Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.

Kharasch, E D; Jubert, C

Kharasch, E D; Jubert, C.

Affiliation

Kharasch ED; Department of Anesthesiology, University of Washington, Seattle 98195, USA. kharasch@u.washington.edu

Anesthesiology ; 91(5): 1267-78, 1999 Nov.

Article in En | MEDLINE | ID: mdl-10551576

Subject(s)

Acetylcysteine/metabolism; Anesthesia, Inhalation; Anesthetics, Inhalation; Ethers/metabolism; Hydrocarbons, Fluorinated/metabolism; Methyl Ethers; Propionates/metabolism; Acetylation; Acetylcysteine/urine; Adult; Aged; Anesthetics, Inhalation/adverse effects; Anesthetics, Inhalation/metabolism; Animals; Cysteine/analogs & derivatives; Cysteine/metabolism; Elective Surgical Procedures; Ethers/urine; Female; Gas Chromatography-Mass Spectrometry; Glutathione/metabolism; Humans; Hydrocarbons, Fluorinated/urine; Inactivation, Metabolic; Male; Methyl Ethers/adverse effects; Methyl Ethers/metabolism; Middle Aged; Propionates/urine; Rats; Sevoflurane

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Collection: 01-internacional Database: MEDLINE Main subject: Propionates / Acetylcysteine / Anesthetics, Inhalation / Ethers / Hydrocarbons, Fluorinated / Anesthesia, Inhalation / Methyl Ethers Type of study: Etiology_studies / Risk_factors_studies Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Anesthesiology Year: 1999 Document type: Article

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