Two cases of disseminated mucormycosis in patients with hematological malignancies and literature review.
Eur J Clin Microbiol Infect Dis
; 17(12): 859-63, 1998 Dec.
Article
in En
| MEDLINE
| ID: mdl-10052550
ABSTRACT
Two cases of disseminated mucormycosis in patients with underlying hematological disease are described. Both patients presented with fever and pulmonary infiltrates which did not respond to empirical treatment with broad-spectrum antibiotics and antifungal agents, and in both patients there was rapid progression with a fatal outcome. All cultures were negative and the diagnosis was made postmortem. A review of the literature revealed only three recent reports of successful treatment of disseminated mucormycosis. Survival correlated with control of the underlying disease and early diagnosis based on histological examination of biopsy specimens from suspected lesions. Therapy consisted of surgical debridement and amphotericin B. Standard therapeutic schedules need to be defined for this infection.
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Collection:
01-internacional
Health context:
6_ODS3_enfermedades_notrasmisibles
Database:
MEDLINE
Main subject:
Leukemia, Myeloid, Acute
/
Leukemia, Lymphoid
/
Mucormycosis
Type of study:
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Eur J Clin Microbiol Infect Dis
Year:
1998
Document type:
Article