 47,XXY or a mosaic karyotype and clinical findings of hypergonadotrophic hypogonadism, small testes, infertility, reduced body hair, gynecomastia, and tall stature. Other conditions like venous disease, autoimmune disorders, mild neurobehavioral deficit, diabetes mellitus, sexual precocity, and osteoporosis may also affect these patients. Different malignancies such as breast cancer, testicular tumors, leukemia, and lymphomas occur in 1%-2% of the cases. Klinefelter syndrome has been associated with other malignancies such as extragonadal germ cell tumors; however, some authors consider this association an unusual finding. We report the molecular cytogenetic studies performed in 4 young males with mediastinal germ cell tumors. In 2 cases, a 47,XXY karyotype was recognized in different tissues by fluorescent in situ hybridization, whereas the other 2 had a normal XY karyotype. We propose that in young patients with mediastinal teratoma, a cytogenetic analysis must always be performed.
Assuntos
Germinoma/patologia , Síndrome de Klinefelter/patologia , Neoplasias do Mediastino/patologia , Teratoma/patologia , Adolescente , Adulto , Cromossomos Humanos X , Cromossomos Humanos Y , Evolução Fatal , Germinoma/genética , Germinoma/cirurgia , Humanos , Hibridização in Situ Fluorescente , Cariotipagem , Síndrome de Klinefelter/genética , Síndrome de Klinefelter/cirurgia , Masculino , Neoplasias do Mediastino/genética , Neoplasias do Mediastino/cirurgia , Teratoma/genética , Teratoma/cirurgiaRESUMO
We measured testosterone levels in 24 patients with nonmosaic Klinefelter syndrome before and at 6 and 12 months after conventional or microdissection testicular sperm extraction. Testosterone levels decreased after surgery by either technique, and they did not recover to baseline concentrations, even when using less invasive microdissection techniques.
Assuntos
Síndrome de Klinefelter/sangue , Síndrome de Klinefelter/genética , Injeções de Esperma Intracitoplásmicas , Testículo/cirurgia , Testosterona/sangue , Coleta de Tecidos e Órgãos/efeitos adversos , Humanos , Síndrome de Klinefelter/cirurgia , Masculino , Mosaicismo , Período Pós-OperatórioRESUMO
OBJECTIVE: To describe a case involving the cryopreservation of testis tissue retrieved from a 15-year-old male teenager with Klinefelter's syndrome. DESIGN: Case report. SETTING: An academic medical center. PATIENT(S): A 15-year-old boy with Klinefelter's syndrome. INTERVENTION(S): Microsurgical testis sperm extraction with cryopreservation of harvested tissue. MAIN OUTCOME MEASURE(S): Spermatozoa within testis tissue. RESULT(S): Successful extraction and cryopreservation of three vials of sperm-containing testis tissue. No effect on subsequent testosterone levels. CONCLUSION(S): Testis tissue extraction in the adequately virilized but azoospermic young male with 47, XXY Klinefelter's syndrome may be a strategy to preserve future biological paternity.
Assuntos
Fertilidade , Síndrome de Klinefelter/fisiopatologia , Síndrome de Klinefelter/cirurgia , Testículo/cirurgia , Coleta de Tecidos e Órgãos , Adolescente , Criopreservação , Humanos , Cariotipagem , Síndrome de Klinefelter/genética , Masculino , Microcirurgia , EspermatozoidesAssuntos
Aspergilose/microbiologia , Aspergillus fumigatus/isolamento & purificação , Doenças do Mediastino/microbiologia , Complicações Pós-Operatórias/microbiologia , Anticorpos Antifúngicos/sangue , Aspergilose/sangue , Aspergilose/diagnóstico por imagem , Aspergillus fumigatus/imunologia , Biópsia , Criança , Humanos , Síndrome de Klinefelter/cirurgia , Masculino , Doenças do Mediastino/sangue , Doenças do Mediastino/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
Klinefelter syndrome is the most frequent sex chromosome anomaly. Affected men characteristically present a tall stature, eunuchoid contours with feminine fat distribution, gynecomastia, hypogonadism, infertility, and behavioral and psychiatric disorders. Diagnosis is confirmed by karyotype, which demonstrates an extra X chromosome. Treatment is mainly directed toward appropriate defeminization. Current treatment consists of testosterone replacement therapy and surgical correction of gynecomastia.
Assuntos
Abdome/cirurgia , Ginecomastia/cirurgia , Síndrome de Klinefelter/cirurgia , Lipectomia , Adulto , Humanos , MasculinoRESUMO
The karyotype 49,XXXXY is a rare form of Klinefelter's syndrome. Various anomalies can be found in this variant--more than other variants of Klinefelter's syndrome. Cleft palate is rarely seen among these anomalies. A cleft palate deformity can be diagnosed early and easily. This deformity should cause one to suspect an uncommon variant of Klinefelter's syndrome. Here we present a patient with an uncommon variant of Klinefelter's syndrome who was diagnosed with the help of the presence of an incomplete cleft palate deformity.
Assuntos
Fissura Palatina/genética , Síndrome de Klinefelter/genética , Pré-Escolar , Fissura Palatina/diagnóstico , Fissura Palatina/cirurgia , Seguimentos , Humanos , Lactente , Cariotipagem , Síndrome de Klinefelter/diagnóstico , Síndrome de Klinefelter/cirurgia , MasculinoRESUMO
We report a case of Klinefelter's syndrome with multiply operated low back (MOB). Psychological and/or psychosocial problems related to MOB have been of recent interest in the field of orthopedic surgery. Based on psychiatric interviews, this case was diagnosed as a somatoform pain disorder of the DSM-III-R somatoform disorders. In addition to psychological problems, the pain was partly explicable by severe osteoporosis, which was prematurely caused by endocrinological disturbances associated with Klinefelter's syndrome. Patients with this syndrome are more likely to develop severe osteoporosis. In the presenile period of Klinefelter's syndrome with severe osteoporosis, liaison psychiatrists may pay attention to somatoform disorders (e.g. somatoform pain disorder and conversion disorder) linked with the MO.
Assuntos
Síndrome de Klinefelter/psicologia , Laminectomia/psicologia , Dor Lombar/psicologia , Complicações Pós-Operatórias/psicologia , Transtornos Somatoformes/psicologia , Densidade Óssea/fisiologia , Diagnóstico Diferencial , Humanos , Síndrome de Klinefelter/diagnóstico , Síndrome de Klinefelter/genética , Síndrome de Klinefelter/cirurgia , Dor Lombar/diagnóstico , Dor Lombar/genética , Dor Lombar/cirurgia , Vértebras Lombares/cirurgia , MMPI , Masculino , Pessoa de Meia-Idade , Osteoporose/diagnóstico , Osteoporose/genética , Osteoporose/psicologia , Osteoporose/cirurgia , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/cirurgia , Teste de Rorschach , Transtornos Somatoformes/diagnóstico , Transtornos Somatoformes/cirurgia , Estenose Espinal/diagnóstico , Estenose Espinal/psicologia , Estenose Espinal/cirurgiaRESUMO
Accurate differentiation of the pathologic state must precede surgical construction of an artificial vagina. Moreover, it is necessary to know whether a uterus is present and whether the psychosexual development of the patient is female. Differential diagnosis is concerned with various forms of intersexuality, especially aplasia and atresia of the vagina. Relevant cases are reported. The author prefers the McIndoe operation, because of its low risk. If the patient has a uterus (i.e. women with AGS with complete masculinization or women with atresia of the vagina) more effective operations should be done, as intercourse and conception are possible after surgery in these women.