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1.
J Theor Biol ; 556: 111311, 2023 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-36257351

RESUMO

Modeling of the biological neurons is a way to understand the architecture of neural networks of the brain. A complex brain network includes the synchronization between some groups of neurons. The dynamic behavior of interactions between groups of slave-master neurons in the neocortical network is unpredictable and challenging. The purpose of synchronizing a neural interaction is to reduce the synchronization error between the chaotic slave-master neurons. This paper uses a proportional-integral-derivative (PID) controller to synchronize master-slave neurons in the fractional-order of the neocortical network model based on dendritic spike frequency adaptation (DSFA) uncertainties and unknown disturbance effects. The purpose of this article is in two parts: First, we implemented the effect of previous states of the neuron conditions by fractional-order of the differential equations in the neocortical network model. Second, by synchronizing the FO neocortical master-slave model by PID controller, we investigated the connection strength of the complex network in chaotic point of view. The optimized PID coefficients and fractional-order were calculated using root mean square error (RMSE) criteria to control the membrane voltage synchronization. The chaotic behavior of the system was evaluated by numerical techniques such as attractor analysis and time series diagrams. The optimal RMSE value for master-slave neurons occurred at fractional-orders 0.89. It is shown that the synchronization of master-slave neurons improves over time, and eventually they are fully synchronized while the controller error is reduced.


Assuntos
Neocórtex , Redes Neurais de Computação , Neurônios/fisiologia , Fatores de Tempo
2.
Vasc Endovascular Surg ; 57(1): 41-47, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36171181

RESUMO

OBJECTIVE: We retrospectively investigated the association between the imaging features of spontaneous isolated superior mesenteric artery dissection (SISMAD) accompanied by total true lumen occlusion and the clinical symptoms to identify the patients at high risk and establish personalized therapeutic options. METHODS: Among 261 patients with SISMAD, we selected 37 with Yun's type III dissection; 35 patients underwent successful conservative management and 2 patients underwent exploratory laparotomy. After discharge, all patients were periodically followed up on an outpatient basis. We recorded patients' general condition, symptoms, time until symptom relief, imaging findings and follow-up results. RESULTS: All patients experienced acute abdominal pain prior to admission, with an onset time of 29.95 ± 24.66 hours. The mean time until relief of abdominal pain in patients who received conservative treatment was 42.17 ± 38.09 hours. Correlation analysis revealed no correlation between the length of dissection or of the occluded segment and abdominal pain intensity. Pain scores were lower and time until pain relief was shorter in patients with a definite arc of Riolan (AOR) on admission than in those without an AOR. No collateral circulation was observed in the two patients who underwent exploratory laparotomy, and distal intestinal perfusion was poor in these cases. Complete and partial remodeling of the superior mesenteric artery (SMA) was observed in 6 and 16 patients, respectively at the 12-month follow-up. Although the SMA remained occluded in 12 patients, abundant collateral circulation was detected. Three patients were lost to follow-up. CONCLUSION: This study highlights that conservative treatment should be attempted as first-line therapy in most patients with Yun's type III SISMAD. Complete AOR can contribute to remission of clinical symptoms during the acute stage. Poor distal blood flow of occluded vessels may serve as an important indicator for identification of patients at high risk of ischemic intestinal necrosis.


Assuntos
Aneurisma Dissecante , Doenças Vasculares , Humanos , Artéria Mesentérica Superior/diagnóstico por imagem , Aneurisma Dissecante/diagnóstico por imagem , Aneurisma Dissecante/terapia , Aneurisma Dissecante/complicações , Estudos Retrospectivos , Resultado do Tratamento , Fatores de Tempo , Dor Abdominal/etiologia
3.
West J Nurs Res ; 45(1): 55-66, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35711105

RESUMO

Prehospital delay after stroke symptom onset is a primary barrier to eligibility for reperfusion therapies. Decision delay is an understudied contributor to prehospital delay. We aimed to explore decision delay as a component of prehospital delay. For this correlational study, 170 Thai acute stroke patients were interviewed to explore their treatment-seeking decision factors: prior stroke knowledge, onset context, and cognitive, emotional, and behavioral factors. Participants' mean age was 61.2 years, and 46% were women. Median decision delay and prehospital delay times were 120 and 372 minutes. Decision delay represented 49% of prehospital delays. Factors shortening decision delay were atrial fibrillation, prior stroke knowledge, perceived cause of symptoms as stroke, perceived severity of symptoms, and advice from bystanders to seek treatment. In contrast, seeking support from others and self-treatment affected prolonged decision delay. Shortening decision delay, often under the patient or bystander control, can reduce overall prehospital delay.


Assuntos
Serviços Médicos de Emergência , Acidente Vascular Cerebral , Humanos , Feminino , Pessoa de Meia-Idade , Masculino , Fatores de Tempo , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/terapia
4.
J Surg Res ; 282: 280-284, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36347128

RESUMO

INTRODUCTION: Acute lower limb ischemia (ALI) is a limb- and potentially life-threatening condition which requires urgent evaluation and treatment. Contemporary data on optimal therapy and prognosis of ALI are lacking, while surgical, hybrid, and foremost endovascular techniques have rapidly evolved over the past decades. Available clinical guidelines are not based on high-level evidence and do not fully reflect day-do-day practice. Contemporary data on etiology, procedural strategies as well as patient outcomes in ALI are urgently needed to improve care and prevent limb loss. The current study was initiated by the European Vascular Research Collaborative (EVRC), established by young European vascular specialists, and aims to provide insight into contemporary treatment strategies in ALI and its clinical results within Europe. In this manuscript we report the rationale and a detailed study protocol. MATERIAL AND METHODS: The proposed study is a prospective, international, multicenter, observational study on ALI (PROMOTE-ALI) (ClinicalTrials.gov - NCT05138679). Patients with ALI (Rutherford classification grade I -III) of one or both lower extremities will be included in the study. The primary endpoint of the study is amputation-free survival (AFS) at 30 d. Secondary endpoints are freedom from target limb reintervention, freedom from complications, clinical outcome of the index leg, and limb salvage and survival at 30 and 90 d after diagnosis of ALI. CONCLUSIONS: ALI remains a challenging condition and due to the heterogeneous etiology, clinical presentation and treatment strategies, a large multicenter study on this topic is needed to gain contemporary data on clinical outcomes and prognosis, especially for modern endovascular techniques. PROMOTE-ALI is expected to provide these data and set a benchmark for future randomized controlled trials (RCTs).


Assuntos
Isquemia , Doenças Vasculares Periféricas , Humanos , Estudos Prospectivos , Resultado do Tratamento , Fatores de Risco , Doença Aguda , Fatores de Tempo , Isquemia/diagnóstico , Isquemia/etiologia , Isquemia/cirurgia , Estudos Observacionais como Assunto , Estudos Multicêntricos como Assunto
5.
J Surg Res ; 282: 93-100, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36265430

RESUMO

INTRODUCTION: Appendectomy for acute appendicitis is the most common pediatric intra-abdominal operation. Current literature supports the notion that modest in-hospital, preoperative delays are not associated with greater patient morbidity. However, there is less certainty regarding the role that hour-of-presentation plays in determining the timing of surgery. Thus, we aimed to evaluate how after-hours presentation may relate to the timing of surgery and to assess the outcomes and resource utilization associated with expedited appendectomy compared to nonexpedited. METHODS: Patient records for children who underwent an appendectomy at a freestanding pediatric hospital from 2015 to 2019 were reviewed. Business hour presentations were defined as arrival at the emergency department from 7 AM to 6 PM. Primary outcomes were hospital length of stay (LOS), cost derived from the Pediatric Health Information System database, perforation, surgical complications, and 30-day readmissions. RESULTS: Nine hundred forty-two patients underwent appendectomy over the study period. The median time to OR was 2.0 h in the expedited cohort and 9.8 h in the nonexpedited group. Presentation during business hours was associated with 4.4 higher odds (P < 0.001) of expedited workflow. Expedited appendectomies were associated with shorter hospital LOS (11.5 h, P < 0.001), less costly admissions ($1,155, P < 0.001); LOS measured in midnights, perforation and readmission rates were similar between groups. CONCLUSIONS: We found reduced resource utilization associated with expedited appendectomy. Additionally, the demonstrated association between the time of presentation to the emergency department (ED) and the timing of surgery may be utilized to inform staffing and resource deployment decisions. Further research regarding the generalizability and sustainability of an expedited presurgical workflow in pediatric appendectomy is certainly indicated.


Assuntos
Apendicite , Humanos , Criança , Apendicite/cirurgia , Apendicite/complicações , Estudos Retrospectivos , Fatores de Tempo , Apendicectomia/efeitos adversos , Tempo de Internação
6.
Respir Physiol Neurobiol ; 307: 103976, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36206973

RESUMO

BACKGROUND: In patients with cystic fibrosis (CF), thoracic morphology and its role in respiratory function is conditioned by anthropometric factors, as well as by pathological changes. While the lungs are continuously monitored, examinations of potential thoracic cage adaptations to the disease are rare. Hence, the aim of this study was to investigate thoracic configuration, and its correlation to spirometry measures over time. METHODS: In total, 344 high-resolution computed tomography (HRCT) examinations from 90 patients were assessed and analysed. Those results were subsequently related to spirometry measurements performed within the same period. RESULTS: The cohort displayed no homogenous change in thoracic configuration over time, and correlation between thoracic area and spirometry variables could not be supported statistically. CONCLUSIONS: Although the current study included a larger cohort of patients with CF compared to previous studies on thoracic morphology, no patient group-specific changes in thoracic configuration were revealed. Furthermore, no correlations between structural findings and functional respiratory measurements were found.


Assuntos
Fibrose Cística , Humanos , Volume Expiratório Forçado , Pulmão , Estudos Retrospectivos , Espirometria/métodos , Tórax/anatomia & histologia , Fatores de Tempo
7.
Clin Podiatr Med Surg ; 40(1): 23-37, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36368846

RESUMO

Ankle syndesmosis injuries include isolated ligamentous rupture, as well as fractures with ligamentous injury. These injuries can significantly affect athletes in all sports, and lead to prolonged recovery and return to sport. Adequate evaluation and diagnosis of these injuries are imperative for treatment and return to play. Many can be treated nonoperatively, but operative treatment is indicated in fractures with syndesmosis disruption and ligamentous injuries with instability. Anatomic reduction and fixation of these injuries will allow functional rehab and return to sport.


Assuntos
Traumatismos do Tornozelo , Traumatismos em Atletas , Fraturas Ósseas , Humanos , Traumatismos do Tornozelo/diagnóstico , Traumatismos do Tornozelo/cirurgia , Articulação do Tornozelo/cirurgia , Fraturas Ósseas/diagnóstico por imagem , Fraturas Ósseas/cirurgia , Fatores de Tempo , Traumatismos em Atletas/diagnóstico , Traumatismos em Atletas/cirurgia
8.
Environ Res ; 216(Pt 2): 114581, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36244443

RESUMO

BACKGROUND: Tuberculosis (TB) is a severe public health problem globally. Previous studies have revealed insufficient and inconsistent associations between air pollutants, meteorological factors and TB cases. Yet few studies have examined the associations between air pollutants, meteorological factors and TB cases in Beijing. OBJECTIVE: The purpose of this study was to explore the impact of air pollutants and meteorological factors on TB in Beijing, and to provide novel insights into public health managers to formulate control strategies of TB. METHODS: Data on the daily case of TB in Beijing during 2014-2020 were obtained from Chinese tuberculosis information management system. Concurrent data on the daily PM10, PM2.5, SO2, NO2, CO and O3, were obtained from the online publication platform of the Chinese National Environmental Monitoring Center. Daily average temperature, average wind speed, relative humidity, sunshine duration and total precipitation were collected from the China Meteorological Science Data Sharing Service System. A distributed lag non-linear model was fitted to identify the non-linear exposure-response relationship and the lag effects between air pollutions, meteorological factors and TB cases in Beijing. RESULTS: In the single-factor model, the excess risk (ER) of TB was significantly positively associated with every 10 µg/m3 increase in NO2 in lag 1 week (ER: 1.3%; 95% confidence interval [CI]: 0.4%, 2.3%) and every 0.1 m/s increase in average wind speed in lag 5 weeks (ER: 0.3%; 95% CI: 0.1%, 0.5%), and was negatively associated with every 10 µg/m3 increase in O3 in lag 1 week (ER: -1.2%; 95% CI: -1.8%, -0.5%), every 5 °C increase in average temperature (ER: -1.7%; 95% CI: -2.9%, -0.4%) and every 10% increase in average relative humidity (ER: -0.4%; 95% CI: -0.8%, -0.1%) in lag 10 weeks, respectively. In the multi-factor model, the lag effects between TB cases and air pollutants, meteorological factors were similar. The subgroup analysis suggests that the effects of NO2, O3, average wind speed and relative humidity on TB were greater in male or labor age subgroup, while the effect of CO was greater in the elderly. In addition, no significant associations were found between PM2.5, SO2, sunshine duration and TB cases. CONCLUSION: Our findings provide a better understanding of air pollutants and meteorological factors driving tuberculosis occurrence in Beijing, which enhances the capacity of public health manager to target early warning and disease control policy-making.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Tuberculose , Masculino , Humanos , Idoso , Feminino , Poluentes Atmosféricos/análise , Pequim/epidemiologia , Dióxido de Nitrogênio , Fatores de Tempo , Poluição do Ar/análise , Conceitos Meteorológicos , China/epidemiologia , Tuberculose/epidemiologia , Tuberculose/etiologia , Material Particulado/análise
9.
Environ Res ; 216(Pt 2): 114644, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36306876

RESUMO

Per- and polyfluoroalkyl substances (PFAS) are anthropogenic chemicals that have been globally distributed. Biological time series data suggest variation in temporal PFAS concentrations due to regulations and the phase-out of multiple PFAS analytes. Nonetheless, biomonitoring temporal trends of PFAS concentrations in raptors has only been done sporadically in Europe at a national scale. In the present study, we examined the concentrations of 28 PFAS in livers of common buzzard (Buteo buteo) collected in Belgium in the period 2000-2005 and in 2021. Despite the regulations and phase-out, the ΣPFAS concentrations remained similar in the livers over the past 20 years. However, over time the abundance of perfluorooctane sulfonate (PFOS), dominant in livers collected in 2000-2005, to the ΣPFAS concentration decreased from 46% to 27%, whereas the abundance of perfluorotetradecanoic acid (PFTeDA), dominant in 2021, increased from 19% to 43%. The PFOS concentrations in the present study did not exceed the Toxicity Reference Values (TRVs), which were determined in liver on the characteristics of an avian top predator. The absence of temporal changes in PFAS concentrations is hypothesized to be due to a lagged response in environmental concentrations compared to atmospheric concentrations.


Assuntos
Ácidos Alcanossulfônicos , Poluentes Ambientais , Falconiformes , Fluorcarbonetos , Aves Predatórias , Animais , Fluorcarbonetos/análise , Bélgica , Ácidos Alcanossulfônicos/análise , Fatores de Tempo , Fígado/química
10.
Forensic Sci Int Genet ; 57: 102661, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35063923

RESUMO

Non-self DNA is normally present on skin due to DNA transfer occurring during daily activities. The understanding of persistence and accumulation of foreign DNA on the neck can assist in the interpretation of DNA evidence collected from an assaulted victim. Establishing the composition and level of non-self DNA present is relevant, especially in cases where the victim cohabits with other individuals, such as partner and children. This study investigated the persistence and accumulation of non-self DNA on the neck, over the course of 24 h. DNA samples were collected from the neck of 20 adult volunteers at three time-points, on two days. The detection of a partner's DNA and DNA from unknown sources was studied in relation to the living arrangement and to the activities performed by each individual. An increased number of non-self alleles were detected over time. Partner's DNA was observed to accumulate during the day and to persist when an individual was absent from the shared home environment. DNA from unknown contributors was found on the neck of individuals that used public transport, attended public spaces and had social interactions. The data acquired from this study will help to increase knowledge on the composition of DNA present on an individual's neck in a daily situation.


Assuntos
Vítimas de Crime , DNA , Adulto , Alelos , Criança , DNA/genética , Humanos , Fatores de Tempo
11.
Rev. urug. enferm ; 17(2): 1-14, dic. 2022.
Artigo em Português | LILACS, BDENF - Enfermagem | ID: biblio-1391902

RESUMO

Objetivo: Avaliar as características das internações de recém-nascidos em uma unidade de terapia intensiva neonatal do extremo sul do Brasil durante um curto período de tempo. Método: Estudo observacional, com 85 neonatos, por dados secundários de pacientes internados na Unidade de Terapia Intensiva Neonatal, nos meses de maio de 2020 a outubro de 2020. Resultados: A prevalência das internações foi do sexo masculino, com diagnóstico de prematuridade, que pesavam entre 1500g e 2499g, não receberam leite materno na primeira hora de vida, receberam visitas dos pais, colo e leite materno durante a internação. As mães tinham mais de 6 consultas de pré-natal e os bebês nasceram de cesárea. Conclusão: O atendimento prestado de forma holística, baseado na ciência e maneira humanizada aos recém-nascidos e aos pais, pode reduzir a mortalidade infantil, trazer maior segurança aos pais e confi ança na equipe assistencial, além de evitar complicações futuras no desenvolvimento infantil.


Objetivo: Evaluar las características de las hospitalizaciones de recién nacidos en una unidad de cuidados intensivos neonatales en el extremo sur de Brasil durante un corto período de tiempo. Método: Estudio observacional, con 85 neonatos, con base en datos secundarios de pacientes hospitalizados en la Unidad de Cuidados Intensivos Neonatales, de mayo de 2020 a octubre de 2020. Resultados: La prevalencia de hospitalizaciones fue del sexo masculino, con diagnóstico de prematuridad, que pesaron entre 1500g y 2499g, no recibió leche materna en la primera hora de vida, recibió visitas de los padres, regazo y leche materna durante la hospitalización. Las madres tuvieron más de 6 consultas prenatales y los bebés nacieron por cesárea. Conclusión: La atención brindada de forma holística, basada en la ciencia y de forma humanizada a los recién nacidos y a los padres, puede reducir la mortalidad infantil, brindar mayor seguridad a los padres y confi anza en el equipo de atención, además de prevenir futuras complicaciones en el desarrollo del niño.


Objective: To evaluate the characteristics of hospitalizations of newborns in a neonatal intensive care unit in the extreme south of Brazil during a short period of time. Method: Observational study, with 85 neonates, based on secondary data from patients hospitalized in the Neonatal Intensive Care Unit, from May 2020 to October 2020. Results: The prevalence of hospitalizations was male, with a diagnosis of prematurity, who weighed between 1500g and 2499g, did not receive breast milk in the fi rst hour of life, received visits from parents, lap and breast milk during hospitalization. The mothers had more than 6 prenatal consultations and the babies were born by cesarean section. Conclusion: The care provided in a holistic way, based on science and in a humanized way to newborns and parents, can reduce infant mortality, bring greater security to parents and confidence in the care team, in addition to preventing future complications in child development.


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Criança , Adolescente , Adulto , Adulto Jovem , Qualidade da Assistência à Saúde , Unidades de Terapia Intensiva Neonatal , COVID-19/epidemiologia , Hospitalização , Fatores Socioeconômicos , Fatores de Tempo , Brasil/epidemiologia , Mortalidade Infantil , Estudos Retrospectivos , Estudos Longitudinais , Humanização da Assistência , Saúde Holística
12.
Braz. j. oral sci ; 21: e225757, jan.-dez. 2022. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1366215

RESUMO

Aim: This study aimed to evaluate the effect of frozen storage on the physical properties of a silicone-based test food material, highly used to evaluate the masticatory performance in research settings. Methods: A total of 1,666 silicone cubes of Optosil Comfort® with 5.6-mm edges were shaped and stored at -18°C. The cubes were subsequently tested for flexural strength (maximum force, displacement, stress, and strain) before breaking (n = 136), changes in weight and size (n = 170), and masticatory performance (n = 1360) at eight timepoints: immediately after cube preparation (baseline, no freezing), and 1, 2, 3 and 4 weeks, and 2, 4 and 6 months after frozen storage. The cubes were thawed 8 h before each assessment. Results: The maximum force, stress, maximum displacement, and deformation values for the cubes were not affected by freezing (P > 0.05). At all of the time points, the cubes exhibited similar weight (P = 0.366) and size (identical values). The masticatory performance for the cubes also showed no differences from baseline through 6 months (P = 0.061). Conclusion: Freezing Optosil Comfort® silicone cubes did not alter the physical and mechanical properties of the material, being suitable to optimize the assessment of masticatory parameters for research purposes


Assuntos
Humanos , Masculino , Adulto , Elastômeros de Silicone , Teste de Materiais/métodos , Fenômenos Físicos , Congelamento , Resistência à Flexão , Mastigação , Fatores de Tempo
13.
PLoS One ; 17(11): e0277050, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36327244

RESUMO

BACKGROUND: Higher postoperative mortality has been observed among patients who received emergency colorectal surgery on the weekend compared to during the week. The aim of this study was to determine whether the weekday of emergency surgery affects the 30-day mortality and postoperative course in emergency colorectal surgery. METHODS: Prospectively acquired data from the 2010-2017 German StuDoQ|Colorectal surgery registries were analysed. Differences in 30-day mortality, transfer and length of stay (MTL30) (primary endpoints), postoperative complications, length of stay and pathological results of resected specimens (secondary endpoints) were assessed. Multivariable analysis was performed to identify independent risk factors for postoperative outcome. RESULTS: In total, 1,174 patients were included in the analysis. Major postoperative complications and the need for reoperation were observed more frequently for emergency colorectal surgery performed during the week compared to the weekend (23.01 vs. 15.28%, p = 0.036 and 17.96% vs. 11.11%, p = 0.040, respectively). In contrast, patients who received emergency surgery on the weekend presented with significantly higher UICC tumour stages (UICC III 44.06 vs. 34.15%, p = 0.020) compared to patients with emergency colorectal surgery on a weekday. Emergency surgery performed during the week was an independent risk factor for the development of severe postoperative complications (OR 1.69 [1.04-2.74], p = 0.033) and need for reoperation (OR 1.79 [1.02-3.05], p = 0.041) in the multivariable analysis. CONCLUSION: Emergency surgery for colorectal carcinoma in Germany is performed with equal postoperative MTL30 and mortality throughout the entire week. However, emergency surgery during the week seems to be associated with a higher rate of severe postoperative complications and reoperation.


Assuntos
Neoplasias Colorretais , Humanos , Tempo de Internação , Fatores de Tempo , Sistema de Registros , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Mortalidade Hospitalar , Estudos Retrospectivos
14.
PLoS One ; 17(11): e0275532, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36327270

RESUMO

In this paper, we propose a portmanteau test for whether a graph-structured network dataset without replicates exhibits autocorrelation across units connected by edges. Specifically, the well known Ljung-Box test for serial autocorrelation of time series data is generalized to the network setting using a specially derived central limit theorem for a weakly stationary random field. The asymptotic distribution of the test statistic under the null hypothesis of no autocorrelation is shown to be chi-squared, yielding a simple and easy-to-implement procedure for testing graph-structured autocorrelation, including spatial and spatial-temporal autocorrelation as special cases. Numerical simulations are carried out to demonstrate and confirm the derived asymptotic results. Convergence is found to occur quickly depending on the number of lags included in the test statistic, and a significant increase in statistical power is also observed relative to some recently proposed permutation tests. An example application is presented by fitting spatial autoregressive models to the distribution of COVID-19 cases across counties in New York state.


Assuntos
COVID-19 , Humanos , COVID-19/epidemiologia , Análise Espacial , Fatores de Tempo , New York
15.
Comput Intell Neurosci ; 2022: 8753323, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36337267

RESUMO

In recent years, anomaly detection techniques in time-series data have been widely used in manufacturing, cybersecurity, and other fields. Meanwhile, various anomaly detection models based on generative adversarial networks (GAN) are gradually used in time-series anomaly detection tasks. However, there are problems of unstable generator training, missed detection of anomalous data, and inconsistency between the discriminator's discriminant and the anomaly detection target in GAN networks. Aiming at the above problems, the paper proposes a DUAL-ADGAN (Dual Anomaly Detection Generative Adversarial Networks) model for the detection of anomalous data in time series. First, the Wasserstein distance satisfying the Lipschitz constraint is used as the loss function of the data reconstruction module, which improves the stability of the traditional GAN network training. Second, by adding a data prediction module to the DUAL-ADGAN model, the distinction between abnormal and normal samples is increased, and the rate of missing abnormal data in the model is reduced. Third, by introducing the Fence-GAN loss function, the discriminator is aligned with the anomaly detection target, which effectively reduces the anomaly data false detection rate of the DUAL-ADGAN model. Finally, anomaly scores derived from the DUAL-ADGAN model are compared with dynamic thresholds to detect anomalies. The experimental results show that the average F1 of the DUAL-ADGAN model is 0.881, which is better than the other nine baseline models. The conclusions demonstrate that the DUAL-ADGAN model proposed in the paper is more stable in training while effectively solving the problems of anomaly miss detection and discriminator inconsistency with the anomaly detection target in the anomaly detection task.


Assuntos
Processamento de Imagem Assistida por Computador , Processamento de Imagem Assistida por Computador/métodos , Fatores de Tempo
16.
Zhonghua Yan Ke Za Zhi ; 58(11): 994-999, 2022 Nov 11.
Artigo em Chinês | MEDLINE | ID: mdl-36348548

RESUMO

Botulinum toxin type A (BTX-A) can change the eye alignment system through chemodenervation on extraocular muscles. The breakdown in the balance of eye alignment system which is supported by agonistic and antagonistic muscles, in combination with brain feedback, can stimulates muscle remodeling to reconstruct new binocular vision and restore eye alignment. Since BTX-A was approved by FDA in 1989 for the treatment of strabismus, it has become one of the important non-surgical treatments for strabismus in children. It has the advantages of low invasiveness, short duration of anesthesia and scar-free after treatment. This review will introduce the history, injection methods, and types of BTX-A, as well as its application in the treatment of various types of strabismus in children.


Assuntos
Toxinas Botulínicas Tipo A , Estrabismo , Criança , Humanos , Toxinas Botulínicas Tipo A/uso terapêutico , Estrabismo/cirurgia , Músculos Oculomotores/cirurgia , Visão Binocular , Fatores de Tempo
17.
Comput Math Methods Med ; 2022: 7828131, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36349145

RESUMO

Tuberculosis (TB) is one of the world's deadliest infectious disease killers today, and despite China's increasing efforts to prevent and control TB, the TB epidemic is still very serious. In the context of the COVID-19 pandemic, if reliable forecasts of TB epidemic trends can be made, they can help policymakers with early warning and contribute to the prevention and control of TB. In this study, we collected monthly reports of pulmonary tuberculosis (PTB) in Guiyang, China, from January 1, 2010 to December 31, 2020, and monthly meteorological data for the same period, and used LASSO regression to screen four meteorological factors that had an influence on the monthly reports of PTB in Guiyang, including sunshine hours, relative humidity, average atmospheric pressure, and annual highest temperature, of which relative humidity (6-month lag) and average atmospheric pressure (7-month lag) have a lagging effect with the number of TB reports in Guiyang. Based on these data, we constructed ARIMA, Holt-Winters (additive and multiplicative), ARIMAX (with meteorological factors), LSTM, and multivariable LSTM (with meteorological factors). We found that the addition of meteorological factors significantly improved the performance of the time series prediction model, which, after comprehensive consideration, included the ARIMAX (1,1,1) (0,1,2)12 model with a lag of 7 months at the average atmospheric pressure, outperforms the other models in terms of both fit (RMSE = 37.570, MAPE = 10.164%, MAE = 28.511) and forecast sensitivity (RMSE = 20.724, MAPE = 6.901%, MAE = 17.306), so the ARIMAX (1,1,1) (0,1,2)12 model with a lag of 7 months can be used as a predictor tool for predicting the number of monthly reports of PTB in Guiyang, China.


Assuntos
COVID-19 , Tuberculose Pulmonar , Tuberculose , Humanos , China/epidemiologia , Incidência , Fatores de Tempo , Pandemias , Tuberculose Pulmonar/epidemiologia , Tuberculose/epidemiologia
19.
Rev Assoc Med Bras (1992) ; 68(10): 1405-1409, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36417644

RESUMO

OBJECTIVE: Malignant cutaneous melanoma is the most aggressive type of skin cancer, and its early detection and prompt initiation of treatment play an important role in reducing disease-associated morbidity and mortality. Many factors influence the diagnosis of melanoma, and its recognition is essential for the development of strategies for its early detection. This study was carried out to Identify the main variables related to the delay in diagnosis of Malignant Cutaneous Melanoma and correlate them with the time interval for making the definitive diagnosis. METHODS: Retrospective analysis of 103 patient records from January 2015 to December 2020 correlating social, economic, demographic, and cultural factors with the time elapsed between the onset of symptoms and the diagnosis of malignant cutaneous melanoma. RESULTS: The average time to seek medical services from the onset of symptoms was 29.54 months. The mean time for a referral from the primary to the referral service was 1.35 months, and the factors that contributed to a faster diagnosis were lesion Breslow (>1 mm), lesion growth, income range (≤1.5 minimum wages), lower phototypes (I and II), not having gone to the Basic Healthcare Units, profession (household), smoking, and type of housing. CONCLUSIONS: Our findings demonstrate that there is still a great delay in the recognition of signs and symptoms related to the diagnosis of malignant cutaneous melanoma in our country, influenced by several socioeconomic and demographic factors.


Assuntos
Melanoma , Neoplasias Cutâneas , Humanos , Melanoma/diagnóstico , Melanoma/epidemiologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Estudos Retrospectivos , Diagnóstico Tardio , Fatores de Tempo , Fatores Socioeconômicos , Demografia
20.
J Acoust Soc Am ; 152(4): 2022, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-36319262

RESUMO

A listening test was conducted with 32 participants to obtain data on emotional changes in response to three types of urban soundscape spatial sequences. By establishing a time series model, the relationship between psychoacoustic parameters of the sequence and changes in the two dimensions of emotion was determined. Results showed that psychoacoustic parameters can explain 44% and 40%-49% of the changes in the pleasantness and arousal dimensions of emotion, respectively. Roughness and fluctuation have the highest correlation with emotional changes, while loudness and articulation index have the lowest correlation with emotional changes. This research verified the lags between psychoacoustic changes in the soundscape and the associated perceived emotion. First, there was a 3-4 s lag between psychoacoustic parameters and emotional changes. Second, changes in roughness and loudness could cause synchronous changes in emotions, while other parameters could cause delayed changes in emotions. Finally, the lag of emotion had a strong and stable explanatory power for emotional changes. This research proves the effectiveness of the time series analysis technology in establishing the dynamic relationship between the acoustic parameters of soundscape sequences and the second-by-second perceived emotions and provides a new data analysis method for in-depth study of soundscape sequence perception.


Assuntos
Acústica , Percepção Auditiva , Humanos , Psicoacústica , Fatores de Tempo , Percepção Auditiva/fisiologia , Emoções/fisiologia
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