Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis.
Cui, Wenpeng; Maimaitiyiming, Hasiyeti; Qi, Xinyu; Norman, Heather; Zhou, Qi; Wang, Xiaojun; Fu, Jian; Wang, Shuxia.
Am J Physiol Renal Physiol
; 306(9): F996-1007, 2014 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-24573388
The cyclic GMP-dependent protein kinase Iα suppresses kidney fibrosis.
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Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling.
Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46.
Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation.
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Pirfenidone suppresses MAPK signalling pathway to reverse epithelial-mesenchymal transition and renal fibrosis.
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation.
N-acetyl-seryl-aspartyl-lysyl-proline mediates the anti-fibrotic properties of captopril in unilateral ureteric obstructed BALB/C mice.
Erythropoietin protects the tubular basement membrane by promoting the bone marrow to release extracellular vesicles containing tPA-targeting miR-144.