Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
Acta cir. bras
; Acta cir. bras;32(3): 194-202, Mar. 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-837694
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats.Methods:
The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH.Results:
No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed.Conclusions:
Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.Key words
Full text:
1
Collection:
01-internacional
Topics:
Aperfeicoar_gestao_SUS
Database:
LILACS
Main subject:
Stilbenes
/
Carotenoids
/
Hepatectomy
/
Liver
/
Antioxidants
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Year:
2017
Document type:
Article