Synthesis of Bcl-2 in response to anthracycline treatment may contribute to an apoptosis-resistant phenotype in leukemic cell lines.

Durrieu, F; Belaud-Rotureau, M A; Lacombe, F; Dumain, P; Reiffers, J; Boisseau, M R; Bernard, P; Belloc, F

Durrieu, F; Belaud-Rotureau, M A; Lacombe, F; Dumain, P; Reiffers, J; Boisseau, M R; Bernard, P; Belloc, F.

Affiliation

Durrieu F; Laboratoire Universitaire d'Hématologie, Université Victor Segalen, Bordeaux, France.

Cytometry ; 36(2): 140-9, 1999 Jun 01.

Article in En | MEDLINE | ID: mdl-10554162

Subject(s)

Antibiotics, Antineoplastic/therapeutic use; Apoptosis/drug effects; Idarubicin/therapeutic use; Leukemia, Myeloid/drug therapy; Leukemia, Myeloid/pathology; Proto-Oncogene Proteins c-bcl-2/biosynthesis; Proto-Oncogene Proteins c-bcl-2/physiology; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; Antibiotics, Antineoplastic/pharmacology; Apoptosis/genetics; Cell Division/drug effects; Ceramides/pharmacology; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm/genetics; Flow Cytometry; Gene Expression Regulation; HL-60 Cells; Humans; Idarubicin/adverse effects; Idarubicin/pharmacology; K562 Cells; Leukemia, Myeloid/genetics; Phenotype; Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins c-bcl-2/genetics; U937 Cells; bcl-2-Associated X Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Idarubicin / Leukemia, Myeloid / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Antibiotics, Antineoplastic Limits: Humans Language: En Journal: Cytometry Year: 1999 Document type: Article

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