Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance.

Kharasch, E D; Jubert, C; Senn, T; Bowdle, T A; Thummel, K E

Kharasch, E D; Jubert, C; Senn, T; Bowdle, T A; Thummel, K E.

Affiliation

Kharasch ED; Anesthesiology Service, Puget Sound Veterans Affairs Health Care System, Seattle, Washington, USA.

J Clin Pharmacol ; 39(7): 664-9, 1999 Jul.

Article in En | MEDLINE | ID: mdl-10392320

Subject(s)

Alfentanil/pharmacokinetics; Anesthetics, Intravenous/pharmacokinetics; Cytochrome P-450 Enzyme System/metabolism; Liver/drug effects; Midazolam/pharmacokinetics; Mixed Function Oxygenases/metabolism; Adult; Alfentanil/blood; Alfentanil/metabolism; Anesthetics, Intravenous/metabolism; Cytochrome P-450 CYP3A; Humans; Liver/enzymology; Male; Metabolic Clearance Rate; Midazolam/blood; Midazolam/metabolism; Middle Aged; Reproducibility of Results; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Midazolam / Alfentanil / Anesthetics, Intravenous / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases / Liver Limits: Adult / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 1999 Document type: Article

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