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1.
Lancet Oncol ; 23(1): e21-e31, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34973228

RESUMO

High-quality randomised clinical trials testing moderately fractionated breast radiotherapy have clearly shown that local control and survival is at least as effective as with 2 Gy daily fractions with similar or reduced normal tissue toxicity. Fewer treatment visits are welcomed by patients and their families, and reduced fractions produce substantial savings for health-care systems. Implementation of hypofractionation, however, has moved at a slow pace. The oncology community have now reached an inflection point created by new evidence from the FAST-Forward five-fraction randomised trial and catalysed by the need for the global radiation oncology community to unite during the COVID-19 pandemic and rapidly rethink hypofractionation implementation. The aim of this paper is to support equity of access for all patients to receive evidence-based breast external beam radiotherapy and to facilitate the translation of new evidence into routine daily practice. The results from this European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus state that moderately hypofractionated radiotherapy can be offered to any patient for whole breast, chest wall (with or without reconstruction), and nodal volumes. Ultrafractionation (five fractions) can also be offered for non-nodal breast or chest wall (without reconstruction) radiotherapy either as standard of care or within a randomised trial or prospective cohort. The consensus is timely; not only is it a pragmatic framework for radiation oncologists, but it provides a measured proposal for the path forward to influence policy makers and empower patients to ensure equity of access to evidence-based radiotherapy.


Assuntos
Comitês Consultivos/normas , Neoplasias da Mama/radioterapia , Fracionamento da Dose de Radiação , Seleção de Pacientes , Radioterapia (Especialidade)/normas , Neoplasias da Mama/patologia , COVID-19/epidemiologia , Consenso , Europa (Continente) , Medicina Baseada em Evidências , Feminino , Humanos , Hipofracionamento da Dose de Radiação
3.
Crit Care ; 26(1): 11, 2022 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-34983611

RESUMO

BACKGROUND: Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and influenza patients. OBJECTIVES: To determine the incidence of putative IPA in critically ill SARS-CoV-2 patients, compared with influenza patients. METHODS: This study was a planned ancillary analysis of the coVAPid multicenter retrospective European cohort. Consecutive adult patients requiring invasive mechanical ventilation for > 48 h for SARS-CoV-2 pneumonia or influenza pneumonia were included. The 28-day cumulative incidence of putative IPA, based on Blot definition, was the primary outcome. IPA incidence was estimated using the Kalbfleisch and Prentice method, considering extubation (dead or alive) within 28 days as competing event. RESULTS: A total of 1047 patients were included (566 in the SARS-CoV-2 group and 481 in the influenza group). The incidence of putative IPA was lower in SARS-CoV-2 pneumonia group (14, 2.5%) than in influenza pneumonia group (29, 6%), adjusted cause-specific hazard ratio (cHR) 3.29 (95% CI 1.53-7.02, p = 0.0006). When putative IPA and Aspergillus respiratory tract colonization were combined, the incidence was also significantly lower in the SARS-CoV-2 group, as compared to influenza group (4.1% vs. 10.2%), adjusted cHR 3.21 (95% CI 1.88-5.46, p < 0.0001). In the whole study population, putative IPA was associated with significant increase in 28-day mortality rate, and length of ICU stay, compared with colonized patients, or those with no IPA or Aspergillus colonization. CONCLUSIONS: Overall, the incidence of putative IPA was low. Its incidence was significantly lower in patients with SARS-CoV-2 pneumonia than in those with influenza pneumonia. Clinical trial registration The study was registered at ClinicalTrials.gov, number NCT04359693 .


Assuntos
COVID-19 , Influenza Humana , Intubação , Aspergilose Pulmonar Invasiva , Adulto , COVID-19/epidemiologia , COVID-19/terapia , Europa (Continente)/epidemiologia , Humanos , Incidência , Influenza Humana/epidemiologia , Influenza Humana/terapia , Aspergilose Pulmonar Invasiva/epidemiologia , Estudos Retrospectivos , SARS-CoV-2
4.
G Ital Cardiol (Rome) ; 23(1): 29-39, 2022 Jan.
Artigo em Italiano | MEDLINE | ID: mdl-34985460

RESUMO

Cardiac arrest (CA) is the third cause of death in Europe. This paper highlights the various treatments for the prevention and early management of CA and provides an overview of available evidence on the CA center concept. The experience of Maggiore Hospital of Bologna, Italy over the last 11 years is also outlined along with the treatments applied to patients with CA and their impact on improving outcomes. The new concept of the "Systems Saving Lives" approach is presented as a potential way for implementing Italian healthcare systems involved in the management of CA patients. Finally, the future perspective of implementation of CA centers in Italy is also described encouraging the healthcare professionals involved in the treatment of CA patients to consider a multidisciplinary approach (including a cardiologist, emergency physician, neurologist, physiatrist, radiologist, and intensivist).


Assuntos
Parada Cardíaca , Europa (Continente) , Previsões , Parada Cardíaca/terapia , Hospitais , Humanos , Itália
5.
Res Dev Disabil ; 121: 104139, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34979356

RESUMO

BACKGROUND: Children with Developmental Language Disorder (DLD) have a significant deficit in spoken language ability which affects their communication skills, education, mental health, employment and social inclusion. AIM: The present study reports findings from a survey by EU network COST ACTION 1406 and aims to explore differences in service delivery and funding of SLT services for children with DLD across Europe and beyond. METHODS AND PROCEDURES: The survey was completed by 5024 European professionals. COST countries were grouped into Nordic, Anglo-Saxon, Continental, Mediterranean, Central/Eastern and Non-European categories. The use of direct, indirect and mixed interventions, and their relationship to funding available (public, private or mixed) were considered for further analysis. OUTCOMES AND RESULTS: The results revealed that for direct therapy, there were more cases than expected receiving private funding. For indirect therapy, fewer than expected received private and more than expected public funding. For mixed therapy, fewer cases than expected received private funding. CONCLUSIONS AND IMPLICATIONS: The results implies that other factors than evidence-based practices, practitioners experience, and patient preferences, drive choices in therapy. More research is needed to gain a better understanding of factors affecting the choice of therapy.


Assuntos
Transtornos do Desenvolvimento da Linguagem , Terapia da Linguagem , Criança , Europa (Continente) , Humanos , Transtornos do Desenvolvimento da Linguagem/terapia , Fala , Fonoterapia
6.
Euro Surveill ; 27(1)2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34991776

RESUMO

We estimate the potential remaining COVID-19 hospitalisation and death burdens in 19 European countries by estimating the proportion of each country's population that has acquired immunity to severe disease through infection or vaccination. Our results suggest many European countries could still face high burdens of hospitalisations and deaths, particularly those with lower vaccination coverage, less historical transmission and/or older populations. Continued non-pharmaceutical interventions and efforts to achieve high vaccination coverage are required in these countries to limit severe COVID-19 outcomes.


Assuntos
COVID-19 , Europa (Continente)/epidemiologia , Hospitalização , Humanos , SARS-CoV-2 , Vacinação
7.
J Environ Manage ; 302(Pt A): 113917, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34700090

RESUMO

Land cover plays an important role in the Earth's climate as it affects multiple biochemical cycles and is critical for food security and biodiversity. As land cover is continuously evolving, influenced by anthropogenic and other factors, the availability of temporally varying land cover data sets of large spatial domains is integral to understanding, monitoring, and informing environmental management efforts. Here we use classification trees to generate annual land cover maps of the European continent for 2001 to 2019 on a ∼250 m resolution. The classification trees are trained using gap-filled and smoothed MODIS normalised difference vegetation index (NDVI) satellite data, as well as CORINE reference land cover data. We apply the bagging ensemble technique on oversampled NDVI data, with an additional majority vote for overlapping segments over the continent-wide domain. We distinguish between 39 land cover classes, with a total classification accuracy of 75% and average precision of 76%. The accuracy varies between the classes, with common classes (e.g. agricultural and forest classes) performing better than rarer ones (e.g. artificial land cover). Over the entire continent, we find that artificial land cover, wetlands, and forests have increased on average by 0.76, 0.50 and 0.22%/year respectively, while the agricultural area has decreased by 0.21%/year. We also quantify these changes in land cover on a national and metropolitan level. Given the near-real-time availability of global NDVI data, we note the potential of the presented approach for generating 'near-real-year' annual land cover data sets of large geographic domains, for the continuous monitoring of land cover change and the effects of interventions.


Assuntos
Monitoramento Ambiental , Florestas , Clima , Europa (Continente) , Áreas Alagadas
8.
Bioresour Technol ; 344(Pt A): 126208, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34715340

RESUMO

The continuous development of technologies involving critical metals, both in Europe and over the world, and geopolitical challenges in areas rich in critical metal sources, imposed increased research efforts to recover them from secondary sources, by eco-efficient processes. Yet, microbes-metal interactions are not sufficiently exploited to recover metals from secondary sources, although they are already used in ore extraction. This review examines and compare strategies and processes involving microorganisms for critical metals recovery, since conventional physico-chemical methods are energy-intensive and often polluting. Two groups of microbial assisted recovery processes are discussed: metal mobilization from metal bearing waste, and selective metal separation from leaching solutions by immobilization on microbial biomass. Because most of the identified microbial technologies are developed on laboratory scale, the increase of biorecovery efficiency is compulsory for enhancing scaling-up potential. Future developments focused on novel microorganisms and high-performance strategies for critical metal recovery by microbial processes are considered.


Assuntos
Metais , Biomassa , Europa (Continente)
9.
Sci Total Environ ; 806(Pt 4): 151462, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34742803

RESUMO

Wildfires are becoming an increasing threat to many communities worldwide. There has been substantial progress towards understanding the proximal causes of increased fire activity in recent years at regional and national scales. However, subcontinental scale examinations of the commonalities and differences in the drivers of fire activity across different regions are rare in the Mediterranean zone of the European Union (EUMed). Here, we first develop a new classification of EUMed pyroregions, based on grouping different ecoregions with similar seasonal patterns of burned area. We then examine the thresholds associated with fire activity in response to different drivers related to fuel moisture, surface meteorology and atmospheric stability. We document an overarching role for variation in dead fuel moisture content (FMd), or its atmospheric proxy of vapor pressure deficit (VPD), as the major driver of fire activity. A proxy for live fuel moisture content (EVI), wind speed (WS) and the Continuous Haines Index (CH) played secondary, albeit important, roles. There were minor differences in the actual threshold values of FMd (10-12%), EVI (0.29-0.36) and CH (4.9-5.5) associated with the onset of fire activity across pyroregions with peak fire seasons in summer and fall, despite very marked differences in mean annual burned area and fire size range. The average size of fire events increased with the number of drivers exceeding critical thresholds and reaching increasingly extreme values of a driver led to disproportionate increases in the likelihood of a fire becoming a large fire. For instance, the percentage of fires >500 ha increased from 2% to 25% as FMd changed from the wettest to the driest quantile. Our study is among the first to jointly address the roles of fuel moisture, surface meteorology and atmospheric stability on fire activity in EUMed and provides novel insights on the interactions across fire activity triggers.


Assuntos
Tempo (Meteorologia) , Incêndios Florestais , Europa (Continente) , Estações do Ano , Vento
10.
J Environ Manage ; 302(Pt A): 114063, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34749082

RESUMO

There is in an ongoing expansion of powerlines as a result of an increasing global demand for energy. Powerlines have the potential to negatively impact wild bird populations through collisions and/or electrocution, and reducing bird powerline collision and electrocution risk is a priority for companies running high-voltage powerlines (known as Transmission System Operators (TSOs)). Most TSOs are legally required to assess any potentially significant impacts via Enivronmental Impact Assessments, and so potentially collect a significant amount of data on the presence of species, species behaviour, and observed mortality rates. The value of such data, if available, for reducing and preventing bird casualties could be enhanced by increasing availability across TSOs and other decision-makers. We review the extent to which the sharing of data is happening across Europe, and how the quality, scope and availability of bird data collected by European TSOs could be improved, through use of a questionnaire and workshop with TSOs, conservationists and academics. Sixteen European TSOs responded to the questionnaire and 30 stakeholders attended the workshop. There was wide recognition of the value of different types of data on birds at powerlines, and a positive attitude to working together to share and enhance data across stakeholders to achieve the shared goal of reducing bird mortalities. Key barriers to the sharing of data included a lack of a centralised database, the lack of standardised methods to collect bird data and concerns over the confidentiality of data and reports. In order to overcome these barriers and develop a collaborative approach to data sharing, and ultimately inform best practice to reduce significant negative impacts on bird populations, we suggest a stepwise approach that (1) develops guidance around the field methods and data to be collected for mitigation effectiveness and (2) shares meta-data/bibliography of studies of powerline impacts/mitigation effectiveness for birds. In time, a more structured approach to the sharing of data and information could be developed, to make data findable, accessible, interoperable and reusable.


Assuntos
Animais Selvagens , Aves , Animais , Bases de Dados Factuais , Europa (Continente)
11.
Meat Sci ; 184: 108623, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34753110

RESUMO

Meat products constitute one of the most important groups of traditional foods. Thanks to the unique and favorable organoleptic characteristics, and high quality, they are willingly chosen by consumers. Lately, there has been a growing concern over the health aspects of these products. Therefore, the aim of this study was to analyze the nutritional value and factors affecting quality and health safety of traditional meat products on the basis of available literature. The study findings have revealed various issues with uniformity of traditional meat products. Products of the same name may differ substantially considering nutritional value. Reports also indicate that there are some discrepancies which can be attributed to product character (traditional/conventional). They mainly concern the content of moisture, protein, salt, fat, and fatty acid profile. Research suggests that traditional meat products may also be associated with some health safety issues, such as the presence of pathogens, polycyclic aromatic hydrocarbons, nitrate and nitrite residues, N-nitrosamines, biogenic amines and heavy metals.


Assuntos
Inocuidade dos Alimentos , Produtos da Carne/normas , Valor Nutritivo , Animais , Europa (Continente) , Contaminação de Alimentos/análise , Produtos da Carne/análise , Produtos da Carne/microbiologia
12.
Food Microbiol ; 102: 103904, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34809936

RESUMO

Evolving testing methods in food Microbiology have resulted in the need for different types of microbiological reference materials. Based on the research articles available in this area, it is evident that development has been quite substantial in chemical testing compared to Microbiology. The primary reason could be the ease of spiking, and recovery in chemical RM as compared to microbiological RM. A significant challenge faced in recovery and stability during the development of quantitative microbiological RM depends on temperature, type of microbiological media used, method of analysis including reconstitution method, interference due to antimicrobial agents in food matrices, and competitor microorganisms present in higher numbers then the target microorganisms. Most of the research papers published on microbiological reference materials are contributed by developed economies were in the information related to complex food matrices are limited. Further analysis of different International Depository Agencies under the Budapest treaty indicates that there are only three institutes based in Europe providing quantitative or assigned value RM. This, in turn, highlights the scarcity in the availability of quantitative RM in Microbiology. This article provides a global overview of the availability of microbiological RM, microbial preservation techniques, protective agents, and elaboration on developing different formats of microbiological RM used in food testing.


Assuntos
Análise de Alimentos/normas , Microbiologia de Alimentos , Europa (Continente) , Padrões de Referência , Temperatura
13.
J Hazard Mater ; 424(Pt A): 127232, 2022 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-34597932

RESUMO

Contaminants of emerging concern (CEC) are a focus in marine protection. Several CECs are released with wastewater effluents to coastal environments and their offshore occurrence has been recently documented. Routine monitoring is key for implementing marine protection acts, however infrastructural, financial, and technical limitations hinder this task along broad spatial transects. Here we show the efficacy of a new infrastructure enabling unmanned sampling of surface water from ships of opportunity in providing reliable and cost-effective routine monitoring of CECs along a Europe-Arctic transect. The distribution and long-range transport of several pharmaceuticals and personal care products, artificial food additives, and stimulants were assessed. Validation of operations through strict procedural and analytical quality criteria is presented. A framework to estimate a compound-specific spatial range (SR) index of marine long-range transport based on monitoring results and information on source spatial distribution, is introduced. Estimated SR values ranged 50-350 km depending on compound, yielding a ranking of long-range transport potential which reflected expectations based on degradation half-lives. SR values were used to calculate prior maps of detection probability that can be used to plan future routine monitoring in the region.


Assuntos
Monitoramento Ambiental , Poluentes Químicos da Água , Europa (Continente) , Navios , Águas Residuárias/análise , Poluentes Químicos da Água/análise
14.
Zool Res ; 43(1): 3-13, 2022 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-34766479

RESUMO

Cenozoic tectonic evolution in the Tethyan region has greatly changed the landforms and environment of Eurasia, driving the evolution of animals and greatly affecting the diversity patterns of Eurasian animals. By combining the latest Tethyan paleogeographic models and some recently published Eurasian zoological studies, we systematically summarize how tectonic evolution in the Tethyan region has influenced the evolution and diversity patterns of Eurasian animals. The convergence of continental plates, closure of Tethys Sea, and Tethyan sea-level changes have directly affected the composition and spatial distribution of Eurasian animal diversity. The topographic and environmental changes caused by Tethyan tectonics have determined regional animal diversity in Eurasia by influencing animal origin, dispersal, preservation, diversification, and extinction. The ecological transformations resulted in the emergence of new habitats and niches, which promoted animal adaptive evolution, specialization, speciation, and expansion. We highlight that the Cenozoic tectonic evolution of the Tethyan region has been responsible for much of the alteration in Eurasian animal distribution and has been an essential force in shaping organic evolution. Furthermore, we generalize a general pattern that Tethyan geological events are linked with Eurasian animal evolution and diversity dynamics.


Assuntos
Distribuição Animal , Biodiversidade , Evolução Biológica , Animais , Ásia , Europa (Continente) , Filogenia
15.
Chemistry ; 28(1): e202104280, 2022 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-34931735

RESUMO

Science and scholarly publishing are transforming! Chemistry-A European Journal, the flagship of the Chemistry Europe family of journals has been transforming and evolving too. We have been working hard over the last year to adapt and improve our processes and workflows to meet the changing requirements of our authors, referees and readers. Read all about these changes, and much more about the journal and Chemistry Europe portfolio in this Editorial.


Assuntos
Publicações Periódicas como Assunto , Editoração , Europa (Continente)
16.
Emerg Infect Dis ; 28(1): 137-138, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34932457

RESUMO

We evaluated invasive pneumococcal disease (IPD) during 8 years of infant pneumococcal conjugate vaccine (PCV) programs using 10-valent (PCV10) and 13-valent (PCV13) vaccines in 10 countries in Europe. IPD incidence declined during 2011-2014 but increased during 2015-2018 in all age groups. From the 7-valent PCV period to 2018, IPD incidence declined by 42% in children <5 years of age, 32% in persons 5-64 years of age, and 7% in persons >65 years of age; non-PCV13 serotype incidence increased by 111%, 63%, and 84%, respectively, for these groups. Trends were similar in countries using PCV13 or PCV10, despite different serotype distribution. In 2018, serotypes in the 15-valent and 20-valent PCVs represented one third of cases in children <5 years of age and two thirds of cases in persons >65 years of age. Non-PCV13 serotype increases reduced the overall effect of childhood PCV10/PCV13 programs on IPD. New vaccines providing broader serotype protection are needed.


Assuntos
Infecções Pneumocócicas , Streptococcus pneumoniae , Adolescente , Adulto , Criança , Pré-Escolar , Europa (Continente)/epidemiologia , Humanos , Lactente , Pessoa de Meia-Idade , Infecções Pneumocócicas/epidemiologia , Infecções Pneumocócicas/prevenção & controle , Vacinas Pneumocócicas , Sorogrupo , Vacinas Conjugadas , Adulto Jovem
17.
Maturitas ; 155: 32-39, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34876247

RESUMO

BACKGROUND: Marital relationship plays an important role in health and wellbeing. However, how marriage is associated with multimorbidity (the co-occurrence of two or more chronic conditions) has not been comprehensively investigated. We aimed to assess the association between marriage and multimorbidity in middle-aged adults. METHODS: We used nationally representative data on 23641 adults aged 50-60 years who participated in four longitudinal studies in the US, UK, Europe, and China (Health and Retirement Study, English Longitudinal Study on Ageing, Survey of Health, Ageing and Retirement in Europe, and China Health and Retirement Longitudinal Study). Respondents were followed up in 2010-11 (baseline), 2012-13, and 2014-15. We used generalized estimating equations to evaluate the associations between marital status (married/partnered or non-married [separated/devoiced/widowed/never married]), marriage duration and multimorbidity, adjusting for socioeconomic and lifestyle factors. RESULTS: Over 4-year follow-up, 24% (n=5699) of respondents experienced separation, divorce, widowhood, or never-married status, and approximately 43% (n=10228) of respondents reported multimorbidity. Those who were not married had a higher odds of multimorbidity (age-, sex- and region-adjusted odds ratio 1.19; 95% confidence interval 1.14 to 1.25). Those who had been married for 21-30 years had a lower odds of experiencing multimorbidity than those married for less than 10 years. The associations remained robust after adjusting for socioeconomic and lifestyle factors. CONCLUSIONS: Marital relationship (status and length) was associated with multimorbidity in middle-aged adults, highlighting the role of marital relationship in shaping the trajectory of health and wellbeing across the life course. These findings provide insight for the prevention and management of chronic disease and multimorbidity.


Assuntos
Casamento , Multimorbidade , China/epidemiologia , Europa (Continente) , Humanos , Estudos Longitudinais , Estado Civil , Pessoa de Meia-Idade , Reino Unido/epidemiologia
18.
Ambio ; 51(1): 135-151, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33983559

RESUMO

Freshwater ecosystems are among the most threatened in the world, while providing numerous essential ecosystem services (ES) to humans. Despite their importance, research on freshwater ecosystem services is limited. Here, we examine how freshwater studies could help to advance ES research and vice versa. We summarize major knowledge gaps and suggest solutions focusing on science and policy in Europe. We found several features that are unique to freshwater ecosystems, but often disregarded in ES assessments. Insufficient transfer of knowledge towards stakeholders is also problematic. Knowledge transfer and implementation seems to be less effective towards South-east Europe. Focusing on the strengths of freshwater research regarding connectivity, across borders, involving multiple actors can help to improve ES research towards a more dynamic, landscape-level approach, which we believe can boost the implementation of the ES concept in freshwater policies. Bridging these gaps can contribute to achieve the ambitious targets of the EU's Green Deal.


Assuntos
Conservação dos Recursos Naturais , Ecossistema , Europa (Continente) , Fertilização , Água Doce , Humanos
19.
Food Chem ; 371: 131178, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-34583186

RESUMO

New microplasma source optical emission spectrometry (OES) for the determination of Na, K, Mg, Ca, and Zn in wine was developed. As the microplasma source, a solution anode glow discharge (SAGD) or a solution cathode glow discharge (SCGD) were employed. The diluted samples solutions (0.5-2%) were directly analyzed (no acid digestion required) and the detection limits of Na, K, Mg, Ca, and Zn were 0.015, 0.03, 3, 12, and 0.1 µg L-1, respectively. The developed method was used for the analysis of wine samples from the province of Lower Silesia (Poland). It was found that 1) red wines were characterized by a higher content of K and Mg, 2) it was possible to discriminate between Regent and Pinot Noir grape varieties (both red) by the concentrations of K and Ca, 3) the concentration of Na in the analyzed wines was lower than that found in wines from other European countries.


Assuntos
Vitis , Vinho , Europa (Continente) , Polônia , Análise Espectral , Vinho/análise
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