Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain.

Peyroche, A; Antonny, B; Robineau, S; Acker, J; Cherfils, J; Jackson, C L

Peyroche, A; Antonny, B; Robineau, S; Acker, J; Cherfils, J; Jackson, C L.

Affiliation

Peyroche A; Service de Biochimie et Génétique Moléculaire, CEA/Saclay, Gif-sur-Yvette, France.

Mol Cell ; 3(3): 275-85, 1999 Mar.

Article in En | MEDLINE | ID: mdl-10198630

Subject(s)

Antifungal Agents/pharmacology; Brefeldin A/pharmacology; Fungal Proteins/metabolism; GTP-Binding Proteins/metabolism; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate/metabolism; Saccharomyces cerevisiae Proteins; Saccharomyces cerevisiae/drug effects; ADP-Ribosylation Factors; Amino Acid Sequence; Amino Acid Substitution; Drug Resistance, Microbial; Fungal Proteins/chemistry; Fungal Proteins/genetics; Fungal Proteins/isolation & purification; GTP-Binding Proteins/chemistry; GTP-Binding Proteins/genetics; GTP-Binding Proteins/isolation & purification; Gene Dosage; Guanosine Triphosphate/metabolism; Kinetics; Molecular Sequence Data; Mutation; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/isolation & purification; Recombinant Fusion Proteins/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/growth & development; Saccharomyces cerevisiae/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Fungal Proteins / GTP-Binding Proteins / Brefeldin A / GTPase-Activating Proteins / Guanine Nucleotide Exchange Factors / Saccharomyces cerevisiae Proteins / Guanosine Diphosphate / Antifungal Agents Language: En Journal: Mol Cell Year: 1999 Document type: Article

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