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1.
Sci Total Environ ; 803: 150084, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-34500274

RESUMO

Currently, the environmental and ecological damage caused by As(V) and Sb(V) co-contamination has attracted widespread attention worldwide. Due to the similar intrinsic structure configuration and electrostatic repulsion of As(V) and Sb(V), the long-standing issue of their low co-removal capacity remains unresolved. In this study, novel Fe-Cu (FC) binary materials with varied Fe/Cu proportions were synthesized via a simple co-precipitation method to co-eliminate aquatic As(V) and Sb(V). A 2/1 ratio of Fe/Cu was determined to be a suitable proportion with a higher co-adsorption capacity, specifically 70.9 mg·g-1 for As(V) and 94.3 mg·g-1 for Sb(V). Detailed morphological and structural analyses indicated that the FC material gradually changed from microscale aggregates to nanoscale spheres with increasing Cu content, accompanied by an increasing crystalline degree and higher surface area. Additionally, the transformation of amorphous ferrihydrite (FO) into FeO(OH) was suppressed by Fe-Cu complexion during the co-adsorption process, in which ferrihydrite (FO) had more adsorption sites than FeO(OH). In addition, the addition of Cu promoted the pHpzc of FC materials from the acidic range into the neutral or alkaline range. The increased potential difference of FC materials accelerated the As(V) and Sb(V) diffusion rate and effectively offset native electrostatic repulsion, which exhibited a considerable effect than the adsorption sites. Through detailed kinetic data analysis, it was determined that the proportion of the diffusion layer thickness around Sb(V) was suppressed to the As(V) level, and the adsorption kinetics of the two species were both promoted by the self-driven force field. All the results indicated that the co-adsorption capacity depended on the coupling contribution of Fe and Cu, where Fe oxide acted as the major adsorption potential and Cu provided a self-driven force for As(V) and Sb(V) diffusion. This study may provide a novel prospective for homogeneous metal ion co-removal.


Assuntos
Óxidos , Poluentes Químicos da Água , Adsorção , Antimônio , Cobre , Concentração de Íons de Hidrogênio , Estudos Prospectivos , Água
2.
Food Chem ; 370: 130933, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-34507211

RESUMO

Cyanidin-3-glucoside (C3G), an anthocyanin constituent of fruits and vegetables. It has been proven to possess numerous health benefits with no side effects. However, the poor stability of C3G is an intractable property that limits its application. Hence, the aim of this study is to improve the stability of C3G through the formation of well dispersed nanoparticles. In this study, C3G loaded ß-CD-EP-CMC nanoparticles exhibited nearly spherical with good disperse and homogeneous morphology. Results also indicated that the nanoparticles formation of grafting of C3G to ß-CD-EP-CMC could significantly improve the stability of C3G to against thermal or light degradation. Collectively, current results strongly aligned with the prospective purpose that the grafting of C3G to ß-CD-EP-CMC nanoparticles could be treated as an effective approach for improving the stability. This study opens a new avenue for the utilization and development of novel wall materials ß-CD-EP-CMC in C3G associated nutraceutical.


Assuntos
Quitosana , beta-Ciclodextrinas , Antocianinas , Epicloroidrina , Estudos Prospectivos
3.
Sci Total Environ ; 803: 150104, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-34525736

RESUMO

China has pledged to achieve peak carbon emissions by 2030 and to be carbon neutral by the mid-century, and buildings will be the "last mile" sector in the transition to carbon neutrality. To help buildings hit the carbon peak goal, we investigate the different emission scales of carbon emission changes of residential and commercial building operations across 30 provinces in China through the carbon Kuznets curve (CKC) model. We observe that (1) more than three-quarters of the samples can be fitted by the CKC model. Most CKCs are the inverted U-shaped, residential and commercial buildings occupying 93% and 90% at the total emission scale, respectively. In addition, the remains can be illustrated as N-shaped curves. (2) Under the premise of CKCs existence, approximately half of the provincial residential and commercial buildings peak at different emission scales, except for emission per floor space (residential: 89%; commercial: 81%). Provinces with better economic development have a higher peaking probability. In the total emissions, the peaking probability in residential buildings is 33% and 50% for provinces with economic indicators <20,000 Chinese Yuan and 30,000-40,000 Chinese Yuan, respectively, and 22% and 67% for commercial buildings, respectively. (3) Taking carbon intensity as a case study, decoupling analysis examines the robustness of the CKC estimation. Overall, we close the gap of the CKC estimation in commercial and residential buildings, and the proposed methods can be treated as a tool for other economies to illustrate the retrospective and prospective trajectories of carbon emissions in building operations.


Assuntos
Dióxido de Carbono , Carbono , Carbono/análise , Dióxido de Carbono/análise , China , Desenvolvimento Econômico , Estudos Prospectivos , Estudos Retrospectivos
4.
J Colloid Interface Sci ; 607(Pt 1): 729-741, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34536933

RESUMO

Multi component reactions over heterogeneous solid acid catalysts are extremely important owing to easy separation, amenable recycling, and prospective scaling up of the process. Here, we are reporting the synthesis of biologically important dihydropyrimidinones over postsynthetic modified Cr-based metal-organic framework materials as heterogeneous catalysts containing the bifunctional Lewis and Brønsted acid sites. Cr-based metal-organic frameworks contained coordinatively unsaturated metal sites as inherent Lewis acid sites, whereas postsynthetic modifications introduced the Brønsted acid sites in the framework. A direct one pot synthesis route was employed to produce the pristine MOF in pure aqueous medium without using any additives. The bulk structure, morphology, surface and bonding properties of the synthesized materials were thoroughly characterized with powder XRD, FTIR, XPS, FE-SEM, TGA, and N2 sorption isotherms. A qualitative evolution of acid strength was carried out over the functionalized MOFs. Among the post synthetic functionalized materials, carboxylic acid functionalized framework exhibited a very high yield of dihydropyrimidinones under solvent less moderate reaction conditions. The catalyst also demonstrated a robust recyclability and wide substrate scope. Comparative study showed a very high catalytic activity of the postsynthetic modified MOFs in comparison to the reported literature. The reaction condition was optimized by varying parameters like solvent, temperature, reaction duration and catalyst loadings. The mechanistic studies indicated the involvement of both the Lewis and Brønsted sites acid sites of the catalysts in the multicomponent reaction.


Assuntos
Estruturas Metalorgânicas , Catálise , Metais , Estudos Prospectivos , Solventes
5.
J Colloid Interface Sci ; 607(Pt 1): 848-856, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34536939

RESUMO

HYPOTHESIS: Cubosomes made from the inverse micellar cubic mesophase (I2) with Fd3m symmetry possess a unique structure of closely packed inverse micelles. These have prospective functionality in sustained drug release. In this study, we hypothesised that similar to fatty acids, various fatty acetate compounds can induce the formation of micellar Fd3m cubosomes in monoolein (MO) nanoparticles. They are different to micellar cubosomes made of MO and a fatty acid, which are pH responsive and can transition from an Fd3m phase to an inverse hexagonal phase (H2) as pH increases. We hypothesised that by co-doping a fatty acetate and fatty acid into MO, precise control of the Fd3m-H2 phase transition pH in nanoparticles can be achieved. EXPERIMENTS: Five unsaturated fatty acetates with hydrocarbon chain lengths between 18 and 24 were added to MO at a weight ratio of 0.45 - 0.60 to form nanoparticles. The nanoparticles were prepared using high-throughput formulation and characterised with synchrotron small angle X-ray scattering (SAXS). MO nanoparticles doped with vaccenyl acetate and vaccenic acid were used to demonstrate the fine control over Fd3m-H2 phase transition pH. FINDINGS: Micellar cubosomes (Fd3m phase) were found in MO nanoparticles doped with fatty acetates. The Fd3m structure was stable in a wide pH range of 2.6 - 8 and at temperatures up to 45 °C. In MO nanoparticles doped with the acetate/acid mixture, the Fd3m-H2 phase transition pH was tuned between pH 5 and pH 7 by adjusting the ratio of vaccenyl acetate and vaccenic acid. As a H2 phase generally offers faster drug release than an Fd3m phase, the pH responsive lipid nanoparticles developed here may find application in orally administrated formulation, where the vehicles must pass a low pH environment in the stomach before reaching neutral pH in the blood.


Assuntos
Cristais Líquidos , Nanopartículas , Acetatos , Ácidos Graxos , Glicerídeos , Concentração de Íons de Hidrogênio , Micelas , Estudos Prospectivos , Espalhamento a Baixo Ângulo , Difração de Raios X
6.
J Affect Disord ; 296: 35-40, 2022 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-34587547

RESUMO

BACKGROUND: The COVID-19 pandemic has led to significant mental health consequences for frontline health care workers (FHCWs). However, no known study has examined the prevalence, determinants, or correlates of posttraumatic growth (PTG) in this population. METHODS: Data were analyzed from a prospective cohort of FHCWs at an urban tertiary care hospital in New York City (NYC). Assessments were conducted during the spring 2020 pandemic peak (Wave 1) and seven months later (Wave 2). Multivariable logistic regression analyses were conducted to identify Wave 1 sociodemographic, occupational, and psychosocial factors associated with PTG at Wave 2, and the association between aspects of PTG with burnout and pandemic-related PTSD symptoms at Wave 2. RESULTS: A total 76.8% of FHCWs endorsed moderate or greater PTG; the most prevalent domains were increased appreciation of life (67.0%), improved relationships (48.7%), and greater personal strength (44.1%). Non-White race/ethnicity, greater levels of positive emotions, pandemic-related PTSD symptoms, dispositional gratitude, and feelings of inspiration were independently associated with PTG. At Wave 2, endorsement of spiritual growth during the pandemic was associated with 52% and 44% lower odds of screening positive for pandemic-related PTSD symptoms and burnout, respectively; greater improvement in relationships was associated with 36% lower odds of screening positive for burnout. LIMITATIONS: Single institution study and use of self-report instruments. CONCLUSIONS: Nearly 4-of-5 FHCWs report pandemic-related PTG, driven largely by salutogenic factors assessed during the pandemic surge. Interventions to bolster these factors may help promote PTG and mitigate risk for burnout and pandemic-related PTSD symptoms in this population.


Assuntos
COVID-19 , Crescimento Psicológico Pós-Traumático , Transtornos de Estresse Pós-Traumáticos , Pessoal de Saúde , Humanos , Pandemias , Estudos Prospectivos , SARS-CoV-2 , Transtornos de Estresse Pós-Traumáticos/epidemiologia
7.
Chemosphere ; 286(Pt 2): 131710, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34343918

RESUMO

Covalent organic frameworks (COFs) are an emergent group of crystalline porous materials that have gained incredible interest in recent years. With foreseeable controllable functionalities and structural configurations, the constructions and catalytic properties of these organic polymeric materials can be controlled to fabricate targeted materials. The specified monomer linkers and pre-designed architecture of COFs facilitate the post-synthetic modifications for introducing novel functions and useful properties. By virtue of inherent porosity, robust framework, well-ordered geometry, functionality, higher stability, and amenability to functionalization, COFs and COFs-based composites are regarded as prospective nanomaterials for environmental clean-up and remediation. This report spotlights the state-of-the-art advances and progress in COFs-based materials to efficiently mitigate pharmaceutical-based environmental pollutants from aqueous solutions. Synthesis approaches, structure, functionalization, and sustainability aspects of COFs are discussed. Moreover, the adsorptive and photocatalytic potential of COFs and their derived nanocomposites for removal and degradation of pharmaceuticals are thoroughly vetted. In addition to deciphering adsorption mechanism/isotherms, the stability, regeneratability and reproducibility are also delineated. Lastly, the outcomes are summed up, and new directions are proposed to widen the promise of COF-based smart materials in diverse fields.


Assuntos
Poluentes Ambientais , Estruturas Metalorgânicas , Preparações Farmacêuticas , Materiais Inteligentes , Estudos Prospectivos , Reprodutibilidade dos Testes
8.
Chemosphere ; 286(Pt 2): 131761, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34375828

RESUMO

The current method of agriculture entails the usage of excessive amounts of pesticides and fertilizers. The blatant use of conventional pesticides and fertilizers over several decades has led to their bioaccumulation with adverse effects on soil biodiversity and the development of resistance by pests. With the decline in clinically useful antibiotics and increase in multi drug resistant microbes, it is imperative to develop new and effective antimicrobial therapies. Growing awareness and demand for efficacious biorational pesticides are on the rise. Silver nanoparticles are widely known antimicrobials and have been in use for several purposes for a long time. This work reviews the implications of applying silver nanoparticles in agriculture and their possible consequences. The physiological and biochemical changes in plants due to the uptake of silver nanoparticles as a consequence of its morphology, capping biomolecules and method of application are comprehensively discussed in this review article. Studies on tolerance levels or stress due to silver nanoparticles by variation in concentration/doses on diverse flora and fauna are also analyzed here. Further, phytotoxicity and genotoxicity due to the metal as well as its transformation in soil, water and sludge are taken into account. We also gauge the potential of biogenic silver nanoparticles-viable antimicrobial agents for enhanced applications in agriculture as biopesticides.


Assuntos
Nanopartículas Metálicas , Prata , Agentes de Controle Biológico , Fertilizantes , Nanopartículas Metálicas/toxicidade , Estudos Prospectivos , Prata/toxicidade
9.
Chemosphere ; 286(Pt 2): 131809, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34388877

RESUMO

BACKGROUND: Humans are regularly exposed to metals and metalloids present in air, water, food, soil and domestic materials. Most of them can cross the placental barrier and cause adverse impacts on the developing foetus. OBJECTIVES: To describe the prenatal concentrations of metals and metalloids and to study the associated sociodemographic, environmental and dietary factors in pregnant Spanish women. METHODS: Subjects were 1346 pregnant women of the INMA Project, for whom the following metals arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), thallium (Tl) and zinc (Zn) were determined in urine, at both the first and the third trimesters of gestation. Sociodemographic, dietary and environmental information was collected through questionnaires during pregnancy. Multiple linear mixed models were built in order to study the association between each metal and metalloid concentrations and the sociodemographic, environmental and dietary factors. RESULTS: The most detected compounds were As, Co, Mo, Sb, Se and Zn at both trimesters. Zn was the element found in the highest concentrations at both trimesters and Tl was detected in the lowest concentrations. We observed significant associations between As, Cd, Cu, Sb, Tl and Zn concentrations and working situation, social class and age. Seafood, meat, fruits, nuts, vegetables and alcohol intake affected the levels of all the metals but Cd and Cu. Proximity to industrial areas, fields and air pollution were related to all metals except Cd, Sb and Se. CONCLUSIONS: This is the first large prospective longitudinal study on the exposure to metals and metalloids during pregnancy and associated factors to include several cohorts in Spain. The present study shows that some modifiable lifestyles, food intakes and environmental factors could be associated with prenatal exposure to metal(loid)s, which may be considered in further studies to assess their relationship with neonatal health outcomes.


Assuntos
Metaloides , Metais Pesados , Monitoramento Ambiental , Feminino , Humanos , Recém-Nascido , Estudos Longitudinais , Metaloides/análise , Metais Pesados/análise , Placenta/química , Gravidez , Gestantes , Estudos Prospectivos , Espanha
10.
Clin Imaging ; 81: 15-23, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34597999

RESUMO

OBJECTIVE: To explore the value of amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI) for differential diagnosis of fibroadenomas and malignant breast tumors. MATERIALS AND METHODS: This prospective study enrolled 56 patients with suspected breast tumors and performed APTw imaging. Based on the histopathology results, patients were divided into group 1 with malignant breast tumors (n = 41) and group 2 with fibroadenomas (n = 15). The measured image parameters (APTw value, ADC value, type of Time of Intensity Curve, maximum tumor diameter in image) and the maximal diameter of the tumors measured from surgical resection were compared between the two groups, and the diagnostic performance based on these parameters was quantified with ROC curve. Spearman's correlation coefficient was used to analyze the association between APTw or ADC values and ER, PR, HER2, and Ki-67 expressions. RESULTS: The intraclass correlation coefficients (ICC = 0.87 and 0.91) indicated a good inter-observer agreement of the measured APTw values. APTw values of malignant lesions were significantly higher than those of fibroadenomas (3.21 ± 1.04% vs 1.50 ± 0.54%, p < 0.001). Area under the curve (AUC) obtained from APTw imaging, DWI, DCE, APTw imaging+DWI, APTw imaging+DWI, and APTw imaging+DWI + DCE was 0.959, 0.897, 0.976, 0.997, and 1 respectively. The APTw value showed a negative correlation with ER expression (r = -0.357). CONCLUSION: APTw imaging yielded similar diagnosis performance in discriminating fibroadenomas and malignant breast tumors when compared to the DCE and better than DWI imaging, and provided supplement information on tumor cell activity to DWI images. The APTw value showed correlations with some prognostic factors for breast cancer.


Assuntos
Neoplasias da Mama , Fibroadenoma , Amidas , Neoplasias da Mama/diagnóstico por imagem , Diferenciação Celular , Imagem de Difusão por Ressonância Magnética , Feminino , Fibroadenoma/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Estudos Prospectivos , Prótons
11.
Clin Imaging ; 81: 87-91, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34655997

RESUMO

OBJECTIVE: To investigate how patients experience a radiologist-patient consultation of imaging findings directly after neck ultrasonography (US), and how much time this consumes. MATERIALS AND METHODS: This prospective randomized study included 109 consecutive patients who underwent neck US, of whom 44 had a radiologist-patient consultation of US results directly after the examination, and 65 who had not. RESULTS: The median ratings of all healthcare quality metrics (friendliness of the radiologist, explanation of the radiologist, skill of the radiologist, radiologist's concern for comfort during the examination, radiologist's concern for patient questions/worries, overall rating of the examination, and likelihood of recommending the examination) were either good/high or very good/very high, without any significant differences between both patient groups. Patients who did not discuss the US results with the radiologist, were significantly more worried during the examination (P = 0.040) and had significantly higher anxiety levels after completion of the US examination (P = 0.027) than patients who discussed the US results with the radiologist. Fifty-one out of 55 responding patients (92.7%) indicated a radiologist-patient consultation of US results to be important. The median duration of US examinations that included a radiologist-patient consultation of US results was 7.57 min (range: 5.15-12.10 min), while the median duration of US examinations without a radiologist-patient consultation of US results was 7.34 min (range: 3.45-14.32 min), without any significant difference (P = 0.637). CONCLUSION: A radiologist-patient consultation of imaging findings after neck US decreases patient anxiety, is desired by most patients, and does not significantly prolong total examination time.


Assuntos
Radiologia , Humanos , Estudos Prospectivos , Radiologistas , Encaminhamento e Consulta , Ultrassonografia
12.
J Med Virol ; 94(1): 404-406, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34460125

RESUMO

The presence of a complex immune dysregulation syndrome has been established in COVID-19 patients. We aimed to assess Th1/Th2 response in COVID-19 patients and its association with disease severity by performing a prospective cohort study in a tertiary hospital COVID-19 referral center. We report no difference between Th1/Th2 responses between patients with severe and mild disease, except for levels of interleukin-6 (IL-6) and IL-10. Future larger studies should examine lung-specific versus systemic inflammatory responses, as well as, diverse immunotypes driving poor clinical outcomes.


Assuntos
COVID-19/imunologia , Interleucina-10/sangue , Interleucina-6/sangue , SARS-CoV-2/imunologia , Células Th1/imunologia , Células Th2/imunologia , Feminino , Grécia , Humanos , Inflamação/patologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Índice de Gravidade de Doença
13.
J Med Virol ; 94(1): 279-286, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34468990

RESUMO

Vaccines have been seen as the most important solution for ending the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study is to evaluate the antibody levels after inactivated virus vaccination. We included 148 healthcare workers (74 with prior COVID-19 infection and 74 with not). They received two doses of inactivated virus vaccine (CoronaVac). Serum samples were prospectively collected three times (Days 0, 28, 56). We measured SARS-CoV-2 IgGsp antibodies quantitatively and neutralizing antibodies. After the first dose, antibody responses did not develop in 64.8% of the participants without prior COVID-19 infection. All participants had developed antibody responses after the second dose. We observed that IgGsp antibody titers elicited by a single vaccine dose in participants with prior COVID-19 infection were higher than after two doses of vaccine in participants without prior infection (geometric mean titer: 898 and 607 AU/ml). IgGsp antibodies, participants with prior COVID-19 infection had higher antibody levels as geometric mean titers at all time points (p < 0.001). We also found a positive correlation between IgGsp antibody titers and neutralizing capacity (rs = 0.697, p < 0.001). Although people without prior COVID-19 infection should complete their vaccination protocol, the adequacy of a single dose of vaccine is still in question for individuals with prior COVID-19. New methods are needed to measure the duration of protection of vaccines and their effectiveness against variants as the world is vaccinated. We believe quantitative IgGsp values may reflect the neutralization capacity of some vaccines.


Assuntos
Anticorpos Neutralizantes/sangue , Anticorpos Antivirais/sangue , Vacinas contra COVID-19/imunologia , Imunogenicidade da Vacina/imunologia , SARS-CoV-2/imunologia , Vacinas de Produtos Inativados/imunologia , Adulto , COVID-19/imunologia , COVID-19/prevenção & controle , Comorbidade , Feminino , Pessoal de Saúde/estatística & dados numéricos , Humanos , Imunização Secundária , Imunoglobulina G/sangue , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Vacinação , Adulto Jovem
14.
J Med Virol ; 94(1): 407-412, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34491572

RESUMO

The ChAdOx1 nCoV-19 vaccine (Oxford University-Astra Zeneca) has demonstrated nearly 70% efficacy against symptomatic COVID-19 in trials and some real-world studies. The vaccine was the first to be approved in India in early January 2021 and is manufactured by the Serum Institute of India. Favorable short-term safety data of the vaccine in India in a real-world setting has been recently demonstrated. Here, we report secondary objective (COVID-19 occurrence) measures of the same ongoing prospective observational study in prioritized recipients of the vaccine. The findings are based on participants who could complete at least 2 months of follow-up (n = 1500; female/male: 472/1028; mean age: 38.8 years). Laboratory confirmed SARS-CoV-2 infection was observed in 27/65 participants (41%) who received a single dose and 271/1435 (19%) who received both doses. Specifically, among doctors, 18/27 (66.7%) one dose recipients and 131/377 (34.7%) fully vaccinated developed SARS-CoV-2 infection. The majority of the cases were mild in all groups, and most were breakthrough infections. The occurrence of "severe" COVID-19 was 7.7 times lower (0.4%) in fully vaccinated participants compared to partially vaccinated (3.1%). Four deaths were observed in the study. One of the four deaths was due to sepsis, two due to unspecified cardiac events, and one due to unspecified post-COVID-19 complications. The results of this preliminary analysis necessitate vigorous research on the performance of vaccines against variants, optimal timing of vaccination, and also optimal timings of effectiveness studies to guide future vaccination policy.


Assuntos
Vacinas contra COVID-19/imunologia , COVID-19/prevenção & controle , Imunogenicidade da Vacina/imunologia , SARS-CoV-2/imunologia , Adulto , COVID-19/epidemiologia , COVID-19/mortalidade , Comorbidade , Feminino , Humanos , Imunização Secundária/estatística & dados numéricos , Índia/epidemiologia , Masculino , Estudos Prospectivos , Índice de Gravidade de Doença , Vacinação
15.
J Med Virol ; 94(1): 303-309, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34491594

RESUMO

Emerging evidence shows co-infection with atypical bacteria in coronavirus disease 2019 (COVID-19) patients. Respiratory illness caused by atypical bacteria such as Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila may show overlapping manifestations and imaging features with COVID-19 causing clinical and laboratory diagnostic issues. We conducted a prospective study to identify co-infections with SARS-CoV-2 and atypical bacteria in an Indian tertiary hospital. From June 2020 to January 2021, a total of 194 patients with laboratory-confirmed COVID-19 were also tested for atypical bacterial pathogens. For diagnosing M. pneumoniae, a real-time polymerase chain reaction (PCR) assay and serology (IgM ELISA) were performed. C. pneumoniae diagnosis was made based on IgM serology. L. pneumophila diagnosis was based on PCR or urinary antigen testing. Clinical and epidemiological features of SARS-CoV-2 and atypical bacteria-positive and -negative patient groups were compared. Of the 194 patients admitted with COVID-19, 17 (8.8%) were also diagnosed with M. pneumoniae (n = 10) or C. pneumoniae infection (n = 7). Confusion, headache, and bilateral infiltrate were found more frequently in the SARS CoV-2 and atypical bacteria co-infection group. Patients in the M. pneumoniae or C. pneumoniae co-infection group were more likely to develop ARDS, required ventilatory support, had a longer hospital length of stay, and higher fatality rate compared to patients with only SARS-CoV-2. Our report highlights co-infection with bacteria causing atypical pneumonia should be considered in patients with SARS-CoV-2 depending on the clinical context. Timely identification of co-existing pathogens can provide pathogen-targeted treatment and prevent fatal outcomes of patients infected with SARS-CoV-2 during the current pandemic.


Assuntos
Formas Bacterianas Atípicas/isolamento & purificação , COVID-19/patologia , Infecções por Chlamydophila/epidemiologia , Coinfecção/epidemiologia , Doença dos Legionários/epidemiologia , Pneumonia por Mycoplasma/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Chlamydophila pneumoniae/isolamento & purificação , Feminino , Humanos , Índia , Legionella pneumophila/isolamento & purificação , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Mycoplasma pneumoniae/isolamento & purificação , Estudos Prospectivos , SARS-CoV-2 , Índice de Gravidade de Doença , Adulto Jovem
16.
Pain Manag ; 12(1): 75-85, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34289734

RESUMO

Aim: Chronic postsurgical pain (CPSP) is a common complication of surgery. This study was conducted to evaluate the efficacy and safety of paresthesia-free, 10-kHz spinal cord stimulation (SCS) as a treatment for CPSP. Patients & methods: Subjects in this prospective, single-arm study had an average pain intensity of ≥5 cm on a 10-cm visual analog scale. The subjects who had pain relief of ≥50% (response) with temporary trial stimulation were permanently implanted with 10-kHz SCS and assessed for 1 year. Results: At 12 months, 94% of subjects were responders to 10-kHz SCS, and 88% had pain remission (visual analog scale ≤2.5 cm). Conclusion: The pain relief was durable in CPSP subjects and the safety profile of 10-kHz SCS was as expected. Clinical Trial registration number: VT005076953 (Privacy Commission of Belgium).


Assuntos
Dor Crônica , Neuralgia , Estimulação da Medula Espinal , Bélgica , Dor Crônica/terapia , Humanos , Neuralgia/etiologia , Neuralgia/terapia , Dor Pós-Operatória/terapia , Estudos Prospectivos , Medula Espinal , Resultado do Tratamento
17.
Pain Manag ; 12(1): 35-43, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34551581

RESUMO

Aim: This study evaluated use of liposomal bupivacaine (LB) versus standard bupivacaine (SB) alone in quadratus lumborum (QL) blocks for laparoscopic colorectal surgery. Materials & methods: In this prospective, randomized controlled trial, patients received QL1 blocks with either LB (40 ml 0.125% SB plus 20 ml of LB) or SB (60 ml of 0.25% SB) with 30 ml per side. Opioid usage, pain scores, side effects and other medications were recorded. Results: For 78 patients (38 LB; 40 SB), all parameters were similar between groups, except that the LB group had a higher 48 h need for metoclopramide. Conclusion: LB provided no analgesic benefit over SB alone for QL blocks. Clinical Trials registration number: NCT03702621.


Assuntos
Bupivacaína , Cirurgia Colorretal , Analgésicos Opioides , Anestésicos Locais , Humanos , Dor Pós-Operatória/tratamento farmacológico , Dor Pós-Operatória/prevenção & controle , Estudos Prospectivos
18.
Otolaryngol Clin North Am ; 55(1): 125-135, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34823711

RESUMO

The days of making a first impression when you meet your patients in person are numbered. Rather, in today's digital age, your prospective patients have likely already formed opinions about you and your practice before they meet you. And these opinions are largely influenced by the information they discover about you online. While you cannot completely control your personal brand or reputation as a physician, you can certainly try by controlling your online narrative: communicate your expertise and your value by effectively using social media, by regularly updating your practice website, and by proactively managing patient satisfaction reflected on physician rating websites. Set yourself apart in a competitive market today by building a strong digital presence.


Assuntos
Satisfação do Paciente , Satisfação Pessoal , Humanos , Marketing , Avaliação de Resultados da Assistência ao Paciente , Estudos Prospectivos
19.
Chemosphere ; 287(Pt 1): 132056, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34481172

RESUMO

Recent findings indicate that plant-root exudates can stimulate plant-associated microorganisms to enhance the biodegradation of contaminants in constructed wetlands. To understand this process, we studied the root-exudation changes of two aquatic plants (Lemna minor and Salvinia natans) upon micropollutants exposure (10, 100 and 1000 µg/L mixes containing naproxen, diclofenac, carbamazepine, and benzotriazole). After a 2-day exposure, plant exudates were collected, extracted and non-target analysis was performed with a gas chromatography-high resolution Orbitrap mass-spectrometer. Plants didn't show morphological or growth differences between the control and spiked reactors, but exudation changes were observed in both plants at all concentration levels. Partial least squares discriminant analysis showed that, for Lemna minor, the increase of micropollutants exposure was linked to the reduction of sugar and fatty acid exudation. This may trigger changes in the microbial community living on complex carbon forms. Instead, in Salvinia natans, micropollutants exposure was linked to the release of long-chain compounds such as cuticular waxes and sesquiterpenoids, which might be related to stress signaling. These results demonstrate that plant micropollutant-exposure at environmentally relevant concentration levels triggers changes in root exudates. This may help to design new strategies to enhance micropollutants degradation in nature based solutions such as in constructed wetlands.


Assuntos
Araceae , Traqueófitas , Exsudatos e Transudatos , Raízes de Plantas , Estudos Prospectivos , Áreas Alagadas
20.
Food Chem ; 372: 131151, 2022 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-34601422

RESUMO

Chloropycean microalgae are looked up as a prospective alternate source for the production of xanthophyll carotenoid lutein. Despite, the market significance and multitude of nutraceutical applications of lutein commercial production from microalgae still remains a challenge due to the prohibitive downstream cost. This necessitates innovative less energy intensive, high lutein yielding green processes. The present work presents a comprehensive study on the rapid green microwave assisted extraction (MAE) of lutein from marine chlorophycean microalgae Chlorella sorokiniana (NIOT-2). The process parameters of microwave assisted alkali pre-treatment like exposure time (ET), alkali concentration (AC) and solid (biomass): liquid (aqueous Potassium hydroxide-KOH) ratio (S: L ratio) were optimized using single factor and response surface method (RSM) experiments. The optimized conditions for microwave assisted alkali pre-treatment (ET:1.47 min; AC: 8.16 M KOH and S:L ratio of 36.8:1 (mg/mL) augmented the lutein yield (20.69 ± 1.2 mg/g) 3.26 fold when compared to conventional extraction (6.35 ± 0.44 mg/g). Lutein extracted using optimized MAE conditions was purified and characterized. Visualization of the MAE extracted algal biomass using Scanning electron microscope confirmed the effective cell disruption. X-ray diffraction (XRD) analysis of microwave assisted alkali treated biomass (83.85%) revealed a significantly higher crystallinity index when compared to untreated control (17.28%). MAE pre-treatment can thus be propounded as a suitable process for lutein extraction from marine microalgae due to its amalgamated rapidity, homogenous heating, less energy intensiveness and high extraction yield.


Assuntos
Chlorella , Microalgas , Biomassa , Luteína , Micro-Ondas , Estudos Prospectivos
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