High and low molecular weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays.

Trbovich, A M; Hughes, F M; Perez, G I; Kugu, K; Tilly, K I; Cidlowski, J A; Tilly, J L

Trbovich, A M; Hughes, F M; Perez, G I; Kugu, K; Tilly, K I; Cidlowski, J A; Tilly, J L.

Affiliation

Trbovich AM; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114 USA.

Cell Death Differ ; 5(1): 38-49, 1998 Jan.

Article in En | MEDLINE | ID: mdl-10200444

Subject(s)

Apoptosis/physiology; Cell Nucleus/enzymology; Deoxyribonucleases/metabolism; Endopeptidases/metabolism; Follicular Atresia/metabolism; Ovarian Follicle/cytology; Animals; Antirheumatic Agents/pharmacology; Apoptosis/drug effects; Caspase 1/metabolism; Caspase Inhibitors; Cell Nucleus/chemistry; Cell-Free System; Cysteine Proteinase Inhibitors/pharmacology; DNA/chemistry; DNA/metabolism; Deoxyribonucleases/antagonists & inhibitors; Diphenylamine/analogs & derivatives; Diphenylamine/pharmacology; Female; Gold Sodium Thiomalate/pharmacology; HeLa Cells; Humans; Molecular Weight; Oligopeptides/pharmacology; Ovarian Follicle/metabolism; Rats; Rats, Sprague-Dawley; Serine Proteinase Inhibitors/pharmacology; Tosyllysine Chloromethyl Ketone/pharmacology; Tosylphenylalanyl Chloromethyl Ketone/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / Cell Nucleus / Apoptosis / Deoxyribonucleases / Follicular Atresia / Ovarian Follicle Limits: Animals / Female / Humans Language: En Journal: Cell Death Differ Year: 1998 Document type: Article

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