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1.
J Med Case Rep ; 18(1): 487, 2024 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-39380124

RESUMO

OBJECTIVE: The objective of the case report is to analyze the clinical manifestations and imaging features of gouty long head of biceps tendinitis, and to summarize the methods and effects of shoulder arthroscopic surgery. CLINICAL PRESENTATION AND INTERVENTION: The clinical data of a 39-year-old Han Chinese female with gouty long head of the biceps tendinitis was retrospectively analyzed, and the clinical manifestations, imaging features, and diagnosis and treatment were analyzed. The patient presented with pain and limited movement of right shoulder joint. Computed tomography showed irregular high-density shadows above the glenoid and adjacent to the coracoid process of the right shoulder. Magnetic resonance imaging revealed superior labrum anterior and posterior injury with edema in the upper recess and axillary sac. After arthroscopic surgery, the "tofu residue" tissue of the long head of the biceps was removed, and the postoperative pathological examination proved that it was gout stone. CONCLUSION: Gouty long head of the biceps tendinitis is a rare disease. Arthroscopic surgery can probe the structural lesions of shoulder cavity in all aspects, improve the surgical accuracy, and reduce the trauma.


Assuntos
Artroscopia , Imageamento por Ressonância Magnética , Articulação do Ombro , Tendinopatia , Humanos , Feminino , Artroscopia/métodos , Tendinopatia/cirurgia , Tendinopatia/diagnóstico por imagem , Adulto , Articulação do Ombro/cirurgia , Articulação do Ombro/diagnóstico por imagem , Gota/cirurgia , Gota/complicações , Gota/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Resultado do Tratamento
2.
Scand J Med Sci Sports ; 34(10): e14732, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39358891

RESUMO

Knowledge of how to treat chronic tendinopathy has advanced in recent years, but the treatment of early tendinopathy is not well understood. The main purpose of this prospective observational study was to investigate if changes occur in clinical and imaging outcomes over 12 weeks in elite athletes with recent debut of tendinopathy. Sixty-five elite adult athletes (24 ± 5 years) with early Achilles or patellar tendinopathy (symptoms < 3 months) were examined at baseline and after 12 weeks. Patients were divided into groups based on the duration of symptoms at the time of inclusion: (T1): 0-1 month, (T2): 1-2 months, or (T3): 2-3 months. Pain-guided activity modification was the only intervention. We assessed the following clinical outcomes: Questionnaires (Victorian Institute of Sports Assessment (VISA)) and pain scores (0-10 numeric rating scale, NRS), structural outcomes from ultrasonography: Thickness, echogenicity, and Doppler flow, and from magnetic resonance imaging: Cross-sectional area (CSA), thickness and length. Tendinopathic Achilles and patellar tendons displayed no significant differences on imaging tendon structural outcomes between T1 (n = 19), T2 (n = 23), and T3 (n = 20) at baseline or after 12 weeks, with one exception: Patellar tendons in T1 were thicker than T2 and T3 at baseline. Although athletes improved clinically on VISA and most NRS scores after 12 weeks, affected tendons with greater thickness, CSA and Doppler flow than contralateral tendons at baseline remained unchanged after 12 weeks. In conclusion, these data suggest that early tendinopathy in elite athletes can improve clinically after 12 weeks while morphology remains unchanged.


Assuntos
Tendão do Calcâneo , Imageamento por Ressonância Magnética , Ligamento Patelar , Tendinopatia , Humanos , Tendinopatia/diagnóstico por imagem , Masculino , Adulto , Estudos Prospectivos , Feminino , Tendão do Calcâneo/diagnóstico por imagem , Ligamento Patelar/diagnóstico por imagem , Adulto Jovem , Atletas , Ultrassonografia , Medição da Dor , Inquéritos e Questionários
3.
Pain Physician ; 27(7): 435-440, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39353114

RESUMO

BACKGROUND: Greater trochanteric pain syndrome (GTPS) is a common cause of lateral hip pain that affects patients' quality of life and functioning. The condition is often associated with tightness of the iliotibial band (ITB) and tendinopathy of the gluteus medius (GMed) tendon, which are subjected to excessive stress and inflammation. A traditional treatment for GTPS is conservative medical management (CMM), which includes but is not limited to physiotherapy, oral anti-inflammatory medication, and/or local steroid injections. Surgery is performed when these treatments fail. The failure of these techniques indicates that some treatments classified as CMM may not be feasible for some patients. OBJECTIVES: This study aimed to evaluate the efficacy and safety of combined GMed and ITB injections for a cohort of CMM-refractory GTPS patients. STUDY DESIGN: A retrospective chart review. SETTING: Single-center, academic hospital. METHODS: Between 01/01/2022 and 12/31/2022, a retrospective analysis of 68 hips that underwent combination GMed-ITB percutaneous ultrasound tenotomy (PUT) was performed. The primary outcome measure was a numeric rating scale (NRS) for hip pain, and the secondary outcome measures were VISA-G (Victorian Institute of Sports Assessment-Gluteal Tendinopathy) scores, sitting-to-standing and walking tolerance, and side-lying tolerance. RESULTS: The patients' NRS scores decreased, and the VISA-G scores and all functional measures increased one year after the procedure, indicating significant improvement in pain and functioning (P < 0.001). Treatment success, defined as 50% reduction in pain and side-lying tolerance, was achieved by 83% of the patients. No major complications were reported. LIMITATIONS: The lack of a comparable cohort reduces the data's interpretative significance. Having a control arm would have enabled a statistical comparison between treated and untreated patients to provide a valid assessment of the procedure's benefit. CONCLUSIONS: This study demonstrated the feasibility and efficacy of combined GMed-ITB PUT as a novel treatment for GTPS in patients who failed CMM. The results showed significant and durable improvement in pain, function, and quality of life at the one-year follow-up. Our study suggests that both ITB and GMed tendons are involved in the pathogenesis of GTPS. The present study compared favorably with previous studies that reported outcomes of either ITB PUT or GMed PUT alone, implying that combining the approaches may offer superior benefits. Furthermore, the study had several strengths, such as the use of a validated outcome measure (VISA-G), the elimination of bias by independent practitioners, and the inclusion of a difficult population with severe pain.


Assuntos
Tenotomia , Humanos , Tenotomia/métodos , Estudos Retrospectivos , Estudos Longitudinais , Feminino , Masculino , Pessoa de Meia-Idade , Idoso , Tendinopatia/cirurgia , Nádegas/cirurgia , Ultrassonografia/métodos , Adulto
4.
Sci Adv ; 10(40): eado2015, 2024 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-39356750

RESUMO

Achilles tendinopathy is often attributed to overuse, but its pathophysiology remains poorly understood. Disruption to the molecular structure of collagen is fundamental for the onset and progression of tendinopathy but has mostly been investigated in vitro. Here, we interrogated the in vivo molecular structure changes of collagen in rat Achilles tendons following treadmill running. Unexpectedly, the tendons' collagen molecules were not mechanically unfolded by running but denatured through proteolysis during physiological post-run remodeling. We further revealed that running induces inflammatory gene expressions in Achilles tendons and that long-term running causes prolonged, elevated collagen degradation, leading to the accumulation of denatured collagen and tendinopathy development. For applications, we demonstrated magnetic resonance imaging of collagenase-induced Achilles tendon injury in vivo using a denatured collagen targeting contrast agent. Our findings may help close the knowledge gaps in the mechanobiology and pathogenesis of Achilles tendinopathy and initiate new strategies for its imaging-based diagnosis.


Assuntos
Tendão do Calcâneo , Colágeno , Imageamento por Ressonância Magnética , Tendinopatia , Tendão do Calcâneo/metabolismo , Tendão do Calcâneo/diagnóstico por imagem , Tendão do Calcâneo/patologia , Animais , Tendinopatia/diagnóstico por imagem , Tendinopatia/metabolismo , Tendinopatia/patologia , Tendinopatia/etiologia , Imageamento por Ressonância Magnética/métodos , Colágeno/metabolismo , Colágeno/química , Ratos , Fenômenos Biomecânicos , Masculino , Corrida , Desnaturação Proteica , Modelos Animais de Doenças , Ratos Sprague-Dawley
5.
Musculoskeletal Care ; 22(3): e1946, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39313414

RESUMO

AIMS: Rotator cuff related shoulder pain (RCRSP) is a prevalent cause of musculoskeletal pain. Patients presenting with this condition often undergo diagnostic imaging. However, many patients appear to have difficulty recalling the nature of their diagnosis. This may impact their rehabilitation outcomes. The aim of this study was to explore peoples' recall of their structural features relating to RCRSP by comparing their recalled description of their condition with the contents of their imaging reports as reported in an online questionnaire. In doing so, we aim to explore the potential emphasis they place on structural features related to their condition. METHODS: This study was a content analysis embedded within a larger survey study published previously. Data containing patients' recall of their diagnosis was used from the study, and analysed using content analysis to quantify content in terms of codes and categories. The aims of frequency, completeness and accuracy of recall were then explored. RESULTS: The analysis identified eight categories of terminology either recalled by patients or reported in imaging reports. The most frequent categories in reports were tendinopathy (71%) and joint (67%), but only 17% and 36% of participant responses contained these codes, respectively. Participants' completeness of recall compared with their imaging report was 30% on average. In terms of accuracy, only 8 out of 95 participants recalled their diagnoses 100% correctly. CONCLUSION: This study indicates that patients have poor overall recall of their RCRSP-related structural features. We contend that participants may have been able to recall what they viewed to be the most prominent structural feature in their imaging findings. It may be important for clinicians to consider the impact of diagnostic labelling, and whether a patient's ability to recall such labelling may have an influence on their outcomes.


Assuntos
Rememoração Mental , Dor de Ombro , Humanos , Dor de Ombro/diagnóstico por imagem , Feminino , Masculino , Pessoa de Meia-Idade , Adulto , Idoso , Inquéritos e Questionários , Tendinopatia/diagnóstico por imagem
6.
Zhongguo Zhen Jiu ; 44(9): 1071-6, 2024 Sep 12.
Artigo em Chinês | MEDLINE | ID: mdl-39318300

RESUMO

The jingjin (sinews/fascia) theory of Huangdi Neijing (The Yellow Emperor's Inner Classic) has a profound systematic theoretical structure of the rehabilitation for tendon disease. On the basis of jingjin system, it puts forward the ideological system of acupuncture rehabilitation for tendon disease, in which, "bi" (impediment) is the main syndrome, and "swift insertion of heated needles, the frequency of needling decided by the effects and taking tender sites as acupoints" (referring to diagnosis, acupoint selection and treatment) is the basic principle. It is believed after recognizing the above theory and principle that the tendon disease should be differentiated according to the four seasons and twelve months so as to timely adjust yin and yang. Through analyzing the statement of deviation of the mouth corner (facial paralysis) in Huangdi Neijing, the paper expounds the main symptoms, etiology and pathogenesis, and the effect of treatment for this disease. It is the specific clinical representation of acupuncture rehabilitation ideological system for tendon disease.


Assuntos
Pontos de Acupuntura , Terapia por Acupuntura , Humanos , Terapia por Acupuntura/história , Tendinopatia/reabilitação , Tendinopatia/terapia , História Antiga , China , Medicina na Literatura/história
7.
Br J Sports Med ; 58(20): 1175-1186, 2024 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-39271248

RESUMO

To develop a core outcome set for Achilles tendinopathy (COS-AT) for use in clinical trials we performed a five-step process including (1) a systematic review of available outcome measurement instruments, (2) an online survey on truth and feasibility of the available measurement instruments, (3) an assessment of the methodological quality of the selected outcome measurement instruments, (4) an online survey on the outcome measurement instruments as COS and (5) a consensus in-person meeting. Both surveys were completed by healthcare professionals and patients. The Outcome Measures in Rheumatology guidelines with a 70% threshold for consensus were followed. We identified 233 different outcome measurement instruments from 307 included studies; 177 were mapped within the International Scientific Tendinopathy Symposium Consensus core domains. 31 participants (12 patients) completed the first online survey (response rate 94%). 22/177 (12%) outcome measurement instruments were deemed truthful and feasible and their measurement properties were evaluated. 29 participants (12 patients) completed the second online survey (response rate 88%) and three outcome measurement instruments were endorsed: the Victorian Institute of Sports Assessment-Achilles questionnaire, the single-leg heel rise test and evaluating pain after activity using a Visual Analogue Scale (VAS, 0-10). 12 participants (1 patient) attended the final consensus meeting, and 1 additional outcome measurement instrument was endorsed: evaluating pain during activity/loading using a VAS (0-10). It is recommended that the identified COS-AT will be used in future clinical trials evaluating the effectiveness of an intervention. This will facilitate comparing outcomes of intervention strategies, data pooling and further progression of knowledge about AT. As COS-AT is implemented, further evidence on measurement properties of included measures and new outcome measurement instruments should lead to its review and refinement.


Assuntos
Tendão do Calcâneo , Consenso , Técnica Delphi , Tendinopatia , Humanos , Tendinopatia/terapia , Avaliação de Resultados em Cuidados de Saúde , Inquéritos e Questionários
8.
Foot Ankle Int ; 45(9): 931-939, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39219246

RESUMO

BACKGROUND: Surgical treatment of insertional Achilles tendinopathy (IAT) historically consists of Achilles tendon debridement with reattachment and excision of the posterosuperior calcaneal prominence with or without a gastrocnemius recession. Zadek osteotomy (ZO) is an alternative to an open midline splitting approach. The purpose of this study was to analyze patient-reported outcomes and complications after percutaneously performed ZO with minimum 2 years' follow-up. METHODS: One hundred eight cases treated with percutaneous ZO with a minimum 2-year follow-up were retrospectively reviewed. Postoperative complications and patient satisfaction were evaluated. Foot Function Index (FFI) and visual analog scale (VAS) scores were recorded at preoperative and follow-up appointments to measure patients' functional outcomes and pain, respectively. RESULTS: Mean follow-up was 41.2 months (range, 24-65). Mean age was 51.8 years (range, 28-81). The mean FFI score improved from 56.1 (range, 47-88) to 11.0 (range, 7-59) postoperatively (P < .001). The mean VAS score improved from 7.7 (range, 5-10) to 0.4 (range, 0-7) postoperatively (P < .001). The overall complication rate was 3.8% (n = 4). Of 104 cases, 98.1% of patients said they were satisfied with their procedure (n = 102) when asked if they were satisfied with their ZO and recovery. CONCLUSION: We found the percutaneous ZO to be a safe and effective intervention for treatment of IAT. At a minimum of 2-year follow-up, this intervention is associated with minimal complications, improved function, reduced pain, and a high rate of patient satisfaction.


Assuntos
Tendão do Calcâneo , Osteotomia , Satisfação do Paciente , Tendinopatia , Humanos , Tendinopatia/cirurgia , Tendão do Calcâneo/cirurgia , Osteotomia/métodos , Estudos Retrospectivos , Pessoa de Meia-Idade , Feminino , Masculino , Adulto , Idoso , Idoso de 80 Anos ou mais , Medição da Dor , Complicações Pós-Operatórias , Calcâneo/cirurgia , Resultado do Tratamento
9.
Comput Methods Programs Biomed ; 256: 108398, 2024 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-39236562

RESUMO

BACKGROUND AND OBJECTIVE: Tendon segmentation is crucial for studying tendon-related pathologies like tendinopathy, tendinosis, etc. This step further enables detailed analysis of specific tendon regions using automated or semi-automated methods. This study specifically aims at the segmentation of Achilles tendon, the largest tendon in the human body. METHODS: This study proposes a comprehensive end-to-end tendon segmentation module composed of a preliminary superpixel-based coarse segmentation preceding the final segmentation task. The final segmentation results are obtained through two distinct approaches. In the first approach, the coarsely generated superpixels are subjected to classification using Random Forest (RF) and Support Vector Machine (SVM) classifiers to classify whether each superpixel belongs to a tendon class or not (resulting in tendon segmentation). In the second approach, the arrangements of superpixels are converted to graphs instead of being treated as conventional image grids. This classification process uses a graph-based convolutional network (GCN) to determine whether each superpixel corresponds to a tendon class or not. RESULTS: All experiments are conducted on a custom-made ankle MRI dataset. The dataset comprises 76 subjects and is divided into two sets: one for training (Dataset 1, trained and evaluated using leave-one-group-out cross-validation) and the other as unseen test data (Dataset 2). Using our first approach, the final test AUC (Area Under the ROC Curve) scores using RF and SVM classifiers on the test data (Dataset 2) are 0.992 and 0.987, respectively, with sensitivities of 0.904 and 0.966. On the other hand, using our second approach (GCN-based node classification), the AUC score for the test set is 0.933 with a sensitivity of 0.899. CONCLUSIONS: Our proposed pipeline demonstrates the efficacy of employing superpixel generation as a coarse segmentation technique for the final tendon segmentation. Whether utilizing RF, SVM-based superpixel classification, or GCN-based classification for tendon segmentation, our system consistently achieves commendable AUC scores, especially the non-graph-based approach. Given the limited dataset, our graph-based method did not perform as well as non-graph-based superpixel classifications; however, the results obtained provide valuable insights into how well the models can distinguish between tendons and non-tendons. This opens up opportunities for further exploration and improvement.


Assuntos
Tendão do Calcâneo , Aprendizado de Máquina , Imageamento por Ressonância Magnética , Redes Neurais de Computação , Máquina de Vetores de Suporte , Humanos , Imageamento por Ressonância Magnética/métodos , Tendão do Calcâneo/diagnóstico por imagem , Processamento de Imagem Assistida por Computador/métodos , Algoritmos , Tendinopatia/diagnóstico por imagem , Tendinopatia/classificação , Tendões/diagnóstico por imagem
10.
Trials ; 25(1): 616, 2024 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-39294797

RESUMO

BACKGROUND: Rotator cuff calcific tendinitis (RCCT) is a common shoulder disease whose main symptoms include shoulder pain, limited mobility, and calcification deposits in the shoulder. Traditional treatment methods have certain limitations, so finding new treatment methods has become the focus of research. Extracorporeal shock wave (ESW) and platelet-rich plasma (PRP) treatments have attracted much attention due to their non-invasive and tissue repair-promoting properties; however, the efficacy of their combined treatment in RCCT remains unclear. METHODS: This study is designed as a single-center, assessment-blind, randomized controlled clinical trial with three parallel groups. Sixty subjects will be recruited and randomly divided into the ESW group, PRP group, and ESW combined with PRP group, in a 1:1:1 ratio. The entire intervention period is 4 weeks, and the follow-up period is 4 weeks. Outcomes will be measured at baseline (T0), after 1 week of intervention (T1), after 2 weeks of intervention (T2), after 4 weeks of intervention (T3), and after an additional 4 weeks of follow-up period (T4). The primary endpoint is the VAS score. Secondary endpoints are ASES, CMS, UCLA, and the location and size of calcified areas. DISCUSSION: This study aims to evaluate the efficacy of ESW therapy combined with PRP in treating RCCT. We compare the effects of single and combined treatments to explore their impact on disease symptoms, functional improvement, and calcification regression. This provides a scientific basis for identifying more effective treatment options. TRIAL REGISTRATION: ClinicalTrials.gov NCT06372600. Registered on April 17, 2024; version 1.


Assuntos
Calcinose , Tratamento por Ondas de Choque Extracorpóreas , Plasma Rico em Plaquetas , Ensaios Clínicos Controlados Aleatórios como Assunto , Manguito Rotador , Tendinopatia , Humanos , Tratamento por Ondas de Choque Extracorpóreas/métodos , Calcinose/terapia , Calcinose/fisiopatologia , Tendinopatia/terapia , Resultado do Tratamento , Manguito Rotador/fisiopatologia , Adulto , Pessoa de Meia-Idade , Feminino , Masculino , Terapia Combinada , Dor de Ombro/terapia , Dor de Ombro/etiologia , Fatores de Tempo , Medição da Dor
11.
Scand J Med Sci Sports ; 34(9): e14726, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39263841

RESUMO

Patellar tendinopathy (PT) typically affects jumping-sport athletes with functional impairments frequently observed. Alterations to the functional organization of corticomotor neurons within the motor cortex that project to working muscles are evident in some musculoskeletal conditions and linked to functional impairments. We aimed to determine if functional organization of corticomotor neuron projections differs between athletes with PT and asymptomatic controls, and if organization is associated with neuromuscular control. We used a cross-sectional design, and the setting was Monash Biomedical Imaging. Basketball and volleyball athletes with (n = 8) and without PT (n = 8) completed knee extension and ankle dorsiflexion force matching tasks while undergoing fMRI. We determined functional organization via identification of the location of peak corticomotor neuron activation during respective tasks (expressed in X, Y, and Z coordinates) and calculated force matching accuracy for both tasks to quantify neuromuscular control. We observed significant interactions between group and coordinate plane for functional organization of corticomotor projections to knee extensors (p < 0.001) and ankle dorsiflexors (p = 0.016). Compared to controls, PT group peak corticomotor activation during the knee extension task was 9.6 mm medial (p < 0.001) and 5.2 mm posterior (p = 0.036), and during the ankle dorsiflexion task 8.2 mm inferior (p = 0.024). In the PT group, more posterior Y coordinate peak activation location during the knee extension task was associated with greater task accuracy (r = 0.749, p = 0.034). Functional organization of corticomotor neurons differed in jumping athletes with PT compared to controls. Links between functional organization and neuromuscular control in the PT group suggest organizational differences may be relevant to knee extension neuromuscular control preservation.


Assuntos
Basquetebol , Imageamento por Ressonância Magnética , Córtex Motor , Tendinopatia , Voleibol , Humanos , Voleibol/fisiologia , Basquetebol/fisiologia , Córtex Motor/fisiologia , Córtex Motor/fisiopatologia , Estudos Transversais , Tendinopatia/fisiopatologia , Masculino , Adulto Jovem , Feminino , Adulto , Neurônios Motores/fisiologia , Ligamento Patelar/fisiopatologia , Ligamento Patelar/fisiologia , Atletas , Estudos de Casos e Controles
12.
Int J Mol Sci ; 25(17)2024 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-39273510

RESUMO

A limited understanding of tendon cell biology in healthy and pathological conditions has impeded the development of effective treatments, necessitating in vitro biomimetic models for studying tendon events. We established a dynamic culture using fibrin scaffolds, bioengineered with tendon stem/progenitor cells (hTSPCs) from healthy or diseased human biopsies and perfused with 20 ng/mL of human transforming growth factor-ß1 for 21 days. Both cell types showed long-term viability and upregulated Scleraxis (SCX-A) and Tenomodulin (TNMD) gene expressions, indicating tenogenic activity. However, diseased hTSPCs underexpressed collagen type I and III (COL1A1 and COL3A1) genes and exhibited lower SCX-A and TNMD protein levels, but increased type I collagen production, with a type I/type III collagen ratio > 1.5 by day 14, matching healthy cells. Diseased hTSPCs also showed constant high levels of pro-inflammatory cytokines, such as IL-8 and IL-6. This biomimetic environment is a valuable tool for studying tenogenic and inflammatory events in healthy and diseased tendon cells and identifying new therapeutic targets.


Assuntos
Colágeno Tipo I , Fibrina , Células-Tronco , Tendões , Alicerces Teciduais , Fator de Crescimento Transformador beta1 , Humanos , Tendões/citologia , Tendões/metabolismo , Alicerces Teciduais/química , Células-Tronco/metabolismo , Células-Tronco/citologia , Fibrina/metabolismo , Fator de Crescimento Transformador beta1/metabolismo , Colágeno Tipo I/metabolismo , Colágeno Tipo I/genética , Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo , Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética , Tendinopatia/metabolismo , Tendinopatia/patologia , Células Cultivadas , Colágeno Tipo III/metabolismo , Colágeno Tipo III/genética , Cadeia alfa 1 do Colágeno Tipo I/metabolismo , Pessoa de Meia-Idade , Masculino , Sobrevivência Celular/efeitos dos fármacos , Engenharia Tecidual/métodos , Proteínas de Membrana
13.
J Musculoskelet Neuronal Interact ; 24(3): 291-300, 2024 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-39219327

RESUMO

OBJECTIVES: To investigate the therapeutic effect and mechanism of Danggui Buxue Tang in the treatment of biceps longus tendon lesions, and to preliminarily explore the relevant factors affecting this injury. METHODS: Using network pharmacology analysis methods, the potential mechanism of Danggui Buxue Tang in treating key lesions of the long head of the biceps brachii muscle was studied. RESULTS: Model analysis revealed 44 protein-protein interactions associated with long head binding. The distribution of 19 strongly correlated targets is Pharmaper>SEA>Stitch>Swiss. Further discovery revealed 17 immune system and inflammation related KEGG pathways with P values less than 0.01. The TNF and sphingolipid signaling pathways are associated with inflammation, while the MAPK signaling pathway is associated with immunity. Finally, it was found that the FoxO and HIF-1 signaling pathways are directly associated with long head restraint injury in the biceps brachii muscle. CONCLUSION: Danggui Buxue Tang inhibits related pathways, regulates the immune system, reduces inflammation, and alleviates disease progression. Danggui Buxue Tang can be an effective choice for treating combined lesions of the long head of the biceps brachii muscle.


Assuntos
Medicamentos de Ervas Chinesas , Farmacologia em Rede , Tendinopatia , Farmacologia em Rede/métodos , Humanos , Medicamentos de Ervas Chinesas/farmacologia , Medicamentos de Ervas Chinesas/uso terapêutico , Tendinopatia/tratamento farmacológico , Transdução de Sinais/efeitos dos fármacos , Transdução de Sinais/fisiologia , Músculo Esquelético/efeitos dos fármacos , Músculo Esquelético/metabolismo , Músculo Esquelético/patologia , Músculos Isquiossurais/efeitos dos fármacos
14.
Bull Hosp Jt Dis (2013) ; 82(4): 266-272, 2024 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-39259953

RESUMO

PURPOSE: The purpose of this study was to compare regimens of eccentric exercise and dry-needling, with and without an ultrasound-guided leukocyte-poor platelet-rich plasma (LP-PRP) injection, in patients with patellar tendinopathy. METHODS: Patients with symptomatic patellar tendinopathy based on physical examination and magnetic resonance imaging and who had failed at least 6 weeks of nonoperative treatment were enrolled and randomized at two centers to receive ultrasound-guided dry-needling (DN) alone or in addition to an injection of LP-PRP coupled with standardized eccentric strengthening exercises. Participants completed patient-reported outcome surveys at baseline and at 3, 6, 9, 12, and 26 weeks post-treatment. The primary outcome measure was the Victorian Institute of Sports Assessment (VISA) score for patellar tendinopathy (VISA-P) at 12 weeks, and secondary measures included the visual analog scale (VAS) for pain, Tegner activity scale, Lysholm knee scale (Lysholm), and Veterans Rand 12-Item Health Survey (VR12) questionnaire at 12 and 26 weeks. RESULTS: Thirty-one subjects were enrolled in the study (15 DN, 16 LP-PRP). Twenty-three patients were available for follow-up at all time points. There were no statistically significant differences between the two groups at baseline. At 12 weeks post-treatment, both the LP-PRP and DN groups demonstrated statistically significant (p < 0.05) improvements from baseline with respect to Lysholm score (34.5 ± 15.1 and 31.7 ± 18.4), VAS pain scale (-1.58 ± 2.1 and -2.8 ± 1.9, respectively), and VISA score (19.2 ± 15.9 and 28.4 ± 19.4, respectively). At 26 weeks post-treatment both groups demonstrated statistically significant (p < 0.05) improvements in Lysholm score (23.6 ± 23.1 and 24.5 ± 17.3, respectively) and VAS pain score (-1.67 ± 2.3 and -2.18 ± 2.9, respectively). The LP-PRP group failed to show significance for VISA-P score from 0 to 26 weeks, though the DN group did (22.0 ± 14.6). There were no statistically significant differences between the two groups in mean VISA, VAS, Lysholm, or the Short Form Health Survey (SF-12) scores at either the 12 week or 26-week follow-up time points. CONCLUSION: The results of the current study demonstrate that both DN and DN plus LP-PRP are effective treatment options in the management of symptomatic patellar tendinopathy, however, LP-PRP did not add any additional improvement over DN alone.


Assuntos
Ligamento Patelar , Plasma Rico em Plaquetas , Tendinopatia , Humanos , Tendinopatia/terapia , Tendinopatia/diagnóstico , Tendinopatia/fisiopatologia , Feminino , Masculino , Adulto , Ligamento Patelar/diagnóstico por imagem , Ligamento Patelar/fisiopatologia , Resultado do Tratamento , Medição da Dor , Terapia por Exercício/métodos , Ultrassonografia de Intervenção , Pessoa de Meia-Idade , Medidas de Resultados Relatados pelo Paciente
15.
J Ultrasound Med ; 43(11): 2027-2038, 2024 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-39136225

RESUMO

Insertional Achilles tendinopathy is an umbrella medical term referring to pain and swelling on the posterior aspect of the calcaneus. High-resolution ultrasound imaging is commonly used in daily practice to assess the pathological changes of the Achilles tendon, cortical bone of the calcaneus, and soft tissues located inside the retrocalcaneal space to optimize the management of relevant patients. To the best of our knowledge, a standardized ultrasound protocol to evaluate the retrocalcaneal bursal complex is lacking in the pertinent literature. In this sense, our step-by-step sonographic approach is intended to be an easy and ready-to-use guide for sonographers/physicians in daily practice to assess this anatomical complex in patients with Achilles tendinopathy. Needless to say, the peculiar histological features of this V-shaped synovial/fibrocartilaginous bursa surrounding the posteroinferior wedge of the Kager's fat pad and the retrocalcaneal space make the examination challenging.


Assuntos
Tendão do Calcâneo , Bolsa Sinovial , Calcâneo , Tendinopatia , Humanos , Tendão do Calcâneo/diagnóstico por imagem , Bolsa Sinovial/diagnóstico por imagem , Calcâneo/diagnóstico por imagem , Tendinopatia/diagnóstico por imagem , Ultrassonografia/métodos , Ultrassonografia/normas
16.
Medicina (Kaunas) ; 60(8)2024 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-39202470

RESUMO

Background and Objectives: Rotator cuff tendonitis (RCT) is one of the most common shoulder pathologies. It causes pain, limits shoulder joint movements, and impairs function. Despite various treatment methods, there are currently no specific guidelines regarding the most effective intervention for RCT. To the best of our knowledge, no studies have compared the effects of Kinesio taping (KT) and cold therapy (CT) on individuals with RCT. To this end, this study aimed to investigate and compare the short-term effects of KT and CT on pain relief and upper extremity functionality in individuals with RCT. Materials and Methods: One hundred and fourteen individuals were assessed for eligibility. Fifty-two individuals with RCT who met the inclusion criteria and agreed to participate were randomly allocated into either the KT or the CT group. A standardized home exercise program was given to all the participants. Their pain intensity, upper extremity function, shoulder range of motion (ROM), and grip strength were evaluated initially and after the three days of KT or CT applications. Results: All the assessment values significantly improved in the KT group. In the CT group, only the pain scores (except for the numerical rating scale (NRS) pain score during activity) were significantly improved in the CT group at the end of the third day of application compared to the initial values (p < 0.05). For all the measurement outcomes, the effects of time × group interactions were statistically significant (p < 0.05) in favor of the KT group, except for the resting pain (p = 0.688). Conclusions: The findings suggest that KT and CT could be used as adjunctive modalities to exercise for resting and night pain relief in patients with RCT. KT also had positive effects on the activity pain, function, ROM, and grip strength. The use of KT along with an exercise program could be a more effective therapeutic choice than the use of CT for improving night pain, activity pain, and upper extremity function during the short-term rehabilitation of RCT patients.


Assuntos
Fita Atlética , Crioterapia , Amplitude de Movimento Articular , Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Crioterapia/métodos , Adulto , Resultado do Tratamento , Manejo da Dor/métodos , Medição da Dor/métodos , Idoso , Extremidade Superior/fisiopatologia , Tendinopatia/terapia , Tendinopatia/fisiopatologia , Tendinopatia/complicações
17.
J Sci Med Sport ; 27(10): 702-707, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39097510

RESUMO

OBJECTIVES: The aim is to assess performance characteristics in jumps and functionality in participants with patellar tendinopathy and compare changes with various tendinopathy treatments in the short and medium term. As a secondary objective, the study aims to verify the relationship between changes in knee functionality assessed by the VISA-P and jump capacity in the different treatment groups. DESIGN: A double-blinded randomized controlled trial. METHODS: Recruitment was conducted at sport clubs, with 48 participants with patellar tendinopathy included in the study. Participants were randomized into groups: dry needling (DN), percutaneous electrolysis (PNE), and sham needling as the control group (CG), all combined with eccentric exercise (EE). Functionality and performance during jumps, including squat jump (SJ) and counter movement jump (CMJ), were assessed. RESULTS: Significant differences were found in functionality between the pre-test and post-test evaluations, as well as between the pre-test and follow-up evaluations, in all three groups (p < 0.001). The DN group experienced an improvement in eccentric power (p = 0.021). A moderate correlation was found between the pre-test and post-test changes in functionality and SJ maximum concentric force (r = 0.63, p < 0.01, CI: 0.1; 0.8), CMJ maximum concentric force (r = 0.52, p = 0.05, CI: -0.01; 0.8), and CMJ eccentric power in the DN group (r = 0.63, p = 0.01, CI: 0.1; 0.8). CONCLUSIONS: Eccentric exercise could be effective in improving functionality in patellar tendinopathy and DN could improve eccentric power in jumps performance. Moreover, the DN group experienced an increase in functionality that correlated with the improvements found in jump performance in eccentric power and concentric strength.


Assuntos
Agulhamento Seco , Ligamento Patelar , Tendinopatia , Humanos , Tendinopatia/terapia , Tendinopatia/fisiopatologia , Masculino , Feminino , Método Duplo-Cego , Adulto , Agulhamento Seco/métodos , Adulto Jovem , Ligamento Patelar/fisiopatologia , Terapia por Exercício/métodos
18.
Orthopadie (Heidelb) ; 53(9): 668-676, 2024 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-39172175

RESUMO

OBJECTIVE: Tendinopathies are diseases that often entail long-term treatment consisting of analgesics, physiotherapy, orthotics, and sparing. The aim of this study was to investigate the effect of a single application of a high-energy PEMF (pulsed electromagnetic field) on pain perception and blood born inflammation parameters. METHODS: 34 patients were randomly assigned to a verum group (10 min PEMF, 0,78 T) or a placebo group (10 min sham condition). Prior to and up to one week after the patient blinded treatment (t1-t5), local pain state was assessed by means of algometry as pain pressure threshold (PPT). Accordingly, heat-shock protein 70 (HSP70) levels were analysed. Statistical analyses included 2­way ANOVA (2â€¯× 5). The clinical trial was registered (DRKS00031321). RESULTS: After randomization and drop-out (verum n = 17, placebo n = 13) baseline-analyses did not reveal significant between-group differences for PPT (p = 0,096), for HSP70 (p = 0,524), or any other sample characteristics (p > 0,05). Pain reduction during one week of observation showed to be significantly higher (p = 0,045, η2 = 0,013) for the PEMF group (PPT: +83 bis +139%) compared to the placebo group (PPT: +10 bis +36%). There were no HSP70 associated effects. CONCLUSIONS: A single bout of high energy PEMF led to an immediate pain relief in tendinopathy patients lasting at least for one week, but the hypothesized underlying HSP70 associated inflammatory pathway could not be confirmed.


Assuntos
Magnetoterapia , Tendinopatia , Humanos , Tendinopatia/terapia , Masculino , Feminino , Magnetoterapia/métodos , Adulto , Pessoa de Meia-Idade , Medição da Dor , Campos Eletromagnéticos , Resultado do Tratamento , Proteínas de Choque Térmico HSP70/metabolismo
19.
Scand J Med Sci Sports ; 34(8): e14712, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39118425

RESUMO

Patellar tendinopathy is more prevalent in males versus female athletes and commonly presents in the medial region of the tendon. Separate measures of patellar tendon strain in the medial, central, and lateral regions of the tendon, however, have not been quantified. The purpose was to investigate the differences in tendon strain between the medial, lateral, and central regions of the patellar tendon in healthy men and women. Strain in the medial and lateral regions of the patellar tendon in healthy participants (10 males, 10 females) was evaluated using ultrasound during isometric quadriceps contractions at 20%, 40%, 60%, 80%, and 100% of maximum voluntary contraction (MVIC) in 60° and 90° of knee flexion. Central strain was also measured at 60% MVIC in 90° of knee flexion. Mixed models were used to determine strain between tendon regions and sex at 60% MVIC in 90° of knee flexion. Sequential modeling was used to fit region, sex, %MVIC, and angle to predict strain. The central region had less strain compared with both medial and lateral regions. The lateral region had higher strain compared with the medial region regardless of sex. Females had higher strain compared with males, regardless of region. Knee position did not influence tendon strain. Patellar tendon strain differs by region and sex. The varying prevalence between sex and in location of patellar tendinopathy may in part be explained by the unbalanced strains. Differential assessment of regional patellar tendon strain may be of importance for understanding injury risk and recovery with exercise.


Assuntos
Ligamento Patelar , Tendinopatia , Ultrassonografia , Humanos , Ligamento Patelar/fisiologia , Ligamento Patelar/diagnóstico por imagem , Masculino , Feminino , Adulto , Adulto Jovem , Fatores Sexuais , Tendinopatia/diagnóstico por imagem , Tendinopatia/fisiopatologia , Músculo Quadríceps/fisiologia , Músculo Quadríceps/diagnóstico por imagem , Contração Isométrica/fisiologia , Fenômenos Biomecânicos
20.
Physiother Res Int ; 29(4): e2125, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39180299

RESUMO

BACKGROUND AND PURPOSE: Understanding physiotherapy practices is important to identify variations from empirical evidence and highlight requirements for training. This survey explored international physiotherapy practices for assessment of lateral elbow tendinopathy (LET). METHODS: Two hundred ninety-nine surveyed physiotherapists from eight member countries of the International Federation of Manual and Orthopaedic Physical Therapists completed the survey. Respondents rated their frequency of use (never, rarely, sometimes, often, and always) for items related to: patient history; diagnostic tests; grip and upper limb strength; cervical and neurological assessment; and medical imaging. To establish practices, the five response categories were dichotomised into routine practice (often, always) and not-routine practice (sometimes, rarely, never). A response rate of ≥70% for each dichotomy was used to determine whether an assessment item was deemed routine practice or not, with items not meeting either criterion considered neither routine nor not-routine practice. RESULTS: Most respondents were from United States (63%). The 'chair pick up test', 'cervical special tests', and 'plain radiograph' met our criteria for not routine practice (i.e., 70%, 72%, and 71%, respectively). All other assessment items did not meet the criteria to be considered routine or not-routine practice. CONCLUSION: The chair pick-up test, cervical spine special tests (e.g., Spurling's test), and plain radiography appear to not be routinely used in the assessment of LET. The finding that no assessment technique met the criteria for routine use may imply that physiotherapists adopt a nuanced approach to selecting clinical assessment items as opposed to routinely applying tests.


Assuntos
Modalidades de Fisioterapia , Humanos , Inquéritos e Questionários , Tendinopatia do Cotovelo/diagnóstico , Feminino , Masculino , Fisioterapeutas , Exame Físico , Cotovelo de Tenista/diagnóstico , Cotovelo de Tenista/reabilitação , Padrões de Prática Médica , Adulto , Tendinopatia/diagnóstico
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