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1.
BMC Psychol ; 10(1): 1, 2022 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-34980253

RESUMO

BACKGROUND: The purpose of the present study was to comprehensively examine the measurement aspects, the prevalence, and the psychological correlates of problem shopping among a large-scale national sample of Turkish adults. RESULT: Participants (N = 24,380, 50% men, M age = 31.79 years, age range = 18-81 years) completed a questionnaire that comprised the Shopping Addiction Risk Questionnaire, the Brief Symptom Inventory, the Positive and Negative Affect Schedule, and the Experiences in Close Relationships-Revised. Results showed that 1.8% of the participants had probable shopping addiction. Being female, being younger, psychiatric distress, positive affect, negative affect, anxious attachment, and avoidant attachment were positive correlates of problem shopping. CONCLUSION: The results of this large sample size study suggest that shopping addiction is not a rare condition in Turkey. Further research is needed to understand different motives that underlie the problematic shopping behavior in the young and female population in comparison to older and male populations. Preventive programs or any interventions for people with PSB needs to address regulation difficulties and development of healthy strategies to cope with psychiatric distress.


Assuntos
Comportamento Aditivo , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Motivação , Prevalência , Inquéritos e Questionários , Turquia/epidemiologia , Adulto Jovem
2.
J Coll Physicians Surg Pak ; 32(1): 25-32, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34983143

RESUMO

OBJECTIVES: To examine the intra-cycle and inter-cycle hormonal changes in the clomiphene citrate (CC) cycle in women with unexplained infertility; and to determine the factors that may predict follicle development or CC failure. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: This study was conducted at the Bagcilar Training and Research Hospital, Istanbul, Turkey from August 2019 to March 2020. METHODOLOGY: Fifty-two women with unexplained infertility were included. Fifty-two cycles given 50 mg of CC but without follicle development were accepted as Group I. In the next cycle, 48 cycles given 100 mg of CC were accepted as Group II. During every cycle, serum hormone (FSH, LH, E2, P4, A4, DHEA­S, T, 17­OHP) levels were measured on days 2, 3, 4 or 5 of the cycle (basal day), and on the days when the leading follicle was triggered (trigger day). Endogenous hormone changes were compared in both the groups with and without follicle development as well as in those who could conceive and those who could not conceive. RESULTS: Basal day FSH and DHEA­S values were found to be statistically significantly higher in women with follicle development than those without follicle development (p = 0.02 and p = 0.039, respectively). The trigger day FSH value was found to be significantly lower in women who conceived compared to the basal day value (p = 0.004). The relatively high P4 value (p = 0.008) on the basal day (contingent upon it was not exceeding the 0.5 ng/mL threshold) and the low FSH value (p = 0.015) on the trigger day were found to be statistically significantly different in women who had conceived compared to those who had not. CONCLUSION: Basal serum FSH, P4 and DHEA­S levels can be used as predictors of ovulation in CC cycles in women with unexplained infertility by determining a threshold value with more comprehensive studies to be conducted in the future. Key Words: Androgens, Ovarian stimulation, Clomiphene citrate, Unexplained infertility, Induction of ovulation, Prediction.


Assuntos
Infertilidade Feminina , Infertilidade , Clomifeno/uso terapêutico , Feminino , Hormônio Foliculoestimulante , Humanos , Infertilidade Feminina/tratamento farmacológico , Indução da Ovulação , Turquia
3.
BMC Health Serv Res ; 22(1): 79, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-35033079

RESUMO

BACKGROUND: Critically ill patients treated in the intensive care units (ICUs) often suffer from side effects and drug-related problems (DRPs) that can be life-threatening. A way to prevent DRPs and improve drug safety and efficacy is to include clinical pharmacists in the clinical team. This study aims to evaluate the classification of drug-related problems and the implementation of clinical pharmacy services by a clinical pharmacist in the ICU of a university hospital in Turkey. METHODS: This study was carried out prospectively between December 2020 and July 2021 in Gazi University Medical Faculty Hospital Internal Diseases ICU. All patients hospitalized in the intensive care unit for more than 24 h were included in the study. During the study, the clinical pharmacist's interventions and other clinical services for patients were recorded. DRPs were classed according to the Pharmaceutical Care Network Europe V.8.02. RESULTS: A total of 151 patients were included during the study period corresponding to 2264 patient-days. Patients with DRPs had a longer hospital stay and a higher mortality rate (p < 0.05). 108 patients had at least one DRP and the total number of DRPs was 206. There was an average of 1.36 DRPs per patient, 71.5% of patients experienced DRP and 89.22 DRPs per 1000 patient-days. A total of 35 ADEs were observed in 32 patients. ADE incidence was per 1000 patient-days 15.45. ADEs were caused by nephrotoxicity (48.57%), electrolyte disorders (17.14%), drug-induced thrombocytopenia (17.14%), liver enzyme increase (8.57%) and other causes (8.57%). Drug selection (40.29%) and dose selection (54.36%) constituted most of the causes of DRPs. Dose change was the highest percentage of planned interventions with a rate of 56.79%. Intervention was accepted at a rate of 90.8% and it was fully implemented. CONCLUSION: In this study, the importance of the clinical pharmacist in the determination and analysis of DRPs was emphasized. Clinical pharmacy services like the one described should be implemented widely to increase patient safety.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Preparações Farmacêuticas , Serviço de Farmácia Hospitalar , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle , Hospitais Universitários , Humanos , Unidades de Terapia Intensiva , Farmacêuticos , Turquia/epidemiologia
4.
Niger J Clin Pract ; 25(1): 44-48, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35046194

RESUMO

Background: This study aimed to develop a valid and reliable questionnaire of knowledge about oral health in childhood and a scale of self-perceived competency for pediatricians. In this way, the contributions of Turkish pediatricians on oral health in childhood and their effects on children's oral health and caregivers will be evaluated. Subjects and Methods: Items were generated from published scientific literature, other questionnaires, and interviewing notes with the pedodontists. The study group examined publications on the preventive oral health of children, and they included items related to children in the item pool. The initial knowledge questionnaire consisted of 23 items and 10 items for the self-perceived competency scale. The content validity of the questionnaire and scale were determined by the assessments of the expert team. The internal consistency of the knowledge questionnaire and test-retest reliability of the self-perceived competency scale was examined. Results: Thirty pediatricians took part in the study. The pediatricians were: 63.3% (n = 19) female and 36.7% (n = 11) male; their mean age was 37.97 ± 3.86 years. Most of the pediatricians were specialists with 83.4% (n = 25). The medical specialization of all pediatricians was university and the working year mean was 10.93 ± 4.28. The knowledge questionnaire had 10 items after content validity and internal consistency reliability investigations. The initial number of items for the self-perception level scale was 10. We excluded five items due to the content validity index. ICC value for 5-item self-perception level scale was calculated as 0.816 (95% CI: 0.606-0.914). Therefore, the scale has a good reliability level. Conclusion: Our knowledge questionnaire and self-perceived competency scale provide a validated and reliable tool in the assessment of pediatricians' knowledge and competency regarding oral health. Pediatricians can test themselves using this knowledge questionnaire and self-perceived competency scale.


Assuntos
Saúde Bucal , Pediatras , Adulto , Criança , Feminino , Humanos , Masculino , Reprodutibilidade dos Testes , Inquéritos e Questionários , Turquia
5.
Neurosciences (Riyadh) ; 27(1): 24-30, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35017287

RESUMO

OBJECTIVES: To investigate catechol-O-methyltransferase (COMT) Val158Met gene polymorphism in MDMA use disorder (MUD) by comparing genotype distributions between MUD patients and healthy controls considering clinical parameters. METHODS: Eighty-two MUD patients' were consecutively admitted to the outpatient psychiatry clinic in May 2019-January 2020, and 95 healthy volunteers were included in the case-control study. We used the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) to determine COMT Val158Met polymorphism. RESULTS: The COMT Val158Met genotype distribution and allele frequencies of the MUD patient group were significantly different from the healthy control group. The Met/Met genotype (OR: 2.692; 95% Cl: 1.272-5.698; p=0.008) and Met allele frequencies (OR: 1.716; 95% Cl: 1.118-2.633; p=0.013) were significantly higher in the control group than in MUD patients. When the COMT Val158Met genotype and allele frequency distributions were compared between 2 groups according to the psychotic symptoms in the MUD patient group, the COMT Val158Met genotype distributions were significantly different between the groups of patients. The percentage of patients with the Val/Val genotype was significantly lower in MUD patients with a psychotic symptom than the MUD patients without a psychotic symptom (OR: 2.625; 95% Cl: 1.069-6.446; p=0.033). CONCLUSION: The COMT Val158Met gene polymorphism was found to be related to the MUD-diagnosed Turkish patients and MDMA-induced psychotic symptoms.


Assuntos
Catecol O-Metiltransferase , N-Metil-3,4-Metilenodioxianfetamina , Psicoses Induzidas por Substâncias/genética , Estudos de Casos e Controles , Catecol O-Metiltransferase/genética , Genótipo , Humanos , N-Metil-3,4-Metilenodioxianfetamina/efeitos adversos , Polimorfismo de Nucleotídeo Único , Turquia
6.
Afr J Paediatr Surg ; 19(2): 89-96, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35017378

RESUMO

Aim: The aim of this study was to evaluate the mortality and morbidity of infants <1 year of age with intestinal obstruction requiring surgical intervention and to investigate the factors affecting mortality and hospital length of stay in paediatric surgery, including albumin-haemoglobin index. Patients and Methods: The records of gastrointestinal paediatric surgeries in the past 10 years of patients who were <1-year-old at Baskent University Konya Hospital were obtained from the hospital and retrospectively studied. Patient characteristics, especially the relationship between albumin haemoglobin index (AHI) and hospital duration and mortality, were examined. According to the surgical areas, it also subjected this relationship to further analysed in subgroups. Results: There were 144 cases who fulfilled the inclusion criteria. Pre-operative serum AHI was analysed using receiver operating characteristics (ROC) curve analyzes. In the ROC analysis, AHI had a diagnostic value in predicting case discharge rates (area under the curve: 0.755, P = 0.001). When the cut-off point was set at 46.18, the sensitivity of the test was 57.5% and the sensitivity for predicting survival was 84%. In the logistic regression model to estimate survival, the odds ratio of AHI was 1.063 (confidence interval: 1.020-1.108, P = 0.004). In subgroup analyzes, AHI positively predicted survival in the NEC group and in the other group. In a linear regression model analysing the effect of AHI on hospital stay of length, AHI explained 10% of the variance in the hospital stay of length variable and significantly and negatively influenced the hospital length variable (ß = -0.319, P = 0.05). In the linear regression model for subgroup analyzes, AHI significantly and negatively predicted hospital length of stay in the NEC and pyloric surgery groups, but positively predicted hospital length of stay in the perforation group. Conclusion: The AHI can be used as a valuable marker to predict the likelihood of discharge and length of hospital stay in paediatric surgical cases <1-year-old.


Assuntos
Albuminas , Procedimentos Cirúrgicos do Sistema Digestório , Hemoglobinas , Mortalidade Hospitalar , Tempo de Internação , Humanos , Lactente , Prognóstico , Curva ROC , Estudos Retrospectivos , Turquia
7.
Clin Lab ; 68(1)2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-35023674

RESUMO

BACKGROUND: Mutations of the BRCA1/2 genes are associated with increased breast and ovarian cancer. The aim of this study was to investigate the founder mutations of the BRCA1 and BRCA2 genes in the Turkish population in the Aegean region as well as their genotype-phenotype correlations. METHODS: All the patients were provided with BRCA1/2 testing criteria according to the National Comprehensive Cancer Network. QIAseq Targeted DNA Panels were used for the BRCA1/2 coding regions. RESULTS: Of the 181 studied patients, 38 (21%) were found to carry pathogenic or likely pathogenic mutations, while 20 (11%) patients were found to carry variants of unknown significance. The most common pathogenic mutations were NM_000059.4:c.2765dup in the BRCA2 gene and NM_007300.4:c.981_982del and NM_007294.3:c. 5266dup in the BRCA1 gene. p.Lys3326* was the most frequently detected variant of unknown significance (6/ 181). Regarding genotype-phenotype correlations, the NM_007300.4:c.981_982del mutation in BRCA1 gene was found to be milder in terms of breast cancer. The most frequent cancers other than those related to BRCA genes, observed in the relatives of the patients who had pathogenic variants and variants of unknown significance, were endometrium cancer and leukemia, respectively. CONCLUSIONS: NM_007294.3:c.5266dup was found to be a candidate founder mutation in the Turkish population. NM_007300.4:c.981_982del mutation seems to have a milder course in terms of breast cancer. A significantly increased frequency of p.Lys3326* variant in breast cancer and ovarian cancer patients compared with that in the 1,000 Genomes Project suggesting that this variant has a slight effect on BRCA2 function.


Assuntos
Neoplasias da Mama , Neoplasias Ovarianas , Proteína BRCA1/genética , Proteína BRCA2 , Neoplasias da Mama/genética , Feminino , Genes BRCA1 , Estudos de Associação Genética , Predisposição Genética para Doença , Humanos , Mutação , Neoplasias Ovarianas/genética , Turquia
8.
Nonlinear Dynamics Psychol Life Sci ; 26(1): 105-121, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34973162

RESUMO

This study investigated the existence of chaotic structure in voting behavior by considering non-economic and macroeconomic factors in Turkey during the period of 03.1986-01.2020. The chaotic structure among the analyzed variables was characterized by Lyapunov exponents that explore the chaotic dynamics of the series. Following, the effects of inflation, unemployment, economic growth and terror on party votes were analyzed by Fourier regression model. Then, the causality among the macroeconomic variables, terror and party groups was analyzed by the Granger causality method. According to our results, there is unidirectional causality from terror to all four party groups. In the context of macroeconomic variables, there is the evidence of bidirectional causality between conservative parties and inflation; unidirectional causality from inflation to center-right and center-left parties. There is no causality between nationalist parties and inflation. Furthermore, center-right and center-left parties have the evidence of no causality with unemployment while there is unidirectional causality from unemployment to conservative and nationalist parties. There is unidirectional causality from economic growth to conservative parties and bidirectional causality between center-right parties and economic growth. However, the center-left and nationalist parties are not the sources of Granger causality of economic growth, and there is no inverse Granger causality relationship between these variables. Therefore, it can be concluded that between the periods 03.1986-01.2020, there was no concern for economic growth in left-wing and nationalist-based parties in Turkey.


Assuntos
Desenvolvimento Econômico , Política , Causalidade , Humanos , Turquia , Desemprego
9.
Environ Monit Assess ; 194(2): 104, 2022 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-35041091

RESUMO

In this study, the seasonal variation, transport routes, and potential source areas of PM10 in the central district of Kirklareli (Turkey) were investigated. It was determined that PM10 concentrations had the highest seasonal average value in autumn and the lowest seasonal average value in spring. Cumulative distributions of PM10 concentrations data set were examined. In order to determine the air mass source and transport routes, the backward trajectories of the air masses obtained by using the hybrid single-particle Lagrangian integrated trajectory (HYSPLIT) model were run and cluster analysis, which is one of the multivariate statistical analyses, was performed. Cluster analysis results revealed that there are five main clusters affecting the receptor site in all four seasons. By defining the PM10 concentrations data as an input to the potential source contribution function (PSCF) model, the probable locations of potential source areas were identified. It has been observed that there are obvious seasonal differences in the potential source areas of PM10. High PSCF values were observed especially in Greece and the Mediterranean during the winter and especially in Albania and Greece during the spring. While high PSCF values were observed especially in the Anatolian side of Istanbul, Kocaeli, Sakarya, and the Black Sea coasts of these regions during the summer, they were observed especially in Izmir and Balikesir during the autumn.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Monitoramento Ambiental , Material Particulado/análise , Estações do Ano , Turquia
10.
Environ Res ; 204(Pt A): 111922, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-34453897

RESUMO

Ipsala district located in the northwest of Turkey is an intensive agricultural area, where paddy cultivation has been carried out for more than 50 years. The main source for drinking water in the area is groundwater. Since large amounts of agrochemicals are applied to the paddy fields, groundwater in the study area can be contaminated with toxic metal (loid)s (TMs). In this study, levels of eight TMs in the drinking water samples taken from the district and its 22 villages in the dry and wet seasons were measured and compared with drinking water quality guidelines. In addition, non-carcinogenic and carcinogenic health risks, and pollution status of TMs were assessed. The mean values of Cd, Ni, Cu, Zn, Mn, Pb, As and Cr in both seasons were below the drinking water limits. High clay content and low infiltration rate of the soils in the study area may have caused low TM concentrations. The TMs levels were higher in the wet season due to high rainfall intensity. Metal pollution indices indicated that groundwater quality is suitable for potable uses. All hazard quotient and hazard index results for children and adults in both seasons were lower than the acceptable risk level of 1. Carcinogenic risk results of As and Cr in both seasons were within or below the acceptable risk range. These findings revealed that the TMs in the drinking water would not pose health risks to the local residents.


Assuntos
Água Subterrânea , Metais Pesados , Poluentes do Solo , Poluentes Químicos da Água , Adulto , Criança , Monitoramento Ambiental , Humanos , Metais Pesados/análise , Metais Pesados/toxicidade , Medição de Risco , Estações do Ano , Poluentes do Solo/análise , Poluentes do Solo/toxicidade , Turquia , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/toxicidade , Qualidade da Água
11.
Ulus Travma Acil Cerrahi Derg ; 28(1): 78-83, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34967430

RESUMO

BACKGROUND: Overtime, agricultural machines have been designed appropriate to more simple needs, instead of tractors which have a wide area of use. An example of these is the 'patpat,' so named because of the sound of the motor, and for which the main purpose is ploughing. METHODS: A patpat is a single-axle, two-wheeled tractor with a trailer attached. In this descriptive study, the descriptive characteristics and causes of death were analyzed of case related to patpat accidents for which autopsies were performed by the Forensic Medicine Institution Trabzon Group Directorate between 2006 and 2017. RESULTS: Information was retrieved from the scene of accident examination documents, and the autopsy and laboratory records. The 21 cases comprised 17 (81%) males and 4 (19%) females, with a mean age of 47.6±20.3 years (median: 57, range: 10-75 years). Of the total accidents, in 85.7% (n=18), no other vehicle was involved. Following the accident, 52.4% (n=11) of the patpats were found at the side of the road, and 33.3% (n=7) at the edge of a stream or at the bottom of a steep valley. The cause of the accident was determined to be that the patpat had overturned on a bend in 33.3% (n=7) cases and in 85.7% (n=18) of cases, the patpat was found overturned or on its side. The most common injury was being thrown from the vehicle (38.1%, n=8), and in 66.7% (n=14) of cases, the deceased was the patpat driver. CONCLUSION: Patpat accidents are a serious problem because of the frequency of use of these vehicles without proper supervision and especially because of the hazardous topographical conditions where they are used.


Assuntos
Acidentes de Trânsito , Acidentes , Adulto , Idoso , Mar Negro , Feminino , Medicina Legal , Humanos , Masculino , Pessoa de Meia-Idade , Veículos Automotores , Turquia/epidemiologia
12.
Ulus Travma Acil Cerrahi Derg ; 28(1): 69-77, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34967431

RESUMO

BACKGROUND: Violence against women deprives women of their rights to enjoy equality, security, dignity, self-worth and fundamental freedoms and devalues them; is one of the most significant social facts that force women to exist at a lower social level than men and constitute a significant obstacle to the formation of healthy societies. This study was conducted to determine the status of exposure to spousal violence of 15 years and older married women living in the city center. METHODS: Family health centers in Elazig Province were visited and 792 married women were selected from the related records by systematic sampling. As a data collection tool, a questionnaire form was used. The questionnaire consists of two parts. In the first part, participants were asked about demographic characteristics such as age, gender, education level, and profession, while in the second part, questions were asked to determine the extent of exposure to violence. Questionnaires were filled out using interview technique by making home visits. RESULTS: It has been found that the low level of education of the wife and her spouse, perception of the economic situation of the family as being bad, and the fact that the woman does not work in an income-generating business can be an important factor in exposing to both physical violence and economic violence by her husband. CONCLUSION: Conclusion: Rate of exposure to spousal violence is high in married women living in the city center of Elazig Province. Education and services should be provided for solving the problem at individual, familial, and social levels.


Assuntos
Maus-Tratos Conjugais , Feminino , Humanos , Masculino , Fatores de Risco , Inquéritos e Questionários , Turquia/epidemiologia , Violência
13.
Pestic Biochem Physiol ; 180: 104985, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34955178

RESUMO

The poultry red mite, Dermanyssus gallinae, is the most important blood sucking ectoparasite of egg laying hens and causes economic losses in poultry farms worldwide. Although various management methods exist, the control of poultry red mites (PRMs) mainly relies on acaricides such as pyrethroids and organophosphates (OPs) in many regions of the world. However, repeated use of these synthetic chemicals has resulted in resistance development causing control failure of PRM. In this study, we investigated acaricide resistance mechanisms of Turkish PRM populations. First, we obtained the COI sequence from 30 PRM populations from different regions in Turkey and identified four different COI haplotypes. Toxicity assays showed that four field-collected PRM populations were highly resistant to the pyrethroid alpha-cypermethrin, with resistance ratios (RRs) varying between 100- and 400-fold, while two of these populations had a RR of more than 24-fold against the OP acaricide phoxim. Biochemical assays showed a relatively higher activity of glutathione-S-transferases and carboxyl-cholinesterases, two well-known classes of detoxification enzymes, in one of these resistant populations. In addition, we also screened for mutations in the gene encoding the voltage-gated sodium channel (vgsc) and acetylcholinesterase 1 (ace-1), the target-site of pyrethroids and OPs, respectively. In all but two PRM populations, at least one vgsc mutation was detected. A total of four target-site mutations, previously associated with pyrethroid resistance, M918T, T929I, F1534L, F1538L were found in domain II and III of the VGSC. The T929I mutation was present in the vgsc of almost all PRM populations, while the other mutations were only found at low frequency. The G119S/A mutation in ace-1, previously associated with OP resistance, was found in PRM for the first time and present in fourteen populations. Last, both alive and dead PRMs were genotyped after pesticide exposure and supported the possible role of target-site mutations, T929I and G119S, in alpha-cypermethrin and phoxim resistance, respectively. To conclude, our study provides a current overview of resistance levels and resistance mutations in Turkish PRM populations and might aid in the design of an effective resistance management program of PRM in Turkey.


Assuntos
Acaricidas , Ácaros , Acaricidas/toxicidade , Acetilcolinesterase , Animais , Galinhas , Turquia
14.
J Sci Food Agric ; 102(2): 813-822, 2022 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-34223652

RESUMO

BACKGROUND: 'Karaerik' is a novel table grape (Vitis vinifera L.) native to Turkey and widely cultivated in areas bordering the city of Erzincan. Because of the demonstrated beneficial effects on human health of the grape phenolic composition, the aim of this work was to conduct a detailed profiling of non-anthocyanin phenolic fractions from different grape tissues of the 'Karaerik' table grape. Both qualitative and quantitative characterization of phenolic compounds were achieved using high-performance liquid chromatography-diode array detection-electrospray ionization-tandem mass spectrometry. Total phenolic content and oxygen radical absorbance capacity were also determined to evaluate the antioxidant properties of this table grape. RESULTS: A high number of non-anthocyanin phenolic compounds was identified in 'Karaerik' table grape skins and seeds, including 11 flavonols, six hydroxycinnamic acid derivatives, two stilbenes, several monomeric and dimeric flavan-3-ols and proanthocyanidins. Quercetin-type derivatives dominated the flavonol profile of grape skins, followed by myricetin type. Tartaric acid esters of three acids (caffeic, coumaric and ferulic acids) were the main hydroxycinnamic acid derivatives in this cultivar. Qualitative and quantitative differences were observed in flavan-3-ol composition among the grape tissues. Proanthocyanidins were the most abundant class of phenolic compounds in 'Karaerik' grapes, being mainly located in seeds. Higher antioxidant capacity values were determined in grape seeds, in correlation with the total phenolic content. CONCLUSION: These results provide useful information for a better understanding of phenolic antioxidants from the 'Karaerik' table grape and will contribute to promoting the varietal identity and health-related properties of this fruit. © 2021 Society of Chemical Industry.


Assuntos
Antioxidantes/química , Fenóis/química , Extratos Vegetais/química , Vitis/química , Cromatografia Líquida de Alta Pressão , Frutas/química , Turquia
15.
Health Soc Care Community ; 30(1): 203-211, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-33894079

RESUMO

Working in agriculture may cause serious health problems due to heavy working conditions and chemical exposure. This Husserlian phenomenological qualitative study was conducted with 22 women working in greenhouse agriculture to investigate the health and social problem(s). In the evaluation of the data, Colaizzi's seven-step content analysis method and thematic analysis were used. The Kappa analysis was performed with two independent experts to measure the reliability of comparative fit, and the value obtained in the analysis was 1.00 (perfect fit). Based on the content analysis, six themes were defined. All participants indicated that they had different reproductive health-related problems. Some participants stated that their children had respiratory system-related problems and that they were subjected to physical, verbal/emotional and sexual violence by their husbands. It is important to provide health education, counselling services and screening programmes for women who work in greenhouse agriculture and thus are in the at-risk group for poor health.


Assuntos
Delitos Sexuais , Agricultura , Criança , Feminino , Humanos , Pesquisa Qualitativa , Reprodutibilidade dos Testes , Turquia
16.
Cancer Invest ; 40(2): 199-209, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34894960

RESUMO

PURPOSE: This study evaluated the efficacy and safety of everolimus (EVE) plus exemestane (EXE) in hormone-receptor positive (HR+), human epidermal growth factor receptor-2-negative (HER2-) metastatic breast cancer (MBC) patients in real-life settings. METHODS: Overall, 204 HR+, HER2- MBC patients treated with EVE + EXE after progressing following prior endocrine treatment were included. Overall survival (OS) and progression-free survival (PFS) and safety data were analyzed. RESULTS: The objective response rate, median PFS, and median OS were 33.4%, 8.9 months, and 23.4 months, respectively. Multivariate analysis revealed that negative progesterone receptor status was a significant determinant of poor treatment response (p = 0.035) and PFS (p = 0.024). The presence of bone-only metastasis was associated with better treatment response (p = 0.002), PFS (p < 0.001), and OS (p = 0.001). CONCLUSION: We confirmed the favorable efficacy and safety profile of EVE + EXE for HR+, HER - MBC patients.


Assuntos
Androstadienos/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Neoplasias da Mama/tratamento farmacológico , Everolimo/administração & dosagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Androstadienos/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias da Mama/metabolismo , Everolimo/uso terapêutico , Feminino , Humanos , Pessoa de Meia-Idade , Metástase Neoplásica , Receptor ErbB-2/metabolismo , Receptores de Estrogênio/metabolismo , Receptores de Progesterona/metabolismo , Estudos Retrospectivos , Análise de Sobrevida , Resultado do Tratamento , Turquia
17.
J Palliat Care ; 37(1): 18-25, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34402330

RESUMO

BACKGROUND: End-of-life care has become an important public health issue in recent years. Place of death is a major component of end-of-life care. Despite attempts to improve end-of-life care, there has not been published any data about place of deaths in Turkey. Aim: This retrospective, cross-sectional study investigates the place of death and trends over the years in geriatric age groups in Turkey. Methods: Patients who were admitted to geriatric outpatient clinic of a university hospital during a 7-year period were included. Place and date of death information were received from the death notification system and recorded as hospital or out-of-hospital death. Demographic and clinical data were collected from the hospital information system. Deaths occurring after March 1, 2020 were not included to eliminate the effect of coronavirus disease-2019 pandemic. Results: A total of 4025 (20.7%) patients were determined to be dead. Approximately three-quarters of deaths (73.0%) occurred in hospital. The number of deaths reported from nursing homes was only 13 (3.0%). Patients with dementia less frequently died in hospital, however, it was not statistically significant (12.4% vs 14.7%, P = .05). The prevalence of death in hospital was significantly higher in patients with chronic renal failure (3.1% vs 1.7%, P = .02). The presence of comorbid conditions such as heart failure, cerebrovascular disease, Parkinson's disease, chronic obstructive pulmonary disease/asthma, and cancer did not affect the place of death (P = .24, .21, .24, .51, and .18). Out-of-hospital mortality increased with advanced age (P < .001). No significant difference was found in the place of death over the years (P = .41). Conclusion: To the best of our knowledge, this is the first study examining the place of death in Turkey, an aging country. Our results may help to establish policies about end-of-life care in elderly people to improve quality of life by using resources effectively.


Assuntos
COVID-19 , Assistência Terminal , Idoso , Estudos Transversais , Humanos , Qualidade de Vida , Estudos Retrospectivos , SARS-CoV-2 , Turquia/epidemiologia
18.
Support Care Cancer ; 30(1): 865-874, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34392415

RESUMO

PURPOSE: This study aims to determine the financial toxicity (FT) level in cancer patients, identify the risk factors associated with this level, and reveal the effect of this level on patient outcomes (health-related quality of life (HRQoL) and treatment non-adherence). METHODS: The data of 316 cancer patients, who were receiving inpatient treatment in an oncology hospital affiliated to a public university in Ankara, Turkey, were ≥ 18 years old, and were receiving chemotherapy for at least 3 months, were evaluated. The data were collected through a face-to-face interview. FT was measured with the COmprehensive Score for financial Toxicity (COST) Measure (v2), HRQoL was measured with the Functional Assessment of Cancer Therapy-General (FACT-G) Scale (v4), and treatment adherence was measured using a questionnaire created by conducting a literature review. RESULTS: Patients were found to experience FT above the moderate level (mean ± SD, 21.85 ± 12.02; median value, 24.0). Younger age, being married, low education level, low monthly household income, and receiving social/economic support for treatment were revealed to be the determinants of high FT. Moreover, as the FT score decreased (as the FT level felt increased), the HRQoL was observed to decrease, and treatment non-adherence increased. CONCLUSION: The results indicate that FT problem is also valid for cancer patients in Turkey despite the system of general health insurance. The FT was found to result from socio-economic characteristics rather than the disease and treatment-related characteristics. The significant associations revealed between FT and patient outcomes emphasize the importance of reducing the FT in cancer patients.


Assuntos
Neoplasias , Qualidade de Vida , Adolescente , Efeitos Psicossociais da Doença , Estresse Financeiro , Humanos , Neoplasias/tratamento farmacológico , Inquéritos e Questionários , Cooperação e Adesão ao Tratamento , Turquia
19.
Int J Food Microbiol ; 361: 109461, 2022 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-34742144

RESUMO

The main objective of this study was to isolate and identify Staphylococcus aureus from retail raw red meat samples and evaluate their enterotoxin gene and antibiotic resistance profiles. A total of 452 retail raw meat samples, including beef (n = 200), sheep (n = 125), and lamb (n = 127) randomly purchased from various supermarkets and butchers in Ankara between July 2019 and November 2020, were tested for the prevalence of S. aureus. The S. aureus strain was identified using morphological and molecular (16S rRNA and nuc gene) methods. Moreover, nine Staphylococcal enterotoxin (SE) genes were screened using polymerase chain reaction. Antibiotic resistance of S. aureus was determined using the phenotypic disc diffusion method. The overall prevalence of S. aureus among screened samples was 21.23%. Additionally, 65.62% of S. aureus strains contained SE gene regions. The predominant SEs in the S. aureus strains were sea (50.79%), followed by sed (25.39%) and seb (23.80%). However, sec, see, seg, seh, sei, and sej genes were never detected. A substantial proportion (40-100%) of the isolates were found resistant to kanamycin, telithromycin, penicillin G, streptomycin, erythromycin, cloxacillin, ampicillin, pristinamycin, nalidixic acid, azithromycin, and ciprofloxacin. Multi-drug resistance (MDR) was observed in 96.87% of the S. aureus strains. These results show a low prevalence of S. aureus in raw red meat samples in Turkey. However, a high rate of SEA raises serious health concerns. Due to the high levels of MDR observed in this study, there is a need to strictly control antibiotic use in animals in Turkey.


Assuntos
Carne Vermelha , Infecções Estafilocócicas , Animais , Bovinos , Resistência Microbiana a Medicamentos , Enterotoxinas/genética , Microbiologia de Alimentos , Carne , Prevalência , RNA Ribossômico 16S , Ovinos , Staphylococcus aureus/genética , Turquia
20.
J Med Virol ; 94(1): 287-290, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34487373

RESUMO

In the 10th month of the pandemic, coronavirus disease 2019 (COVID-19) vaccination was given first to healthcare workers in Turkey after receiving emergency use approval from the Ministry of Health. This study, which was performed at the COVID-19 reference center in Ankara (the capital of Turkey) aimed to evaluate the seroconversion rate of the CoronaVac vaccine. The anti-spike immunoglobulin G response to the two-dose vaccination was retrospectively examined in healthcare workers who had no previous history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The postvaccine seroconversion rate was investigated by measuring the antibody levels of healthcare workers who had received CoronaVac. Vaccination was administered as 600 SU in 28-day intervals. The healthcare workers' anti-SARS-CoV-2 immunoglobulin G levels were used to determine the seroconversion rate 2 months after the second dose of the vaccine. Of the healthcare workers, 22.9% (n = 155) were seronegative. The younger the age of the participant, the higher the level of anti-SARS-CoV-2 immunoglobulin G. Furthermore, anti-SARS-CoV-2 immunoglobulin G levels were much higher in women than men.


Assuntos
Anticorpos Neutralizantes/sangue , Anticorpos Antivirais/sangue , Vacinas contra COVID-19/imunologia , COVID-19/prevenção & controle , Imunização Secundária/métodos , SARS-CoV-2/imunologia , Adulto , Idoso , COVID-19/imunologia , Proteínas do Nucleocapsídeo de Coronavírus/imunologia , Feminino , Pessoal de Saúde/estatística & dados numéricos , Humanos , Esquemas de Imunização , Imunoglobulina G/sangue , Masculino , Pessoa de Meia-Idade , Fosfoproteínas/imunologia , Estudos Retrospectivos , Soroconversão/fisiologia , Turquia , Vacinas de Produtos Inativados/imunologia , Vacinas Sintéticas/imunologia , Adulto Jovem
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