Synthesis of glycal amides from amino acid esters by carbonylative coupling reaction
European J Org Chem, v. 2022, n. 30, e202200332, ago. 2022
Article
in En
| SES-SP, SESSP-IBPROD, SES-SP
| ID: bud-4473
Responsible library:
BR78.1
ABSTRACT
Glycal amides were prepared for the first time by reacting 2-iodo-D-glycals with L-amino acid esters via a Pd-catalyzed carbonylative cross-coupling reaction, by using Mo(CO)6 as the carbon monoxide source. Glycal amides were synthesized in moderate to good yields under our optimized conditions. In addition, the acetyl groups of the glucal amides could be readily removed to obtain the corresponding trihydroxy derivatives in good yields.
Full text:
1
Collection:
06-national
/
BR
Database:
SES-SP
/
SESSP-IBPROD
Language:
En
Journal:
European J Org Chem
Year:
2022
Document type:
Article