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1.
J Colloid Interface Sci ; 608(Pt 1): 424-434, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-34626986

RESUMO

HYPOTHESIS: Electrostatic attractions between the anionic head group of sodium alkylsulphates and the positively charged inner surface of halloysite nanotubes (HNTs) drive to the formation of tubular inorganic micelles, which might be employed as nanoreactors for the confinement of non polar compounds in aqueous media. On this basis, sodium alkylsulphates/halloysite hybrids could be efficient nanocatalysts for organic reactions occurring in water. EXPERIMENTS: Sodium decylsulphate (NaDeS) and sodium dodecylsulphate (NaDS) were selected for the functionalization of the halloysite cavity. The composition, the structure and the surface charge properties of the hybrid nanotubes were determined. The actual formation of inorganic micelles was explored by studying the microviscosity and polarity characteristics of the surfactant modified nanotubes through fluorescence spectroscopy experiments using DiPyme as probe. The performances of the sodium alkylsulphates/halloysite composites as micellar catalysts for the Belousov-Zhabotinsky (BZ) reaction were investigated. FINDINGS: The halloysite functionalization with sodium alkylsulphates generated the formation of hydrophobic microdomains with an enhanced microviscosity. Compared to the surfactant conventional micelles, the functionalized nanotubes induced larger enhancements on the rate constant of the BZ reaction. This is the first report on the surfactant/halloysite hybrids showing their efficiencies as reusable nanocatalysts, which are dependent on their peculiar microviscosity and polarity properties.


Assuntos
Micelas , Nanotubos , Catálise , Argila , Nanotecnologia
2.
Methods Mol Biol ; 2404: 247-266, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34694613

RESUMO

Advancements in imaging technologies, especially approaches that allow the imaging of single RNA molecules, have opened new avenues to understand RNA regulation, from synthesis to decay with high spatial and temporal resolution. Here, we describe a protocol for single-molecule fluorescent in situ hybridization (smFISH) using three different approaches for synthesizing the fluorescent probes. The three approaches described are commercially available probes, single-molecule inexpensive FISH (smiFISH), and in-house enzymatically labeled probes. These approaches offer technical and economic flexibility to meet the specific needs of an experiment. In addition, we provide a protocol to perform automated smFISH spot detection using the software FISH-quant.


Assuntos
Hibridização in Situ Fluorescente , RNA/genética , Corantes Fluorescentes , Nanotecnologia , RNA Mensageiro
3.
Bioresour Technol ; 344(Pt A): 126171, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34695586

RESUMO

The need to develop sustainable alternatives for pretreatment and hydrolysis of lignocellulosic biomass (LCB) is a massive concern in the industrial sector today. Breaking down of LCB yields sugars and fuel in the bulk scale. If explored under nanotechnology, LCB can be refined to yield high-performance fuel sources. The toxicity and cost of conventional methods can be reduced by applying nanoparticles (NPs) in refining LCB. Immobilization of enzymes onto NPs or used in conjugation with nanomaterials would instill specific and eco-friendly options for hydrolyzing LCB. Nanomaterials increase the proficiency, reusability, and stability of enzymes. Notably, magnetic NPs have bagged their place in the downstream processing of LCB effluents due to their efficient separation and cost-effectiveness. The current review highlights the role of nanotechnology and its particles in refining LCB into various commercial precursors and value-added products. The relationship between nanotechnology and LCB refinery is portrayed effectively in the present study.


Assuntos
Biocombustíveis , Lignina , Biomassa , Hidrólise , Nanotecnologia
4.
Talanta ; 238(Pt 2): 123018, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34808569

RESUMO

Mass spectrometry (MS)-based proteomics have been extensively applied in clinical practice to discover potential protein and peptide biomarkers. However, the traditional sample pretreatment workflow remains labor-intensive and time-consuming, which limits the application of MS-based proteomic biomarker discovery studies in a high throughput manner. In the current work, we improved the previously reported procedure of the simple and rapid sample preparation methods (RSP) by introducing macroporous ordered siliceous foams (MOSF), namely RSP-MOSF. With the aid of MOSF, we further reduced the digestion time to 10 min, facilitating the whole sample handling process within 30 min. Combining with 30 min direct data independent acquisition (DIA) of LC-MS/MS, we accomplished a serum sample analysis in 1 h. Comparing with the RSP method, the performance of protein and peptide identification, quantitation, as well as the reproducibility of RSP-MOSF is comparable or even outperformed the RSP method. We further applied this workflow to analyze serum samples for potential candidate biomarker discovery of pancreatic cancer. Overall, 576 serum proteins were detected with 41 proteins significantly changed, which could serve as potential biomarkers for pancreatic cancer. Additionally, we evaluated the performance of RSP-MOSF method in a 96-well plate format which demonstrated an excellent reproducibility of the analysis. These results indicated that RSP-MOSF method had the potential to be applied on an automatic platform for further scaled analysis.


Assuntos
Neoplasias Pancreáticas , Proteômica , Biomarcadores , Cromatografia Líquida , Humanos , Nanotecnologia , Neoplasias Pancreáticas/diagnóstico , Reprodutibilidade dos Testes , Manejo de Espécimes , Espectrometria de Massas em Tandem , Fluxo de Trabalho
5.
Virology ; 565: 58-64, 2022 01 02.
Artigo em Inglês | MEDLINE | ID: mdl-34739917

RESUMO

Porcine Epidemic Diarrhea (PED) is a highly contagious intestinal disease which mostly caused by Porcine Epidemic Diarrhea Virus (PEDV). The PED has caused huge economic losses to the pig industry all over the world and a valid PEDV vaccine is needed to prevent the infection. In this study, we constructed expression plasmid based on the spike (S) gene of the epidemic PEDV strain. The recombinant eukaryotic S (Se) and prokaryotic S (Sp) subunit proteins were expressed and purified as vaccine antigens. We designed a new subunit vaccine based on S proteins, adjuvanted with layered double hydroxide (LDH). The results indicated that the LDH adjuvanted subunit vaccines induced a better immune effect in terms of antibody level and cellular immune response. In conclusion, this study showed a new design of a PEDV subunit vaccine with nanotechnology and demonstrated the potential for its clinical application.


Assuntos
Infecções por Coronavirus/imunologia , Hidróxidos/química , Imunidade , Nanopartículas/química , Vírus da Diarreia Epidêmica Suína/imunologia , Glicoproteína da Espícula de Coronavírus/imunologia , Vacinas de Subunidades/imunologia , /química , Animais , Anticorpos Antivirais , Infecções por Coronavirus/prevenção & controle , Infecções por Coronavirus/veterinária , Infecções por Coronavirus/virologia , Epidemias , Células HEK293 , Humanos , Nanotecnologia/métodos , Proteínas Recombinantes/imunologia , Suínos , Doenças dos Suínos/prevenção & controle , Doenças dos Suínos/virologia , /métodos
6.
Chemosphere ; 289: 133252, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34902385

RESUMO

Nanotechnology, as an emerging science, has taken over all fields of life including industries, health and medicine, environmental issues, agriculture, biotechnology etc. The use of nanostructure molecules has revolutionized all sectors. Environmental pollution is a great concern now a days, in all industrial and developing as well as some developed countries. A number of remedies are in practice to overcome this problem. The application of nanotechnology in the bioremediation of environmental pollutants is a step towards revolution. The use of various types of nanoparticles (TiO2 based NPs, dendrimers, Fe based NPs, Silica and carbon nanomaterials, Graphene based NPs, nanotubes, polymers, micelles, nanomembranes etc.) is in practice to diminish environmental hazards. For this many In-situ (bioventing, bioslurping, biosparging, phytoremediation, permeable reactive barrier etc.) and Ex-situ (biopile, windrows, bioreactors, land farming etc.) methodologies are employed. Improved properties like nanoscale size, less time utilization, high adaptability for In-situ and Ex-situ use, undeniable degree of surface-region to-volume proportion for possible reactivity, and protection from ecological elements make nanoparticles ideal for natural applications. There are distinctive nanomaterials and nanotools accessible to treat the pollutants. Each of these methods and nanotools depends on the properties of foreign substances and the pollution site. The current designed review highlights the techniques used for bioremediation of environmental pollutants as well as use of various nanoparticles along with proposed In-situ and Ex-situ bioremediation techniques.


Assuntos
Recuperação e Remediação Ambiental , Nanoestruturas , Poluentes do Solo , Biodegradação Ambiental , Nanotecnologia , Solo , Poluentes do Solo/análise , Água
7.
Environ Pollut ; 295: 118722, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-34952184

RESUMO

Nanotechnology is a rapidly developing technology that will have a significant impact on product development in the next few years. The technology is already being employed in cutting-edge cosmetic and healthcare products. Nanotechnology and nanoparticles have a strong potential for product and process innovation in the food industrial sector. This is already being demonstrated by food product availability made using nanotechnology. Nanotechnologies will have an impact on food security, packaging materials, delivery systems, bioavailability, and new disease detection materials in the food production chain, contributing to the UN Millennium Development Goals targets. Food products using nanoparticles are already gaining traction into the market, with an emphasis on online sales. This means that pre- and post-marketing regulatory frameworks and risk assessments must meet certain standards. There are potential advantages of nanotechnologies for agriculture, consumers and the food industry at large as they are with other new and growing technologies. However, little is understood about the safety implications of applying nanotechnologies to agriculture and incorporating nanoparticles into food. As a result, policymakers and scientists must move quickly, as regulatory systems appear to require change, and scientists should contribute to these adaptations. Their combined efforts should make it easier to reduce health and environmental impacts while also promoting the economic growth of nanotechnologies in the food supply chain. This review highlighted the benefits of a number of nano enabled agrochemicals/materials, the potential health impacts as well as the risk assessment and risk management for nanoparticles in the agriculture and food production chain.


Assuntos
Agroquímicos , Nanotecnologia , Agricultura , Indústria Alimentícia , Humanos , Medição de Risco
8.
Nanoscale ; 14(2): 219-238, 2022 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-34935841

RESUMO

Living things in nature have evolved with unique morphologies, structures, materials, behaviors, and functions to survive in complex natural environments. Nature has inspired the design ideas, preparation methods, and applications of versatile micro/nanomotors. This review summarizes diverse nature-inspired micro/nanomotors, which can be divided into five groups: (i) natural morphology-inspired micro/nanomotors, whose shapes are designed to imitate the morphologies of plants, animals, and objects in nature. (ii) Natural structure-inspired micro/nanomotors, which use structures from plants, red blood cells, and platelet cells as components of micro/nanomotors, or directly use sperm cells and microorganisms as the engines of micro/nanomotors. (iii) Natural behavior-inspired micro/nanomotors, which are proposed to mimic natural behaviors such as motion behavior, swarm behavior, and communication behavior between individuals. (iv) Micro/nanomotors inspired by both natural morphology and behavior. Nature makes it possible for synthetic micro/nanomotors to possess interesting morphologies, novel preparation methods, new propulsion modes, innovative functions, and broad applications. The nature-inspired micro/nanomotors could provide a promising platform for various practical fields.


Assuntos
Nanotecnologia , Animais , Humanos
9.
Biosens Bioelectron ; 195: 113658, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34706323

RESUMO

DNA origami is widely used as a translocation carrier to assist solid-state nanopore analysis, e.g., soft linear origami carrier and special-shaped origami structures. In the linear origami carriers based nanopore sensing, molecular modifications induced tiny structural and charge changes, can result in significant variations on translocation signals to facilitating single-molecule sensing. However, an understanding on the influences of surface modifications on special-shaped DNA origami structures during solid-state (SS) nanopores translocation is still far elusive. Herein, we reported a surface modification strategy using aptamer/target-binding to influence the translocation of the shaped origami ribbon carrier through SS-nanopore. Our measurements indicate that the translocation signal variations can respond to ATP/aptamer binding on the carrier surface, even to the surface modifications induced by spatial distributions and enzyme catalysis. Meanwhile, the results also suggest a possibility to identify small spatial and electronic changes on DNA origami by using SS-nanopore. We envision that the surface aptamer-binding influenced origami translocation strategy could find more applications in origami carrier assisted SS-nanopore sensing and detection.


Assuntos
Técnicas Biossensoriais , Nanoporos , DNA , Nanotecnologia , Oligonucleotídeos
10.
Talanta ; 237: 122913, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34736650

RESUMO

Sensitivity and credibility detecting histamine (HA) as an important neurotransmitter in biofluids is of importance in analytical science and physiology. Surface-enhanced Raman spectroscopy (SERS) is able to realize the high sensitivity with single molecules level, but providing the high sensitivity for HA with a small cross section remains a challenge. Here we develop the metal complex-based SERS nanoprobe nitrilotriacetic acid-Ni2+ (NTA-Ni2+) combined with self-assemble Au NPs active substrates for sensitive detection of HA. The NTA-Ni2+ can capture the HA molecules close to Au NPs substrates and then amplify the Raman signals of HA owing to the formation of a complex of NTA-Ni2+-HA. The self-assemble Au film through the evaporation-driven method can provide the high-density hot spots substrate with high stability and reproducibility. The NTA-Ni2+ decorated Au NPs as nanoprobe responds to HA with 1 µM level of sensitivity. More importantly, the developed SERS nanoprobe composing of NTA-Ni2+ and self-assemble Au NPs can be utilized to detect and monitor the HA spiked into serum, indicating the potential prospect in analysis of HA in complex specimen.


Assuntos
Ouro , Nanopartículas Metálicas , Histamina , Nanotecnologia , Reprodutibilidade dos Testes , Análise Espectral Raman
11.
Toxicol Mech Methods ; 32(1): 1-17, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34350812

RESUMO

Silica nanoparticles (SiNPs) have been widely used in nanotechnology, and more attention has been paid to their safety evaluation. However, there are still inconsistent conclusions about the genotoxicity of SiNPs. A systematic review was conducted to explore whether SiNPs have genotoxicity followed by a meta-analysis of in vivo and in vitro murine genotoxicity tests. A total of 26 eligible studies were identified in this meta-analysis through a detailed process of inclusion and exclusion, which included 9 in vivo studies, 15 in vitro studies, and 2 in both. The results of in vitro studies showed that SiNPs exposure significantly increased the indicators of the comet assay, such as tail DNA content (T DNA%), tail length (TL), and olive tail moment (OTM). Indicators of mutagenicity had not been affected in vitro studies, such as mutation frequency (MF) and micronucleus (MN) frequency. There was a significant increase in MN frequency, but there was no influence on T DNA% in vivo. Results of subgroup analysis indicated that size and treatment time of SiNPs were the associated factors in vitro genotoxicity. The size of SiNPs, <21 nm, induced more DNA damage than larger sized SiNPs. It could induce MN formation when the treatment time of SiNPs was <12 h, and even more DNA damage when the exposure time over 12 h. SiNPs can induce genotoxicity both in vivo and in vitro. Comet assay may be more sensitive to detect in vitro genotoxicity, and MN frequency may be more suitable to detect in vivo genotoxicity.


Assuntos
Nanopartículas , Dióxido de Silício , Animais , Ensaio Cometa , Dano ao DNA , Camundongos , Nanopartículas/toxicidade , Nanotecnologia , Dióxido de Silício/toxicidade
12.
J Colloid Interface Sci ; 605: 766-778, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34371422

RESUMO

The reasonable design of the structure and composition of catalysts was essential to improve the catalytic performance of advanced oxidation processes (AOPs). Herein, we reported a simple strategy to synthesize hierarchical Co3O4-C@CoSiOx yolk-shell nanoreactors with multiple active components by using metal-organic frameworks (MOFs). The novel nanoreactors are further used to activate peroxymonosulfate (PMS) for ciprofloxacin (CIP) degradation. The effects of reaction parameters (pH value, co-existing ions, reaction temperature, etc.) on CIP degradation were systematically investigated. Especially, ∼98.2% of CIP was degraded within 17 min under the optimal conditions, together with the low cobalt leaching and excellent reusability. The appreciable catalytic performance improvement might be due to the synergistic effect of the structure and component design: (1) the hierarchical yolk-shell structure endowed the catalyst with high surface area (∼232.47 m2/g) and fully exposed active sites; (2) abundant highly active ≡Co-OH+ were formed on the surface of CoSiOx; (3) the presence of oxygen vacancies and nitrogen-doped carbon promoted the decomposition of PMS through a non-radical process. The results revealed both the radical (SO4∙-, ∙OH and O2∙-) and non-radical (1O2 and direct charge transfer) should be responsible for the CIP degradation. Moreover, the possible degradation pathways of CIP were proposed through the identification of intermediates using LC-MS/MS techniques and density functional theory (DFT) calculation. Our work highlights that multi-component catalysts derived from MOFs with novel structure have broad application prospects in AOPs.


Assuntos
Ciprofloxacina , Espectrometria de Massas em Tandem , Cromatografia Líquida , Nanotecnologia , Peróxidos
13.
Chemosphere ; 286(Pt 3): 131892, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34418663

RESUMO

The research and technological advancements observed in the latest years in the nanotechnology field translated into significant application developments in various areas. This is particularly true for the renewable polymers area, where the nano-reinforcement of biobased materials leads to an increase in their technique and economic competitiveness. The efforts were predominantly focused on materials development and energy consumption minimization. However, attention must also be given to the widespread commercialization and the full characterization of any particular potential toxicological and environmental impact. Some of the most important nanomaterials used in recent years as fillers in the bioplastic industry are graphene-based materials (GBMs). GBMs have high surface area and biocompatibility and have interesting characterizations such as strangeness and flexibility. In this paper, the current state of the art for these GBMs in the bioplastics area, their challenges, and the strategies to overcome them are analyzed.


Assuntos
Grafite , Nanoestruturas , Nanotecnologia , Polímeros
14.
Chemosphere ; 287(Pt 2): 132083, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34488054

RESUMO

One of the most favorable environmental applications of nanotechnology has been in air pollution remediation in which different nanomaterials are used as nanoadsorbents, nanocatalysts, nanofilters, and nanosensors. The nanomaterials have the ability to adsorb several contaminants existing in the air. Also, certain semiconducting nanomaterials materials can be used for photocatalytic remediation. Air contamination control can also be achieved by nanostructured membranes with pores sufficiently small to separate various pollutants from the exhaust. Nanomaterial enabled sensors are also used for the detection of harmful gases such as hydrogen sulfide, sulphur dioxide, and nitrogen dioxide. Conversely, because of the uncertainties in addition to irregularities in size, shape as well as chemical compositions, the existence of some nanomaterials might cause harmful effects on the environment along with the health of people. Thus, concerns were expressed about the transport and conversion of nanoparticles discharged into the surroundings. This review critically examined and assessed the present literature on the application of nanomaterials in the air, together with its negative impacts. The main focus is placed on the application of carbon-based and metal-based nanomaterials for air pollution remediation. It is noted that these nanomaterials demonstrating fascinating properties for improving the environmental pollution remediation system.


Assuntos
Poluentes Ambientais , Recuperação e Remediação Ambiental , Nanopartículas , Nanoestruturas , Humanos , Nanotecnologia
15.
Int J Nanomedicine ; 16: 8069-8086, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34934313

RESUMO

Bacteria and their derivatives (membrane vesicles, MVs) exhibit great advantages for targeting hypoxic tumor cores, strong penetration ability and activating immune responses, holding great potential as auspicious candidates for therapeutic and drug-delivery applications. However, the safety issues and low therapeutic efficiency by single administration still need to be solved. To further optimize their performance and to utilize their natural abilities, scientists have strived to modify bacteria with new moieties on their surface while preserving their advantages. The aim of this review is to give a comprehensive overview of a non-genetic engineering modification strategy that can be used to optimize the bacteria with nanomaterials and the design strategy that can be used to optimize MVs for better targeted therapy. Here, the advantages and disadvantages of these processes and their applicability for the development of bacteria-related delivery system as antitumor therapeutic agents are discussed. The prospect and the challenges of the above targeted delivery system are also proposed.


Assuntos
Antineoplásicos , Neoplasias , Antineoplásicos/uso terapêutico , Bactérias , Sistemas de Liberação de Medicamentos , Humanos , Nanotecnologia , Neoplasias/tratamento farmacológico
16.
Proc Natl Acad Sci U S A ; 118(51)2021 12 21.
Artigo em Inglês | MEDLINE | ID: mdl-34903662

RESUMO

In the past decade, a great effort has been devoted to develop new biosensor platforms for the detection of a wide range of analytes. Among the various approaches, magneto-DNA assay platforms have received extended interest for high sensitive and specific detection of targets with a simultaneous manipulation capacity. Here, using nitrogen-vacancy quantum centers in diamond as transducers for magnetic nanotags (MNTs), a hydrogel-based, multiplexed magneto-DNA assay is presented. Near-background-free sensing with diamond-based imaging combined with noninvasive control of chemically robust nanotags renders it a promising platform for applications in medical diagnostics, life science, and pharmaceutical drug research. To demonstrate its potential for practical applications, we employed the sensor platform in the sandwich DNA hybridization process and achieved a limit of detection in the attomolar range with single-base mismatch differentiation.


Assuntos
Diamante/química , Espectroscopia de Ressonância Magnética/métodos , Nitrogênio/química , Técnicas Biossensoriais , DNA , Nanopartículas/química , Nanotecnologia
17.
Small Methods ; 5(9): e2100402, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34928055

RESUMO

In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors in regulating a wide range of biochemical pathways. The ability to intimately control the cell fate and tissue activities makes RNA-based drugs the most fascinating family of bioactive agents. However, achieving a widespread application of RNA therapeutics in humans is still a challenging feat, due to both the instability of naked RNA and the presence of biological barriers aimed at hindering the entrance of RNA into cells. Recently, material scientists' enormous efforts have led to the development of various classes of nanostructured carriers customized to overcome these limitations. This work systematically reviews the current advances in developing the next generation of drugs based on nanotechnology-assisted RNA delivery. The features of the most used RNA molecules are presented, together with the development strategies and properties of nanostructured vehicles. Also provided is an in-depth overview of various therapeutic applications of the presented systems, including coronavirus disease vaccines and the newest trends in the field. Lastly, emerging challenges and future perspectives for nanotechnology-mediated RNA therapies are discussed.


Assuntos
Vacinas contra COVID-19/administração & dosagem , COVID-19/terapia , Sistemas de Liberação de Medicamentos/métodos , Nanoestruturas/administração & dosagem , Nanotecnologia/métodos , RNA/administração & dosagem , SARS-CoV-2/imunologia , COVID-19/imunologia , COVID-19/prevenção & controle , COVID-19/virologia , Vacinas contra COVID-19/imunologia , Humanos , Nanoestruturas/química , RNA/química , SARS-CoV-2/isolamento & purificação
18.
PLoS One ; 16(12): e0260854, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34905556

RESUMO

The present study is related to the analytical investigation of the magnetohydrodynamic flow of Ag - MgO/ water hybrid nanoliquid with slip conditions via an extending surface. The thermal radiation and Joule heating effects are incorporated within the existing hybrid nanofluid model. The system of higher-order partial differential equations is converted to the nonlinear system of ordinary differential equations by interpreting the similarity transformations. With the implementation of a strong analytical method called HAM, the solution of resulting higher-order ordinary differential equations is obtained. The results of the skin friction coefficient, Nusselt number, velocity profile, and temperature profile of the hybrid nanofluid for varying different flow parameters are attained in the form of graphs and tables. Some important outcomes showed that the Nusselt number and skin friction are increased with the enhancement in Eckert number, stretching parameter, heat generation parameter and radiation parameter for both slip and no-slip conditions. The thermal profile of the hybrid nanofluid is higher for suction effect but lower for Eckert number, stretching parameter, magnetic field, heat generation and radiation parameter. For both slip and no-slip conditions, the hybrid nanofluid velocity shows an upward trend for both the stretching and mixed convection parameters.


Assuntos
Simulação por Computador , Convecção , Campos Magnéticos , Temperatura Alta , Hidrodinâmica , Óxido de Magnésio , Nanotecnologia/métodos , Prata , Água/química
19.
ACS Nano ; 15(12): 18608-18623, 2021 12 28.
Artigo em Inglês | MEDLINE | ID: mdl-34910476

RESUMO

Nanotechnology has important roles to play in international efforts in sustainability. We discuss how current and future capabilities in nanotechnology align with and support the United Nations' Sustainable Development Goals. We argue that, as a field, we can accelerate the progress toward these goals both directly through technological solutions and through our special interdisciplinary skills in communication and tackling difficult challenges. We discuss the roles of targeting solutions, technology translation, the circular economy, and a number of examples from national efforts around the world in reaching these goals. We have formed a network of leading nanocenters to address these challenges globally and seek to recruit others to join us.


Assuntos
Desenvolvimento Sustentável , Nações Unidas , Nanotecnologia
20.
AAPS PharmSciTech ; 23(1): 32, 2021 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-34931256

RESUMO

Nanostructured lipid carriers (NLC) were developed as an alternative carrier system optimizing limitations found in topical treatments for superficial fungal infections, such as limited permeation through the skin. However, few published studies are focused on standardization and characterization of determinant variables of these lipid nanosystems' quality. Thus, this systematic review aims to compile information regarding the selection of lipids, surfactants, and preparation method that intimately relates to the final quality of this nanotechnology. For this, the search was carried with the following descriptors: 'nanostructured lipid carriers', 'topical', 'antifungal' separated by the Boolean operators 'and', present in the titles of the databases: Science Direct, Scopus and Pubmed. The review included experimental articles focused on the development of nanostructured lipid carriers targeted for topical application with antifungal activity, published from 2015 to 2021. Review articles, clinical studies, and studies on the development of other nanocarriers intended for other routes of administration were excluded from the study. The research included 26 articles, of which 58% were developed in India and Brazil, 53% published in the years 2019 and 2020. As for the selection of antifungal drugs incorporated into NLCs, the azole class had a preference over other classes, voriconazole being incorporated into 5 of the 26 developed NLC studied. It was also observed a predominance of medium chain triglycerides (MCT) as a liquid lipid and polysorbate 80 as a surfactant. Among other results, this review compiles the influences of each of the variables discussed in the quality parameters of NLCs, in order to guide future research involving the development of this technology. Graphical Abstract.


Assuntos
Antifúngicos , Nanotecnologia , Brasil , Índia , Lipídeos
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