Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches.
Chem Pharm Bull (Tokyo)
; 68(1): 34-45, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31902900
Chemoprobe-based assays of histone lysine demethylase 1A target occupation enable <i>in vivo</i> pharmacokinetics and pharmacodynamics studies of KDM1A inhibitors.
A chemoprobe tracks its target.
Inhibitors of Protein Methyltransferases and Demethylases.
The mechanism of OTUB1-mediated inhibition of ubiquitination.
3D-QSAR (CoMFA, CoMSIA), molecular docking and molecular dynamics simulations study of 6-aryl-5-cyano-pyrimidine derivatives to explore the structure requirements of LSD1 inhibitors.
Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8.
Types of Ubiquitin Ligases.
Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors.
Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors.
PIASÎ³ controls stability and facilitates SUMO-2 conjugation to CoREST family of transcriptional co-repressors.