A case of chronic neutrophilic leukemia with deletion (11)(q23).
Cancer Genet Cytogenet
; 110(1): 70-1, 1999 Apr.
Article
in En
| MEDLINE
| ID: mdl-10198627
ABSTRACT
We report a case of chronic neutrophilic leukemia (CNL) in a 68-year-old man. Karyotype showed a clonal abnormality, never described before in CNL 46,XY,del(11)(q23). Southern blot analysis of the MLL gene did not reveal any rearrangement, and reverse transcriptase polymerase chain reaction (RT-PCR) analysis did not show any fusion of BCR-ABL. Treatment with hydroxyurea and cytosine arabisonide was ineffective.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 11
/
Leukemia, Neutrophilic, Chronic
/
Chromosome Deletion
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Cancer Genet Cytogenet
Year:
1999
Document type:
Article