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1.
BMC Infect Dis ; 24(1): 1036, 2024 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-39333883

RESUMO

We report the case of a young woman sough care for disseminated form of Yersinia enterocolitica infection (pseudoappendicitis with mesenteric lymph node, arthralgia, glomerulonephritis and hepatitis) diagnosed on Western Blot method for the detection of Yersinia antibodies. The patient also presented a rare concomitant cutaneous manifestation, as Sweet's syndrome, confirmed histologically. Neutrophilic dermatosis is an exceptional skin features among post-infectious autoimmune disorders when encountering Yersinia enterocolitica infection in clinical practice.


Assuntos
Síndrome de Sweet , Yersiniose , Yersinia enterocolitica , Humanos , Yersinia enterocolitica/isolamento & purificação , Feminino , Yersiniose/complicações , Yersiniose/microbiologia , Síndrome de Sweet/tratamento farmacológico , Síndrome de Sweet/patologia , Síndrome de Sweet/diagnóstico , Adulto , Anticorpos Antibacterianos/sangue
3.
Pediatr Infect Dis J ; 42(12): 1041-1044, 2023 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-37725804

RESUMO

BACKGROUND: Yersinia infection is known to present with Kawasaki disease (KD)-like symptoms although differentiating the 2 has been a challenge. The present study aimed to describe the clinical characteristics and prevalence of Yersinia infection presenting with KD-like symptoms. METHODS: The present, prospective, multicenter study enrolled patients who received a diagnosis of KD between January 2021 and January 2022 at 2 hospitals in Tokyo. Stool samples were collected within 3 days of the start of KD treatment, and cultures were performed for Yersinia . Clinical history and symptoms suggestive of Yersinia infection were also evaluated. RESULTS: During the study period, 141 KD patients were screened and 117 patients with evaluable stool samples were registered. Only 1 patient was positive for Yersinia pseudotuberculosis , which was detected from both stool and blood cultures. The patient was refractory to KD treatment but improved after initiation of appropriate antibiotic therapy. CONCLUSIONS: Routine screening for Yersinia is not appropriate for patients with KD and should be limited to certain patients in high-risk areas and those who are refractory to the standard KD treatment.


Assuntos
Síndrome de Linfonodos Mucocutâneos , Yersiniose , Infecções por Yersinia pseudotuberculosis , Yersinia pseudotuberculosis , Humanos , Síndrome de Linfonodos Mucocutâneos/complicações , Síndrome de Linfonodos Mucocutâneos/diagnóstico , Síndrome de Linfonodos Mucocutâneos/epidemiologia , Infecções por Yersinia pseudotuberculosis/complicações , Infecções por Yersinia pseudotuberculosis/diagnóstico , Infecções por Yersinia pseudotuberculosis/epidemiologia , Estudos Prospectivos , Yersiniose/complicações , Yersiniose/epidemiologia
4.
APMIS ; 131(6): 284-293, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-36932839

RESUMO

We investigated if diarrhoea-causing bacteria, including Yersinia species, could mimic the symptoms of appendicitis and lead to surgery. This prospective observational cohort study (NCT03349814) included adult patients undergoing surgery for suspected appendicitis. Rectal swabs were analysed with polymerase chain reaction (PCR) for Yersinia, Campylobacter, Salmonella, Shigella and Aeromonas spp. Blood samples were analysed routinely and with an in-house ELISA serological test for Yersinia enterocolitica antibodies. We compared patients without appendicitis and patients with appendicitis confirmed by histopathology. The outcomes included PCR-confirmed infection with Yersinia spp., serologic-confirmed infection with Y. enterocolitica, PCR-confirmed infection with other diarrhoea-causing bacteria and Enterobius vermicularis confirmed by histopathology. A total of 224 patients were included, 51 without and 173 with appendicitis, and followed for 10 days. PCR-confirmed infection with Yersinia spp. was found in one patient (2%) without appendicitis and no patients (0%) with appendicitis (p = 0.23). Serology was positive for Y. enterocolitica for the same patient without appendicitis and two patients with appendicitis (p = 0.54). Campylobacter spp. were detected in 4% vs 1% (p = 0.13) of patients without and with appendicitis, respectively. Infection with Yersinia spp. and other diarrhoea-causing microorganisms in adult patients undergoing surgery for suspected appendicitis was rare.


Assuntos
Apendicite , Laparoscopia , Yersiniose , Yersinia enterocolitica , Humanos , Adulto , Apendicite/diagnóstico , Apendicite/cirurgia , Apendicite/etiologia , Yersiniose/diagnóstico , Yersiniose/complicações , Yersiniose/microbiologia , Estudos Prospectivos , Diarreia/diagnóstico , Laparoscopia/efeitos adversos
5.
Intern Med ; 62(10): 1479-1485, 2023 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-36198596

RESUMO

We herein report a rare case of Yersinia enterocolitica enteritis with a fever and abdominal pain followed by erythema nodosum (EN) a few days later. The diagnosis was confirmed based on characteristic colonoscopy and computed tomography findings, pathology, and mucosal culture. Yersinia enteritis is a curable disease provided a proper diagnosis and treatment are performed. Although EN is a rare clinical course, it should still be considered as a differential diagnosis.


Assuntos
Enterite , Eritema Nodoso , Yersiniose , Yersinia enterocolitica , Humanos , Yersiniose/complicações , Yersiniose/diagnóstico , Eritema Nodoso/complicações , Eritema Nodoso/diagnóstico , Enterite/complicações , Enterite/diagnóstico , Diagnóstico Diferencial
6.
N Z Med J ; 135(1549): 113-116, 2022 02 04.
Artigo em Inglês | MEDLINE | ID: mdl-35728146

RESUMO

We report a case of myopericarditis associated with Yersinia enterocolitica infection in an otherwise well 50-year-old man. We discuss the clinical features, microbiology and treatment of this rare cause of myopericarditis.


Assuntos
Yersiniose , Yersinia enterocolitica , Humanos , Masculino , Pessoa de Meia-Idade , Nova Zelândia , Yersiniose/complicações , Yersiniose/diagnóstico , Yersiniose/tratamento farmacológico
7.
J Surg Res ; 270: 12-21, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34628159

RESUMO

BACKGROUND: Yersinia infection affects terminal ileum and lymph nodes and could therefore mimic the symptoms of appendicitis. We aimed to systematically characterise the suspected or confirmed abdominal diseases and/or surgeries associated with Yersinia infection. MATERIALS AND METHODS: This systematic review and meta-analysis was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A protocol (CRD42016053252) was uploaded to PROSPERO. The searches were conducted in PubMed and EMBASE on October 2, 2020. Original reports on patients with abdominal surgical diseases were included. The primary outcome was to characterise suspected or confirmed abdominal surgical diseases and/or surgeries associated with Yersinia infection, while the secondary outcomes were the positive rate of Yersinia species for each disease and surgery, and to investigate the rate of Yersinia spp. in different geographic regions. We calculated the weighted mean prevalence of positive tests for Yersinia spp. for the different diseases and surgeries according to the detection method and for subgroups based on geographic region. RESULTS: From the search, 33 studies were included in the systematic review and 18 in the meta-analysis. Across geographic regions, the weighted mean prevalence for Yersinia spp. was 51% (95% CI 34%-69%) in mesenteric lymphadenitis, 65% (95% CI 45%-85%) in terminal ileitis, and 8% (95% CI 2%-15%) in normal appendices. CONCLUSIONS: Around half of the patients with mesenteric lymphadenitis and terminal ileitis were serologically positive for infections with Yersinia spp. Yersinia infection may cause unnecessary surgery for suspected appendicitis due to symptoms from mesenteric lymphadenitis or terminal ileitis.


Assuntos
Apendicite , Apêndice , Doença de Crohn , Linfadenite Mesentérica , Yersiniose , Apendicite/complicações , Apendicite/diagnóstico , Apendicite/cirurgia , Apêndice/patologia , Doença de Crohn/complicações , Humanos , Linfadenite Mesentérica/diagnóstico , Linfadenite Mesentérica/etiologia , Linfadenite Mesentérica/patologia , Yersiniose/complicações , Yersiniose/diagnóstico , Yersiniose/epidemiologia
8.
BMJ Case Rep ; 14(7)2021 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-34230045

RESUMO

Yersinia enterocolitica is a Gram-negative bacterium that causes foodborne illnesses, typically characterised by acute febrile gastroenteritis and is associated with a variety of manifestations. Isolated febrile illness without gastrointestinal symptoms is rare. We report a case of Y. enterocolitica infection with severe anicteric hepatitis. A 33-year-old Chinese man with no significant medical history presented on multiple occasions to the emergency department with recurrent high-grade fever and chills, but without gastrointestinal symptoms. Hepatic panel showed rising transaminases that peaked at Aspartate Aminotransferase (AST) of 991 U/L and Alanine Aminotransferase (ALT) of 1664 U/L. CT of the abdomen revealed terminal ileitis and mesenteric adenitis. As part of workup, we found positive serology for Y. enterocolitica Ultimately, he improved with supportive care. This case highlights the importance of thorough workup of terminal ileitis and 'Crohn's mimics' which ultimately revealed a unifying diagnosis; and an important addition to the workup for undifferentiated severe isolated hepatocellular liver injury.


Assuntos
Doença de Crohn , Linfadenite Mesentérica , Yersiniose , Yersinia enterocolitica , Adulto , Humanos , Fígado , Masculino , Yersiniose/complicações , Yersiniose/diagnóstico
9.
BMC Infect Dis ; 21(1): 517, 2021 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-34078290

RESUMO

BACKGROUND: We report an unusual case of infective colitis by Yersinia enterocolitica complicated by microliver abscesses mimicking multiple liver metastases in a 79 yr old female without any risk factors for bacteriaemia by this pathogen. CASE PRESENTATION: The patient was admitted to the Internal Medicine with Stroke Care ward of University Policlinico "P. Giaccone" in Palermo because of the appearance of diarrhoea. After the antimicrobial treatment for infective colitis, the clinicians observed a persistently increased white blood cells (WBC) count and multiple hepatic lesions; after having excluded any neoplastic disease and inflammatory bowel disease (IBD), blood cultures positive for Y. enterocolitica allowed to establish the final diagnosis was infective micro liver abscesses consequent to infective colitis due to Y. enterocolitica, which were successfully treated with cefixime and doxycycline. CONCLUSIONS: This case report should make clinicians reflect on how complex the differential diagnosis between microliver abscesses and metastasis could be and the possibility of bacteriaemia by Y. enterocolitica even without iron overload conditions.


Assuntos
Colite/diagnóstico , Abscesso Hepático/diagnóstico , Neoplasias Hepáticas/diagnóstico , Yersiniose/diagnóstico , Yersinia enterocolitica/isolamento & purificação , Idoso , Antibacterianos/uso terapêutico , Bacteriemia/complicações , Bacteriemia/diagnóstico , Bacteriemia/tratamento farmacológico , Colite/complicações , Colite/tratamento farmacológico , Diagnóstico Diferencial , Feminino , Humanos , Abscesso Hepático/tratamento farmacológico , Abscesso Hepático/etiologia , Resultado do Tratamento , Yersiniose/complicações , Yersiniose/tratamento farmacológico
12.
J Immunol Res ; 2020: 7439506, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33274243

RESUMO

Yersinia enterocolitica O:3 is mentioned among the most common arthritogenic pathogens. Bacterial components (including lipopolysaccharide (LPS)) may persist in the joint after eradication of infection. Having an adjuvant activity, LPS may enhance production of anticollagen antibodies, involved in the pathogenesis of rheumatoid arthritis. Furthermore, its ability to activate complement contributes to the inflammation. The aim of this work was to investigate whether Yersinia LPS (coinjected with collagen) is associated with arthritis progression or other pathological effects and to elucidate the mechanism of this association. It was demonstrated that murine mannose-binding lectin C (MBL-C) recognizes the inner core heptoses of the Rd1 chemotype LPS of Yersinia. In addition, the Rd1 LPS activates the MBL-associated serine protease 1 (MASP-1) stronger than the S and Ra chemotype LPS and comparable to Klebsiella pneumoniae O:3 LPS. However, in contrast to the latter, Yersinia Rd1 LPS was associated neither with the adjuvancity nor with the enhancement of pathological changes in animal paws/impairment of motility. On the other hand, it seemed to be more hepatotoxic when compared with the other tested endotoxins, while the enlargement of inguinal lymph nodes and drop in hepatic MBL-C expression (at the mRNA level) were independent of LPS chemotype. Our data did not suggest no greater impact Y. enterocolitica O:3 on the development or severity of arthropathy related to anticollagen antibody-induced arthritis in mice, although its interaction with MBL-C and subsequent complement activation may contribute to some adverse effects.


Assuntos
Artrite Reumatoide/etiologia , Lipopolissacarídeos/farmacologia , Yersiniose/complicações , Yersiniose/imunologia , Yersinia enterocolitica/imunologia , Animais , Artrite Experimental , Artrite Reumatoide/metabolismo , Artrite Reumatoide/patologia , Autoimunidade , Biomarcadores , Colágeno/efeitos adversos , Colágeno/imunologia , Lectina de Ligação a Manose da Via do Complemento/imunologia , Suscetibilidade a Doenças , Masculino , Lectina de Ligação a Manose/metabolismo , Camundongos , Fenótipo , Ligação Proteica , RNA Mensageiro/genética , Yersiniose/microbiologia
14.
Pediatr Emerg Care ; 35(7): e118-e120, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31219970

RESUMO

Yersinia enterocolitica infection, or yersiniosis, is a common cause of gastroenteritis in developing nations, but the disease is less common in the developed world. Yersiniosis typically presents as a self-limited gastroenteritis in an immunocompetent patient and rarely progresses to the more fulminant disseminated form. Certain patient populations are at greater risk of disseminated disease, and providers caring for these patients should have heightened suspicion for invasive disease. Patients dependent on serial transfusion therapy, such as those with inherited hemoglobinopathies, often have chronically elevated serum iron levels. These patients are at increased risk of fulminant yersiniosis due to the bacteria's siderophilic nature. Yersinia infection can be devastating in these patients, and early intervention with empiric antibiotics combined with targeted resuscitation can be essential in their care. The following case illustrates the utility for heightened surveillance, early intervention, and guided resuscitation in the management of this at-risk population.


Assuntos
Transfusão de Eritrócitos/efeitos adversos , Yersiniose/complicações , Yersinia enterocolitica/isolamento & purificação , Talassemia beta/complicações , Bacteriemia/etiologia , Criança , Humanos , Masculino , Yersiniose/diagnóstico , Yersiniose/transmissão , Talassemia beta/terapia
15.
BMJ Case Rep ; 20182018 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-30323099

RESUMO

We present the case of a fit and well 12-year-old boy who presented with signs and symptoms suggestive of appendicitis. On laparoscopy, he was found to have a sinister-looking right iliac fossa mass with associated mesenteric lymphadenopathy. He proceeded to have an oncological right hemicolectomy, while the subsequent histology returned an unexpected result. The aim of this report is to highlight an unusual and complex clinical presentation in a young patient presenting with right iliac fossa pain.


Assuntos
Enterocolite/diagnóstico , Enterocolite/microbiologia , Granuloma/diagnóstico , Granuloma/microbiologia , Yersiniose/diagnóstico , Apendicite/diagnóstico , Criança , Diagnóstico Diferencial , Humanos , Masculino , Yersiniose/complicações , Yersinia enterocolitica/isolamento & purificação
16.
PLoS One ; 13(3): e0193573, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29494692

RESUMO

Dendritic cells (DCs) play critical functions in the initiation of immune responses. Understanding their role in reactive arthritis (ReA) will help delineate the pathogenesis of this arthropathy. In early studies, we detected IL-12/23p40 deregulation in Yersinia entercolitica (Ye)-induced ReA in TNFRp55-deficient (TNFRp55-/-) mice. In this study, we assessed the contribution of DCs in this overproduction. First, greater levels of IL-12/23p40, IFN-γand IL-17A were confirmed in supernatants of lipopolysaccharide (LPS)-stimulated TNFRp55-/-splenocytes obtained on arthritis onset (day 14 after Ye infection). Later, DCs were identified as a precise source of IL-12/23p40 since increased frequency of splenic IL-12/23p40+DCs was detected in TNFRp55-/- mice. After robust in vivo amplification of DCs by injection of Fms-like tyrosine kinase 3-Ligand (Flt3L)-transfected BL16 melanoma, DCs were purified. These cells recapitulated the higher production of IL-12/23p40 under TNFRp55deficiency. In agreement with these results, TNFRp55-/- DCs promoted Th1 and Th17 programs by co-culture with WT CD4+lymphocytes. A mechanistic study demonstrated that JNK and p38 MAPK pathways are involved in IL-12/23p40 overproduction in purified TNFRp55-/- DCs as well as in the JAWS II cell line. This deregulation was once again attributed to TNFRp55 deficiency since CAY10500, a specific inhibitor of this pathway, compromised TNF-mediated IL-12/23p40 control in LPS-stimulated WT DCs. Simultaneously, this inhibition reduced IL-10 production, suggesting its role mediating IL-12/23p40 regulation by TNFRp55 pathway. These results provide experimental data on the existence of a TNFRp55-mediated anti-inflammatory circuit in DCs. Moreover, these cells may be considered as a novel target in the treatment of ReA.


Assuntos
Artrite Reativa/imunologia , Células Dendríticas/imunologia , Subunidade p40 da Interleucina-12/metabolismo , Receptores Tipo I de Fatores de Necrose Tumoral/genética , Células Th1/citologia , Células Th17/citologia , Receptores Chamariz do Fator de Necrose Tumoral/genética , Yersiniose/complicações , Yersinia enterocolitica/imunologia , Animais , Artrite Reativa/patologia , Linhagem Celular , Polaridade Celular , Técnicas de Cocultura , Modelos Animais de Doenças , Humanos , Sistema de Sinalização das MAP Quinases , Camundongos , Camundongos Knockout , Proibitinas , Baço/imunologia , Yersiniose/imunologia
17.
Appl Health Econ Health Policy ; 16(2): 243-257, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29313242

RESUMO

OBJECTIVES: The main objective of this study was to derive cost estimates of five major foodborne illnesses (campylobacteriosis, salmonellosis, enterohemorrhagic Escherichia coli (EHEC), yersiniosis and shigellosis) in Sweden. These estimates provide a necessary contribution to perform future cost-benefit analyses aimed at reducing the burden of foodborne disease. A secondary aim was to obtain estimates of the true number of cases that occur in the community, thus providing necessary ground for calculating costs. METHODS: The true number of cases for each foodborne illness was simulated by multiplying the reported number of cases by sequential multipliers, one for each potential source of information loss about a case. This assessment of the true number of cases was then used to estimate the number of cases of sequelae for each illness. An incidence-based analysis was then used to calculate direct medical and non-medical costs, as well as indirect costs. Data for estimating the true number of cases for each illness were primarily based on an expert panel, while the derivation of costs mainly utilized national registries, databases and published literature. RESULTS: The estimated number of cases was between 7- and 11-fold higher than the reported number of cases, indicating the importance of taking information loss into account when calculating costs. By far the most common pathogen of the five was campylobacter, with an estimated 101,719 (90% credibility interval [CI] 59,640-158,025) human cases occurring annually. For salmonella, 19,678 (90% CI 8394-40,456) cases were estimated to occur each year, while the other three pathogens were less common, with a yearly incidence of approximately 2500-5500 cases each. The total cost for the five pathogens (including sequelae) amounted to €142 million annually. Campylobacter was the most costly pathogen, representing 69% of the total costs. Salmonellosis and EHEC constituted 18 and 9% of these costs, respectively, while yersiniosis and shigellosis represented approximately 2% each. Costs for sequelae were significant and accounted for approximately 50% of the total costs. CONCLUSIONS: Our simulations indicated that campylobacter infection was more common and more costly than salmonella, EHEC, yersinia and shigella combined. Estimated costs for all illnesses were highly influenced by (1) considering potential information losses about cases in the population (which increased costs 7- to 11-fold), and (2) taking account of post-infection sequelae (which doubled the costs).


Assuntos
Efeitos Psicossociais da Doença , Doenças Transmitidas por Alimentos/economia , Infecções por Campylobacter/complicações , Infecções por Campylobacter/economia , Infecções por Campylobacter/epidemiologia , Disenteria Bacilar/complicações , Disenteria Bacilar/economia , Disenteria Bacilar/epidemiologia , Infecções por Escherichia coli/complicações , Infecções por Escherichia coli/economia , Infecções por Escherichia coli/epidemiologia , Feminino , Doenças Transmitidas por Alimentos/complicações , Doenças Transmitidas por Alimentos/epidemiologia , Custos de Cuidados de Saúde/estatística & dados numéricos , Humanos , Incidência , Masculino , Modelos Econômicos , Intoxicação Alimentar por Salmonella/complicações , Intoxicação Alimentar por Salmonella/economia , Intoxicação Alimentar por Salmonella/epidemiologia , Suécia/epidemiologia , Yersiniose/complicações , Yersiniose/economia , Yersiniose/epidemiologia
18.
Wiad Lek ; 70(3 pt 1): 520-522, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28711901

RESUMO

Current issue deals with an interesting clinical case of a rare infectious disease in a Caucasian young male patient, caused by Yersinia enterocоlitica. Infection proceeded in the development of secondary focal form, which was accompanied by prolonged polyarthritis. We described a clinical case of secondary focal form with prolonged polyarthritis caused by Y. enterocolitica O:3 serogroup in young patient with the purpose of focusing on the early clinical and laboratory diagnosistics of Yersiniosis that would minimize the role of medical errors in diagnostics made by general practitioners. This case deserves the attention of internal medicine specialists, physicians of the specialty ≪general practitioners≫, rheumatologists, infectious disease specialists taking into consideration the clinics and immunopathogenesis, as well as a high evidence of a prolonged clinical course and chronicity of this disease. It has accented on the feasibility of early serological diagnostics and etiotropic antibiotic therapy of the disease.


Assuntos
Artrite/etiologia , Yersiniose/complicações , Yersinia enterocolitica , Artrite/microbiologia , Artrite/patologia , Humanos , Masculino , Yersiniose/diagnóstico , Yersiniose/patologia , Adulto Jovem
19.
Intern Med ; 56(10): 1239-1242, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28502944

RESUMO

We report a case of reactive arthritis (ReA) triggered by Yersinia enterocolitica enteritis. A 24-year-old Japanese man developed polyarthritis in the lower limbs. Two weeks prior to these symptoms, he noted diarrhea, right lower abdominal pain and a fever. Y. enterocolitica was not isolated from a stool culture; however, he was diagnosed with ReA based on the colonoscopic findings of a high anti-Y. enterocolitica antibody titer and HLA-B27 antigen positivity. Following treatment with methotrexate and steroids, his arthritis improved. This is the first reported Japanese case of ReA in the English literature after a gastrointestinal infection caused by Y. enterocolitica.


Assuntos
Antirreumáticos/uso terapêutico , Artrite Reativa/tratamento farmacológico , Artrite Reativa/etiologia , Metotrexato/uso terapêutico , Esteroides/uso terapêutico , Yersiniose/complicações , Adulto , Povo Asiático , Gastroenteropatias/complicações , Gastroenteropatias/tratamento farmacológico , Humanos , Masculino , Proibitinas , Resultado do Tratamento , Yersinia enterocolitica/efeitos dos fármacos , Adulto Jovem
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