Human and mouse SYBL1 gene structure and expression.
Gene
; 240(1): 233-8, 1999 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-10564831
ABSTRACT
SYBL1 is a gene in the 320kb human pseudo-autosomal region at the terminus of Xq and Yq. In contrast to other pseudoautosomal genes, SYBL1 is inactivated on one X in every female cell, and is also inactive on the Y of male cells. Hypermethylation of the CpG island associated with the human gene is involved in this phenomenon. In an attempt to further examine its regulation, the genomic organization of the X-linked mouse Sybl1 homolog was analyzed and compared with the human gene. Human and mouse show the same exon number, exon-intron junctions and a highly conserved basal promoter. The structural and functional conservation of basal regulatory regions suggests that inactivation is imposed by similar auxiliary epistatic regulatory mechanism.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genes
/
Membrane Proteins
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Gene
Year:
1999
Document type:
Article