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Rev. cuba. endocrinol ; 32(1): e273, 2021. tab, graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1289392


Introducción: La búsqueda de nuevos fármacos o de productos naturales que mejoren la calidad de la atención y los resultados en el tratamiento de la diabetes mellitus continúan. La Moringa oleifera tiene variados usos y es uno de los productos naturales que desde hace años se evalúa con este fin, por sus sustanciales propiedades curativas. Objetivo: Evaluar los efectos de la Moringa oleifera como un producto natural con posibilidades de ser usado en pacientes con diabetes mellitus. Método: Se utilizaron como buscadores de información científica a SciELO, PubMed, Google y a Google Académico. La estrategia de búsqueda incluyó los siguientes términos como palabras claves: Moringa oleifera, diabetes mellitus, propiedades antidiabéticas, reacciones adversas. Se evaluaron artículos de revisión, de investigación y páginas Web que, en general, tenían menos de 10 años de publicados, en idioma español, portugués e inglés, y que hicieran referencia específicamente al tema de estudio a través del título. Esto permitió evaluar 120 artículos, de los cuales 64 fueron referenciados. Conclusiones: La Moringa oleifera es una planta que constituye un producto natural con propiedades nutracéuticas y funcionales. Puede usarse como un coadyuvante en los tratamientos convencionales indicados para el tratamiento de la diabetes mellitus, lo cual dependería de los resultados de ensayos clínicos rigurosos, que permitan dilucidar si realmente es capaz de contribuir a lograr en el humano, un control glucémico eficaz, sin efectos secundarios importantes e incluso ayudar a mejorar algunas de las complicaciones y comorbilidades que habitualmente acompañan a la diabetes mellitus(AU)

Introduction: The search of new drugs or natural products that improve the quality of care and the results of diabetes mellitus treatment continue. Moringa oleifera has different uses and is one of the natural products that have been assessed through the years with that purpose, due to its considerable curative properties. Objective: Assess the effects of Moringa oleifera as a natural product with chances of being used in patients with diabetes mellitus. Methods: There were used as scientific information searchers ScieELO, PubMed, Google and Google Scholar. The search strategy included the following terms as keywords: Moringa oleifera, diabetes mellitus, anti-diabetic properties, adverse reactions. Review articles, research articles and web pages were assessed; in general terms, those had less than 10 years of being published, were in Spanish, Portuguese and English languages, and were making specific reference in the title to the studied subject. This allowed assessing 120 articles, of which 64 were quoted. Conclusions: Moringa oleifera is a plant that constitutes a natural product with nutraceutical and functional properties. It can be used as a contributory agent in conventional treatments indicated for diabetes mellitus, which will depend on the results of strict clinical trials that allow to clarify if it is actually capable of contributing to achieve an efficient glycemic control in humans, without relevant side effects, or even to help improving some of the complications and comorbidities that usually accompany diabetes mellitus(AU)

Humanos , Qualidade da Assistência à Saúde , Suplementos Nutricionais , Moringa oleifera/efeitos adversos , Diabetes Mellitus/etiologia , Medicamentos de Referência , Literatura de Revisão como Assunto , Bases de Dados Bibliográficas
Braz. J. Pharm. Sci. (Online) ; 55: e18005, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1039053


Moringa leaves and spinach used as vegetables containing cyanogens and polyphenols having suspected antithyroidal activity; however, detailed studies in this aspect found unavailable. Goitrogenic/antithyroid potentiality of those plant foods of Indian origin was evaluated. To explore the goitrogenic/antithyroid effect of those plant foods cyanogenic glucosides, glucosinolates, thiocyanate and polyphenol content were measured. These plant foods were fed with diet regularly to adult male albino rats for 30 and 60 days respectively, followed by evaluation of morphological and functional status of thyroid,as thyroid gland weight, the activity status of thyroid hormone synthesizing enzymes viz. TPO, Na+-K+-ATPase, deiodinase I, thyroid hormone profiles, thyroid histoarchitecture as well as urinary iodine and thiocyanate. In moringa leaves and spinach fed diet, there was a significant increase in urinary excretion of thiocyanate and iodine, enlargement of thyroid gland along with hypertrophy of thyroid follicles and altered in the activities of thyroid hormone synthesizing enzymes with concomitant changes of thyroid hormone profiles. Effects were more severe in moringa leaves treated group than that of spinach. Biochemical analysis moringa leaves and spinach reveal that those are rich sources of goitrogens and their prolonged consumption gradually developed a relative state of biochemical and morphological hypothyroidism.

Animais , Masculino , Ratos , Antitireóideos/análise , Moringa oleifera/efeitos adversos , Spinacia oleracea/efeitos adversos , Hipotireoidismo , Índia/etnologia
R. bras. Ci. avíc. ; 20(4): 817-824, Oct.-Dec. 2018. tab
Artigo em Inglês | VETINDEX | ID: vti-19748


Although in-feed antibiotics work for broiler chicken's growth, they are a source of public health hazard. Therefore, there is a need for alternates which can act as growth promoter without deleterious effects on the health of meat consumers. Moringa oleifera is one such phytobiotic which is reported to possess antimicrobial and immuno-modulatory properties. This study investigated the effect of Moringa oleifera leaf powder (MOLP) supplementation on meat quality and bone morphometry of broiler. One-day-old chicks (n=100), divided into five groups (four replicates with n=5), were fed a basal diet (control group) or same diet supplemented with 6, 9, 12 or 15 g/kg MOLP. On d-35, two birds per replicate were euthanized to collect samples of breast muscle, blood and tibia bone. The MOLP supplementation significantly increased pH of breast muscle and ash percentage of tibia bone. The diameter of breast muscle fibres and also weight and weight length index of tibia bone significantly increased with 12 and 15 g/kg MOLP. The water holding capacity (WHC) of breast muscle was significantly higher with 9 and 15 g/kg MOLP; whereas robusticity index of tibia bone significantly decreased with 12 and 15 g/kg MOLP inclusion compared to the control group. In conclusion, dietary supplementation of Moringa oleifera leaf powder (12g/kg) increased pH, water holding capacity, and muscle fibre diameter of breast muscle and also weight, ash percentage and density indices of tibia bone in broiler chickens.(AU)

Animais , Recém-Nascido , Moringa oleifera/efeitos adversos , Aditivos Alimentares/efeitos adversos , Galinhas/crescimento & desenvolvimento , Galinhas/anatomia & histologia , Músculos Peitorais , Tíbia , Anti-Infecciosos , Fatores Imunológicos
J Clin Pharm Ther ; 43(5): 626-632, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29920710


WHAT IS KNOWN AND OBJECTIVE: Moringa oleifera (MO) Lam (Moringaceae) is commonly used as food supplement and as medicine in most African countries where malaria is also endemic. Therefore, co-administration of MO with antimalarials is a possibility. This study investigated the effects of MO leaves powder on the pharmacokinetics of amodiaquine (AQ) in human subjects. METHODS: Twenty healthy volunteers were recruited for the 3-period study. In the first period, a single dose of AQ tablet (10 mg/kg) was administered orally after an overnight fast. After a 7-day washout period, AQ was co-administered with MO. For the third period, each subject took 3 g MO once daily for 7 days and on the 8th day, MO was co-administered with AQ. The plasma concentrations of amodiaquine and desethylamodiaquine (DEAQ) were simultaneously determined using a validated HPLC method. RESULTS AND DISCUSSION: The results showed a significant decrease (P = .037) in the Cmax of AQ after concurrent administration (CA) with MO, whereas after pretreatment (PT), there was a 32% decrease in the Cmax of AQ. For the metabolite, DEAQ, Cmax increased significantly (P = .006) by 79.36%, and Cmax in PT was significantly higher than (P = .001) that of the CA arm of the study. AUC of DEAQ increased significantly by 40.4% (P = .006) and by 188% (P = .001) after CA and PT, respectively. WHAT IS NEW AND CONCLUSION: The study established pharmacokinetic interaction between AQ and MO when given together or following a long period of ingestion of MO. This may have clinical implications for malaria therapy.

Amodiaquina/farmacocinética , Moringa oleifera/efeitos adversos , Folhas de Planta/efeitos adversos , Pós/efeitos adversos , Adulto , Amodiaquina/análogos & derivados , Antimaláricos/farmacocinética , Feminino , Voluntários Saudáveis , Interações Ervas-Drogas/fisiologia , Humanos , Masculino , Comprimidos/farmacocinética , Adulto Jovem
Biomed Pharmacother ; 98: 609-618, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29289835


Inflammation is a key component of many clinical conditions that affect the temporomandibular joint (TMJ) and Moringa oleifera Lam. has been used to treat inflammatory diseases. Here, we evaluated the toxicological effects on mice of a naturally-occurring isothiocyanate from M. oleifera and its seven analogue molecules. Further, the anti-nociceptive and anti-inflammatory effects on a rat model of TMJ inflammatory hypernociception were assessed. The systemic toxicological profile was determined in mice over a 14-day period: MC-1 1 µg/kg; MC-D1 1 µg/kg, MC-D3 100 µg/kg, MC-D6 1 µg/kg, MC-D7 1 µg/kg, MC-D8 1 µg/kg, MC-D9 10 µg/kg, and MC-H 1 µg/kg. The safest molecules were assayed for anti-nociceptive efficacy in the formalin (1.5%, 50 µL) and serotonin (255 mg) induced TMJ inflammatory hypernociception tests. The anti-inflammatory effect was evaluated through the vascular permeability assay using Evans blue. Further, the rota-rod test evaluated any motor impairment. Among the tested molecules, MC-D7, MC-D9, and MC-H were not toxic at the survival rate test, biochemical, and hystological analysis. They reduced the formalin-induced TMJ inflammatory hypernociception, but only MC-H decreased the serotonin-induced TMJ inflammation, suggesting an adrenergic receptor-dependent effect. They diminished the plasmatic extravasation, showing anti-inflammatory activity. At the rota-rod test, no difference was observed in comparison with control groups, reinforcing the hypothesis of anti-nociceptive effetc without motor impairment in animals. The analogues MC-D7, MC-D9, and MC-H were safe at the tested doses and efficient in reducing the formalin-induced TMJ hypernociception in rats. Our next steps include determining their mechanisms of anti-nociceptive action.

Analgésicos/farmacologia , Anti-Inflamatórios/farmacologia , Inflamação/tratamento farmacológico , Isotiocianatos/química , Moringa oleifera/efeitos adversos , Moringa oleifera/química , Dor/tratamento farmacológico , Analgésicos/efeitos adversos , Analgésicos/química , Animais , Anti-Inflamatórios/efeitos adversos , Anti-Inflamatórios/química , Modelos Animais de Doenças , Feminino , Inflamação/metabolismo , Masculino , Camundongos , Dor/metabolismo , Extratos Vegetais/efeitos adversos , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Ratos , Ratos Wistar , Articulação Temporomandibular/efeitos dos fármacos
Ci. Rural ; 44(12): 2197-2203, Dec. 2014. tab, graf
Artigo em Inglês | VETINDEX | ID: vti-27846


This study aimed to evaluate the antifungal activity of M. oleifera extracts against fungi isolated from farmed prawns and test the toxicity of the extracts on larvae of Macrobrachium amazonicum. The ethanol extracts of pods, seeds, leaves, stems and flowers and chloroform extract of flowers of M. oleifera were tested against 14 strains of Candida spp. and 10 strains of Hortaea werneckii isolated from farming water and the digestive tract of M. amazonicum. Antifungal activity was determined by microdilution, based on the M27-A3 and M38-A2 CLSI documents. Toxicity was evaluated by exposing larvae of M. amazonicum at concentrations between 10-1000mg mL-1, counting dead larvae (CL50) after 24 hours. The best results were verified with the chloroform extract of flowers, acting against all tested strains, with MICs ranging from 0.019 to 2.5 mg mL-1. Ethanol extracts of leaves, flowers and seeds acted against 22/24, 21/24 and 20/24 strains, respectively. The extract of pods was only effective against strains of Candida spp. (14/24) and extract of stem only against four strains of H. werneckii (4/24). Extracts of seeds, flowers (chloroform fraction), stems and leaves showed low or no toxicity, whereas extracts of pods and flowers (ethanol fraction) showed moderate toxicity. Thus, the antifungal activity of these extracts agaisnt Candida spp. and H. werneckii was observed, a wide margin of safety for larvae of M. amazonicum, demonstrating to be promising for the sustainable management of effluents from M. amazonicum farming.(AU)

Este estudo teve como objetivo avaliar a atividade antifúngica de extratos de M. oleifera frente a fungos isolados de camarões, cultivados em água doce, e testar a toxicidade dos extratos em larvas de Macrobrachium amazonicum. Os extratos etanólicos de vagens, sementes, folhas, caules e flores e o extrato clorofórmico de flores de M. oleifera foram testados contra 14 cepas de Candida spp. e 10 cepas de Hortaea werneckii isolados da água de cultivo e do trato digestório de M. amazonicum. A atividade antifúngica foi determinada por microdiluição, com base nos documentos M27-A3 e M38-A2 do CLSI. A toxicidade foi avaliada por exposição das larvas de M. amazonicum a concentrações entre 10-1000 mg mL-1 dos extratos, realizando contagem de larvas mortas (CL50), após 24 horas. Os melhores resultados foram verificados com o extrato clorofórmico de flores, agindo frente a todas as cepas testadas, com concentrações inibitórias mínimas variando entre 0,019-2,5 mg mL-1. O extrato etanólico de folhas, flores e sementes agiu ante 22/24, 21/24 e 20/24 cepas, respectivamente. O extrato de vagens foi eficaz contra cepas de Candida spp. (14/24) e o extrato de caule apenas contra quatro cepas de H. werneckii (4/24). Os extratos de sementes, flores (fração clorofórmica), caules e folhas apresentaram baixa ou nenhuma toxicidade, enquanto que extratos de vagens e flores (fração etanólica) apresentaram toxicidade moderada. Assim, observou-se atividade antifúngica dos extratos em Candida spp . e H. werneckii com uma ampla margem de segurança para as larvas de M. amazonicum, demonstrando ser promissor para o manejo sustentável dos efluentes do cultivo de M. amazonicum.(AU)

Moringa oleifera/efeitos adversos , Candida , Palaemonidae , Antifúngicos
J Complement Integr Med ; 102013 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-23652639


The seeds of Moringa oleifera were collected, air-dried, pulverized, and subjected to cold extraction with methanol. The methanol extract was screened phytochemically for its chemical components and used for acute and sub-acute toxicity studies in rats. The phytochemical screening revealed the presence of saponins, tannins, terpenes, alkaloids, flavonoids, carbohydrates, and cardiac glycosides but the absence of anthraquinones. Although signs of acute toxicity were observed at a dose of 4,000 mg kg-1 in the acute toxicity test, and mortality was recorded at 5,000 mg kg-1, no adverse effect was observed at concentrations lower than 3,000 mg kg-1. The median lethal dose of the extract in rat was 3,873 mg kg-1. Sub-acute administration of the seed extract caused significant (p<0.05) increase in the levels of alanine and aspartate transferases (ALT and AST), and significant (p<0.05) decrease in weight of experimental rats, at 1,600 mg kg-1. The study concludes that the extract of seeds of M. oleifera is safe both for medicinal and nutritional uses.

Peso Corporal/efeitos dos fármacos , Fígado/efeitos dos fármacos , Moringa oleifera/química , Compostos Fitoquímicos/análise , Extratos Vegetais/química , Sementes/química , Alanina Transaminase/sangue , Animais , Aspartato Aminotransferases/sangue , Feminino , Dose Letal Mediana , Fígado/enzimologia , Masculino , Moringa oleifera/efeitos adversos , Compostos Fitoquímicos/efeitos adversos , Extratos Vegetais/efeitos adversos , Extratos Vegetais/toxicidade , Ratos , Ratos Wistar , Sementes/efeitos adversos , Testes de Toxicidade Aguda
Ars Vet. ; 29(2): 98-103, 20130000.
Artigo em Português | VETINDEX | ID: vti-11844


Avaliar a qualidade microbiológica de amostras de água em comunidades que utilizam águas de fontes alternativas para o consumo humano, utilizando extrato de sementes de Moringa oleifera e radiação solar, além de fornecer subsídios para o uso destes tratamentos. MÉTODOS: O método dos tubos múltiplos foi utilizado para determinar o número mais provável de coliformes totais e termotolerantes e a quantificação de microrganismos mesófilos em nove amostras de água provenientes de fontes alternativas (poços). Tais amostras foram obtidas na cidade de Cruz das Almas, localizada na região do Recôncavo, no estado da Bahia, Brasil. RESULTADOS: O número de amostras da água tratadas com sementes de moringa e expostas ao sol por duas, cinco e doze horas apresentaram redução nas concentrações de CT/CF de 1,52 log (56,51%), 1,88 log (64,83%) e de 2,14 log (71,33%), respectivamente. Já a taxa de redução para os microrganismos mesófilos após exposição ao sol de duas, cinco e doze horas foram respectivamente de 0,24 log (11,60%), 0,18 log (10,11%) e de 1,25 log (65,78%). CONCLUSÕES: A radiação solar foi eficiente na remoção bacteriana, porém usada concomitantemente com o extrato das sementes de Moringa oleifera não foi eficiente para reduzir a carga de coliformes termotolerantes a zero. Apenas a redução dos microrganismos mesófilos alcançou os níveis determinados por lei(AU)

To evaluate the microbiological quality of water samples in communities that use alternative sources of water for human consumption treated with Moringa oleifera seed extract and solar radiation, and to provide subsidies for using these treatments. METHODS: The multiple tube method was used to determine the most probable number of total coliforms and thermotolerant mesophile microorganisms in nine water samples from alternative sources (wells). These samples were obtained in Cruz das Almas, in the Reconcavo Baiano region, state of Bahia, Brazil. RESULTS: The number of water samples treated with Moringa seeds and exposed to the sun for two, five and twelve hours showed a reduction in the concentrations of TC/FC 1.52 log (56.51%), 1.88 log (64.83%) and 2.14 log (71.33%), respectively. The reduction rate of mesophile microorganisms after sun exposure for two, five and twelve hours were 0.24 log (11.60%), 0.18 log (10.11%) and 1.25 log (65.78%), respectively. CONCLUSIONS: Although solar radiation was effective in removing bacteria, the concomitant use with Moringa oleifera seeds extract was not effective to reduce fecal coliform load to zero. Therefore, only mesophile microorganisms reached the levels required by the legislation(AU)

Animais , Moringa oleifera/efeitos adversos , Moringa oleifera/microbiologia , Purificação da Água , Radiação Solar/análise