Facilitation of <i>I</i> <sub>Kr</sub> current by some hERG channel blockers suppresses early afterdepolarizations.
Furutani, Kazuharu; Tsumoto, Kunichika; Chen, I-Shan; Handa, Kenichiro; Yamakawa, Yuko; Sack, Jon T; Kurachi, Yoshihisa.
J Gen Physiol
; 151(2): 214-230, 2019 02 04.
Artigo em Inglês | MEDLINE | ID: mdl-30674563
Cryo-EM Structure of the Open Human Ether-à-go-go-Related K<sup>+</sup> Channel hERG.
Temperature Dependence of the Biophysical Mechanisms Underlying the Inhibition and Enhancement Effect of Amiodarone on hERG Channels.
Selectivity filter modalities and rapid inactivation of the hERG1 channel.
Gating mechanism of Kv11.1 (hERG) K<sup>+</sup> channels without covalent connection between voltage sensor and pore domains.
Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C.
Increased Smooth Muscle Kv11.1 Channel Expression in Pulmonary Hypertension and Protective Role of Kv11.1 Channel Blocker Dofetilide.
Structural implications of hERG K<sup>+</sup> channel block by a high-affinity minimally structured blocker.
A helical segment makes potassium channels go-go.
Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.
Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL).