Preparation of N'-substituted anilino-N-methyl-N'nitrosoureas as candidate antitumor agents.
Arch Pharm Res
; 17(6): 420-3, 1994 Dec.
Article
in En
| MEDLINE
| ID: mdl-10319151
ABSTRACT
Various N'-substituted anilino-N-methyl-N'-nitrosoureas(2a-n) were easily prepared from the reaction of substituted phenylhydrazines (3-, 4-CH3, 3-, 4-OCH3, 3-, 4-F, 3-, 4-Cl, 4-Br, 2-, 3-, 4-NO2, 2, 4-(NO2)2 with methyl isocyanate, followed by the nitrosation with 99% HCOOH and dry sodium nitrite powder. Surprisingly of these series of analogus, the anilino-nitrosoureas substituted with electron-withdrawing nitro groups (2k-n) showed significantly low ED50 values of 1.4-3.4 micrograms/ml. In addition, none of these compounds substituted with electron-donating groups exhibited cytotoxicities.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aniline Compounds
/
Antineoplastic Agents
/
Nitrosourea Compounds
Limits:
Animals
Language:
En
Journal:
Arch Pharm Res
Year:
1994
Document type:
Article