Targeted expression of Bcl-2 in mouse oocytes inhibits ovarian follicle atresia and prevents spontaneous and chemotherapy-induced oocyte apoptosis in vitro.

Morita, Y; Perez, G I; Maravei, D V; Tilly, K I; Tilly, J L

Morita, Y; Perez, G I; Maravei, D V; Tilly, K I; Tilly, J L.

Affiliation

Morita Y; Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School, Boston 02114, USA.

Mol Endocrinol ; 13(6): 841-50, 1999 Jun.

Article in En | MEDLINE | ID: mdl-10379884

Subject(s)

Apoptosis/genetics; Follicular Atresia/genetics; Oocytes/metabolism; Oocytes/pathology; Proto-Oncogene Proteins c-bcl-2/genetics; Receptors, Cell Surface; Animals; Apoptosis/drug effects; Doxorubicin/pharmacology; Egg Proteins/genetics; Female; Gene Expression Regulation; Humans; Litter Size; Membrane Glycoproteins/genetics; Mice; Mice, Transgenic; Oocytes/drug effects; Ovarian Follicle/pathology; Ovulation; Pregnancy; Proto-Oncogene Proteins c-bcl-2/metabolism; Zona Pellucida Glycoproteins

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Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Apoptosis / Receptors, Cell Surface / Proto-Oncogene Proteins c-bcl-2 / Follicular Atresia Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Mol Endocrinol Year: 1999 Document type: Article

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