A case of chronic neutrophilic leukemia with deletion (11)(q23).

Terré, C; Garcia, I; Bastie, J N; Mayeur, D; Decombe, L; Gruyer, P; Berger, R; Castaigne, S

Terré, C; Garcia, I; Bastie, J N; Mayeur, D; Decombe, L; Gruyer, P; Berger, R; Castaigne, S.

Affiliation

Terré C; Laboratoire de Cytogénétique, Hôpital André Mignot, Le Chesnay, France.

Cancer Genet Cytogenet ; 110(1): 70-1, 1999 Apr.

Article in En | MEDLINE | ID: mdl-10198627

ABSTRACT

ABSTRACT

We report a case of chronic neutrophilic leukemia (CNL) in a 68-year-old man. Karyotype showed a clonal abnormality, never described before in CNL 46,XY,del(11)(q23). Southern blot analysis of the MLL gene did not reveal any rearrangement, and reverse transcriptase polymerase chain reaction (RT-PCR) analysis did not show any fusion of BCR-ABL. Treatment with hydroxyurea and cytosine arabisonide was ineffective.

Subject(s)

Chromosome Deletion; Chromosomes, Human, Pair 11; Leukemia, Neutrophilic, Chronic/genetics; Aged; Humans; Male

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Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 11 / Leukemia, Neutrophilic, Chronic / Chromosome Deletion Limits: Aged / Humans / Male Language: En Journal: Cancer Genet Cytogenet Year: 1999 Document type: Article

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