Clonidine inhibits and phorbol acetate activates glutamate release from rat spinal synaptoneurosomes.

Shinomura, T; Nakao, S; Adachi, T; Shingu, K

Shinomura, T; Nakao, S; Adachi, T; Shingu, K.

Affiliation

Shinomura T; Department of Anesthesia, Kyoto University Hospital, Japan. shino@kuhp.kyoto-u.ac.jp

Anesth Analg ; 88(6): 1401-5, 1999 Jun.

Article in En | MEDLINE | ID: mdl-10357352

Subject(s)

Adrenergic alpha-Agonists/pharmacology; Clonidine/pharmacology; Cyclic AMP-Dependent Protein Kinases/metabolism; Glutamic Acid/metabolism; Protein Kinase C/metabolism; Spinal Cord/metabolism; Synaptosomes/metabolism; Tetradecanoylphorbol Acetate/pharmacology; 4-Aminopyridine/pharmacology; Animals; Calcium/physiology; Colforsin/pharmacology; Dose-Response Relationship, Drug; Enzyme Activation; Glutamate Dehydrogenase/metabolism; In Vitro Techniques; Male; Potassium Chloride/pharmacology; Rats; Rats, Wistar; Spectrometry, Fluorescence; Spinal Cord/drug effects; Spinal Cord/ultrastructure; Synaptosomes/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Synaptosomes / Protein Kinase C / Tetradecanoylphorbol Acetate / Clonidine / Cyclic AMP-Dependent Protein Kinases / Adrenergic alpha-Agonists / Glutamic Acid Limits: Animals Language: En Journal: Anesth Analg Year: 1999 Document type: Article

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