Fetal muscle biopsy as a diagnostic tool in Duchenne muscular dystrophy.
Prenat Diagn
; 19(10): 921-6, 1999 Oct.
Article
in En
| MEDLINE
| ID: mdl-10521816
ABSTRACT
Duchenne muscular dystrophy (DMD) is a relentless progressive disorder, leading to severe disability during childhood and death in adolescence or early adulthood. In most families, prenatal diagnosis is readily achieved by molecular detection of DNA deletions using chorionic villi or amniocytes, or by linkage analysis. In some cases, however, molecular methods fail to provide a definitive diagnosis and in such cases in utero fetal muscle biopsy may serve as a diagnostic option. We describe three families in whom fetal muscle biopsy was performed, focusing on the prenatal diagnostic dilemmas, the indications and timing for in utero fetal muscle biopsy, and the difficulties encountered.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prenatal Diagnosis
/
Muscular Dystrophy, Duchenne
/
Fetal Diseases
/
Muscles
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Prenat Diagn
Year:
1999
Document type:
Article