Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance.
Arch Dermatol
; 135(10): 1237-42, 1999 Oct.
Article
in En
| MEDLINE
| ID: mdl-10522672
ABSTRACT
BACKGROUND:
In addition to the well-defined hereditary primary ichthyoses, many sporadic or less well-defined keratinization disorders with or without systemic manifestations have been reported. Herein we describe ichthyosiform dermatosis associated with type 2 diabetes mellitus. OBSERVATIONS The patients were members of a large Arab family with heavy consanguinity. Eighteen members were affected with a variously severe scaly disorder. They showed migratory polycyclic keratotic scaly plaques evolving into diffuse generalized scaling or complete remission. Acanthosis nigricans-like lesions were also noted, and there was an association with type 2 diabetes mellitus. A scarcity of intercorneocyte lamellae and reduction in lamellar body contents were observed.CONCLUSIONS:
We could not find a report of a similar dermatosis. Furthermore, an association between ichthyosis and diabetes has not been documented. Therefore, we believe that this may constitute a new entity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Ichthyosiform Erythroderma, Congenital
/
Diabetes Mellitus, Type 2
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Arch Dermatol
Year:
1999
Document type:
Article