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1.
Braz. j. biol ; 84: e250739, 2024. tab
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1355896

RESUMO

Abstract Several reasons may underlie the dramatic increase in type2 diabetes mellitus. One of these reasons is the genetic basis and variations. Vitamin D receptor polymorphisms are associated with different diseases such as rheumatoid arthritis and diabetes. The aim of this study is to investigate the possible association of two identified mutations ApaI (rs7975232) and TaqI (rs731236). Eighty-nine healthy individuals and Fifty-six Type 2 Diabetic (T2D) patients were investigated using RFLP technique for genotyping and haplotyping as well. The distribution of Apal genotypes was not statistically significant among the control (P=0.65) as well as for diabetic patients (P=0.58). For Taql allele frequencies of T allele was 0.61 where of G allele was 0.39. The frequency distribution of Taql genotypes was not statistically significant among the control (P=0.26) as well as diabetic patients (P=0.17). Relative risk of the allele T of Apa1 gene is 1.28 and the odds ratio of the same allele is 1.53, while both estimates were < 1.0 of the allele G. Similarly, with the Taq1 gene the relative risk and the odds ratio values for the allele T are 1.09 and 1.27 respectively and both estimates of the allele C were 0.86 for the relative risk and 0.79 for the odds ratio. The pairwise linkage disequilibrium between the two SNPs Taq1/apa1 was statistically significant in control group (D = 0.218, D' = 0.925 and P value < 0.001) and similar data in diabetic groups (D = 0.2, D' = 0.875 and P value < 0.001). These data suggest that the T allele of both genes Apa1 and Taq1 is associated with the increased risk of type 2 diabetes. We think that we need a larger number of volunteers to reach a more accurate conclusion.


Resumo Várias razões podem estar subjacentes ao aumento dramático da diabetes mellitus tipo 2. Um desses motivos é a base genética e variações. Os polimorfismos do receptor da vitamina D estão associados a diferentes doenças, como artrite reumatoide e diabetes. O objetivo deste estudo é investigar a possível associação de duas mutações identificadas ApaI (rs7975232) e TaqI (rs731236). Oitenta e nove indivíduos saudáveis ​​e 56 pacientes com diabetes tipo 2 (T2D) foram investigados usando a técnica RFLP para genotipagem e haplotipagem também. A distribuição dos genótipos Apal não foi estatisticamente significativa entre o controle (P = 0,65), bem como para os pacientes diabéticos (P = 0,58). Para as frequências do alelo Taql, o alelo T foi de 0,61, onde o alelo G foi de 0,39. A distribuição de frequência dos genótipos Taql não foi estatisticamente significativa entre o controle (P = 0,26), bem como os pacientes diabéticos (P = 0,17). O risco relativo do alelo T do gene Apa1 é 1,28 e a razão de chances do mesmo alelo é 1,53, enquanto ambas as estimativas foram < 1,0 do alelo G. Da mesma forma, com o gene Taq1, os valores de risco relativo e razão de chances para o alelo T são 1,09 e 1,27, respectivamente, e ambas as estimativas do alelo C foram de 0,86 para o risco relativo e 0,79 para o odds ratio. O desequilíbrio de ligação par a par entre os dois SNPs Taq1 / apa1 foi estatisticamente significativo no grupo de controle (D = 0,218, D' = 0,925 e valor P < 0,001) e dados semelhantes em grupos diabéticos (D = 0,2, D' = 0,875 e valor P < 0,001). Esses dados sugerem que o alelo T de ambos os genes Apa1 e Taq1 está associado ao aumento do risco de diabetes tipo 2. Achamos que precisamos de um número maior de voluntários para chegar a uma conclusão mais precisa.


Assuntos
Humanos , Receptores de Calcitriol/genética , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/epidemiologia , Arábia Saudita , Estudos de Casos e Controles , Polimorfismo de Nucleotídeo Único , Frequência do Gene , Genótipo
2.
Rev. bras. med. esporte ; 29(spe1): e2022_0185, 2023. tab
Artigo em Inglês | LILACS | ID: biblio-1394853

RESUMO

ABSTRACT Introduction Disparate to the development of society, health indices in Chinese college students have shown a pronounced decline in recent years. Government concern over this recent challenge has encouraged research for practical solutions, including optimized physical activity protocols. Objective Explore the effects of an exercise intervention on the health of Chinese university students. Methods Full-time university students (80 males and 55 females) were selected and randomly assigned into two groups. Before and after the experiment, the college students' body composition scale and exercise experience were tested, focusing on the relationship between exercise prescription and changes in physical and mental health indicators. Results The body fat percentage of male and female students decreased significantly after the experiment. After eight weeks of the exercise prescription experiment, the weight of male and female college students was controlled or reduced. The suggested exercise prescription achieved a good moderating effect on the weight of the volunteers. There was a significant difference between the two groups, indicating that the experiment had a beneficial effect on vital capacity (p<0.01). Conclusion The suggested exercise prescription proved to be feasible to guide and intervene in the physical exercise of college students aiming at a beneficial impact on the physical health of college students. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


RESUMO Introdução Díspares ao desenvolvimento da sociedade, os índices de saúde nos estudantes universitários chineses apresentam uma queda acentuada nos últimos anos. A preocupação governamental sobre esse recente desafio tem incentivado pesquisas para soluções práticas, incluindo protocolos de atividades físicas otimizados. Objetivo Explorar os efeitos da intervenção por exercícios físicos na saúde dos estudantes universitários chineses. Métodos Universitários de período integral (80 homens e 55 mulheres) foram selecionados e distribuídos aleatoriamente em dois grupos. Antes e depois do experimento, foi testada a escala de composição corporal e experiência de exercício dos universitários, com foco na relação entre prescrição de exercício e mudanças nos indicadores de saúde física e mental. Resultados O percentual de gordura corporal de estudantes do sexo masculino e feminino diminuiu significativamente após o experimento. Após 8 semanas de experimento de prescrição de exercícios, o peso de estudantes universitários do sexo masculino e feminino foi controlado ou reduzido. A prescrição de exercícios sugerida alcançou um bom efeito moderador no peso dos voluntários. Houve diferença significativa entre os dois grupos, indicando que o experimento teve efeito benéfico sobre a capacidade vital (p<0,01). Conclusão A prescrição de exercícios sugerida demonstrou-se viável para orientar e intervir no exercício físico dos universitários visando um impacto benéfico sobre a saúde física nos universitários. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción A diferencia del desarrollo de la sociedad, los índices de salud de los estudiantes universitarios chinos muestran un fuerte descenso en los últimos años. La preocupación de los gobiernos por este reciente desafío ha fomentado la investigación de soluciones prácticas, entre ellas la optimización de los protocolos de actividad física. Objetivo Explorar los efectos de la intervención de ejercicio en la salud de los estudiantes universitarios chinos. Métodos Se seleccionaron estudiantes universitarios a tiempo completo (80 hombres y 55 mujeres) y se asignaron al azar en dos grupos. Antes y después del experimento, se analizó la escala de composición corporal de los estudiantes universitarios y su experiencia con el ejercicio, centrándose en la relación entre la prescripción de ejercicio y los cambios en los indicadores de salud física y mental. Resultados El porcentaje de grasa corporal de los estudiantes masculinos y femeninos disminuyó significativamente después del experimento. Tras 8 semanas del experimento de prescripción de ejercicio, el peso de los estudiantes universitarios de ambos sexos se controló o redujo. La prescripción de ejercicio sugerida logró un buen efecto moderador en el peso de los voluntarios. Hubo una diferencia significativa entre los dos grupos, lo que indica que el experimento tuvo un efecto beneficioso sobre la capacidad vital (p<0,01). Conclusión La prescripción de ejercicio sugerida demostró ser factible para guiar e intervenir en el ejercicio físico de los estudiantes universitarios apuntando a un impacto beneficioso en la salud física de los estudiantes universitarios. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.


Assuntos
Humanos , Masculino , Feminino , Serviços de Saúde para Estudantes , Terapia por Exercício , Obesidade/terapia , Redução de Peso , Índice de Massa Corporal , Estudos de Casos e Controles
3.
Rev. bras. med. esporte ; 29(spe1): e2022_0190, 2023. tab
Artigo em Inglês | LILACS | ID: biblio-1394851

RESUMO

ABSTRACT Introduction A healthy body depends on several factors, and physical exercise is one of the main factors. Research results on the physical health of female university students show that although the general health status of Chinese female students is good, the quality of physical performance at university continues to show a slow downward trend. Objective To explore the effects of different exercises on the fat mass and lean weight indices of female university students. Methods 60 female students who participated in aerobics and ball games training in the Physical Education Department of a university were randomly divided into a control group and a training group, with 30 volunteers in each group. The experimental group performed intensive aerobics training and ball training. In contrast, no intervention was performed in the control group, and indicators were collected and analyzed according to current literature. Results After eight weeks of the intervention protocol, the body weight, body fat weight, lean weight, body surface area, and body fat ratio of the control group had no significant changes from the period before the experiment (P > 0.05). In the training group, fat weight decreased significantly (p<0.01), lean mass weight increased significantly (p<0.01), body fat ratio decreased (p<0.01), and body weight and body surface area had no significant changes (p>0.05). PTH and FSH in the training group were significantly higher than in the control group (P < 0.05). As the aerobic exercise level improved in the experimental group, the weight and abdominal skinfold thickness in the exercise group showed a downward trend. Conclusion There is a general correlation between BMI and body fat content and its body distribution in college women. Compared to men, BMI is better suited to describe the fat metabolism of college women. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


RESUMO Introdução Um corpo saudável depende de vários fatores e o exercício físico é um dos principais. Os resultados de pesquisa na saúde física das estudantes universitárias mostram que apesar do estado de saúde geral das estudantes chinesas serem bons, a qualidade no desempenho físico na universidade continua a mostrar uma lenta tendência de queda. Objetivo Explorar os efeitos de distintos exercícios sobre os índices de gordura e massa magra de universitárias. Métodos 60 alunas que participaram de treinamento de aeróbica e jogos de bola no Departamento de Educação Física de uma universidade foram divididas aleatoriamente em grupo de controle e grupo de treinamento, com 30 voluntárias em cada grupo. O grupo experimental realizou treinamento intensivo de aeróbica e treinamento com bola, enquanto nenhuma intervenção foi executada no grupo controle, a coleta e análise dos indicadores foi executada segundo a literatura corrente. Resultados Após 8 semanas do protocolo de intervenção, o peso corporal, peso da gordura corporal, peso magro, área de superfície corporal e relação de gordura corporal do grupo controle não tiveram alterações significativas em relação ao período anterior ao experimento (P > 0,05). No grupo de treinamento, o peso da gordura diminuiu significativamente (p<0,01), o peso da massa magra aumentou significativamente (p<0,01), a relação de gordura corporal diminuiu (p<0,01), o peso corporal e a superfície corporal não sofreram alterações significativas (p>0,05). O PTH e FSH no grupo de treinamento foram significativamente maiores do que os do grupo controle (P < 0,05). Com a melhora do nível de exercício aeróbico no grupo experimental, o peso e a espessura da dobra cutânea abdominal no grupo de exercício apresentaram uma tendência de queda. Conclusão Há uma correlação geral entre o IMC e o teor de gordura corporal e a sua distribuição corporal em universitárias. Em comparação com os homens, o IMC é mais adequado para descrever o metabolismo de gordura de universitárias. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción Un cuerpo sano depende de varios factores y el ejercicio físico es uno de los principales. Los resultados de la investigación sobre la salud física de las estudiantes universitarias muestran que, aunque el estado de salud general de las estudiantes chinas es bueno, la calidad del rendimiento físico en la universidad sigue mostrando una lenta tendencia a la baja. Objetivo Explorar los efectos de diferentes ejercicios sobre los índices de grasa y peso magro de estudiantes universitarias. Métodos 60 alumnas que participaban en el entrenamiento de aeróbic y juegos de pelota en el Departamento de Educación Física de una universidad fueron divididas aleatoriamente en un grupo de control y un grupo de entrenamiento, con 30 voluntarias en cada grupo. El grupo experimental realizó un entrenamiento aeróbico intensivo y un entrenamiento con balón, mientras que en el grupo de control no se llevó a cabo ninguna intervención; la recogida y el análisis de los indicadores se realizaron de acuerdo con la literatura actual. Resultados Tras 8 semanas del protocolo de intervención, el peso corporal, el peso de la grasa corporal, el peso magro, la superficie corporal y la proporción de grasa corporal del grupo de control no presentaron cambios significativos en comparación con el periodo anterior al experimento (P > 0,05). En el grupo de entrenamiento, el peso de la grasa disminuyó significativamente (p<0,01), el peso de la masa magra aumentó significativamente (p<0,01), la proporción de grasa corporal disminuyó (p<0,01), el peso corporal y la superficie corporal no tuvieron cambios significativos (p>0,05). La PTH y la FSH en el grupo de entrenamiento fueron significativamente mayores que las del grupo de control (P < 0,05). Con la mejora del nivel de ejercicio aeróbico en el grupo experimental, el peso y el grosor del pliegue cutáneo abdominal en el grupo de ejercicio mostraron una tendencia a la baja. Conclusión Existe una correlación general entre el IMC y el contenido de grasa corporal y su distribución en las estudiantes universitarias. En comparación con los hombres, el IMC es más adecuado para describir el metabolismo de las grasas de las estudiantes universitarias. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.


Assuntos
Humanos , Feminino , Esportes , Estudantes , Índice de Massa Corporal , Tecido Adiposo , Saúde da Mulher , Estudos de Casos e Controles
4.
Rev. bras. med. esporte ; 29: e2022_0162, 2023. graf
Artigo em Inglês | LILACS | ID: biblio-1394829

RESUMO

ABSTRACT Introduction: Although the current method of muscle stretching in gymnastics teaching in colleges and universities can reduce sports fatigue, it has been shown to have little effect on the well-being of athletes because it requires a long recovery time from psychological fatigue. Progressive muscle relaxation training is a method that uses the basic principle of sympathetic nerve activity to reduce the impact of negative emotions psychologically and relieve fatigue physiologically, requiring a further study of its impact on muscle protein. Objective: Explore the effect of high-intensity gymnastics on skeletal muscle protein and study the progressive muscle relaxation training method post-workout adjustment. Methods: After three weeks of training, excluding the standard deviations in the experimental data caused by the athletes' irregular movements, the athletes' blood lactate content and heart rate were counted and recorded. The collected data were analyzed using Excel software to integrate and compare the data using the T-test method. Results: After exercise training, the skeletal muscle function indices of the subjects increased to different degrees. From the point of view of heart rate recovery efficiency, the rate of heart rate decline of progressive relaxation training was higher than that of the two groups, and the degree of fluctuation was lower than that of the two groups, indicating that the level of recovery in heart rate of progressive relaxation training was better. Conclusion: The action of the high-intensity gymnastics team has a good effect on improving the athletes' skeletal muscle and skeletal muscle proteins. Post-exercise conditioning training plays an important role in athletes' physical recovery. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


RESUMO Introdução: Embora o método de alongamento muscular atual no ensino de ginástica em faculdades e universidades consiga reduzir a fadiga esportiva, tem se mostrado pouco eficaz no bem-estar dos atletas por exigir grande tempo de recuperação da fadiga psicológica. O treinamento progressivo de relaxamento muscular é um método que usa o princípio básico da atividade nervosa simpática para reduzir o impacto das emoções negativas psicologicamente e aliviar a fadiga fisiologicamente, necessitando de mais estudos do seu impacto sobre a proteína muscular. Objetivo: Explorar o efeito da ginástica de alta intensidade sobre as proteínas musculares esqueléticas e estudar o método de treinamento progressivo de relaxamento muscular no ajuste pós-treino. Métodos: Após 3 semanas de treinamento, excluídos os desvios-padrão nos dados experimentais causados pelos movimentos irregulares dos atletas, foram contabilizados e registrados os conteúdos de lactato sanguíneo e frequência cardíaca dos atletas. Analisou-se os dados coletados, com o software Excel, para integrar e comparar os dados pelo método de teste-T. Resultados: Após o treinamento do exercício, os índices de função muscular esquelética dos sujeitos aumentaram em diferentes graus. Do ponto de vista da eficiência da recuperação da frequência cardíaca, a taxa de declínio da frequência cardíaca do treinamento de relaxamento progressivo foi maior do que a dos dois grupos, o grau de flutuação foi menor do que o dos dois grupos, indicando que o nível de recuperação na frequência cardíaca do treinamento de relaxamento progressivo foi melhor. Conclusão: A ação da equipe de ginástica de alta intensidade tem um bom efeito na melhoria do músculo esquelético e das proteínas musculares esqueléticas dos atletas. O treinamento de condicionamento pós-exercício desempenha um papel importante na recuperação física dos atletas. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción: Aunque el método actual de elongación muscular en la enseñanza de la gimnasia en colegios y universidades consigue reducir la fatiga deportiva, se ha demostrado que tiene poco efecto en el bienestar de los atletas porque requiere un largo tiempo de recuperación de la fatiga psicológica. El entrenamiento de la relajación muscular progresiva es un método que utiliza el principio básico de la actividad nerviosa simpática para reducir el impacto de las emociones negativas desde el punto de vista psicológico y aliviar la fatiga desde el punto de vista fisiológico, lo que requiere un estudio más profundo de su impacto en la proteína muscular. Objetivo: Explorar el efecto de la gimnasia de alta intensidad sobre la proteína del músculo esquelético y estudiar el método de entrenamiento de relajación muscular progresiva en el ajuste posterior al entrenamiento. Métodos: Después de 3 semanas de entrenamiento, excluyendo las desviaciones estándar en los datos experimentales causadas por los movimientos irregulares de los atletas, se contó y registró el contenido de lactato en sangre y la frecuencia cardíaca de los atletas. Los datos recogidos se analizaron, con el programa informático Excel, para integrar y comparar los datos mediante el método de la prueba T. Resultados: Tras el entrenamiento con ejercicios, los índices de función del músculo esquelético de los sujetos aumentaron en diferentes grados. Desde el punto de vista de la eficacia de la recuperación de la frecuencia cardíaca, el índice de disminución de la frecuencia cardíaca del entrenamiento de relajación progresiva fue mayor que el de los dos grupos, el grado de fluctuación fue menor que el de los dos grupos, lo que indica que el nivel de recuperación de la frecuencia cardíaca del entrenamiento de relajación progresiva fue mejor. Conclusión: La acción del equipo de gimnasia de alta intensidad tiene un buen efecto en la mejora del músculo esquelético y de las proteínas del músculo esquelético de los atletas. El entrenamiento de acondicionamiento posterior al ejercicio desempeña un papel importante en la recuperación física de los deportistas. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.


Assuntos
Humanos , Masculino , Músculo Esquelético/química , Treinamento Intervalado de Alta Intensidade/métodos , Proteínas Musculares/análise , Composição Corporal , Estudos de Casos e Controles
5.
Braz. j. biol ; 83: e249104, 2023. tab
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1339389

RESUMO

Abstract The present study was designed to evaluate the strength of association of raised plasma homocysteine concentration as a risk factor for coronary heart disease independent of conventional risk factor. It was a case control study conducted at Punjab Institute of Cardiology Lahore. A total of 210 subjects aged 25 to 60 years comprising of 105 newly admitted patients of CHD as cases and 105 age and sex matched healthy individuals with no history of CHD as control were recruited for the study. Fasting blood samples were obtained from cases and controls. Plasma homocysteine was analyzed by fluorescence polarization immunoassay (FPIA) method on automated immunoassay analyzer (Abbott IMX). Total cholesterol, triglyceride and HDL cholesterol were analyzed using calorimetric kit methods. The concentration of LDL cholesterol was calculated using Friedewald formula. The patients were also assessed for traditional risk factors such as age, sex, family history of CVD, hypertension, smoking and physical activity, and were compared with control subjects. The collected data was entered in SPSS version 24 for analysis and interpretation.The mean age in controls and experimental groups were 43.00± 8.42 years and 44.72± 8.59 years with statistically same distribution (p- value= 0.144). The mean plasma homocysteine for cases was 22.33± 9.22 µmol/L where as it was 12.59±3.73 µmol/L in control group. Highly significant difference was seen between the mean plasma level of homocysteine in cases and controls (p˂0.001).Simple logistic regression indicates a strong association of coronary heart disease with hyperhomocysteinemia (OR 7.45), which remained significantly associated with coronary heart disease by multivariate logistic regression (OR 7.10, 95%C1 3.12-12.83, p=0.000). The present study concludes that elevated levels of Plasma homocysteine is an independent risk factor for coronary heart disease independent of conventional risk factors and can be used as an indicator for predicting the future possibility for the onset of CVD.


Resumo O presente estudo foi desenhado para avaliar a força da associação da concentração elevada de homocisteína no plasma como um fator de risco para doença cardíaca coronária independente do fator de risco convencional. Foi um estudo de caso-controle realizado no Punjab Institute of Cardiology Lahore. Um total de 210 indivíduos com idade entre 25 e 60 anos, compreendendo 105 pacientes recém-admitidos de CHD como casos e 105 indivíduos saudáveis ​​pareados por idade e sexo sem histórico de CHD como controle, foi recrutado para o estudo. Amostras de sangue em jejum foram obtidas de casos e controles. A homocisteína plasmática foi analisada pelo método de imunoensaio de polarização de fluorescência (FPIA) em analisador de imunoensaio automatizado (Abbott IMX). Colesterol total, triglicerídeos e colesterol HDL foram analisados ​​usando métodos de kit calorimétrico. A concentração de colesterol LDL foi calculada pela fórmula de Friedewald. Os pacientes também foram avaliados para fatores de risco tradicionais, como idade, sexo, história familiar de DCV, hipertensão, tabagismo e atividade física, e foram comparados com indivíduos de controle. Os dados coletados foram inseridos no SPSS versão 24 para análise e interpretação. A média de idade nos grupos controles e experimentais foi de 43,00 ± 8,42 anos e 44,72 ± 8,59 anos com distribuição estatisticamente igual (p-valor = 0,144). A homocisteína plasmática média para os casos foi de 22,33 ± 9,22 µmol / L, enquanto no grupo controle foi de 12,59 ± 3,73 µmol / L. Diferença altamente significativa foi observada entre o nível plasmático médio de homocisteína em casos e controles (p ˂ 0,001). A regressão logística simples indica uma forte associação de doença cardíaca coronária com hiper-homocisteinemia (OR 7,45), que permaneceu significativamente associada com doença cardíaca coronária por multivariada regressão logística (OR 7,10, 95% C1 3,12-12,83, p = 0,000). O presente estudo conclui que níveis elevados de homocisteína plasmática são fator de risco independente para doença cardíaca coronária, independentemente dos fatores de risco convencionais, e pode ser usado como um indicador para prever a possibilidade futura de aparecimento de DCV.


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Doença das Coronárias/embriologia , Hiper-Homocisteinemia/diagnóstico , Hiper-Homocisteinemia/epidemiologia , Estudos de Casos e Controles , Fatores de Risco , Jejum
6.
Rev. bras. med. esporte ; 29(spe1): e2022_0184, 2023. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1394858

RESUMO

ABSTRACT Introduction Although the overall physical health of university students has positive rates in recent years, indicators such as body composition, vital capacity, and flexibility have declined, following the indicators of speed and strength. Several studies corroborate the beneficial impacts of strength training, accelerating the metabolism of university students, reducing injuries and joint pain, and increasing flexibility, bone density, and self-image of obese students. In light of this situation, the government, through schools and related departments, encourage effective measures to control the current situation under a new context. Objective Study the impacts of strength training on the physical fitness of college students. Methods 70 male college students in a physical education institute were randomly divided into an experimental group and a control group, with 35 people in each group. Systematically protocoled and scientifically validated physical exercises were performed for eight weeks. After the implementation of physical exercise, physical quality indicators were evaluated. Results Functional physical training raised the scores of several sports of male college students. There was also an effective reduction in blood pressure in obese youth, improvement in vascular elasticity index, vital capacity, cardiovascular system function, exercise capacity, and strengthening physique. The results of the seven FMS tests were significantly improved. Physical function training can significantly improve and strengthen students' core, hip, shoulder, knee, and ankle stability and flexibility. Conclusion Strength training has been shown to improve college students' physical health indices. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


RESUMO Introdução Embora a saúde física geral dos estudantes universitários tenha índices positivos nos últimos anos, indicadores como a composição corporal, a capacidade vital e a flexibilidade tiveram um declínio, acompanhando os indicadores de velocidade e força. Vários estudos corroboram sobre os impactos benéficos do treinamento de força, acelerando o metabolismo dos estudantes universitários, reduzindo lesões e dores articulares, aumentando a flexibilidade, densidade óssea e a autoimagem dos estudantes obesos. Diante dessa situação, o governo, por intermédio das escolas e departamentos correlacionados incentiva medidas eficazes para controlar a situação atual sob um novo contexto. Objetivo Estudar os impactos do treino de força sobre a aptidão física dos estudantes universitários. Métodos 70 estudantes universitários do sexo masculino em um instituto de educação física foram divididos aleatoriamente em grupo experimental e grupo controle, com 35 pessoas em cada grupo. Exercícios físicos sistematicamente protocolados e cientificamente validados foram executados por oito semanas. Após a implementação do exercício físico, avaliou-se os indicadores de qualidade física. Resultados O treinamento físico funcional elevou as pontuações de vários esportes de estudantes universitários do sexo masculino. Também houve redução efetiva na pressão arterial de jovens obesos, melhora do índice de elasticidade vascular, capacidade vital, função do sistema cardiovascular, capacidade de exercício e alcançar o propósito de fortalecer o físico. Os resultados dos sete testes de FMS foram significativamente aprimorados. O treinamento em funções físicas pode melhorar e fortalecer significativamente a estabilidade do core dos alunos, estabilidade e flexibilidade do quadril, ombro, joelho e tornozelo. Conclusão O treinamento de força demonstrou-se eficaz em melhorar os índices de saúde física nos estudantes universitários. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.


RESUMEN Introducción Aunque la salud física general de los estudiantes universitarios presente índices positivos en los últimos años, indicadores como la composición corporal, la capacidad vital y la flexibilidad tuvieron un descenso, acompañando a los indicadores de velocidad y fuerza. Varios estudios corroboran los efectos beneficiosos del entrenamiento de fuerza, acelerando el metabolismo de los estudiantes universitarios, reduciendo las lesiones y el dolor articular, aumentando la flexibilidad, la densidad ósea y la autoimagen de los estudiantes obesos. Ante esta situación, el gobierno, a través de las escuelas y los departamentos relacionados, impulsa medidas eficaces para controlar la situación actual en un nuevo contexto. Objetivo Estudiar el impacto del entrenamiento de fuerza en la condición física de los estudiantes universitarios. Métodos 70 estudiantes universitarios varones de un instituto de educación física fueron divididos aleatoriamente en grupo experimental y grupo de control, con 35 personas en cada grupo. Se realizaron ejercicios físicos sistemáticamente protocolizados y científicamente validados durante ocho semanas. Tras la realización del ejercicio físico, se evaluaron los indicadores de calidad física. Resultados El entrenamiento físico funcional aumentó las puntuaciones de varios deportes de los estudiantes universitarios masculinos. También hubo una reducción efectiva de la presión arterial de los jóvenes obesos, la mejora del índice de elasticidad vascular, la capacidad vital, la función del sistema cardiovascular, la capacidad de ejercicio y lograr el propósito de fortalecer el físico. Los resultados de las siete pruebas FMS mejoraron significativamente. El entrenamiento de la función física puede mejorar y fortalecer significativamente la estabilidad del core, la cadera, el hombro, la rodilla y el tobillo de los estudiantes y la flexibilidad. Conclusión El entrenamiento de fuerza ha demostrado ser eficaz para mejorar los índices de salud física de los estudiantes universitarios. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.


Assuntos
Humanos , Masculino , Estudantes , Exercício Físico , Aptidão Física/fisiologia , Força Muscular/fisiologia , Universidades , Estudos de Casos e Controles
7.
Int J Cancer ; 152(2): 203-213, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36043555

RESUMO

Opium use was recently classified as a human carcinogen for lung cancer by the International Agency for Research on Cancer. We conducted a large, multicenter case-control study evaluating the association between opium use and the risk of lung cancer. We recruited 627 cases and 3477 controls from May 2017 to July 2020. We used unconditional logistic regression analyses to estimate the odds ratios (OR) and 95% confidence intervals (CI) and measured the association between opium use and the risk of lung cancer. The ORs were adjusted for the residential place, age, gender, socioeconomic status, cigarettes, and water pipe smoking. We found a 3.6-fold risk of lung cancer for regular opium users compared to never users (95% CI: 2.9, 4.6). There was a strong dose-response association between a cumulative count of opium use and lung cancer risk. The OR for regular opium use was higher for small cell carcinoma than in other histology (8.3, 95% CI: 4.8, 14.4). The OR of developing lung cancer among opium users was higher in females (7.4, 95% CI: 3.8, 14.5) than in males (3.3, 95% CI: 2.6, 4.2). The OR for users of both opium and tobacco was 13.4 (95% CI: 10.2, 17.7) compared to nonusers of anything. The risk of developing lung cancer is higher in regular opium users, and these results strengthen the conclusions on the carcinogenicity of opium. The association is stronger for small cell carcinoma cases than in other histology.


Assuntos
Carcinoma de Células Pequenas , Neoplasias Pulmonares , Dependência de Ópio , Carcinoma de Pequenas Células do Pulmão , Humanos , Feminino , Masculino , Dependência de Ópio/epidemiologia , Estudos de Casos e Controles , Ópio/efeitos adversos , Irã (Geográfico)/epidemiologia , Carcinoma de Pequenas Células do Pulmão/epidemiologia , Carcinoma de Pequenas Células do Pulmão/etiologia , Neoplasias Pulmonares/induzido quimicamente , Neoplasias Pulmonares/epidemiologia
8.
Int J Cancer ; 152(2): 172-182, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36059225

RESUMO

Pancreatic cancer (PC) is highly fatal, and its incidence is increasing in the United States. Population-based registry studies suggest associations between a few autoimmune conditions and PC risk, albeit based on a relatively small number of cases. We conducted a population-based, nested case-control study to examine the associations between autoimmune conditions and PC risk within the Surveillance, Epidemiology, and End Results Program (SEER)-Medicare population. Incident primary malignant PC cases (n = 80 074) were adults ≥66 years and diagnosed between 1992 and 2015. Controls (n = 320 296) were alive at the time cases were diagnosed and frequency-matched to cases (4:1 ratio) by age, sex, and year of diagnosis. We used multivariable-adjusted, unconditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 45 autoimmune conditions identified from Medicare claims. Eight autoimmune conditions including ankylosing spondylitis (OR = 1.45; 95% CI: 1.14-1.84), Graves' disease (OR = 1.18; 95% CI: 1.03-1.34), localized scleroderma (OR = 1.27; 95% CI: 1.06-1.52), pernicious anemia (OR = 1.08; 95% CI: 1.02-1.14), primary sclerosing cholangitis (OR = 1.37; 95% CI: 1.18-1.59), pure red cell aplasia (OR = 1.31; 95% CI: 1.16-1.47), type 1 diabetes (OR = 1.11; 95% CI: 1.07-1.15), and ulcerative colitis (OR = 1.18; 95% CI: 1.07-1.31) were associated with increased PC risk (false discovery rate-adjusted P values <.10). In subtype analyses, these conditions were associated with pancreatic ductal adenocarcinoma, whereas only ulcerative colitis was associated with pancreatic neuroendocrine tumors. Our results support the hypothesis that autoimmune conditions may play a role in PC development.


Assuntos
Doenças Autoimunes , Colite Ulcerativa , Neoplasias Pancreáticas , Humanos , Idoso , Adulto , Estados Unidos/epidemiologia , Estudos de Casos e Controles , Medicare , Pâncreas , Neoplasias Pancreáticas/epidemiologia , Neoplasias Pancreáticas/etiologia , Doenças Autoimunes/complicações , Doenças Autoimunes/epidemiologia
9.
Behav Brain Res ; 437: 114126, 2023 Feb 02.
Artigo em Inglês | MEDLINE | ID: mdl-36167216

RESUMO

BACKGROUND: Vascular endothelial growth factor (VEGF) and platelets seem to reflect the Alzheimer's disease (AD) associated either with vascular impairment or disease. This study aimed to compare the circulating levels of VEGF and platelets between AD patients and healthy older adults. METHODS: Seventy-two older adults, divided in 40 older adults (Clinical Dementia Rating Scale - CDR = 0); and 32 Alzheimer's disease patients (clinically diagnosed - CRD = 1) participated in the present study. The groups were paired by sex, age, comorbidities and educational level. The primary outcomes included circulating plasma VEGF and platelet levels obtained by blood collection. RESULTS: The VEGF levels were significantly different between the groups (p = 0.03), with having a large effect size ( η2 =18.15), in which the AD patients presented lower levels compared to healthy older adults. For platelets, the comparison showed a tendency to difference (p = 0.06), with a large effect size (η2 =12.95) between the groups. CONCLUSION: The VEGF levels and the platelet numbers were reduced in AD patients, suggesting that angiogenic factors could be modified due to AD.


Assuntos
Doença de Alzheimer , Fator A de Crescimento do Endotélio Vascular , Idoso , Humanos , Doença de Alzheimer/sangue , Estudos de Casos e Controles , Fator A de Crescimento do Endotélio Vascular/sangue
10.
Fam Community Health ; 46(1): 79-86, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36322616

RESUMO

Congestive heart failure (CHF) readmissions are frequent and costly but preventable. The purpose of this study was to analyze socioeconomic and health-related factors of CHF readmissions by examining the relationship between 30-day readmissions of individuals with CHF and their payer status, race, ethnicity, primary language spoken, living arrangement, and comorbidities. This retrospective case-control study used secondary data from 450 CHF patients admitted to a not-for-profit Northern Virginia hospital from July 2014 to December 2017. Data were analyzed using χ 2 and logistic regression. Living arrangements and comorbid chronic renal failure (CRF) were statistically significant predictors of CHF readmissions; all other factors were nonsignificant. Patients who lived with family and those in assisted living facilities were less likely to be readmitted than those who lived alone (odds ratio [OR] = 0.2 and 0.5, respectively). Patients without CRF were less likely to be readmitted than those who had CRF (OR = 0.6). This study contributes data to inform community-based health programs tailored toward frequently readmitted individuals due to CHF exacerbation.


Assuntos
Insuficiência Cardíaca , Readmissão do Paciente , Humanos , Estudos Retrospectivos , Estudos de Casos e Controles , Insuficiência Cardíaca/complicações , Insuficiência Cardíaca/epidemiologia , Insuficiência Cardíaca/terapia , Fatores Socioeconômicos , Fatores de Risco
11.
Gene ; 851: 147025, 2023 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-36328193

RESUMO

BACKGROUND: LRP5 (Lipoprotein Receptor 5) is one of the representatives of the low-density lipoprotein receptors family that play a crucial role in the process of bone homeostasis and bone remodeling. The role of LRP5 single nucleotide polymorphisms (SNPs) rs3736228 and rs4988321 has been associated with the susceptibility to osteoporosis and bone fracture. The frequency of mentioned LRP5 SNPs is unknown among RA (Rheumatoid Arthritis) patients. The case-control study was designed to determine the association of targeted SNPs among RA patients. METHODOLOGY: Patients were selected by ACR/EULAR 2010 criteria. After ethical approval blood samples of patients and healthy individuals were collected. DNA was extracted from the whole blood followed by amplification of the targeted region by T-ARMS PCR (Tetra-primer Amplification Refractory Mutation System) obtained product was observed on agarose gel electrophoresis. The data were analyzed by statistical and bioinformatic tools. RESULTS: It was observed that the SNPs rs3736228 and rs4988321 showed significant association with the risk of RA [χ2 = 44, p =< 0.001, O.R 95 % CI = 2.495, (1.865 âˆ¼ 3.337), p =< 0.001] and [χ2 = 85, p =< 0.001, O.R 95 % CI = 2.05, (1.571 âˆ¼ 2.69), p =< 0.001] respectively. Haplotypes AT, GC, and GT were found to be significantly associated with the risk of RA. Furthermore, both SNPs were in 40 % LD (Linkage Disequilibrium). CONCLUSIONS: The study revealed that SNPs rs3736228 and rs4988321 were significantly associated with the increased susceptibility to RA. The study serves as the baseline data considering targeted SNPs and their association with the progression of the disease. The study might be utilized for the development of potential biomarker for diagnostic purposes and in the precision medicine approach.


Assuntos
Artrite Reumatoide , Polimorfismo de Nucleotídeo Único , Humanos , Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/genética , Densidade Óssea/genética , Estudos de Casos e Controles , Haplótipos , Artrite Reumatoide/genética , Lipoproteínas LDL , Predisposição Genética para Doença , Frequência do Gene , Genótipo
12.
Environ Res ; 216(Pt 3): 114727, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36356671

RESUMO

BACKGROUND: Phthalates are endocrine-disrupting chemicals linked to a higher risk of numerous chronic health outcomes. Diet is a primary source of exposure, but prior studies exploring associations between dietary patterns and phthalate exposure are limited. OBJECTIVES: We evaluated the associations between dietary patterns and urinary phthalate biomarkers among a subset of postmenopausal women participating in the Women's Health Initiative (WHI). METHODS: We included WHI participants selected for a nested case-control study of phthalates and breast cancer (N = 1240). Dietary intake was measured via self-administered food frequency questionnaires at baseline and year-3. We used these data to calculate scores for alignment with the Dietary Approach to Stop Hypertension (DASH), alternative Mediterranean (aMed), and Dietary Inflammatory Index (DII) diets. We measured 13 phthalate metabolites and creatinine in 2-3 urine samples per participant collected over 3-years when all participants were cancer-free. We fit multivariable generalized estimating equation models to estimate the cross-sectional associations. RESULTS: DASH and aMed dietary scores were inversely associated with the sum of di(2-Ethylhexyl) phthalate (-6.48%, 95% CI -9.84, -3.00; -5.23%, 95% CI -8.73, -1.60) and DII score was positively associated (9.00%, 95% CI 5.04, 13.11). DASH and aMed scores were also inversely associated with mono benzyl phthalate and mono-3-carboxypropyl phthalate. DII scores were positively associated with mono benzyl phthalate and the sum of di-n-butyl phthalate. DISCUSSION: Higher dietary alignment with DASH and aMed dietary patterns were significantly associated with lower concentrations of certain phthalate biomarkers, while an inflammatory diet pattern was associated with higher phthalate biomarker concentrations. These findings suggest that dietary patterns high in fruits, vegetables, and low-fat foods and low in processed foods may be useful in avoiding exposure to phthalates.


Assuntos
Pós-Menopausa , Saúde da Mulher , Humanos , Feminino , Estudos de Casos e Controles , Estudos Transversais , Biomarcadores/urina
13.
Environ Res ; 216(Pt 3): 114740, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36356668

RESUMO

Air pollution with particulate matter is an established lung carcinogen. Studies have suggested an association with breast cancer, but the evidence is inconsistent. METHODS: From nationwide registers, we identified all breast cancer cases (n = 55 745) in Denmark between 2000 and 2014. We matched one control for each case on age and year of birth. We used a multi-scale dispersion model to estimate outdoor concentrations of particulate matter <2.5 µm (PM2.5), elemental carbon (EC) and nitrogen dioxide (NO2) as time-weighted average over all addresses up to 20 years prior to diagnosis. We calculated odds ratios (OR) and 95% confidence intervals (CI) by conditional logistic regression with adjustment for marital status, educational level, occupational status, personal income, region of origin, medication and area-level socio-economic indicators. RESULTS: A 10 µg/m3 higher PM2.5 was associated with an OR for breast cancer of 1.21 (95% CI: 1.11-1.33). The corresponding ORs for EC (per 1 µg/m3) and NO2 (per 10 µg/m3) were 1.03 (95% CI: 1.00-1.07) and 1.03 (95% CI: 1.01-1.06), respectively. In multi-pollutant models, the OR for PM2.5 changed only little, whereas ORs for EC or NO2 approached the null. In an analysis of persons below 55 years, PM2.5 was associated with an OR of 1.32 (95% CI: 1.09-1.60) per 10 µg/m3 increase. CONCLUSION: We found evidence of an association between the investigated air pollutants and breast cancer, especially PM2.5. There were indications that the association differed by age at diagnosis. We were not able to include all potential confounders and thus, results should be interpreted with caution.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Neoplasias da Mama , Humanos , Feminino , Dióxido de Nitrogênio/análise , Estudos de Casos e Controles , Neoplasias da Mama/induzido quimicamente , Neoplasias da Mama/epidemiologia , Exposição Ambiental/análise , Poluição do Ar/efeitos adversos , Poluição do Ar/análise , Material Particulado/análise , Poluentes Atmosféricos/toxicidade , Poluentes Atmosféricos/análise , Carbono/análise , Dinamarca/epidemiologia
14.
Libyan J Med ; 18(1): 2132628, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36433836

RESUMO

Vitiligo is a multifactorial dermatosis with many etiological hypotheses that have been suggested for its occurrence. To our knowledge, few epidemiological studies are available on vitiligo induction factors and particularly on the role of exposure to chemicals in the onset of the disease has been found. Therefore, there is need to investigate the relationship between vitiligo and chemical exposures in order to understand this mysterious disease. We conducted a case-control study of patients with vitiligo whose diagnosis was made by a specialist in dermatology. The total study period was of 6 months extending from 1 July to 31 December 2019. The minimum sample size was determined as 46 cases and 92 controls. The control group was gender, age, and professional status matched to the vitiligo group. In the binary logistic regression model, household chemicals/colored toothpaste use, a history of a repeated antibiotic use, and an occupational exposure to phenol/catechol derivatives were significantly associated with vitiligo (three to fourfold increase). Our results suggest that chemical factors play a key role in the occurrence of vitiligo. Therefore, prevention of this dermatosis requires the identification of exposure to the incriminated chemicals in any patient followed for vitiligo. The earlier the diagnosis of 'chemical' or chemically aggravated vitiligo, the better the prognosis for this disease.


Assuntos
Vitiligo , Humanos , Vitiligo/induzido quimicamente , Vitiligo/epidemiologia , Vitiligo/diagnóstico , Estudos de Casos e Controles , Incidência , Tunísia/epidemiologia , Fenóis
15.
Environ Res ; 216(Pt 1): 114510, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36220441

RESUMO

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no cure. Although the etiology of sporadic ALS is largely unknown, environmental exposures may affect ALS risk. OBJECTIVE: We investigated relationships between exposure to long-term ambient particulate matter (PM) and gaseous air pollution (AP) and ALS mortality. METHODS: Within the Women's Health Initiative (WHI) cohort of 161,808 postmenopausal women aged 50-79 years at baseline (1993-1998), we performed a nested case-control study of 256 ALS deaths and 2486 matched controls with emphasis on PM constituents (PM2.5, PM10, and coarse PM [PM10-2.5]) and gaseous pollutants (NOx, NO2, SO2, and ozone). Time-varying AP exposures estimates were averaged 5, 7.5, and 10 years prior to ALS death using both a GIS-based spatiotemporal generalized additive mixed model and ordinary kriging (empirical and multiple imputation, MI). Conditional logistic regression was used to estimate the relative risk of ALS death. RESULTS: In general, PM2.5 and PM10-related risks were not significantly elevated using either method. However, for PM10-2.5, odds ratios (ORs) were >1.0 for both methods at all time periods using MI and empirical data for PM10-2.5 (coarse) except for 5 and 7.5 years using the kriging method with covariate adjustment. CONCLUSION: This investigation adds to the body of information on long-term ambient AP exposure and ALS mortality. Specifically, the 2019 US Environmental Protection Agency (EPA) Integrated Science Assessment summarized the neurotoxic effects of PM2.5, PM10, and PM10-2.5. The conclusion was that evidence of an effect of coarse PM is suggestive but the data is presently not sufficient to infer a causal relationship. Further research on AP and ALS is warranted. As time from symptom onset to death in ALS is ∼2-4 years, earlier AP measures may also be of interest to ALS development. This is the first study of ALS and AP in postmenopausal women controlling for individual-level confounders.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Esclerose Amiotrófica Lateral , Feminino , Humanos , Esclerose Amiotrófica Lateral/epidemiologia , Poluentes Atmosféricos/toxicidade , Poluentes Atmosféricos/análise , Estudos de Casos e Controles , Poluição do Ar/efeitos adversos , Poluição do Ar/análise , Material Particulado/toxicidade , Material Particulado/análise , Exposição Ambiental/efeitos adversos , Exposição Ambiental/análise , Saúde da Mulher
16.
Gene ; 851: 146969, 2023 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-36261089

RESUMO

BACKGROUND: We previously reported on the association between ESR1 and ESR2 gene variants and heightened risk of breast cancer (BC). Here we investigated the association of common ESR1 and ESR2 gene variants with triple negative BC (TNBC). METHODS: This retrospective case-control study involved 488 BC patients (130 TNBC, 358 non-TNBC patients). ESR1 (rs2234693, rs9340799, rs3020314, rs3798577) and ESR2 (rs928554, rs944459, rs4986938, rs1256049, rs1256030, rs1271572) genotyping was done by real-time PCR. RESULTS: While minor allele frequencies (MAF) of ESR1 variants were comparable between TNBC and non-TNBC subjects, significantly higher ESR2 rs1256049 MAF was seen in TNBC patients. Significantly higher frequency of ESR1 rs3798577 T/C and C/C genotypes were noted in TNBC cases, and significant differences were seen in ESR2 rs928554, rs1256049, and rs1271572 genotype distribution. Increased TNBC risk was associated with ESR1 rs3798577 T/C and C/C genotypes according to codominant and dominant models, while positive association of ESR2 rs928554 with TNBC was seen according to codominant and recessive models, and positive association of ESR2 rs1256049 with TNBC was seen according to codominant and dominant models. Positive interactions were noted between ESR2 rs1271572-ESR1 rs3020314, ESR2 rs1271572-ESR1 rs9340799, and ESR2 rs1271572-ESR1 rs2234693, ESR2 rs4986938-ESR1 rs2234693, and ESR2 rs928554-ESR1 rs9340799. Haplotype analysis confirmed the positive association of ESR1 CATT with TNBC, while ACGGCTC and ACGGTT ESR2 haplotypes were positively associated with TNBC. CONCLUSION: Results of this study confirmed the association of unique ESR1 and ESR2 genetic variants with altered risk of TNBC. This suggests possible diagnostic and prognostic role of these variants with TNBC independent of their association with BC.


Assuntos
Receptores de Estrogênio , Neoplasias de Mama Triplo Negativas , Humanos , Receptores de Estrogênio/genética , Estudos de Casos e Controles , Receptor beta de Estrogênio/genética , Receptor alfa de Estrogênio/genética , Polimorfismo de Nucleotídeo Único , Neoplasias de Mama Triplo Negativas/genética , Estudos Retrospectivos , Genótipo , Predisposição Genética para Doença
17.
Gene ; 851: 147008, 2023 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-36283602

RESUMO

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic, lifelong disease. The molecular mechanisms and pathophysiology of T2DM have not yet been fully elucidated. Dysregulation of the long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) is considered one of the main contributing factors of the dysfunction found in many diseases, including those of the endocrine system. The aim of this study was to investigate the association between lncRNA MALAT1 single nucleotide polymorphisms (SNPs) and T2DM in the Chinese Han population. METHODS: We genotyped three SNPs (rs3200401 C > T, rs619586 A > G, rs11227209 C > G) of the MALAT1 gene, including 571 T2DM patients and 526 controls. The association between different genotypes and the risk of T2DM was analyzed using logistic regression, and the results were expressed by odds ratio (OR) and its 95% confidence interval (95%CI), and then stratified by age, sex, and BMI. P < 0.05 on both sides was considered as statistically significant. RESULTS: We found that the CT + TT genotypes of the rs3200401 polymorphism were significantly associated with an increased risk of T2DM in Chinese Han population (OR = 1.77; 95% CI:1.35-2.33; Padjusted < 0.001), whereas MALAT1 rs619586 AG + GG genotypes were associated with a reduced risk of T2DM (OR = 0.67; 95% CI:0.48-0.94; Padjusted = 0.021). Subsequent stratified analysis showed that compared with the rs3200401 CC genotype, CT + TT genotypes were associated with an increased risk of T2DM in the male, female, age ≥ 65 years, and BMI ≥ 24 subgroups (OR = 1.68, 95% CI:1.10-2.56, Padjusted = 0.016; OR = 1.83, 95% CI:1.27-2.62, Padjusted = 0.001; OR = 1.86, 95% CI:1.38-2.52, Padjusted < 0.001; OR = 2.13, 95% CI:1.45-3.15, Padjusted < 0.001; respectively). Haplotype analysis showed that T-A-C haplotype had a 1.533-fold increased risk of T2DM (95% CI, 1.208-1.945, P < 0.001) and C-G-G was associated with a decreased risk of T2DM. No significant association was found between rs11227209 and T2DM risk (P > 0.05). CONCLUSION: The results suggest that MALAT1 rs619586 and rs3200401 confer susceptibility for T2DM in the Chinese Han population and provide new genetic targets for the treatment of diabetes and its complications in the future.


Assuntos
Diabetes Mellitus Tipo 2 , RNA Longo não Codificante , Humanos , Masculino , Feminino , Idoso , Polimorfismo de Nucleotídeo Único , RNA Longo não Codificante/genética , Estudos de Casos e Controles , Predisposição Genética para Doença , Diabetes Mellitus Tipo 2/genética , China
18.
J Interpers Violence ; 38(1-2): NP1787-NP1814, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35475706

RESUMO

There has been a significant amount of research on correlates of bullying victimization, but most prior studies are descriptive and do not distinguish between different types of bullying. The current study used a case-control study design to explore factors related to different types of bullying victimization, including physical, relational, verbal, sexual, property, and poly-bullying victimization. This study was conducted in a southern city in China, including 3054 cases who self-reported being victims of school bullying and 3054 controls who reported not being involved in any school bullying in the past 12 months. Each victim case was matched with a control on gender, school, and grade level. Univariate logistic analyses and multivariate conditional logistic regression analyses were used to identify factors associated with being a victim of school bullying. Results suggest physical bullying victimization was only associated with a family-level characteristic (parenting style) while the other four types of bullying victimization (relational, verbal, sexual, and property bullying) and poly-bullying victimization were associated with multiple social domain variables at individual, family, and school levels. Findings from this study provide evidence of factors for different types of bullying victimization and have implications for potential measures to prevent bullying. Measures from multiple social domains, including individual, family and school (e.g., developing healthy behaviors, improving social skills, positive parent-child interactions, building trust between teachers and peers, and forming strong friendships), should be considered in order to effectively prevent adolescent victimization from bullying.


Assuntos
Bullying , Vítimas de Crime , Adolescente , Humanos , Criança , Estudos de Casos e Controles , Instituições Acadêmicas , China
19.
Clin Chem Lab Med ; 61(1): 154-161, 2023 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-36287134

RESUMO

OBJECTIVES: Immune checkpoint inhibitors (ICIs) cause a variety of toxicities, including immune-related adverse events (irAEs), but there are no biomarkers to predict their development. Guidelines recommend measuring circulating cardiac troponin I (cTnI) during ICI therapy to detect related cardiotoxicities. Moreover, elevated cTnI has also been associated with worse outcomes in non-cardiac patients, including cancer. Thus here, we investigated whether cTnI levels were higher in patients with irAEs. METHODS: The study consisted of three groups; 21 cancer patients undergoing ICI immunotherapies who presented with irAEs, four patients without irAEs, and 20 healthy controls. Patient samples were assessed at baseline (n=25), during ICI treatment (n=25, median=6 weeks of treatment) and at toxicity (n=6, median=13 weeks of treatment). In addition to blood high sensitivity cardiac troponin I (hs-cTnI), anti-thyroglobulin (TG) and anti-thyroid peroxidase (TPO) antibodies were also quantitated to detect thyroid dysfunction, constituting the second leading toxicity (23.8%) after pneumonitis (28.6%). RESULTS: Four patients with irAEs (n=4/21; 19%) and one without irAEs (n=1/4; 25%) showed higher hs-cTnI levels at any time-point; the remaining had physiological levels. None of these patients developed cardiotoxicity. Concurrent elevated levels of anti-thyroid antibodies and hs-cTnI were detected in one patient with thyroid dysfunction (n=1/5, 20%). However, these antibodies were also elevated in three patients (n=3/16, 19%) with non-thyroid irAEs and in up to 40% of healthy controls. CONCLUSIONS: hs-cTnI was not elevated in patients with irAEs, but larger studies are needed to confirm these observations.


Assuntos
Antineoplásicos Imunológicos , Inibidores de Checkpoint Imunológico , Neoplasias , Humanos , Antineoplásicos Imunológicos/efeitos adversos , Cardiotoxicidade , Estudos de Casos e Controles , Inibidores de Checkpoint Imunológico/efeitos adversos , Neoplasias/tratamento farmacológico , Neoplasias/complicações , Estudos Retrospectivos , Doenças da Glândula Tireoide , Troponina I
20.
J Proteomics ; 271: 104769, 2023 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-36372392

RESUMO

OBJECTIVE: This study aims to find new plasma biomarkers in early pregnancy. DESIGN: The original study enrolled 1219 pregnant women. We investigated protein expression profiles of placental tissues from women with GDM (n = 89) and normal glucose tolerance (NGT) (n = 83). Maternal plasma samples between two groups in early and middle pregnancy were used for validation of candidate biomarkers. METHODS: Differentially expressed proteins (DEPs) were identified by label-free quantitative proteomics from human placenta samples between two groups. Several DEPs were validated in plasma by Luminex assays. An automatic biochemical analyzer was used to detect blood lipid indexes. The associations of GAL-3BP with biochemical indicators were demonstrated by Pearson's correlation analysis. Binary logistic regression was used to model potential predictive indicators in early pregnancy of GDM. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic accuracy of the predictive model and the value of GAL-3BP. RESULTS: 123 DEPs were found in placenta involved in ribosomal function, pancreatic secretion, oxidative phosphorylation, and inflammatory signaling pathway. Plasma GAL-3BP are significantly higher in women with GDM than NGT in the first (p = 0.008) and second (p = 0.026) trimester, but C9 and VWF have no difference. The predictive value of GAL-3BP in the first trimester of pregnancy (AUC 0.64) is better than that in the second trimester (AUC 0.61), and combined predictive model of TG and GAL-3BP at early pregnancy has greater predictive and diagnostic value for GDM (AUC 0.69) than individual GAL-3BP (AUC 0.64). CONCLUSIONS: Plasma TG and GAL-3BP has good predictive and diagnostic value at early pregnancy, suggesting that these two indicators may be used as biomarkers for early prediction and diagnosis of GDM. SIGNIFICANCE: The advantage of this study is that circulating TG and GAL-3BP might differentiate the progress of women with GDM and normal glucose tolerance (NGT) at the early stage of pregnancy. It is the first study to consider the role of GAL-3BP as an early predictive biomarker in the development of GDM during the whole pregnancy. Another advantage is that volunteers in this study were recruited from two provinces in China to eliminate the impacts of environmental confounders. The similar changes of blood glucose/lipid indicators for women with GDM and NGT in both regions was found in the first and second trimester of pregnancy, which added to the reliability of analytical results.


Assuntos
Diabetes Gestacional , Feminino , Gravidez , Humanos , Diabetes Gestacional/diagnóstico , Diabetes Gestacional/metabolismo , Estudos de Casos e Controles , Reprodutibilidade dos Testes , Placenta/química , Biomarcadores/metabolismo , Glicemia/metabolismo , China , Lipídeos
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