Management of cerebral metastases from malignant melanoma: results of a combined, simultaneous treatment with fotemustine and irradiation.
J Neurooncol
; 43(2): 173-8, 1999 Jun.
Article
in En
| MEDLINE
| ID: mdl-10533730
ABSTRACT
We report results of a conservative treatment for brain metastases from malignant melanoma with a combination of irradiation and chemotherapy (fotemustine and/or DTIC). To date, 12 patients have been treated. There was a complete remission of the brain metastases in four patients. In two patients a partial remission was observed. The mean survival of the responder was 8.2 months (95% confidence interval 3.8-12.6 months). The most common side effects were thrombocytopenia, leukopenia, and alopecia. Altogether, the treatment was well tolerated. As the outcome of patients with brain metastases from malignant melanoma is generally poor, this combined chemo- and radiation therapy may provide improved care for such patients.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organophosphorus Compounds
/
Brain Neoplasms
/
Melanoma
/
Antineoplastic Agents
/
Nitrosourea Compounds
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Neurooncol
Year:
1999
Document type:
Article